van Gend, David It was to be the "new dawn" of stem cell science, but it was a false dawn. Every year for a decade the press releases of Geron Corp, a stem cell company in the US, reassured investors that their world-first treatment using embryonic stem cells in spinal injury was going to be approved "next year".1 And every year the regulating authority in the US, the FDA, failed to give approval, asking instead for further reassurance about the safety (...) of the trial. Finally, coinciding with the election of President Obama and the prospect of a new, liberated era of embryonic research, the FDA overcame its qualms and gave the go-ahead. (shrink)

La función cognitiva de la metáfora, en alguna de las versiones contemporáneas que la reivindican, alcanza un rango fundamental, pues con ella se pretende describir el modo en que se constituyen los sistemas conceptuales. Al respecto, intentaré mostrar sus límites, que surgen de la desatención a los procesos de formación lingüística; en su caso la formación de la palabra. A continuación, presentaré los rasgos de una teoría de la metáfora como enunciado, que aprovecha los rendimientos lingüísticos de esa formación para (...) establecer una relación tensiva con los conceptos. (shrink)

This is the first complete, one-volume English translation of the ancient Chinese text Xunzi, one of the most extensive, sophisticated, and elegant works in the tradition of Confucian thought. Through essays, poetry, dialogues, and anecdotes, the Xunzi articulates a Confucian perspective on ethics, politics, warfare, language, psychology, human nature, ritual, and music, among other topics. Aimed at general readers and students of Chinese thought, Eric Hutton’s translation makes the full text of this important work more accessible in English than ever (...) before. Named for its purported author, the Xunzi has long been neglected compared to works such as the Analects of Confucius and the Mencius. Yet interest in the Xunzi has grown in recent decades, and the text presents a much more systematic vision of the Confucian ideal than the fragmented sayings of Confucius and Mencius. In one famous, explicit contrast to them, the Xunzi argues that human nature is bad. However, it also allows that people can become good through rituals and institutions established by earlier sages. Indeed, the main purpose of the Xunzi is to urge people to become as good as possible, both for their own sakes and for the sake of peace and order in the world. In this edition, key terms are consistently translated to aid understanding and line numbers are provided for easy reference. Other features include a concise introduction, a timeline of early Chinese history, a list of important names and terms, cross-references, brief explanatory notes, a bibliography, and an index. (shrink)

Al asomarme a este texto descubro la disposición personal que anima su vocación pedagógica, y que cada uno de los lectores podrá advertir apenas comience a transitar su lectura. Si bien muchas de sus reflexiones convergen en lo que llamaríamos una propuesta clásica en la materia, esta convergencia está tematizada con cierta originalidad en dos aspectos: 1) por la lectura hermenéutica de los problemas, y 2), por su abordaje al objetivo pedagógico que alienta su vocación. Al respecto, no deja de (...) sorprendernos la invitación reiterada que formula al lector a fin de que atienda el ejemplo complementario a un contenido, al punto que uno tiene la sensación de estar en plena clase con la guía de un docente, quien con dedicada solicitud acompaña la problemática teórica con ejemplos adecuados para una mejor comprensión. En realidad, esta particular propedéutica que anima al autor se completa con explicar oportunamente un abordaje abiertamente hermenéutico a los mismos problemas, curiosidad que desarrolla específicamente en la segunda parte de la obra. Pero el punto exacto de su propósito queda resumido en este párrafo: "introduzco un tema que vertebra todo el texto: la vinculación del conocimiento científico con el provisto por el mundo de la vida". H. Daniel Dei Carlos Emilio Gende tiene a su cargo cátedras de Epistemología y Filosofía del lenguaje en carreras de la Universidad Nacional del Comahue, donde dirige el Proyecto "Aplicaciones del concepto de interpretación: percepción, metáfora y texto". Conferencista en Universidades del extranjero y Profesor invitado al Doctorado en Filosofía de la Universidad de Lanús. Dirige la revista Horizontes filosóficos, del Centro de estudios en Filosofía de las ciencias y Hermenéutica filosófica del Comahue e integra los comités académicos de varias revistas. Es autor de Lenguaje e interpretación en Paul Ricoeur (2007) y La interpretación de las metáforas (2019), ambos publicados por esta editorial. PROMETEO LIBROS ARGENTINA Este libro contiene el desarrollo de los siguientes temas, entre otros: - La legitimación filosófica del conocimiento científico - El conocimiento vehiculizado en proposiciones verdaderas - Las ciencias fácticas como resultado de una clasificación - El lenguaje como uno de los procesos semióticos - Dimensión pragmática: los usos o funciones del lenguaje - La dimensión semántica: el caso de la definición - De la abstracción perceptiva a la abstracción conceptual - El inductivismo: rasgos y deficiencias - El falsacionismo: versión superadora - Las razones de los problemas - Supuestos filosóficos de una mentalidad científica Con este libro usted podrá explorar mas sobre esta interesante faceta de las ciencias. ¡Adquiera ya este libro y aproveche este completo análisis! TAGS: conocimiento científico, enfoque hermenéutico, dimensión semántica, falsacionismo, abstracción, filosofía, ciencias fácticas. (shrink)

Starting from a generalconsideration about the role of the hermeneutic it is afirmed that its centralproblem is to interpretate the written texts. This obvious fact implies a demarcation of two complementary issues, to which Paul Ricoeur pays specialattention: A) the fiel of application of the inter..

1. Sae sidae rŭl yŏrŏ gan saramdŭl -- 2. Ŏdum ŭi sidae.

Information can be public among a group. Whether or not information is public matters, for example, for accounts of interdependent rational choice, of communication, and of joint intention. A standard analysis of public information identifies it with (some variant of) common belief. The latter notion is stipulatively defined as an infinite conjunction: for p to be commonly believed is for it to believed by all members of a group, for all members to believe that all members believe it, and so (...) forth. This analysis is often presupposed without much argument in philosophy. Theoretical entrenchment or intuitions about cases might give some traction on the question, but give little insight about why the identification holds, if it does. The strategy of this paper is to characterize a practical-normative role for information being public, and show that the only things that play that role are (variants of) common belief as stipulatively characterized. In more detail: a functional role for “taking a proposition for granted” in non-isolated decision making is characterized. I then present some minimal conditions under which such an attitude is correctly held. The key assumption links this attitude to beliefs about what is public. From minimal a priori principles, we can argue that a proposition being public among a group entails common commitment to believe among that group. Later sections explore partial converses to this result, the factivity of publicity and publicity from the perspective of outsiders to the group, and objections to the aprioricity of the result deriving from a posteriori existential presuppositions. (shrink)

The present study investigated the effect of Parkinson’s disease (PD) on prospective memory (PM) tasks by varying the emotional content of the PM actions. Twenty-one older adults with PD and 25 healthy older adults took part in the present study. Participants performed three virtual days in the Virtual Week task. On each virtual day, participants performed actions with positive, negative or neutral content. Immediately following each virtual day, participants completed a recognition task to assess their retrospective memory for the various (...) prospective memory tasks. PD patients were less accurate than the control group at both PM accuracy and recognition task accuracy. The effect of emotional valence was also evident, indicating that all participants were more accurate on positive PM tasks than both negative and neutral. This study confirmed PM impairment in PD patients and extended previous research showing how positive emotional stimuli can influence PM performance. (shrink)

We describe a short model-theoretic proof of an extended normal form theorem for derivations in predicate logic which implies in PRA a normal form theorem for the arithmetic derivations . Consider the Gentzen-type formulation of predicate logic with invertible rules. A derivation with proper variables is one where a variable b can occur in the premiss of an inference L but not below this premiss only in the case when L is () or () and b is its eigenvariable. Free (...) variables of such derivation are eigenvariables and free variables of its last sequent. Then any sequent derivable in predicate logic has a cut-free derivation with proper variables where the main formula of any antecedent rule is underivable. The proof is by a simple modification of the construction of a countermodel of the formula from the open branch of its canonical proof-search tree. It extends to intuitionistic and higher order systems. The proof of the corresponding normalization theorem outlined in [8] uses the passage to the infinitary derivations enriched by finitary derivations. The normal form after a modification to make it decidable can be considered as a realization of Gentzen's idea stated at the end of [2], that his notion of reduction for arithmetic can be extended to other fields of mathematics. (shrink)

Traditionally, empathy is conceived of as a cognitive function that governs how people think during social interactions, and is considered as largely impervious to change. However, developments in psychology and neuroscience show that empathy is grounded in neural substrates of emotionally communicative behaviour and so is learned through imitation and other forms of cultural learning. This also means that abnormal patterns of empathic function can develop through adverse life experiences, or that empathy may fail to develop in young people with (...) neurodevelopmental disorders. Nevertheless, by focussing on empathy as a quality of social interaction and affective expression in the here and now, and by appreciating that it is as a special form of sensorimotor skill, pathways to training and fostering better development of empathy can be identified. (shrink)

We present a cut-elimination proof for simple type theory with an axiom of choice formulated in the language with an epsilon-symbol. The proof is modeled after Takahashi's proof of cut-elimination for simple type theory with extensionality. The same proof works when types are restricted, for example for second-order classical logic with an axiom of choice.

The differential aging effect is shown to be valid in any physically reasonable extension of the special theory of relativity which includes a description of accelerating observers. Einstein's controversial assumption—the clock hypothesis—is avoided. Instead, it is sufficient to assume accessibility—that it is possible to travel from one inertial observer to another and then return to the first in a reasonable manner. Since Minkowski space-time displays this accessibility property, there must be an error in Sachs's quaternion development of general relativity. No (...) assumptions concerning measurements—proper time—of accelerating observers are necessary, nor are assumptions concerning special features of their motion—uniform acceleration. (shrink)

Bazzocchi disposes the text of the Tractatus in a user-friendly manner, exactly as Wittgenstein's decimals advise. This discloses the logical form of the book by distinct reading units, linked into a fashioned hierarchical tree. The text becomes much clearer and every reader can enjoy, finally, its formal and literary qualities.

The leading ethical position on placebo-controlled clinical trials is that whenever proven effective treatment exists for a given condition, it is unethical to test a new treatment for that condition against placebo. Invoking the principle of clinical equipoise, opponents of placebo-controlled trials in the face of proven effective treatment argue that they (1) violate the therapeutic obligation of physicians to offer optimal medical care and (2) lack both scientific and clinical merit. We contend that both of these arguments are mistaken. (...) Clinical equipoise provides erroneous ethical guidance in the case of placebo-controlled trials, because it ignores the ethically relevant distinction between clinical trials and treatment in the context of clinical medicine and the methodological limitations of active-controlled trials. Placebo controls are ethically justifiable when they are supported by sound methodological considerations and their use does not expose research participants to excessive risks of harm. (shrink)

The AGI alignment problem has a bimodal distribution of outcomes with most outcomes clustering around the poles of total success and existential, catastrophic failure. Consequently, attempts to solve AGI alignment should, all else equal, prefer false negatives (ignoring research programs that would have been successful) to false positives (pursuing research programs that will unexpectedly fail). Thus, we propose adopting a policy of responding to points of philosophical and practical uncertainty associated with the alignment problem by limiting and choosing necessary assumptions (...) to reduce the risk of false positives. Herein we explore in detail two relevant points of uncertainty that AGI alignment research hinges on---meta-ethical uncertainty and uncertainty about mental phenomena---and show how to reduce false positives in response to them. (shrink)

In a recent article Duncan Purves, Ryan Jenkins, and B. J. Strawser argue that in order for a decision in war to be just, or indeed the decision to resort to war to be just, it must be the case that the decision is made for the right reasons. Furthermore, they argue that this requirement holds regardless of how much good is produced by said action. In this essay I argue that their argument is flawed, in that it mistakes what (...) makes an agent morally good for what makes an act morally good. I argue that the main thrust of Purves et al.’s argument in fact undermines the conclusion they wish to draw, and that the reasons for one’s action do not make an in principle difference to the morality of actions in war. I further argue that this position undermines the traditional ad bellum just war constraint of right intention, and that the morality of actions in war is, at core, only concerned with outcomes. I conclude by clarifying that one’s reasons for action do in fact matter when deciding to enter war or kill in war, but only because one’s reasons significantly impact the way in which one acts. The purpose of this paper is to clear the theoretical space by showing why intentions/reasons do not in principle matter when assessing the morality of war (or killing), but this should not be taken as an argument that we should ignore intentions/reasons altogether. (shrink)

Transplantation of vital organs has been premised ethically and legally on "the dead donor rule" (DDR)—the requirement that donors are determined to be dead before these organs are procured. Nevertheless, scholars have argued cogently that donors of vital organs, including those diagnosed as "brain dead" and those declared dead according to cardiopulmonary criteria, are not in fact dead at the time that vital organs are being procured. In this article, we challenge the normative rationale for the DDR by rejecting the (...) underlying premise that it is necessarily wrong for physicians to cause the death of patients and the claim that abandoning this rule would exploit vulnerable patients. We contend that it is ethical to procure vital organs from living patients sustained on life support prior to treatment withdrawal, provided that there is valid consent for both withdrawing treatment and organ donation. However, the conservatism of medical ethics and practical concerns make it doubtful that the DDR will be abandoned in the near future. This leaves the current practice of organ transplantation based on the "moral fiction" that donors are dead when vital organs are procured. (shrink)

This bilingual volume—English and German on facing pages—brings together the writings Wittgenstein composed during his stay in Dublin between October 1948 and March 1949, one of his most fruitful periods. He later drew more than half of his remarks for Part II of Philosophical Investigations from this Dublin manuscript. A direct continuation of the writing that makes up the two volumes of Remarks on the Philosophy of Psychology, this collection offers scholars a glimpse of Wittgenstein's preliminary thinking on one of (...) his most important works. G. H. von Wright and Heikki Nyman both teach at the University of Helsinki. (shrink)

A basic question of medical ethics is whether the norms governing medical practice should be understood as the application of principles and rules of the common morality to medicine or whether some of these norms are internal or proper to medicine. In this article we describe and defend an evolutionary perspective on the internal morality of medicine that is defined in terms of the goals of clinical medicine and a set of duties that constrain medical practice in pursuit of these (...) goals. This perspective is developed by means of a critical examination of the essentialist conception of the internal morality of medicine advocated by Edmund Pellegrino and the critique of internal morality approaches by Robert Veatch and Tom Beauchamp. (shrink)

Studies of coexistence are based ultimately on the assumption that competitive exclusion is a general and accredited phenomenon in nature. However, the ecological and evolutionary impact of interspecific competition is of questionable significance. Review of three reputed examples of competitive exclusion in the field (Aphytis wasps, red and grey squirrels, and triclads) demonstrates that the widely-accepted competition-based interpretations are unlikely, that alternative explanations are overlooked, and that all other reported cases need critical reinvestigation. Although interspecific competition does undoubtedly occur, the (...) evidence suggests it is usually too weak and intermittent a force to achieve competitive exclusion or any other ecologically-significant result, except perhaps rarely and on a minor scale. Coexistence and community structure are therefore not ecological conditions to be especially accounted for, especially since their inherently comparative methods generate information that is largely superficial. Alternative questions that relate directly to species, the units of diversity, are discussed and they emphasize the primary habitat requirements of species, which are fixed during speciation. Neither the comparative approach of coexistence studies, nor the investigation of pattern is likely to be profitable, since the acquisition of species-specific characteristics during speciation requires historical research. At least one alternative theory of ecology, based on the close adaptation of organisms to the environment, is available. (shrink)

The practice of voluntary physician‐assisted death as a last resort is compatible with doctors' duties to practice competently, to avoid harming patients unduly, to refrain from medical fraud, and to preserve patients' trust. It therefore does not violate physicians' professional integrity.