Armstrong's Materialist Theory of Mind is one of a handful of texts that began the physicalist revolution in the philosophy of mind. In this collection, distinguished philosophers examine what we still owe to it, how to expand it, as well as looking back on how it came about.

Ende Oktober 2014 organisierte das Martin-Heidegger-Institut in Wuppertal die erste internationale Tagung uber Heideggers "Schwarze Hefte" in Deutschland. Im Fruhjahr desselben Jahres hatte die Veroffentlichung der "Uberlegungen," der ersten Reihe der "Schwarzen Hefte," gezeigt, dass Heidegger zwischen 1938 und 1941 in seinen Aufzeichnungen antisemitische Gedanken auftreten lasst. Es war und ist die Frage, welche Motive den Philosophen dabei leiteten. Wie sind jene Ausserungen zu verstehen? Wie weit betreffen sie Heideggers Denken uberhaupt? Der Band versammelt die Resultate dieser Tagung. Er enthalt (...) Aufsatze von Jean-Luc Nancy, Donatella Di Cesare, Francoise Dastur, Danielle Cohen-Levinas u.a. (shrink)

The past 50 years have seen an accumulation of evidence suggesting that associative learning depends on high-level cognitive processes that give rise to propositional knowledge. Yet, many learning theorists maintain a belief in a learning mechanism in which links between mental representations are formed automatically. We characterize and highlight the differences between the propositional and link approaches, and review the relevant empirical evidence. We conclude that learning is the consequence of propositional reasoning processes that cooperate with the unconscious processes involved (...) in memory retrieval and perception. We argue that this new conceptual framework allows many of the important recent advances in associative learning research to be retained, but recast in a model that provides a firmer foundation for both immediate application and future research. (shrink)

Creativity is an important quality that has been linked with problem solving, achievement, and scientific advancement. It has previously been proposed that creative individuals pay greater attention to and are able to utilize information that others may consider irrelevant, in order to generate creative ideas (e.g., Eysenck, 1995). In this study we investigated whether there was a relationship between creativity and greater learning about irrelevant information. To answer this question, we used a self-report measure of creative ideation and a blocking (...) task, which involved learning about irrelevant stimuli. We failed to find evidence for this association, with a Bayes Factor indicating support for no relationship between these measures. While it is possible that a different measure of creative ideation, for example one which does not rely on self-report, may produce different results, a more lucrative research direction may be focusing on the link between creativity and cognitive flexibility, in line with suggestions by Zabelina and Robinson (2010). (shrink)

Background: Editorial peer review is universally used but little studied. We examined the relationship between external reviewers' recommendations and the editorial outcome of manuscripts undergoing external peer-review at the Journal of General Internal Medicine. Methodology/Principal Findings: We examined reviewer recommendations and editors' decisions at JGIM between 2004 and 2008. For manuscripts undergoing peer review, we calculated chance-corrected agreement among reviewers on recommendations to reject versus accept or revise. Using mixed effects logistic regression models, we estimated intra-class correlation coefficients at the (...) reviewer and manuscript level. Finally, we examined the probability of rejection in relation to reviewer agreement and disagreement. The 2264 manuscripts sent for external review during the study period received 5881 reviews provided by 2916 reviewers; 28% of reviews recommended rejection. Chance corrected agreement on rejection among reviewers was 0.11. In mixed effects models adjusting for study year and manuscript type, the reviewer-level ICC was 0.23 and the manuscript-level ICC was 0.17. The editors' overall rejection rate was 48%: 88% when all reviewers for a manuscript agreed on rejection and 20% when all reviewers agreed that the manuscript should not be rejected. Conclusions/Significance: Reviewers at JGIM agreed on recommendations to reject vs. accept/revise at levels barely beyond chance, yet editors placed considerable weight on reviewers' recommendations. Efforts are needed to improve the reliability of the peer-review process while helping editors understand the limitations of reviewers' recommendations. © 2010 Kravitz et al. (shrink)

Humanity needs a way to pool scientific community opinion quickly and efficiently on a given statement of interest. This should be on a very large scale, such that one can have confidence that the result reflects international scientific opinion. For this pilot project (2022-23), we developed tailored architecture in the form of a novel polling platform, to survey a network of scientists at 30 academic institutions around the world. Personal, one-to-one emails were sent to all relevant scientists at those institutions, (...) asking them for their position on our pilot statement, "Science has put it beyond reasonable doubt that COVID-19 is caused by a virus." Scientists answered by clicking a URL embedded in the email, and confirming their response on a 5-point Likert scale. Voting was anonymous, with the token linking the scientist to their vote being destroyed upon voting, and their response logged against the demographics of scientific field of expertise (broadly construed) and institution for subsequent data analysis. (shrink)

The sudden onset of severe traumatic brain injury (sTBI) is an event suffered by millions of individuals each year. Regardless of this frequency in occurrence, accurate prognostication remains difficult to achieve among physicians. There are many variables that affect this prognosis. Physicians are expected to assess the clinical indications of the brain injury while considering other factors such as patient quality of life, patient preferences, and environmental context. However, this lack of certainty in prognosis can ultimately affect treatment recommendations and (...) prompt clinical ethical issues at the bedside, as it leaves room for physician bias and interpretation. In this article, we introduce data on neurosurgeon values that may shed light on the process physicians and patients involved in sTBI undergo. In doing so, we highlight the many nuances in decision-making for patients suffering from sTBI and discuss potential solutions to better patient-physician or surrogate-physician interactions. (shrink)

In this response, we provide further clarification of the propositional approach to human associative learning. We explain why the empirical evidence favors the propositional approach over a dual-system approach and how the propositional approach is compatible with evolution and neuroscience. Finally, we point out aspects of the propositional approach that need further development and challenge proponents of dual-system models to specify the systems more clearly so that these models can be tested.

It has become a commonplace that "images" were central to the twentieth century and that their role will be even more powerful in the twenty-first. But what is an image and what can an image be? _Releasing the Image_ understands images as something beyond mere representations of things. Releasing images from that function, it shows them to be self-referential and self-generative, and in this way capable of producing forms of engagement beyond spectatorship and subjectivity. This understanding of images owes much (...) to phenomenology—the work of Husserl, Heidegger, and Merleau-Ponty—and to Gilles Deleuze's post-phenomenological work. The essays included here cover historical periods from the Romantic era to the present and address a range of topics, from Cézanne's painting, to images in poetry, to contemporary audiovisual art. They reveal the aesthetic, ethical, and political stakes of the project of releasing images and provoke new ways of engaging with embodiment, agency, history, and technology. (shrink)

: Are incorrect judgments on false belief tasks better explained within the framework of a conceptual change theory or a bias theory? Conceptual change theory posits a change in the form of reasoning from 3 to 4 years old while bias theory posits that processing factors are responsible for errors among younger children. The results from three experiments showed that children who failed a test of false belief took as long to respond as those who passed, and both groups of (...) children took longer to respond to belief questions than to questions about prior states of reality. These results seem to support the bias theory. (shrink)

One rationale policy-makers sometimes give for declining to fund a service or intervention is on the grounds that it would be ‘unaffordable’, which is to say, that the total cost of providing the service or intervention for all eligible recipients would exceed the budget limit. But does the mere fact that a service or intervention is unaffordable present a reason not to fund it? Thus far, the philosophical literature has remained largely silent on this issue. However, in this article, we (...) consider this kind of thinking in depth. Albeit with certain important caveats, we argue that the use of affordability criteria in matters of public financing commits what Parfit might have called a ‘mistake in moral mathematics’. First, it fails to abide by what we term a principle of ‘non-perfectionism’ in moral action: the mere fact that it is practically impossible for you to do all the good that you have reason to do does not present a reason not to do whatever good you can do. And second, when used as a means of arbitrating between which services to fund, affordability criteria can lead to a kind of ‘numerical discrimination’. Various attendant issues around fairness and lotteries are also discussed. (shrink)

This paper describes the application of eight statistical and machine-learning methods to derive computer models for predicting mortality of hospital patients with pneumonia from their findings at initial presentation. The eight models were each constructed based on 9847 patient cases and they were each evaluated on 4352 additional cases. The primary evaluation metric was the error in predicted survival as a function of the fraction of patients predicted to survive. This metric is useful in assessing a model’s potential to assist (...) a clinician in deciding whether to treat a given patient in the hospital or at home. We examined the error rates of the models when predicting that a given fraction of patients will survive. We examined survival fractions between 0.1 and 0.6. Over this range, each model’s predictive error rate was within 1% of the error rate of every other model. When predicting that approximately 30°K of the patients will survive, all the models have an error rate of less than 1.5%. The models are distinguished more by the number of variables and parameters that they contain than by their error rates; these differences suggest which models may be the most amenable to future implementation as paper-based guidelines. (shrink)

This volume brings together eminent theologians, philosophers and political theorists to discuss such questions as how religious understandings have shaped the moral landscape of contemporary culture; the possible contributions of theology and theologically informed moral argument to contemporary public life; the problem of religious and moral discourse in a pluralistic society; and the proper relationship between religion and culture.

The idea that there could be spatially extended mereological simples has recently been defended by a number of metaphysicians (Markosian 1998, 2004; Simons 2004; Parsons (2000) also takes the idea seriously). Peter Simons (2004) goes further, arguing not only that spatially extended mereological simples (henceforth just extended simples) are possible, but that it is more plausible that our world is composed of such simples, than that it is composed of either point-sized simples, or of atomless gunk. The difficulty for (...) these views lies in explaining why it is that the various sub-volumes of space occupied by such simples, are not occupied by proper parts of those simples. Intuitively at least, many of us find compelling the idea that spatially extended objects have proper parts at every sub-volume of the region they occupy. It seems that the defender of extended simples must reject a seemingly plausible claim, what Simons calls the geometric correspondence principle (GCP): that any (spatially) extended object has parts that correspond to the parts of the region that it occupies (Simons 2004: 371). We disagree. We think that GCP is a plausible principle. We also think it is plausible that our world is composed of extended simples. We reconcile these two notions by two means. On the one hand we pay closer attention to the physics of our world. On the other hand, we consider what happens when our concept of something—in this case space—contains elements not all of which are realized in anything, but instead key components are realized in different features of the world. (shrink)

Titles and abstracts for the Pitt-London Workshop in the Philosophy of Biology and Neuroscience: September 2001.

Many philosophical naturalists eschew analysis in favor of discovering metaphysical truths from the a posteriori, contending that analysis does not lead to philosophical insight. A countercurrent to this approach seeks to reconcile a certain account of conceptual analysis with philosophical naturalism; prominent and influential proponents of this methodology include the late David Lewis, Frank Jackson, Michael Smith, Philip Pettit, and David Armstrong. Naturalistic analysis is a tool for locating in the scientifically given world objects and properties we quantify over in (...) everyday discourse. This collection gathers work from a range of prominent philosophers who are working within this tradition, offering important new work as well as critical evaluations of the methodology. Its centerpiece is an important posthumous paper by David Lewis, "Ramseyan Humility," published here for the first time. The contributors first address issues of philosophy of mind, semantics, and the new methodology's a priori character, then turn to matters of metaphysics, and finally consider problems regarding normativity. Conceptual Analysis and Philosophical Naturalism is one of the first efforts to apply this approach to such a wide range of philosophical issues. _Contributors: _David Braddon-Mitchell, Mark Colyvan, Frank Jackson, Justine Kingsbury, Fred Kroon, David Lewis, Dustin Locke, Kelby Mason, Jonathan McKeown-Green, Peter Menzies, Robert Nola, Daniel Nolan, Philip Pettit, Huw Price, Denis Robinson, Steve Stich, Daniel Stoljar The hardcover edition does not include a dust jacket. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Spinoza on Self-Preservation and Self-DestructionMitchell GabhartI wish to examine a difficulty that arises in Spinoza’s treatment of selfhood as it pertains to the possibility of self-destruction. The troublesome problem of selfhood is one which I will not solve but which I hope to illuminate. What I hope to do is shed light on Spinoza’s conception of human essence as necessarily self-affirming, and therefore of willful self-destruction as impossible. Yet (...) this issue too is troubling since the accounts Spinoza provides of suicides all have one thing in common: suicide always involves being overcome by the external environment, i.e., the environment operating in a way contrary to the nature of the agent. Thus, all suicide is a sign of an internal weakness in the face of a hostile world. To provide the needed contrast to the suicidal agent, necessarily a state of the utmost bondage or servitude, I will first sketch Spinoza’s theory of the passions, their remedy, the characteristics of the active free agent, and his curious account of immortality. Then I turn to the problem in his account of suicide: I contend that he cannot make meaningful a distinction between suicide and any other form of death.2.I begin with Spinoza’s analysis of human motivation, the elements of which are the affects, which he defines (E3D2) as the body’s power of acting being increased or diminished as well as the idea of those affections.1 Spinoza classifies [End Page 613] emotions, i.e., affects under the attribute of mind, into two types: actions and passions.2 Spinoza does not (contrary to his predecessor Descartes) posit the existence of a separate faculty such as will to transform passions into actions. Rather, “we act when something happens, in us or outside us, of which we are the adequate cause, i.e., (by E3D1) when something in us or outside us follows from our nature, which can be clearly and distinctly understood through it alone.”3 Conversely, we are acted upon “when something happens in us, or something follows from our nature, of which we are only a partial cause.”4 Consequently it is not necessary to oppose will and intellect in order to differentiate action from passion. The mind includes both adequate and inadequate ideas (E3P1) and therefore can be alternately both agent and patient.The departure from Descartes is striking: since (1) ideas either are or are not adequate and (2) each adequate idea carries its own certitude (E2P43), the need for a separate faculty of assent, which is what volition must amount to, is nullified. Instead, volition and appetite are considered by Spinoza to be no more than distinct manifestations of one central striving, the former a purely mental description and the latter an account of both mental and physical aspects of the individual.5Spinoza introduces the key term conatus to characterize the activity of modes but it is a concept which also bears the burden of accounting for the individuality, indeed the essence, of finite modes. The principle of conatus is defined by Spinoza as a striving (E3P7), i.e., “that striving by which each thing strives to persevere in its own being is nothing but the actual essence of the thing.”6 This [End Page 614] striving to persevere in one’s existence—a striving which continues for an indefinite time (E3P8)—must, of course, undergo both successes and failures. Modes, such as the human individual, exist conditionally, as finite and temporally changing constituents of the substantial reality which Spinoza refers to as “God or Nature.” So, human beings are entities possessing (1) an essential identity through an indefinite duration and (2) a consciousness of that identity which alternately resists or succumbs to outside forces.Thus, their existence can be thought of as merely adjectival, which poses difficulties in understanding self-identity. Vital, it seems, to an acceptable conception of identity is some principle of individuation—something which makes Peter distinct from Paul.7 Let us first then sketch the account of individuation that Spinoza proposes. It is important to bear in mind first that conatus is a striving of the organism as... (shrink)

In this paper I do two things: (1) I support the claim that there is still some confusion about just what the Quine-Putnam indispensability argument is and the way it employs Quinean meta-ontology and (2) I try to dispel some of this confusion by presenting the argument in a way which reveals its important meta-ontological features, and include these features explicitly as premises. As a means to these ends, I compare Peter van Inwagen’s argument for the existence of properties (...) with Putnam’s presentation of the indispensability argument. Van Inwagen’s argument is a classic exercise in Quinean meta-ontology and yet he claims – despite his argument’s conspicuous similarities to the Quine-Putnam argument – that his own has a substantially different form. I argue, however, that there is no such difference between these two arguments even at a very high level of specificity; I show that there is a detailed generic indispensability argument that captures the single form of both. The arguments are identical in every way except for the kind of objects they argue for – an irrelevant difference for my purposes. Furthermore, Putnam’s and van Inwagen’s presentations make an assumption that is often mistakenly taken to be an important feature of the Quine-Putnam argument. Yet this assumption is only the implicit backdrop against which the argument is typically presented. This last point is brought into sharper relief by the fact that van Inwagen’s list of the four nominalistic responses to his argument is too short. His list is missing an important – and historically popular – fifth option. (shrink)

In this essay I show that Structuralism, in order to combat the impression that it is “untenable and outmoded,” needs to be attached to a phenomenology of transcendental intersubjectivity. My argument for this conclusion is: 1) that Peter Caws is right in arguing that Structuralism needs a notion of the transcendental subject because its objects, qua intentional, presuppose such a subject; 2) the objects withwhich Structuralism is concemed are objects in the sense that Husserl speaks of objects ofthe spiritual (...) world; and, 3) the spiritual world, indeed the world in general, is constituted intersubjectively. Therefore, Structuralism needs a notion of transcendental intersubjectivity.Dans cet essai, je démontre que le structuralisme doit être rattaché à une phénoménologie de l’intersubjectivité transcendantale afin d’éviter l’impression qu’il donne d’être «intenable et démodé». J’appuie cette conclusion à l’aide des arguments suivants: 1) Peter Caws a raison d’arguer que le structuralisme a besoin d’une notion de sujet transcendantal parce que ses objets, en tant qu’intentionnels, présupposent un tel sujet; 2) les objets dont s’occupe le structuralisme sont des objets au sens oú Husserl parle d’objets du monde spirituel; et 3) le monde spirituel, enfait le monde en général, est constitué de façon intersubjective. Ainsi, le structuralisme requiert une notion d’intersubjectivité transcendantale. (shrink)

In a series of articles (Pagin, 2004, 2009), Peter Pagin has argued that assertion is not a social speech act, introducing a method (which we baptize ‘the P-test’) designed to refute any account that defines assertion in terms of its social effects. This paper contends that Pagin's method fails to rebut the thesis that assertion is social. We show that the P-test is both unreliable (because it overgenerates counterexamples) and counterproductive (because it ultimately provides evidence in favor of some (...) social accounts). Nonetheless, we contend that assertion is not fully social. We defend an intermediate view according to which assertion is only a partly social speech act: assertions both commit the speaker to a proposition (a social component) and present their propositional content as true (a non-social component). The upshot is that assertion is in some important respect social, although it cannot be defined solely in terms of its social effects. (shrink)

In "How Do We Know It Is Now Now?" David Braddon-Mitchell (Analysis 2004) develops an objection to the thesis that the past is real but the future is not. He notes my response to this, namely that the past, although real, is lifeless and (a fortiori?) lacking in sentience. He argues, however, that this response, which I call 'the past is dead hypothesis', is not tenable if combined with 'special relativity'. My purpose in this reply is to argue that, on (...) the contrary, 'special relativity' supports the thesis that the future is unreal. (shrink)

How should we undertand the role of norms—especially epistemic norms—governing assertive speech acts? Mitchell Green (2009) has argued that these norms play the role of handicaps in the technical sense from the animal signals literature. As handicaps, they then play a large role in explaining the reliability—and so the stability (the continued prevalence)—of assertive speech acts. But though norms of assertion conceived of as social norms do indeed play this stabilizing role, these norms are best understood as deterrents and not (...) as handicaps. This paper explains the stability problem for the maintenance of animal signals, and so human communication, for we are animals too, after all; the mechanics of the handicap principle; the role of deterrents and punishments as an alternative mechanism; and the role of social norms governing assertion for the case of human communication. (shrink)

A historical perspective on the future of the car Content Type Journal Article Pages 1-3 DOI 10.1007/s11016-010-9479-z Authors Peter D. Norton, Department of Science, Technology and Society, University of Virginia, Charlottesville, VA 22904-4744, USA Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.

The question naturally arises: Is public art inherently violent, or is it a provocation to violence? Is violence built into the monument in its very conception? Or is violence simply an accident that befalls some monuments, a matter of the fortunes of history? The historical record suggests that if violence is simply an accident that happens to public art, it is one that is always waiting to happen. The principal media and materials of public art are stone and metal sculpture (...) not so much by choice as by necessity. “A public sculpture,” says Lawrence Alloway, “should be invulnerable or inaccessible. It should have the material strength to resist attack or be easily cleanable, but it also needs a formal structure that is not wrecked by alterations.”12 The violence that surrounds public art is more, however, than simply the ever-present possibility of an accident—the natural disaster or random act of vandalism. Much of the world’s public art—memorials, monuments, triumphal arches, obelisks, columns, and statues—has a rather direct reference to violence in the form of war or conquest. From Ozymandias to Caesar to Napoleon to Hitler, public art has served as a kind of monumentalizing of violence, and never more powerfully than when it presents the conqueror as a man of peace, imposing a Napoleonic code or a pax Romana on the world. Public sculpture that is too frank or explicit about this monumentalizing of violence, whether the Assyrian palace reliefs of the ninth century b.c., or Morris’s bomb sculpture proposal of 1981, is likely to offend the sensibilities of a public committed to the repression of its own complicity in violence.13 The very notion of public art as we receive it is inseparable from what Jürgen Habermas has called “the liberal model of the public sphere,” a dimension distinct from the economic, the private, and the political. This ideal realm provides the space in which disinterested citizens may contemplate a transparent emblem of their own inclusiveness and solidarity, and deliberate on the general good, free of coercion, violence, or private interests.14 12. Lawrence Alloway, “The Public Sculpture Problem,” Studio International 184 : 124.13. See Leo Bersani and Ulysse Dutoit, “The Forms of Violence,” October, no. 8 : 17-29, for an important critique of the “narrativization” of violence in Western art and an examination of the alternative suggested by the Assyrian palace reliefs.14. Habermas first introduced this concept in The Structural Transformation of the Public Sphere: An Inquiry into a Category of Bourgeois Society, trans. Thomas Burger and Frederick Lawrence . First published in 1962, it has since become the focus of an extensive literature. See also Habermas’s short encyclopedia article, “The Public Sphere,” trans. Sara Lennox and Frank Lennox, New German Critique 1 : 49-55, and the introduction to it by Peter Hohendahl in the same issue, pp. 45-48. I owe much to the guidance of Miriam Hansen and Lauren Berlant on this complex and crucial topic. W. J. T. Mitchell, editor of Critical Inquiry, is Gaylord Donnelly Distinguished Service Professor of English and art at the University of Chicago. His recent book is Iconology: Image, Text, Ideology. (shrink)

We give the proof of a theorem of Jensen and Zeman on the existence of a global □ sequence in the Core Model below a measurable cardinal κ of Mitchell order ) equal to κ++, and use it to prove the following theorem on mutual stationarity at n.Let ω1 denote the first uncountable cardinal of V and set to be the class of ordinals of cofinality ω1.TheoremIf every sequence n m. In particular, there is such a model in which for (...) all sufficiently large m<ω, the class of measurables λ with oM≥ωm is, in V, stationary below m+2. (shrink)

We determine exact consistency strengths for various failures of the Singular Cardinals Hypothesis (SCH) in the setting of the Zermelo-Fraenkel axiom system ZF without the Axiom of Choice (AC). By the new notion of parallel Prikry forcing that we introduce, we obtain surjective failures of SCH using only one measurable cardinal, including a surjective failure of Shelah's pcf theorem about the size of the power set of $\aleph _{\omega}$ . Using symmetric collapses to $\aleph _{\omega}$ , $\aleph _{\omega _{1}}$ , (...) or $\aleph _{\omega _{2}}$ , we show that injective failures at $\aleph _{\omega}$ , $\aleph _{\omega _{1}}$ , or $\aleph _{\omega _{2}}$ can have relatively mild consistency strengths in terms of Mitchell orders of measurable cardinals. Injective failures of both the aforementioned theorem of Shelah and Silver's theorem that GCH cannot first fail at a singular strong limit cardinal of uncountable cofinality are also obtained. Lower bounds are shown by core model techniques and methods due to Gitik and Mitchell. (shrink)

Riverside Park is an illustrated tribute to Frederick Law Olmsted's "other" New York City sanctuary. Since its conception in the 1870s, the park has undergone a number of transformations and suffered from periods of misuse and neglect, but in 1984, much-needed renovations turned this city oasis into what is today one of Manhattan's most beautiful attractions. "If the West Side does not stir you, you are a clod, past redemption."-Robert Moses Millions visit the Upper West Side landmark annually, and despite (...) the heavy use, thousands of volunteers keep the grounds pristine. The park is now being extended southward as part of Manhattan's plan to reclaim the island's six hundred miles of waterfront, and Riverside Drive-Olmsted's curving thoroughfare flanking the park-has long been one of Manhattan's premier addresses. "I often feel drawn to the Hudson River.... I never get tired of looking at it; it hypnotizes me."-Joseph Mitchell, from The Rivermen From the time it was carved out of an unpromising landscape, Riverside Park has continued to reinvent itself. Using photographs, illustrations, poems, and original and excerpted narrative, Edward Grimm and E. Peter Schroeder tell the intriguing story of a symbol of the modern revitalization of New York City. "Riverside Park will be a genuine riverside reservation, dedicated forever to the use of the people, beautiful in the highest sense."-The New York World, April 24, 1892 *Includes the official Riverside Park Fund Map of 2007*. (shrink)

It may be concluded that Mitchell's peace evolutionism incorporated most of the features of the cooperationist and Novicovian traditions. He questioned the conflict paradigm that underpinned biological militarism, and reinforced a holistic and more peaceful model of nature by reference to the emerging discipline of ecology. His “restrictionist” objections to the deterministic tendencies of much prevailing biosocial thought combined philosophical with biological arguments to assert that human history was sui generis, based upon the unique development of human consciousness and the (...) cultural transmission of knowledge. Mitchell's opposition to biological militarism reflected Victorian anxieties about the legitimacy of evolutionary ethics. However, he introduced an innovatory note, linked to the “modernist” intellectual milieu of the time, when he put objections to the use of analogy on the grounds (1) that the Darwinist paradigm had not been properly established, and (2) that scientific laws themselves were uncertain and subjective.The first objection related to the bitter controversies that racked the biological world in the 1900s when mutation theory thrust the Darwinian concept of natural selection into temporary disrepute. In this respect Mitchell encoutered continuing Darwinist orthodoxy, not least from peace biology itself, while confusion was added by his personal devotion to Darwinism and his sociopolitical suspicion of Mendelian hereditarianism. The later triumph of a new Darwinian synthesis under men like R. A. Fisher made Mitchell's criticisms seem outmoded. In the second respect, Mitchell's attack on the primacy of naturalistic science echoed the epistemology of the “new physics” and movements such as German neo-Kantianism. However, positivism was still deeply embedded in Britain, indeed enjoying a resurgence from the last decade of the nineteenth century.79 Mitchell's critique of the Darwinist version of it seems to have been too novel and puzzling to influence a generation still convinced of the soundness of the science.Mitchell made more impact when he put his objections to the use of analogy on the grounds of professional methodology. As a naturalist, he could argue:It is impossible to make correct comparisons even between an insect and spider, two creatures so closely allied that only zoologists would separate them, unless we could trace the qualities of the insect and of the spider respectively down to their common ancestor, and in so doing we should almost certainly lose all that made the comparison interesting and significant, and be left with little more than the qualities common to all protoplasm..., It is quite true that the whole web of life is in physical and physiological community, but considerations drawn from any part of it require so much modification before they can be applied to any other part, that they become merely verbal.80This type of criticism was to have a more lasting heritage. Chalmers Mitchell is worth remembering as an articulate early spokesman of a persistent, if often embattled, modern tradition that has resisted interpretations of human nature and history based upon genetic determinants or immutable biological laws, or upon the use of animal analogies to generalize too freely about human aggression and war. (shrink)

In the same year, 1961, Peter D. Mitchell and Robert R.J.P. Williams both put forward hypotheses for the mechanism of oxidative phosphorylation in mitochondria and photophosphorylation in chloroplasts. Mitchell's proposal was ultimately adopted and became known as the chemiosmotic theory. Both hypotheses were based on protons and differed markedly from the then prevailing chemical theory originally proposed by E.C. Slater in 1953, which by 1961 was failing to account for a number of experimental observations. Immediately following the publication of (...) Williams's hypothesis and before his own was published, Mitchell initiated a correspondence. Examination of the letters shows the development of a dispute based on the validity of the proposals, who should have priority and particularly whether Mitchell had drawn on Williams's work without acknowledgement. We have concluded that Mitchell's proposals were original although it is evident that prior to the correspondence Williams had considered and rejected a proposition similar to Mitchell's theory. However, a major cause of the dispute was the difference in disciplinary backgrounds of Mitchell, a microbial biochemist and Williams, a chemist. (shrink)

Mitchell's formulation of the chemiosmotic theory of oxidative phosphorylation in 1961 lacked any experimental support for its three central postulates. The path by which Mitchell reached this theory is explored. A major factor was the role of Mitchell's philosophical system conceived in his student days at Cambridge. This system appears to have become a tacit influence on his work in the sense that Polanyi understood all knowledge to be generated by an interaction between tacit and explicit knowing. Early in his (...) life Mitchell had evolved a simple philosophy based on fluctoids, fluctids and statids which was developed in a thesis submitted for the Ph.D. at the University of Cambridge, England. This aspect of his work was rejected by the examiners and became a tacit element in his intellectual development. It is argued from his various publications that this philosophy can be traced as an underlying theme behind much of Mitchell's theoretical writing in the 50's leading, through his notion of vectorial metabolism, to the formulation and amplification of the chemiosmotic theory in the sixties. This philosophy formed the basis for Mitchell of his understanding of biological systems and gave him his unique approach to cell biology. (shrink)

In the same year, 1961, Peter D. Mitchell and Robert R.J.P. Williams both put forward hypotheses for the mechanism of oxidative phosphorylation in mitochondria and photophosphorylation in chloroplasts. Mitchell's proposal was ultimately adopted and became known as the chemiosmotic theory. Both hypotheses were based on protons and differed markedly from the then prevailing chemical theory originally proposed by E.C. Slater in 1953, which by 1961 was failing to account for a number of experimental observations. Immediately following the publication of (...) Williams 's hypothesis and before his own was published, Mitchell initiated a correspondence. Examination of the letters shows the development of a dispute based on the validity of the proposals, who should have priority and particularly whether Mitchell had drawn on Williams 's work without acknowledgement. We have concluded that Mitchell's proposals were original although it is evident that prior to the correspondence Williams had considered and rejected a proposition similar to Mitchell's theory. However, a major cause of the dispute was the difference in disciplinary backgrounds of Mitchell, a microbial biochemist and Williams, a chemist. (shrink)

Attempts to solve the puzzling problem of oxidative phosphorylation led to four very different hypotheses each of which suggested a different view of the ATP synthase, the phosphorylating enzyme. During the 1960s and 1970s evidence began to accumulate which rendered Peter Mitchell’s chemiosmotic hypothesis, the novel part of which was the proton translocating ATP synthase (ATPase), a plausible explanation. The conformational hypothesis of Paul Boyer implied an enzyme where ATP synthesis was driven by the energy of conformational changes in (...) the respiratory proteins. This was finally abandoned as an explanation of the overall process. Nevertheless the conformational understanding of the enzyme became an acceptable proposal during the early 1970s and eventually led Boyer to a view of the enzyme that incorporated both hypotheses. The correspondence between Mitchell and Boyer, both Nobel laureates, exposes their different approaches to both this enzyme and to the hypotheses of oxidative phosphorylation and illuminates a key step in the development of bioenergetics. In particular Boyer was suspicious of proton gradients, because he could not envisage a chemical mechanism for the synthesis of ATP, while Mitchell distrusted conformational arguments because he believed the proton must act vectorially at the active site of the enzyme. This resulted in two different views of the mechanisms operating in this enzyme. Ultimately while Boyer was able to marry the two approaches, Mitchell retained his insistence on the role of the proton at the active site and was thus unable to give significance to Boyer’s conformational ideas. The underlying issues in this debate are discussed particularly with reference to the differing styles of Boyer and Mitchell and the influence of molecular biology, especially the development of protein technology. (shrink)