We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Questions about the relevance and value of various liberal concepts are at the heart of important debates among feminist philosophers and social theorists. Although many feminists invoke concepts such as rights, equality, autonomy, and freedom in arguments for liberation, some attempt to avoid them, noting that they can also reinforce and perpetuate oppressive social structures. In Challenging Liberalism Schwartzman explores the reasons why concepts such as rights and equality can sometimes reinforce oppression. She argues that certain forms of abstraction and (...) individualism are central to liberal methodology and that these give rise to a number of problems. Drawing on the work of feminist moral, political, and legal theorists, she constructs an approach that employs these concepts, while viewing them from within a critique of social relations of power. (shrink)

_Business Ethics and the Natural Environment_ examines the present status of relations between corporate enterprise and the natural environment in the world today. •Discusses such questions as: What obligations does a corporation have toward the environment? To respect entities unprotected by law? To care about future generations? •Argues that environmentally-friendly business practices yield dividends exceeding expectations, and that the competitive firm of the 21st century will follow “green” standards •Provides a background in ethics, a survey of business ethics, an account (...) of environmental philosophy, an overview of environmental legal issues, and an account of the problems associated with globalization. (shrink)

Legal definitions of rape traditionally required proof of both force and nonconsent. Acknowledging the difficulty of demonstrating the conjunction of force and nonconsent, many feminists argue that rape should be defined based on one element or the other. Instead of debating which of these two best defines the crime of rape, I argue that this framework is problematic, and that both force and nonconsent must be situated in a critique of social power structures. Catharine MacKinnon provides such a critique, and (...) she reframes rape as a matter of gender inequality. However, rather than rejecting the force/nonconsent dichotomy, MacKinnon focuses exclusively on force, which she thinks can be reconceived to include inequalities. Considering the #MeToo movement and feminist efforts to use Title IX to address campus rape, I argue that the concept of consent is more flexible than MacKinnon suggests and that “affirmative consent” can challenge this liberal model. In requiring active communication, affirmative consent shifts responsibility for rape, opens space for women’s sexual agency, and allows for the transformation of rape culture. Thus, I argue that rape should be defined by the use of force, the lack of affirmative consent, or the presence of both elements. (shrink)

: This paper investigates the mutual embeddedness of "nature" and "culture," as well as the intersections between race, gender, and sexuality, in the story of the HeLa cell line as viewed by a practicing feminist scientist. It provides a feminist analysis of the scientific discourse surrounding the HeLa cell line, and explores how feminist theories of science can provide a constructive and critical lens through which laboratory scientists can view their work.

_Business Ethics and the Natural Environment_ examines the present status of relations between corporate enterprise and the natural environment in the world today. •Discusses such questions as: What obligations does a corporation have toward the environment? To respect entities unprotected by law? To care about future generations? •Argues that environmentally-friendly business practices yield dividends exceeding expectations, and that the competitive firm of the 21st century will follow “green” standards •Provides a background in ethics, a survey of business ethics, an account (...) of environmental philosophy, an overview of environmental legal issues, and an account of the problems associated with globalization. (shrink)

This paper investigates the mutual embeddedness of “nature” and “culture,” as well as the intersections between race, gender, and sexuality, in the story of the HeLa cell line as viewed by a practicing feminist scientist. It provides a feminist analysis of the scientific discourse surrounding the HeLa cell line, and explores how feminist theories of science can provide a constructive and critical lens through which laboratory scientists can view their work.

In responding to Anderson, Tobin, and Mills, I focus on questions about non-ideal theory, normative individualism, and standpoint theory. In particular, I ask whether feminist theorizing can be "liberal" and yet not embody the problematic forms of abstraction and individualism described in "Challenging Liberalism". Ultimately, I call for methods of theorizing that illuminate and challenge oppressive social hierarchies.

Feminists, critical race scholars, and other social‐justice theorists sometimes object to “abstraction” in liberal normative theory. Arguing that oppression affects individual agents in powerful yet subtle ways, they contend that allegedly abstract theories often reinforce oppressive power structures. Here I critically examine and ultimately reject Onora O'Neill's “abstraction without idealization” as a solution to this problem. Because O'Neill defines abstraction as simply the “bracketing of certain predicates,” her methodology fails to guide decisions about what to bracket and what to include (...) in the theory. Moreover, it may not be possible to abstract without also relying on some particular ideals. While abstraction is unavoidable, I conclude that it must be employed with greater attention to sociopolitical hierarchies and by using ideals that do not collude with structures of oppression. I discuss the work of Susan Babbitt and Elizabeth Anderson as examples of how nonoppressive ideals might be incorporated into normative theory. (shrink)

The upcoming U.S. Supreme Court decision in Dobbs v. Jackson Women’s Health Organization has the potential to eliminate or severely restrict access to legal abortion care in the United States. We a...

Feminist philosophers have questioned whether liberal theory can account for the phenomenon of adaptive preferences, specifically women’s preferences that are formed under conditions of sexist oppression. In this paper, I examine the argument of one feminist who addresses the problem of women’s “deformed desires” by relying on a liberal framework. Assessing her argument, I conclude that liberalism provides inadequate resources for responding to this issue since it errs in understanding adaptive preferences as exceptional, provides little explanation of how changes in (...) individual preferences are motivated, and often fails to identify the adaptive nature of such preferences. I illustrate my arguments through a brief discussion of women’s choices around motherhood and sexuality, and I conclude by offering several suggestions of how an alternative theory might better address the problems raised by preference adaptation in the context of oppression. (shrink)

A set of science‐inspired cosmic narratives referred to as the Epic of Evolution and the Universe Story or, collectively, the new cosmology, proposes to bring humans closer to nature by placing us into the broader narrative of the cosmos. This article responds to commentary and critique on my book Consecrating Science: Wonder, Knowledge, and the Natural World, which critically examines these science‐based cosmic narratives and their particular and problematic modes and objects of wonder. Themes include the relationship of wonder to (...) science and ethical engagement; the question of whether wonder, grounded in everyday sensory experience, can scale up to the level of global environmental problems; the relevance of wonder to nonideal environments and negative affects like fear or grief; and the importance of humanistic and religious studies scholarship for critiquing grand narratives of science, among other themes. I also respond to claims that my book misdiagnoses and distorts the work of the new cosmology and its claims to wonder. (shrink)

Feminist philosophers have questioned whether liberal theory can account for the phenomenon of adaptive preferences, specifically women’s preferences that are formed under conditions of sexist oppression. In this paper, I examine the argument of one feminist who addresses the problem of women’s “deformed desires” by relying on a liberal framework. Assessing her argument, I conclude that liberalism provides inadequate resources for responding to this issue since it errs in understanding adaptive preferences as exceptional, provides little explanation of how changes in (...) individual preferences are motivated, and often fails to identify the adaptive nature of such preferences. I illustrate my arguments through a brief discussion of women’s choices around motherhood and sexuality, and I conclude by offering several suggestions of how an alternative theory might better address the problems raised by preference adaptation in the context of oppression. (shrink)

In her recent book, Perfectionism and Contemporary Feminist Values, Kimberly Yuracko argues that perfectionism is a promising theory for feminists, and she suggests that “what really motivates and drives feminists’ arguments is not a neutral commitment to freedom or equality but a perfectionist commitment to a particular, albeit inchoate, vision of human flourishing.” In my paper, I explore the connections between feminism, perfectionism, and critiques of liberal neutrality by focusing critical attention on Yuracko’s arguments. After summarizing Yuracko’s position, I contend (...) that she wrongly portrays feminists as criticizing the “choices” of individual women, rather than attacking the structures of power in which these choices are situated. By misconstruing feminist arguments in this way, Yuracko suggests that feminists are endorsing a form of liberal neutrality, rather than offering a critique of such neutrality in favor of a more radical analysis.In the second half of my paper, I develop an alternative analysis, which I call “equality as non-domination,” which I think more accurately describes many of the feminist arguments Yuracko considers. I compare my alternative account to both liberal neutrality and to Yuracko’s perfectionism. Because feminism is centrally concerned with criticizing social structures of domination and unjust hierarchy, I conclude that it cannot be understood as falling squarely on either side of the neutrality/perfectionism debate. (shrink)

In her recent book, Perfectionism and Contemporary Feminist Values, Kimberly Yuracko argues that perfectionism is a promising theory for feminists, and she suggests that “what really motivates and drives feminists’ arguments is not a neutral commitment to freedom or equality but a perfectionist commitment to a particular, albeit inchoate, vision of human flourishing.” In my paper, I explore the connections between feminism, perfectionism, and critiques of liberal neutrality by focusing critical attention on Yuracko’s arguments. After summarizing Yuracko’s position, I contend (...) that she wrongly portrays feminists as criticizing the “choices” of individual women, rather than attacking the structures of power in which these choices are situated. By misconstruing feminist arguments in this way, Yuracko suggests that feminists are endorsing a form of liberal neutrality, rather than offering a critique of such neutrality in favor of a more radical analysis.In the second half of my paper, I develop an alternative analysis, which I call “equality as non-domination,” which I think more accurately describes many of the feminist arguments Yuracko considers. I compare my alternative account to both liberal neutrality and to Yuracko’s perfectionism. Because feminism is centrally concerned with criticizing social structures of domination and unjust hierarchy, I conclude that it cannot be understood as falling squarely on either side of the neutrality/perfectionism debate. (shrink)

A casebook in environmental ethics that presents the classic cases with adequate detail so the students experience real situations in order to learn how serious and complex the issues are. The authors present a balanced, impartial account of these events that will interest and challenge students.

Popular interest in the topic of food has exploded in the past decade. Due in part to books by Michael Pollan, Barbara Kingsolver, and Eric Schlosser and films such as Food, Inc., Super Size Me, and Forks over Knives, people are starting to think critically about where their food originates, how it is processed, and how their consumption choices affect the environment, nonhuman animals, and other people. At the same time, there is rising concern about the dangers of obesity. Although (...) the voices raising these concerns are by no means monolithic, one of the most common solutions offered to various food-related issues is the suggestion that people educate themselves and make.. (shrink)

This chapter contains section titled: Introduction: How Brent Spar Changed the Rules The Brent Spar was not Alone: Two Sentinel Cases What is Going on? The Power Shift Third Sector, Global Civil Society Dealing with Attacks from CSOs Challenges for the CSOs The Ultimate Hope for the CSOs Case 7: Monsanto and the Genetically Modified Organisms Notes.

Is good morality the natural outcome of profitable business practices? The thesis explored here is one version of the recent literature on corporate culture, typified by the bestselling In Search of Excellence — that the corporation that creates a strong culture, one that best serves the customer, the product, and the employee, must also be profitable. The thesis turns out to have an historical parallel in Plato's Republic (subtitled, I suppose, In Search of Justice). Parallel virtues can be worked out (...) for state and corporation. In the end, profitability turns out not to be a necessary consequence of excellence, just as Plato's Ideal state turned out to be mortal. (shrink)

Lisa Tessman’s Moral Failure: On the Impossible Demands of Morality raises important questions about ideal theory, oppression, and the role of action guidance in normative philosophy. After a brief overview of feminist and anti-racist philosophers’ critiques of ideal theory, I examine Tessman’s claim that nonideal oppression theorists focus too narrowly on action guidance and thereby obscure other important normative issues, such as the problem of moral failure. Although I agree with Tessman’s advocacy of a wider focus—and with her suggestion (...) that situations of inevitable moral failure are particularly important to examine in contexts of oppression—I question whether nonideal oppression theorists actually emphasize action guidance to the exclusion of other concerns. I conclude with a brief examination of the way that ideal and nonideal theory have been defined and understood in debates about normative methodology, and I suggest that a move away from Rawls’s account of the ideal/nonideal distinction would benefit feminists and other oppression theorists. (shrink)

Swedish scientist and theologian Emanuel Swedenborg wrote volumes upon volumes based on the understanding he gained through visits to the spiritual world and from conversations with its inhabitants. For new readers of Swedenborg, knowing where to start and what to read can present an insurmountable task. This volume is a good starting point and provides samples of some of his most powerful writings, now available in new, contemporary translations. What happens to our souls after we die? What is the afterlife (...) like? What is the nature of God? Of evil? What can we do during our lives to help guide us to heaven? What kinds of answers can we find in the Bible? Selections from some of Swedenborg’s most popular works—_Heaven and Hell_, _Divine Love and Wisdom_, _Divine Providence_, _Secrets of Heaven_, and _True Christianity_—answer these questions and more. Ideal for those new to Swedenborg’s theology, _A Swedenborg Sampler_ offers tastes from a rich smorgasbord of spiritual insight. (shrink)

Everyone knows that somehow we must protect the natural environment as part of the ethical imperatives of doing business, especially in the era of globalization of business. But where, actually, do we find the structure of ethical imperatives that will support that “must”? The drawbacks of several candidates, some of them discussed in papers elsewhere in this volume, are considered, then supplemented with the Japanese concept of kyosei as supplying a missing link between ethics and the land. In the end, (...) some questions are raised about the possibility of success of the entire environmental enterprise in face of the provisions of global trade agreements. (shrink)

Can business be a moral enterprise? -- Employee rights and responsibilities : the internal constituencies of business -- Customers, community, and world : the external constituencies of business.

Traditional medical ethics, developed to apply to the contingencies of individual fee-for-service medical practice, do not always seem to speak to the problems of the new forms and locations of health care: the medical team, the hospital, the organized health-care profession, and the society as a whole as guarantor of all health care and education. It is the purpose of this issue of The Journal of Medicine and Philosophy to articulate guidelines for describing and attributing responsibility for health care in (...) these collective providers. This introduction attempts to provide the conceptual apparatus for a discussion of collective responsibility in health care, by the elucidation of the multiple meanings of "responsibility" and the articulation of three standard models for collective responsibility. In the light of these models, the question is put: can the health-care professions and their various subunits and institutions accept and exercise moral responsibility for health care? Its importance is stressed, and its answer left to the contributors. CiteULike Connotea Del.icio.us What's this? (shrink)

We argue that the goal of natural excellence, discoverable by scientific observation of the species, is appropriately called good, and the proper object of human development and education. That affirmation stands, but we are forced to acknowledge several conceptual difficulties (in the deliberate creation of “natural” excellences, for example, and in cases of plurality of excellences) and a final inability to reconcile human freedom—surely part of the natural excellence of human life—with the need to prevent humans from using that freedom (...) to sacrifice it (through, for instance, drugs, self-indulgence, and emotional enthusiasms). (shrink)

We argue that the goal of natural excellence, discoverable by scientific observation of the species, is appropriately called good, and the proper object of human development and education. That affirmation stands, but we are forced to acknowledge several conceptual difficulties (in the deliberate creation of “natural” excellences, for example, and in cases of plurality of excellences) and a final inability to reconcile human freedom—surely part of the natural excellence of human life—with the need to prevent humans from using that freedom (...) to sacrifice it (through, for instance, drugs, self-indulgence, and emotional enthusiasms). (shrink)

This volume contains a rich and varied selection of classic writings in philosophy and ethics through the ages.This volume features selections from Eastern religions, Native America, feminist perspectives, existentialism and environmentalism as well writing from Plato, Aristotle, Thomas Hobbes, John Locke, John Rawls, Immanuel Kant, Adam Smith, John Stuart Mill and others. For anyone interested in learning about the evolution of ethics and ethical thought in America.

This chapter contains section titled: Why Study Ethics? Philosophical Ethics: Defending Judgments Case 1: New England Fisheries Appendix: Decision Procedures For Ethics Notes.

This chapter contains section titled: An Introduction and Forewarning Business as Arena of Moral Dilemmas The Factory and the Worker The Uneasy Compromise Case 2: Hooker Chemical & Love Canal.