A translation of Werner Hamacher’s essay “Andere Schmerzen,” which he was unable to complete before his death on July 7, 2017. The essay analyzes the connection between pain and language in the work of Pindar, Sophocles, Cicero, Seneca, Kant, Hegel, and Valéry.

This study examines the public's and physicians' willingness to support deception of insurance companies in order to obtain necessary healthcare services and how this support varies based on perceptions of physicians' time pressures. Based on surveys of 700 prospective jurors and 1617 physicians, the public was more than twice as likely as physicians to sanction deception (26% versus 11%) and half as likely to believe that physicians have adequate time to appeal coverage decisions (22% versus 59%). The odds of public (...) support for deception compared to that of physicians rose from 2.48 to 4.64 after controlling for differences in time perception. These findings highlight the ethical challenge facing physicians and patients in balancing patient advocacy with honesty in the setting of limited societal resources. (shrink)

A translation of Werner Hamacher’s essay “Andere Schmerzen,” which he was unable to complete before his death on July 7, 2017. The essay analyzes the connection between pain and language in the work of Pindar, Sophocles, Cicero, Seneca, Kant, Hegel, and Valéry.

This NATO Advanced Study Institute centered on large-scale molecular systems: Quantum mechanics, although providing a general framework for the description of matter, is not easily applicable to many concrete systems of interest; classical statistical methods, on the other hand, allow only a partial picture of the behaviour of large systems. The aim of the ASI was to present both aspects of the subject matter and to foster interaction between the scientists working in these important areas of theoretical physics and theoretical (...) chemistry. The quantum-mechanical part was mostly based on the operator-algebraic formulation of quantum mechanics and comprised quantum statistics of infinite systems with special em phasis on macroscopic observables, equilibrium conditions, irreversibility on the one hand, symmetry breaking for molecules in the radiation field and macroscopic quantum phenomena in the theory of superconductivity (BCS-theory) on the other hand. In addition, phase-space methods for many-body systems were also presented. Statistical physics was the main topic in the other lectures of the School; much emphasis was put on the statistical features of macros copic ("large") systems, the lectures dealt with mass and energy transport im polymers, in gels and in microemulsions, with aggregation and growth phenomena, with relaxation in complex, correlated systems, with conduction and optical properties of polymers, and with the means of describing disordered systems, above all fractals and related hierarchical models. (shrink)

Während der größte Teil der Bevölkerung die kieferorthopädische Therapie, also die Veränderung der Zahn- bzw. Kieferstellung, als eine Behandlung betrachtet, die vor allem auf eine Verbesserung des Erscheinungsbildes zielt, sehen der kieferorthopädische und zahnärztliche Berufsstand sowie auch private und öffentliche Kostenträger in bestimmten Abweichungen von Zahn- oder Kieferstellungen eine Gefährdung der oralen Gesundheit und der Funktionsfähigkeit des Gebisses. Letztere Auffassung bestimmt das ärztliche Handeln in der Kieferorthopädie und begründet auch die Übernahme zumindest bestimmter Leistungen durch die gesetzlichen Krankenkassen. Anhand aktueller (...) wissenschaftlicher Erkenntnisse lassen sich jedoch in vielen Fällen keine (akuten oder potentiellen) gesundheitlichen oder essentiellen funktionellen Beeinträchtigungen und Risiken abweichender Zahnstellungen nachweisen. Ziel dieses Aufsatzes ist es, diesem Widerspruch nachzugehen. Im Folgenden werden wir aufzeigen, welche Faktoren die Anbieter kieferorthopädischer Leistungen beeinflussen, welches die entscheidenden Gründe und Grundlagen für die Behandlung sind und an welchen Kriterien sich die Leistungsübernahme durch die Krankenkassen orientiert. Dabei wird deutlich werden, dass die formalen Kriterien von Behandlung und Kostenübernahme, die tatsächliche Behandlungs- und Kostenerstattungspraxis, die Erwartungen derjenigen, die Behandlungsleistungen in Anspruch nehmen und der aktuelle Stand der Forschung zu erwartbaren Funktionsbeeinträchtigungen durch Zahnstellungsvariationen nicht zwanglos zu vereinbaren sind. Erforderlich erscheint ein interdisziplinärer normativer Diskurs über die Frage, wie die diagnostizierten Spannungen aufzulösen wären. Als Anregung für einen solchen Diskurs werden wir im Ausblick alternative Lösungsstrategien vorstellen. (shrink)

The allocation of any scarce health care resource, especially a lifesaving resource, can create profound ethical and legal challenges. Liver transplant allocation currently is based upon urgency, a sickest-first approach, and does not utilize capacity to benefit. While urgency can be described reasonably well with the MELD system, benefit encompasses multiple dimensions of patients’ well-being. Currently, the balance between both principles is ill-defined. This survey with 502 participants examines how urgency and benefit are weighted by different stakeholders. Liver transplant patients (...) favored the sickest-first allocation, although all other groups tended to favor benefit. Criteria of a successful transplantation were a minimum survival of at least 1 year and recovery of functional status to being ambulatory and capable of all self-care. An individual delisting decision was accepted when the 1-year survival probability would fall below 50%. Benefit was found to be a critical variable that may also trigger the willingness to donate organs. The strong interest of stakeholder for successful liver transplants is inadequately translated into current allocation rules. (shrink)

Background The allocation of any scarce health care resource, especially a lifesaving resource, can create profound ethical and legal challenges. Liver transplant allocation currently is based upon urgency, a sickest-first approach, and does not utilize capacity to benefit. While urgency can be described reasonably well with the MELD system, benefit encompasses multiple dimensions of patients’ well-being. Currently, the balance between both principles is ill-defined. Methods This survey with 502 participants examines how urgency and benefit are weighted by different stakeholders. Results (...) Liver transplant patients favored the sickest-first allocation, although all other groups tended to favor benefit. Criteria of a successful transplantation were a minimum survival of at least 1 year and recovery of functional status to being ambulatory and capable of all self-care. An individual delisting decision was accepted when the 1-year survival probability would fall below 50%. Benefit was found to be a critical variable that may also trigger the willingness to donate organs. Conclusions The strong interest of stakeholder for successful liver transplants is inadequately translated into current allocation rules. (shrink)

Philosophers of science traditionally have ignored the details of scientific research, and the result has often been theories that lack relevance either to science or to philosophy in general. In this volume, leading philosophers of biology discuss the limitations of this tradition and the advantages of the "naturalistic turn"—the idea that the study of science is itself a scientific enterprise and should be conducted accordingly. This innovative book presents candid, informal debates among scholars who examine the benefits and problems of (...) studying science in the same way that scientists study the natural world. Callebaut achieves the effect of face-to-face engagement through separate interviews with participants. Contributors include William Bechtel, Robert Brandon, Richard M. Burian, Donald T. Campbell, Patricia Churchland, Jon Elster, Ronald N. Giere, David L. Hull, Philip Kitcher, Karin Knorr Cetina, Bruno Latour, Richard Levins, Richard C. Lewontin, Elisabeth Lloyd, Helen Longino, Thomas Nickles, Henry C. Plotkin, Robert J. Richards, Alexander Rosenberg, Michael Ruse, Dudley Shapere, Elliott Sober, Ryan Tweney, and William Wimsatt. "Why can't we have both theoretical ecology and natural histories, lovingly done?"—Philip Kitcher "Don't underestimate the arrogance of philosophers!"—Elisabeth Lloyd. (shrink)

It has been and still is commonly believed by geologists and historians of geology alike that geological theory is an extrapolation from the empirical knowledge of the geology of a region. Abraham Gottlob Werner (1749-1817), whose theory concerning the origin of basalt and the minor role of volcanoes and the major role of water in the history of the earth's crust was eventually proven wrong in some respects, is usually cited as the prime example of a geologist who had (...) not ventured beyond the confines of his native region, Saxony, and had developed a universal geological theory based almost entirely on his observations of that region. In this essay I show that the geology of Saxony played a relatively unimportant role in the development of Werner's universal geological theory; that he became a neptunist before he had closely examined the geology of Saxony; and that his explanation of the history of the earth's crust was as reasonable, if not more reasonable, than the explanations brought forth by those of his contemporaries who opposed his views. (shrink)

Review of "The Timeless Way of Building." Book by Christopher Alexander.

The concept of social performance is a major theoretical innovation of the strong program in cultural sociology, championed by Jeffrey C. Alexander. This article offers a critical assessment of Alexander’s last four monographs on political performances with the explicit aim of contributing to the future development of the performance approach. After an outline of Alexander’s theory of performance, I continue to discuss his book-length empirical contributions, highlighting the innovations introduced by each study. Confronting Alexander’s research strategies (...) with his theoretical framework, I propose a recalibration of his ‘liberal’ sociology of performance, bringing ‘conservative’ aspects of political culture back in, first of all particularity and historicity. This entails a rethinking of performance effects in terms of ‘resonances’ attuned to particular audiences and a deeper hermeneutic engagement with specific historical backgrounds of collective representations in order to overcome the one-sidedness of Alexander’s constructivist approach. (shrink)

Das Nichtwissen ist in aller Munde. Von Nichtwissenskulturen in der zweiten oder reflexiven Moderne ist die Rede, von Agnotologie als neuem Forschungszweig, von wicked problems und ihren clumsy solutions. Wo Nichtwissen sich durch Komplexitäts­steigerung unwiderruflich im zu Wissenden einnistet, fordert es als Grenze, Schranke und Kehrseite des Wissens die sogenannte Wissensgesellschaft heraus. Vor allem Risiko­poten­ziale und Gefahren kommen hier in den Blick, von denen wir gerade genug wissen, um Wissensansprüche zu formulieren, die sich womöglich nie einlösen lassen. Das klassisch erkenntnistheoretische (...) Problem: „Was können wir wissen?“ steht heute in einem Spannungsverhältnis zu der wissenspolitischen Frage: „Was müssen wir wissen?“ Was wir wissen müssen, ist einerseits so viel wie nötig, wenn es um Fragen von Sicherheit und Gesundheit geht – andererseits aber so wenig wie möglich, wenn es in Alltag, Wirtschaft oder Wissen­schaft darauf ankommt, Wissen an technische Systeme oder Expertenkulturen zu delegieren. Bezeichnet politisch handlungsorientiertes und wissenschaftliches Nichtwissen zunächst ein Defizit, ist technisches Nichtwissen gleichermaßen erstrebenswert und problematisch. Einige, die Technik für angewandtes Wissen halten, mögen darin eine contradictio in adjecto sehen, manche sich um eine dem technischen Nichtwissen geschuldeten Technik­feindlichkeit sorgen, andere daraus die nötige Demut gegen verstiegene Allmachts­fantasien beziehen, während ihre Gegenspieler von Maschinen träumen, die über den Horizont intellektueller Nachvollziehbarkeit immer weiter hinauseilen. Mit Beiträgen von: Suzana Alpsancar, Lars Bullmann, Marcus Burkhardt, Eoin Carney, Pelle Ehn, Stefan Frisch, Gerhard Gamm, Petra Gehring, Till Greite, Hans Hasse, Andreas Kaminski, Gregor Kanitz, Matthias Koch, Christian Köhler, Johannes Lenhard, Alexandre Métraux, Alfred Nordmann, Tanja Paulitz, Tom Poljanšek, Sandra Pravica, Katrin Solhdju, Werner Sombart, Florian Sprenger, Sebastian Vehlken und Rüdiger Zill. (shrink)

This book presents the first detailed account of Werner Heisenberg’s failed attempt to find a theory of everything in the autumn of his career. It further investigates what we can learn from his failure in relation to the search for a final theory of physics, an endeavour that continues to define research in fundamental physics to this day. Thereby it provides the first historically informed contribution to the current debate on post-empirical physics and the state of particle physics.

For years now the “Tübingen School”, represented above all by Konrad Gaiser and Hans Krämer, has had an important position, philologically and philosophically speaking, in current research on Plato. Its richly documented and constantly sophisticated “New Image of Plato” has resulted in a “para-digm-change” in Plato-interpretation as well as developing many of its aspects. It revises the basic attitude, which can be traced back to Schleiermacher, that Plato’s published dialogues are the one authentic source for any adequate and complete comprehension (...) of Platonic thought. By contrast it is especially Krämer and Gaiser who in numerous publications have energetically—and to great effect—drawn attention to what have since Aristotle come to be known as the “unwritten doctrines” and—taking up and modifying specific intentions of L. Robin, J. Stenzel, P. Wilpert and others—attempted to present them not only as a necessary supplement to the dialogues of Plato but even more as the systematically conceived centre, the “essential” in Platonic thought. This hermeneutical maxim has made it possible to reconstruct the basic features of a principles-theory for Plato which not only constitutes the systematic fundament of the Platonic dialogues but has become decisive for the basic conceptual and ontological structure of Neoplatonism and the philosophical systems which are connected with it materially and historically speaking. This has not meant suppressing the dialogues or demoting them to a “quarry” for the real-authentic: thanks to the principles-theory and the theorems connected with it, much which used to have to appear as a break, as something enigmatic or giving rise to discrepancy or aporia, can now be understood in a more thorough way, a way which is more intense in terms of argumentation and even more complex in terms of substance, without that which Plato considered it impossible to say being laid bare in a dull abstraction. Thomas Alexander Szlezák’s book testifies to the degree to which taking seriously those doctrines of Plato which he himself was very “serious” about can be productive—precisely for a new interpretation of the dialogues themselves. Amidst the virtually endless deluge of publications on Plato, a deluge which continues to swell to worrying proportions because of superfluous repetition, Szlezák’s book stands out very strikingly through the originality of its perspective, through the consistent realization of a basic idea which is highly instructive for the subject-matter at hand and through the thoroughness of its examination of competing and above all of opposing ideas which are—with greater or lesser reason—sceptical as regards the new Plato paradigm. Plato’s criticism—discussed in great detail by Szlezák—of the written communicating of philosophical thought becomes for him the key to the question as to the relationship of the oral pursuit of philosophy and the written presentation of the living dialogue. In accordance with Platonic writing-critique it is very much intrinsic to the philosophical logos that it can defend itself, can help itself, that it is in a position productively to continue the questions which are placed in it and which it is asked and in so doing refer to “timiotera”, to “all that is more valuable”, i.e. more extensively justified; not only must these “timiotera” not be explicitly stated, but they ought consciously to be held back, to be omitted and reserved for conversations with real friends who are capable of understanding a higher problem-level. Books, thus also dialogues published in written form, are not inherently able to do this: they “are constantly saying the same thing” and remind one at times of “the prolonged din of cymbals”. It follows from this that “he who has knowledge”, he who has knowledge of “timiotera” and has a sensible attitude towards them, “Plato” the author of philosophical book-dialogues, quite consciously and consistently omits the “problems which are especially to do with principle”. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Architectonic, Truth, and RhetoricGlenn Alexander MageeScientists, we are often told, employ "aesthetic criteria" in their work: a scientific theory must be "simple" and "elegant" if it is to be a good candidate for truth.1 Is this also true of philosophers? Do philosophers rely (implicitly or explicitly) on aesthetic criteria in the development of their ideas, not simply in order to make their ideas accessible or palatable but also (...) as a guide to truth? This question bears on the relationship between art and philosophy, between art and truth, and between beauty and truth. If the answer is yes, then is there a point at which the line between art and philosophy becomes blurred? This is often claimed, though almost always in reference to the way in which philosophers use metaphor and rhetoric to express their ideas. However, I am suggesting in addition that the line may be blurred not just in the expression of their ideas but in the very form or structure they give to their philosophies. This aesthetic moment is not dispensable. On the contrary, philosophers make their thought into an aesthetic object because of a tacit, pre-reflective intuition that the beautiful is the true. In what follows, I will argue for this thesis and explore its implications.I.First of all, the philosophers I have in mind are philosophers in the classic sense: creators of systematic worldviews, those who aim at knowledge of the whole. I have in mind, therefore, thinkers like Plato, Aristotle, Plotinus, [End Page 59] Aquinas, Spinoza, Leibniz, Kant, Schelling, and Hegel, among others. All these thinkers are alike in that they do not approach philosophy piecemeal, as a set of disconnected "problems." Instead, they take the aim of philosophy to be to give a complete account of what is real. In the introduction to The Phenomenology of Spirit, for instance, Hegel writes that philosophy is "actual cognition of what truly is" (1977, 46). This is a definition one can imagine Plato and Aristotle—indeed almost all of the great philosophers—agreeing with. Philosophical knowledge, in this classical understanding, becomes a whole of ideas in which each element depends on every other and nothing of significance is left out. (Perhaps the best example of such a philosophy is, again, Hegel's.) It is only to "systems" of philosophy that our question about aesthetic criteria in philosophy is applicable,2 for it is only when a number of ideas are taken together into an overall structure and given a fundamental unity that a philosophy can become "beautiful" or "ugly."The Greek word sustema literally means "things which stand together or are made to stand together so as to form a whole" or "a whole compounded of several parts" (Klein 1985, 201). The Greeks applied the word to many things but never, it seems, to thought. Then, as Jacob Klein writes, "from about the year 1600 on there is a sudden and most remarkable shift: book after book appears under titles like 'System of Logic,' 'System of Rhetoric,' 'System of Grammar,' 'System of Theology,' 'System of Ethics and Politics,' 'System of Physics,' 'System of Jurisprudence,' 'System of Astronomy,' of Arithmetic, of Geography, of Medicine and even 'System of Systems' " (1985, 201). According to Klein, systematic philosophy is a response to the peculiar anxiety of modernity expressed so well by Yeats: "Things fall apart"—and we need a philosophical system to put them back together again.The idea of a system of philosophy cannot, however, be dismissed merely as a "modern invention," for it is a legitimate extension of the Greek concept of sustema. The Greek philosophers would not have reflected on their activity as "systematic" because they regarded themselves as describing a reality that was itself a sustema. Pressed to explain what philosophers are, Pythagoras, according to legend, compared them to the theoroi or onlookers at the Olympic Games. As Werner Jaeger writes of the legend, "The comparison depends on the ambiguity of the word theorein, which means both watching a spectacle and contemplation and research in the ' theoretical' sense" (1962, 432). Reality is a sustema; the philosopher's account of reality is a reflection of it and thus is itself a sustema... (shrink)

Il libro di Petra Werner, ricercatrice alla Alexander-von-Humboldt-Forschungsstelle dell’Accademia delle Scienze di Berlino (Berlin-Brandebur- gische Akademie der Wissenschaften), costituisce un contributo singolare nel panorama degli studi sulla vita, le opere e il pensiero di Alexander von Humboldt (1769-1859). Werner analizza, per la prima volta all’interno della Humboldt-Forschung, il rapporto di Humboldt con le arti figurative e con l’arte, studiando e valutando la sua corrispondenza epi...

This volume celebrates the life achievements of Jason W. Brown, who, along with Jean Piaget, Heinz Werner, Alexander Luria and the Wurzburg school, has significantly contributed to the development of a process-based theory of brain/mind capable of challenging the currently fashionable modularist or cybernetic approaches to understanding human thought and feeling. As a paradigm, Brown's microgenetic theory is thus applicable in both brain science (where Brown was inspired by the pioneering work of Schilder and Pick) and the philosophy (...) of mind (where the influence of Bergson, Whitehead, Cassirer, and Merleau-Ponty can be seen). Essays with a range of focus as wide as Brown's expertise have been collected in such diverse areas as neuropsychology (microstructure of action, symptomatology, neuro-rehabilitation, neurolinguistics, locationism), theoretical psychology (consciousness, hypnosis, morphogenesis, personality development, psychoanalysis, Buddhist psychology, mysticism), and philosophy of mind (evolutionary epistemology, emergence/novelty/creativity, subjectivity, will and action, Whiteheadian process philosophy).". (shrink)

The seminal work by one of the most important thinkers of the twentieth century, Physics and Philosophy is Werner Heisenberg's concise and accessible narrative of the revolution in modern physics, in which he played a towering role. The outgrowth of a celebrated lecture series, this book remains as relevant, provocative, and fascinating as when it was first published in 1958. A brilliant scientist whose ideas altered our perception of the universe, Heisenberg is considered the father of quantum physics; he (...) is most famous for the Uncertainty Principle, which states that quantum particles do not occupy a fixed, measurable position. His contributions remain a cornerstone of contemporary physics theory and application. Book jacket. (shrink)

There is an underlying assumption in the social sciences that consciousness and social life are ultimately classical physical/material phenomena. In this ground-breaking book, Alexander Wendt challenges this assumption by proposing that consciousness is, in fact, a macroscopic quantum mechanical phenomenon. In the first half of the book, Wendt justifies the insertion of quantum theory into social scientific debates, introduces social scientists to quantum theory and the philosophical controversy about its interpretation, and then defends the quantum consciousness hypothesis against the (...) orthodox, classical approach to the mind-body problem. In the second half, he develops the implications of this metaphysical perspective for the nature of language and the agent-structure problem in social ontology. Wendt's argument is a revolutionary development which raises fundamental questions about the nature of social life and the work of those who study it. (shrink)

This is Werner S. Pluhar's translation of Immanuel Kant's Critique of Judgment (Kritik der Urtheilskraft) for Hackett Publications (Indianapolis, Indiana). ISBN 9780872200258 (paperback).

The contributions of few contemporary scientists have been as far reaching in their effects as those of Nobel Laureate Werner Heisenberg.

The Information Artifact Ontology (IAO) was created to serve as a domain‐neutral resource for the representation of types of information content entities (ICEs) such as documents, data‐bases, and digital im‐ages. We identify a series of problems with the current version of the IAO and suggest solutions designed to advance our understanding of the relations between ICEs and associated cognitive representations in the minds of human subjects. This requires embedding IAO in a larger framework of ontologies, including most importantly the Mental (...) Func‐tioning Ontology (MFO). It also requires a careful treatment of the aboutness relations between ICEs and associated cognitive representa‐tions and their targets in reality, which implies in turn a new treatment of the relation of truthmaking. (shrink)

While classifications of mental disorders have existed for over one hundred years, it still remains unspecified what terms such as 'mental disorder', 'disease' and 'illness' might actually denote. While ontologies have been called in aid to address this shortfall since the GALEN project of the early 1990s, most attempts thus far have sought to provide a formal description of the structure of some pre-existing terminology or classification, rather than of the corresponding structures and processes on the side of the patient. (...) We here present a view of mental disease that is based on ontological realism and which follows the principles embodied in Basic Formal Ontology and in the application of BFO in the Ontology of General Medical Science. We analyzed statements about what counts as a mental disease provided in the research agenda for the DSM-V, and in Pies' model. The results were used to assess whether the representational units of BFO and OGMS were adequate as foundations for a formal representation of the entities in reality that these statements attempt to describe. We then analyzed the representational units specific to mental disease and provided corresponding definitions. Our key contributions lie in the identification of confusions and conflations in the existing terminology of mental disease and in providing what we believe is a framework for the sort of clear and unambiguous reference to entities on the side of the patient that is needed in order to avoid these confusions in the future. (shrink)

This Is A New Release Of The Original 1868 Edition.

Based on the Ontology for General Medical Science, we propose definitions for biomarkers of various types of. These definitions provide not only a complete formal representation of what biomarkers are according to the Institute of Medicine (IOM), but also remove the ambiguities and inconsistencies encountered in the documentation provided by the IOM.

The goal of the OBO (Open Biomedical Ontologies) Foundry initiative is to create and maintain an evolving collection of non-overlapping interoperable ontologies that will offer unambiguous representations of the types of entities in biological and biomedical reality. These ontologies are designed to serve non-redundant annotation of data and scientific text. To achieve these ends, the Foundry imposes strict requirements upon the ontologies eligible for inclusion. While these requirements are not met by most existing biomedical terminologies, the latter may nonetheless support (...) the Foundry’s goal of consistent and non-redundant annotation if appropriate mappings of data annotated with their aid can be achieved. To construct such mappings in reliable fashion, however, it is necessary to analyze terminological resources from an ontologically realistic perspective in such a way as to identify the exact import of the ‘concepts’ and associated terms which they contain. We propose a framework for such analysis that is designed to maximize the degree to which legacy terminologies and the data coded with their aid can be successfully used for information-driven clinical and translational research. (shrink)

What is honor? Has its meaning changed since ancient times? Is it an outmoded notion? Does it still have the power to direct our behavior? In this provocative book Alexander Welsh considers the history and meaning of honor and dismisses the idea that we live in a post-honor culture. He notes that we have words other than _honor_, such as _respect_, _self-respect_, and personal _identity_, that show we do indeed care deeply about honor. Honor, he argues, is a continuing (...) process of respect that motivates or constrains members of a peer group. Honor’s dictates function as moral imperatives. Surprisingly, little systematic study of the history of honor in Western culture has been attempted. Offering a welcome remedy, Welsh provides a genealogy of approaches to the subject, mining some of the most influential texts of the Western tradition. He rereads with fascinating results the works of Aristotle, Cicero, Shakespeare, Mandeville, Montesquieu, Rousseau, Kant, Adam Smith, and others. With a sharp focus on the intersection of honor and ethics in both literature and philosophy, Welsh invites new and constructive debate on a topic of vital interest. (shrink)

The medial prefrontal cortex (mPFC) has been the subject of intense interest as a locus of cognitive control. Several computational models have been proposed to account for a range of effects, including error detection, conflict monitoring, error likelihood prediction, and numerous other effects observed with single-unit neurophysiology, fMRI, and lesion studies. Here, we review the state of computational models of cognitive control and offer a new theoretical synthesis of the mPFC as signaling response–outcome predictions. This new synthesis has two interacting (...) components. The first component learns to predict the various possible outcomes of a planned action, and the second component detects discrepancies between the actual and intended responses; the detected discrepancies in turn update the outcome predictions. This single construct is consistent with a wide array of performance monitoring effects in mPFC and suggests a unifying account of the cognitive role of medial PFC in performance monitoring. (shrink)