Cloning

, from Oxford Uehiro Centre for Practical Ethics Julian Savulescu’s comment on the ethics of using embryos for medical research. To be published in The Age.

Abstract: Under traditional Jewish Law (halacha), assessment of human reproductive cloning (HRC) has been formulated along four lines of inquiry, which I discussed in Part I of this paper. Therein I also analyze five relevant doctrines of Talmudic Law, concluding that under with a risk-benefit analysis HRC fails to fulfill the obligation ‘to be fruitful and multiply’ and should be strictly prohibited. Here, I review of the topic from an exigetical Biblical and Kabbalistic perspective, beginning with exploring comments of the (...) Ramban (Nachmanides) which suggest Kabbalistic insights very much in keeping with current biology. In this Part II of the paper, I expand and annotate statements of the Ramban on the interrelationship of the reproductive faculties of an organism and its soul by examining the development of the spiritual states of plant, animal and human and noting the commensurate evolution with its reproductive facilities. Speculating that the reproductive mechanism of each species is indelibly related to its soul-state, I suggest that interfering with human sexual reproduction by HRC has the same effect the Ramban argues is the result of Kilayim (interbreeding), i.e., wrecking havoc with the Universe. In Part III, I postulate a biologic explanation for warnings found in the Golemic Literature and suggest that these allude to the importance of maintaining human genetic diversity through sexual reproduction. The conclusions I reached after evaluating the propriety of HRC under a Kabbalistic/metaphysical index comports with those I reached using a traditional legal /halachic inquiry in Part I. Thus, both systems arrive at the conclusion that HRC is in violation of the divine and natural order and constitute a distinct biological threat to the survival of the human species, a conclusions in accord with current scientific thinking. (shrink)

The British writer John Wyndham explored societal effects of surprising or mystical events. A paradigmatic example is The Midwich Cuckoos, which portrays identical-looking children born without sexual intercourse. I propose a reading strategy that focuses on the fictional spatial order and analyses how the construction of the children’s otherness interferes with the village’s demarcation. Furthermore, I interpret the mysterious pregnancies as a reference to basic embryo research in the 1950s – cloning. Finally, I scrutinize Wyndham’s negotiation of utilitarianism throughout the (...) novel and his critique of truly utilitarian decisions that are based on constructions of Otherness. (shrink)

When the phrase “playing God” is used in debates concerning the use of new technologies, such as cloning or genetic engineering, it is usually interpreted as a warning not to interfere with God’s creation or nature. I think that this interpretation of “playing God” arguments as a call to non-interference with nature is too narrow. In this paper, I propose an alternative interpretation of “playing God” arguments. Taking an argumentation theory approach, I provide an argumentation scheme and accompanying critical questions (...) that capture the moral concerns expressed by “playing God” arguments. If I am right, then “playing God” arguments should be understood, not as a warning to leave God’s creation or nature alone, but rather as an invitation to think carefully about all the ways in which the use of new technologies could go seriously wrong. (shrink)

Cloning research caught a great deal of attention when Dolly the sheep was born (§4). While some fear surrounded the attainment (§§14-15), Wilmutʼs research itself has grown well, providing a less vicious manner to gain ES cells (§12). In this article, we review the progress of cloning research along with the concern of medical circles about its application to reproductive cloning, that is to say, making replicas of human beings (§§16-21). Note that all the content is ascribed to the author (...) alone, not to Musashino University. (shrink)

This book provides an entry-level introduction to philosophical ethics, theories of moral reasoning, and selected issues in applied ethics. Chapter 1 describes the importance of philosophical approaches to ethical issues, the general dialectical form of moral reasoning, and the broad landscape of moral philosophy. Chapter 2 presents egoism and relativism as challenges to the presumed objectivity and unconditionality of morality. Chapters 3, 4 and 5 discuss utilitarianism, deontology, and virtue ethics, respectively. Each chapter begins with a general overview of the (...) characteristic theory of value and moral reasoning and proceeds to present a more refined account based on a prominent historical source (Mill, Kant, and Aristotle, respectively). It then discusses strengths and weaknesses of the theory from a contemporary perspective, including more recent developments, defenses, and critiques. Each chapter includes an appendix in which secondary, less prominent, or more complex issues are discussed. Chapters 6-9 address in detail a prominent area of applied ethics: 6. abortion, 7. assisted dying, 8. Biotechnology, 9. Animals and eating. Each of these chapters presents an introduction to the topic, including definitions, historical and contemporary developments and contexts, etc.; the various questions and issues involved; and an application of each theory from multiple points of view. Each chapter also includes a set of primary readings along with an extensive bibliography. Chapter 10 discusses four more areas of applied ethics: War, Torture, and Terrorism; Capital Punishment; Environmental Ethics; and Same-Sex Marriage. The treatment of these topics focuses mainly on the introductory material. While there is some discussion of the various ethical arguments, it is less comprehensive or detailed compared to other chapters. However, several primary resources are listed to supplement the discussion in the textbook. (shrink)

This chapter introduces the two main philosophical questions that are raised by the prospect of extinct species being brought back from the dead—namely, the ‘Authenticity Question’ and the ‘Ethical Question’. It distinguishes different types of de-extinction, and different methods by which de-extinction can be accomplished. Finally, it examines the aims of wildlife conservation with a view to whether they are compatible with de-extinction, or not.

[Selected as EDITOR'S CHOICE] Background: Extant surveys of people’s attitudes toward human reproductive cloning focus on moral judgments alone, not emotional reactions or sentiments. This is especially important given that some (esp. Leon Kass) have argued against such cloning on the grounds that it engenders widespread negative emotions, like disgust, that provide a moral guide. Objective: To provide some data on emotional reactions to human cloning, with a focus on repugnance, given its prominence in the literature. Methods: This brief mixed-method (...) study measures the self-reported attitudes and emotions (positive or negative) toward cloning from a sample of participants in the United States. Results: Most participants condemned cloning as immoral and said it should be illegal. The most commonly reported positive sentiment was by far interest/curiosity. Negative emotions were much more varied, but anxiety was the most common. Only about a third of participants selected disgust or repugnance as something they felt and an even smaller portion had this emotion come to mind prior to seeing a list of options. Conclusions: Participants felt primarily interested and anxious about human reproductive cloning. They did not primarily feel disgust or repugnance. This provides initial empirical evidence that such a reaction is not appropriately widespread. (shrink)

An influential argument in bioethics involves appeal to disgust, calling on us to take it seriously as a moral guide (e.g. Kass, Miller, Kahan). Some argue, for example, that genetic enhancement, especially via human reproductive cloning, is repellant or grotesque. While objectors have argued that repugnance is morally irrelevant (e.g. Nussbaum, Kelly), I argue that the problem is more fundamental: it is psychologically irrelevant. Examining recent empirical data suggests that disgust’s influence on moral judgment may be like fatigue: an exogenous (...) influence, yielding a “performance error” that does not reflect our understanding of moral matters. This conclusion also challenges appeals to repugnance on other topics (such as homosexuality) and generally downplays the importance of disgust in moral discourse. (shrink)

The technique of nuclear transplantation – popularly known as cloning – has been integrated into several different histories of twentieth century biology. Historians and science scholars have situated nuclear transplantation within narratives of scientific practice, biotechnology, bioethics, biomedicine, and changing views of life. However, nuclear transplantation has never been the focus of analysis. In this article, I examine the development of nuclear transplantation techniques, focusing on the people, motivations, and institutions associated with the first successful nuclear transfer in metazoans in (...) 1952. The conflict between embryologists and geneticists over the mechanisms of differentiation motivated Robert Briggs to pursue nuclear transplantation experiments as a way to resolve the debate. Briggs worked at the Lankenau Hospital Research Institute, a research facility devoted to the study of cancer. The goal of understanding cancer would play a role in the development of the technique, and the story of nuclear transplantation sheds light on the role that biomedical contexts play in biological research in the second half of the twentieth century. (shrink)

The creation of life has always spurred literary and cinematic productivity. Due to scientific progress in the fields of microbiology and genetics, countless novels and films today reflect the idea of human cloning more than other ideas. While the clone is often seen as the epitome of the posthuman, contemporary texts and films tend to modify the concept and humanize the clone. It can be said that fictional literature and films play a pivotal role in the construction, modification, and circulation (...) of concepts. Based on a cognitive linguistic concept of concept, the clone will be analyzed as an epistemic object. Focusing on conceptual processes of the configuration of knowledge, this article will show how the process of conceptualization works in literary texts and films and describe the techniques by which categories and concepts are constantly modified. Thus, it will be argued that literature and film play an active part in shaping a society's stock of knowledge. (shrink)

Im deutschen Embryonenschutz- und im Stammzellgesetz sind zwei Rechtsbegriffe von 'Embryo' definiert worden, die sich auf die Zelleigenschaft der Totipotenz stützen und dieser damit eine ontologische und normative Bedeutung beimessen, die angesichts der vielfältigen divergierenden Intuitionen und Argumente zur sogenannten Statusfrage nicht leicht zu rechtfertigen ist. Der vorliegende Beitrag diskutiert die Schwierigkeiten, den ontologischen, moralischen und rechtlichen Status totipotenter Humanzellen plausibel zu begründen, und argumentiert insbesondere, dass zwischen Grundannahmen der Substanzontologie und naturphilosophischen Kontinuitätsüberlegungen unaufhebbare Spannungen bestehen, die der Gesetzgeber durch (...) seine Legaldefinitionen einseitig gelöst hat, ohne über hinreichend belastbare Argumente zu verfügen. (shrink)

I evaluate a hypothetical society of human clones. Cloning implies the production of exact copies of an organism from a replication of one of the organism’s cells without any recourse to the genealogical protocol of male and female reproduction. I thus pose the question: Can we regard a cloned copy of Mr. James as a son of Mr. James or Mr. James once again? I consider certain implications of human cloning to the concepts of individual uniqueness, and thus of genealogical (...) family tree and the future of the naming and identification of humanity? (shrink)

This paper explores how current United States policies for funding nonreproductive cloning are justified and argues against that justification. I show that a common conceptual framework underlies the national prohibition on the use of public funds for cloning research, which I call the simple argument. This argument rests on two premises: that research harming human embryos is unethical and that embryos produced via fertilization are identical to those produced via cloning. In response to the simple argument, I challenge the latter (...) premise. I demonstrate there are important ontological differences between human embryos (produced via fertilization) and clone embryos (produced via cloning). After considering the implications my argument has for the morality of publicly funding cloning for potential therapeutic purposes and potential responses to my position, I conclude that such funding is not only ethically permissible, but also humane national policy. (shrink)

Bettina Schöne-Seifert and Marco Stier present a host of detailed and intriguing arguments to the effect that potentiality arguments have to be viewed as outdated due to developments in stem cell research, in particular the possibility of re-setting the development potential of differentiated cells, such as skin cells. However, their argument leaves them without an explanation of the intuitive difference between skin cells and human beings, which seems to be based on the assumption that a skin cell is merely part (...) of a human organism, while an embryo is at some point a human organism. An appropriately designed concept of the human organism can explain the difference, but also has the potential of re-dividing the argumentative landscape along familiar lines. (shrink)

This study explores the social representations of cloning taking in consideration a series of associated emotions and the subjects' level of religiosity. The participants in our study consisted of 356 subjects of different ages and professions. The data collection included four tasks for the subjects to fill in. First, they had to fill in a free task association: starting from the stimulus-word „cloning" they had to associate five words or expressions, and then rank these five words according to their importance. (...) The second task required polarity association for each of the expressions; thus, the subjects had to evaluate them as positive, negative or neutral in relation to „cloning". The third task was a questionnaire evaluating the level of religiosity (28 items). The last task included a list of 35 emotions (positive as well as negative) which subjects had to associate on a scale from 1 to 10 with the bio-medical procedure of cloning. The data analysis was focused on comparing the different groups defined in relation to the level of religiosity, affective polarity, age and level of education. We used the prototipicality technique, developed in the framework of the social representation's theory, in order to identify the elements of the social representations of cloning belonging to the previously mentioned variables. . (shrink)

Clones, Fakes and Posthumans: Cultures of Replication explores cloning and related phenomena that inform each other, like twins, fakes, replica, or homogeneities, through a cultural prism. What could it mean to think of a cloning mentality? Could it be that a “cloning culture” has made biotechnological cloning desirable in the first place, and vice versa that biotechnological cloning then enforces technologies of social and cultural cloning? What does it mean to say that a culture replicates? If biotechnological cloning has to (...) do with choice and repetitive reproduction of selected characteristics, how are those kinds of desires expressed socially, politically and culturally? Lifting the issue of cloning above the biotechnological domain, we problematize the cultural context, including modernity’s readiness to imitate and manipulate nature, and the skewed privileging of desirable socialities as a basis for exclusive replication. We also explore possible relations between a cloning mentality and a consumer society that fosters a brand-name mentality. The construction and implementation of copy-prone technological and symbolic items are at the very heart of the consumer society and its modes of mass production as they have emerged from and seek to articulate, define, and refine modernity and modernization. (shrink)

Stem cell research is very promising. The use of human embryos has been confronted with objections based on ethical and religious positions. The recent production of reprogrammed adult (induced pluripotent) cells does not – in the opinion of scientists – reduce the need to continue human embryonic stem cell research. So the debate continues.Islam always encouraged scientific research, particularly research directed toward finding cures for human disease. Based on the expectation of potential benefits, Islamic teachings permit and support human embryonic (...) stem cell research. The majority of Muslim scholars also support therapeutic cloning. This permissibility is conditional on the use of supernumerary early pre-embryos which are obtained during infertility treatment in vitro fertilization (IVF) clinics. The early pre-embryos are considered in Islamic jurisprudence as worthy of respect but do not have the full sanctity offered to the embryo after implantation in the uterus and especially after ensoulment.In this paper the Islamic positions regarding human embryonic stem cell research and therapeutic cloning are reviewed in some detail, whereas positions in other religious traditions are mentioned only briefly.The status of human embryonic stem cell research and therapeutic cloning in different countries, including the USA and especially in Muslim countries, is discussed. (shrink)

The aim of this paper is to scrutinize a contemporary standoff in the American debate over the moral permissibility of human reproductive cloning in its prospective use as a eugenic enhancement technology. I shall argue that there is some significant and under-appreciated common ground between the defenders and opponents of human cloning. Champions of the moral and legal permissibility of cloning support the technology based on the right to procreative liberty provided it were to become as safe as in vitro (...) fertilization and that it be used only by adults who seek to rear their clone children. However, even champions of procreative liberty oppose the commodification of cloned embryos, and, by extension, the resulting commodification of the cloned children who would be produced via such embryos. I suggest that a Kantian moral argument against the use of cloning as an enhancement technology can be shown to be already implicitly accepted to some extent by champions of procreative liberty on the matter of commodification of cloned embryos. It is in this argument against commodification that the most vocal critics of cloning such as Leon Kass and defenders of cloning such as John Robertson can find greater common ground. Thus, I endeavor to advance the debate by revealing a greater degree of moral agreement on some fundamental premises than hitherto recognized. (shrink)

This study has a twofold objective: firstly, it aims to examine the main types of argument that have been formulated against human cloning, to identify their presuppositions and to evaluate their strength; secondly, it aims to argue that the most important objections against human cloning are philosophical and religious, in particular the objection that human cloning represents a radical form of disenchantment or an abuse of rationality. The birth of a cloned mammal, a sheep named Dolly, which was announced on (...) 23 February 23 1997, began a wide public debate on the morality of human cloning. I shall try to show that this debate should not be limited only to ethical and legal considerations, since it has more profound ramifications. The science of cloning is rooted in a certain metaphysical background, which, discreetly, but firmly, accompanies its spectacular promises, and which has profound consequences on our metaphysical and religious beliefs. This background needs to be openly discussed and evaluated. Moreover, it warrants the special attention of philosophers and religious thinkers alike. . (shrink)

The American Journal of Bioethics, Volume 11, Issue 9, Page 37-39, September 2011.

This paper reviews three levels of discourse on human reproductive cloning in Japan: everyday life, fundamental theory, and public policy. In addition to articles with headlines on HRC in the Asahi Shimbun newspaper, 224 publications were found on HRC and categorized by publication year, author specialties, and contents. Contents of 100 publications were assigned to the following categories: cultural differences, acceptance of HRC, aversions to HRC, arguments against HRC , rebuttals and utilitarian arguments, arguments concerning regulation, and ethical principles, including (...) the right to healthcare and children's rights and welfare. An opinion poll and public policy were also reviewed. Bioethics on HRC in Japan is primarily based on Western ethics and is communitarianistic, but some arguments are traditionally anti-anthropocentric and vitalistic. Public policy does not seem to reflect bioethical principles, but instead reflects practical needs. (shrink)

McGovern, Kevin This article explores the report of the 2010 independent review committee into Australia's cloning and embryo research laws. Its author, the Director of the Centre, was one of the five members of this committee.

The advances in biotechnology have given rise to a discussion concerning the strong emotional reaction expressed by the public towards biotechnological innovations. This reaction has been named the ‘Yuck-factor’ by several theorists of bioethics. Leon Kass, the former chairman of the President's council on bioethics, has appraised this public reaction as ‘an emotional expression of deep wisdom, beyond reason's power fully to articulate it’.1 Similar arguments have been forwarded by the Catholic Church, several Protestant denominations and the Pro-Life movement. Several (...) bioethicists have, however, opposed the idea of a disgust-based morality.2Recent findings in cognitive science support the view that the strong negative emotions people often experience when faced with biotechnological ideas are not expressions of inner wisdom. The negative emotions may rather be the result of a cognitive violation the biotechnological innovations easily cause.Due to their evolutionary background, people have certain automatic and quick cognitive tendencies routinely used for categorizing and reasoning about nature, usually termed ‘folk biology’. Biotechnological processes like hybridisation and cloning clearly violate several of the cognitive rules people naturally apply for the explanation and categorization of their natural environment.As the cognitive tendencies routinely applied to the explanation of biological world are violated, an emotional response of fear, disgust and of something unnatural being underway is easily provoked. It is suggested in this paper that the reason behind the Yuck-factor is not a deep inner wisdom, but a violation of natural human cognitive tendencies concerning the biological world. (shrink)

Genomic interventions ex utero and in utero are already a reality in medicine. It is plausible to believe that this reality will lead to therapies at the preimplantation level, especially where such interventions are the only safe and effective way to truly prevent human suffering and disease in offspring. The plausibility of this type of genomic therapy is of particular interest for prospective parents who are Roman Catholic, since in vitro fertilization provides the only means by which an offspring’s genome (...) may be accessed prior to implantation. The goal of this essay is to provide a review of two traditional methodologies in Roman Catholic moral thought and the potential moral quandary they present Roman Catholic parents: adherence to moral teaching prohibiting IVF or relief of gene-based disease in their child. After finding little resolution of this quandary through these two methodologies, the essay proposes as an alternative a third approach that leans heavily on John Henry Cardinal Newman’s understanding of doctrinal development. National Catholic Bioethics Quarterly 11.4 : 735–756. (shrink)

It is technically possible to clone a human being. The result of the procedure would be a human being in its own right. Given the current level of cloning technology concerning other animals there is every reason to believe that early human clones will have shorter-than-average life-spans, and will be unusually prone to disease. In addition, they would be unusually at risk of genetic defects, though they would still, probably, have lives worth living. But with experimentation and experience, seriously unequal (...) prospects between cloned and noncloned people should erode. We shall ignore arguments about cloning that focus on the potential for harm to the fetus or resultant human being, where harm is understood solely in terms of physical and mental health. Unless the resultant people would generally have lives worth living there is no positive case for cloning, or any other form of reproduction, for that matter. If the resultant beings will generally have lives worth living there is a prima facie case for allowing cloning. We imagine the case in which the resultant beings will have lives well worth living. (shrink)

In analysing the position adopted by the United Kingdom over therapeutic cloning, this paper will endeavour to examine the question of regulation, its necessity and extent. This will be achieved through considering different models of relevant theoretical discourse before, in applying that discourse to identified systems of regulation, the advantages and pitfalls of each system will be assessed in the hope of reaching a solution appropriate to the sensitive, yet dynamic, needs of the issue.

It will be remembered that the introductory chapter to this paper differentiated between human therapeutic cloning and embryonic stem cell research, with the former concept encapsulating the latter one. In turning to examine the current system of regulation found within the United Kingdom this has particular relevance as it is only the practice of therapeutic cloning – the creation and use of an embryo – which engages with the regulative measures adopted.

Dignitas personae has garnered significant attention both inside and outside Roman Catholic circles, but it lacks the argumentative force not only to present the Church’s ethical judgment but also to persuade non-sympathetic readers. More direct engagement with contrary views would provide a stronger foundation for constructing arguments in public discourse. This article highlights various assertions found in Dignitas personae which call for greater explicit argumentation. Subjects treated include the ontological and moral status of human embryos, prenatal adoption, potentially abortifacient contraceptives, (...) reproductive cloning, and alternatives to human embryonic stem cell research, such as induced pluripotent stem cells and animal–human chimeras. (shrink)

. In the wake of the February 1997 announcement that Dolly the sheep had been cloned, Muslim religious scholars together with Muslim scientists held two conferences to discuss cloning from an Islamic perspective. They were organized by two influential Islamic international religioscientific institutions: the Islamic Organization of Medical Sciences and the International Islamic Fiqh Academy. Both institutions comprise a large number of prominent religious scholars and well‐known scientists who participated in the discussions at the conferences. This article gives a comprehensive (...) analysis of these conferences, the relation between science and religion as reflected in the discussions there, and the further influence of these discussions on Muslims living in the West. Modern discussions on Islamic bioethics show that formulating an Islamic perspective on these issues is not the exclusive prerogative of religious scholars. Formulating such perspectives has become a collective process in which scientists play an essential role. Such a collective approach strengthens the religious authority of Muslim scholars and makes it more influential rather than undermining it. (shrink)