Biofilms can be viewed as tissue‐like structures in which microorganisms are organized in a spatial and functional sophisticated manner. Biofilm formation requires the orchestration of a highly integrated network of regulatory proteins to establish cell differentiation and production of a complex extracellular matrix. Here, we discuss the role of the essential Bacillus subtilis biofilm activator RemA. Despite intense research on biofilms, RemA is a largely underappreciated regulatory protein. RemA forms donut‐shaped octamers with the potential to assemble into dimeric superstructures. The (...) presumed DNA‐binding mode suggests that RemA organizes its target DNA into nucleosome‐like structures, which are the basis for its role as transcriptional activator. We discuss how RemA affects gene expression in the context of biofilm formation, and its regulatory interplay with established components of the biofilm regulatory network, such as SinR, SinI, SlrR, and SlrA. We emphasize the additional role of RemA played in nitrogen metabolism and osmotic‐stress adjustment. (shrink)

Background Inadequate knowledge among health care providers (HCPs) and parents of affected children limits the understanding and utility of secondary genetic findings (SFs) in under-represented populations in genomics research. SFs arise from deep DNA sequencing done for research or diagnostic purposes and may burden patients and their families despite their potential health importance. This study aims to evaluate the perspective of both groups regarding SFs and their choices in the return of results from genetic testing in the context of orofacial (...) clefts.Methods Using an online survey, we evaluated the experiences of 252 HCPs and 197 parents across participating cleft clinics in Ghana and Nigeria toward the return of SFs across several domains.Results Only 1.6% of the HCPs felt they had an expert understanding of when and how to incorporate genomic medicine into practice, while 50.0% agreed that all SFs should be returned to patients. About 95.4% of parents were willing to receive all the information from genetic testing (including SFs), while the majority cited physicians as their primary information source (64%).Conclusions Overall, parents and providers were aware that genetic testing could help in the clinical management of diseases. However, they cited a lack of knowledge about genomic medicine, uncertain clinical utility, and lack of available learning resources as barriers. The knowledge gained from this study will assist with developing guidelines and policies to guide providers on the return of SFs in sub-Saharan Africa and across the continent. (shrink)

Had more philosophers of science come from chemistry, their thinking would have been different. I begin by looking at a typical chemical paper, in which making something is the leitmotif, and conjecture/refutation is pretty much irrelevant. What in fact might have been, might be, different? The realism of chemists is reinforced by their remarkable ability to transform matter; they buy into reductionism where it serves them, but make no real use of it. Incommensurability is taken without a blink, and actually (...) serves. The preeminence of synthesis in chemistry could have led philosophers of science to take more seriously questions of aesthetics within science, and to find a place in aesthetics for utility. The necessary motion twixt macroscopic and microscopic views of matter in modern chemistry leads to the coexistence of symbolic and iconic representations. And in another way to the deliberate, creative violation of categories. (shrink)

We study model theory of actions of finite groups on substructures of a stable structure. We give an abstract description of existentially closed actions as above in terms of invariants and PAC structures. We show that if the corresponding PAC property is first order, then the theory of such actions has a model companion. Then, we analyze some particular theories of interest (mostly various theories of fields of positive characteristic) and show that in all the cases considered the PAC property (...) is first order. (shrink)

Why do we formulate arguments? Usually, things such as persuading opponents, finding consensus, and justifying knowledge are listed as functions of arguments. But arguments can also be used to stimulate reflection on one’s own reasoning. Since this cognitive function of arguments should be important to improve the quality of people’s arguments and reasoning, for learning processes, for coping with “wicked problems,” and for the resolution of conflicts, it deserves to be studied in its own right. This contribution develops first steps (...) towards a theory of reflective argumentation. It provides a definition of reflective argumentation, justifies its importance, delineates it from other cognitive functions of argumentation in a new classification of argument functions, and it discusses how reflection on one’s own reasoning can be stimulated by arguments. (shrink)

Among the many problems posed by Peirce's concept of abduction is how to determine the scope of this form of inference, and how to distinguish different types of abduction. This problem can be illustrated by taking a look at one of his best known definitions of the term:Abduction is the process of forming an explanatory hypothesis. It is the only logical operation which introduces any new idea; for induction does nothing but determine a value, and deduction merely evolves the necessary (...) consequences of a pure hypothesis.The second half of this quote is not part of the definition, but an explanation of it. However, it adds something to this definition because it says implicitly that there are only three logical.. (shrink)

This volume contains thirteen original essays on weakness of will by scholars of contemporary philosophy and the history of philosophy. It covers the major periods of Western philosophy.

Wicked problems—that is, problems that can be framed in a number of different ways, depending on who is looking at them—pose ethical challenges for professionals that have scarcely been recognized as such. Even though wicked problems are all around us, they are rarely addressed in education. A reason for this failure might be that wicked problems pose almost insurmountable challenges in educational settings. This contribution shows how students can learn to cope with wicked problems in problem-based learning projects that are (...) structured by the Reflect! platform. (shrink)

Analyzing causation in terms of Woodward's interventionist theory and describing the structure of the world in terms of causal powers are usually regarded as quite different projects in contemporary philosophy. Interventionists aim to give an account of how causal relations can be empirically discovered and described, without committing themselves to views about what causation really is. Causal powers theorists engage in precisely the latter project, aiming to describe the metaphysical structure of the world. In this paper, I argue that interventionism (...) can benefit from incorporating considerations about causal powers. I describe a previously undiscussed problem for Woodward's definition of an intervention variable that arises when interventionist causal models include disjunctive variables. This problem is solved not by excluding disjunctive (or logically compound) variables per se, but by excluding variables whose values represent disjunctions of too different causal powers. This suggests that interventionism and causal powers theories may be less distant from each other than is often assumed. (shrink)

Uncertainty regarding potential disciplinary action may give physicians pause when considering whether to accept a chronic pain patient or how to treat a patient who may require long-term or high doses of opioids. Surveys have shown that physicians fear potential disciplinary acrion for prescribing controlled substances and that physicians will, in some cases, inadequately prescribe opioids due to fear of regulatory scrutiny. Prescribing opioids for long-term pain management, particularly noncancer pain management, has been controversial; and boards have investigated and, in (...) some cases, disciplined physicians for such prescribing. While in virtually all of these cases the disciplinary actions were successfully appealed, news of the success was not often as well-publicized as news of the disciplinary actions, leaving some physicians confused about their potential liability when prescribing opioids for pain. The confusion has perhaps increased as a result of two relatively recent cases, one where a physician was successfully disciplined by a state medical board for undertreatment of his patients’ pain, and another where the physician was successfully sued for inadequate pain treatment. (shrink)

The most controversial aspect of the interpretation of Scotus’s modal theory concerns the question of whether things are possible because God knows them to be possible, or whether they are possible independently from God. I argue that Scotus thought that the possibles are possibles because of God’s knowledge of them. I adduce a number of relevant texts that previous 20th century discussions of this interpretational problem have not taken into account. In addition, I discuss the modal theory of Francis of (...) Meyronnes (14th century) as well as the reception of Scotus’s modal theory by two Scotists of the 17th century, i.e., John Punch and Bartholomew Mastrius. (shrink)

The possible-worlds analysis of propositions identifies a proposition with the set of possible worlds where it is true. This analysis has the hitherto unnoticed consequence that a proposition depends for its existence on the existence of every proposition that entails it. This peculiar consequence places the possible-worlds analysis in conflict with the conjunction of two compelling theses. One thesis is that a phrase of the form ‘the proposition that S’ is a rigid designator. The other thesis is that a proposition (...) which is directly about an object – a singular proposition – depends for its existence on the existence of the object. I defend these theses and conclude that the cost of the possible-worlds analysis is prohibitively high. (shrink)

Defining the distinction between intrinsic and extrinsic properties has turned out to be one of the most difficult and controversial tasks in contemporary metaphysics. It is generally assumed that a definition of intrinsicness should aim to avoid as many counterexamples as possible and reduce the notion to less controversial philosophical notions. In this paper, the author argues for a new methodological approach to defining intrinsicness. Rather than trying to cover as many intuitive examples as possible, a definition of intrinsicness should (...) reflect the crucial features of our intuitive understanding of the notion, and one of these features is that the intrinsic/extrinsic distinction has to be characterized in a non-reductive way. (shrink)

All human languages are characterised by inherent synchronic variability (Hudson, Cognitive Linguistics 8: 73–108, 1997, English Language and Linguistics 11: 383–405, 2007a) and are subject to change over time. Consequently, due to this central role of variation and change, any explanatorily adequate cognitive theory of language should aim to account for both of these phenomena. The present special issue explores how usage-based Construction Grammars can address issues of linguistic variation and change. In particular, focusing on English, we will show how (...) constructionist approaches provide new insights for the study of variation and change in the English language as well as how data from English can help to refine construction grammar theories. This introduction will give a short overview of aspects of constructionist approaches to language which are of relevance to the modelling of linguistic variation and change. In addition to our discussion of the modelling of synchronic and diachronic variation in construction grammar, we provide an overview of the topics addressed by the seven articles in this special issue. (shrink)

Based on a typology of five basic forms of abduction, I propose a new definition of abductive insight that empha sizes in particular the inferential structure of a belief system that is able to explain a phenomenon after a new, abductive ly created component has been added to this system or the entire system has been abductively restructured. My thesis is, first, that the argumentative structure of the pursued problem solution guides abductive creativity and, second, that diagrammatic reasoning—if conceptualized according (...) to the requirements defined by Charles Peirce—can support this guidance. This support is mainly possible based on the normative power of the system of representation that has to be used to construct diagrams and to perform experiments with them. (shrink)

While it is unproblematic that someone evil causes further evil, it is difficult to explain how a good person can cause his or her first evil act. Augustine, denying that something good can be the cause of evil, concludes that the first moral evil has only a ‘deficient cause’, not an efficient cause, which is to say that it has no explanation. By contrast, Aquinas and Scotus hold that the first moral evil has a cause, that the cause is something (...) good, and that it is an efficient cause: the will. For Aquinas, the will can cause its first evil act only if it is momentarily non-culpably deficient, in that it does not make the intellect actually consider the moral rule relevant to the choice. For Scotus, no such occurrent deficiency is presupposed in the will causing its first evil act; the will’s freedom suffices. Yet there is surprising agreement: at bottom, Aquinas and Scotus both trace the first moral evil to the will’s ability for alternatives and no further. Thus their view converges with Augustine’s claim that evil ultimately has no efficient cause. (shrink)

According to Field’s influential incompleteness objection, Tarski’s semantic theory of truth is unsatisfactory since the definition that forms its basis is incomplete in two distinct senses: (1) it is physicalistically inadequate, and for this reason, (2) it is conceptually deficient. In this paper, I defend the semantic theory of truth against the incompleteness objection by conceding (1) but rejecting (2). After arguing that Davidson and McDowell’s reply to the incompleteness objection fails to pass muster, I argue that, within the constraints (...) of a non-reductive physicalism and a holism concerning the concepts of truth, reference and meaning, conceding Field’s physicalistic inadequacy conclusion while rejecting his conceptual deficiency conclusion is a promising reply to the incompleteness objection. (shrink)

ArgumentIn spring 1888, an anonymous critic raised severe doubts about Ernst Mach's and Peter Salcher's studies, published one year before, on the processes in the air caused by very rapid projectiles. Paraphrasing the experiments for the French popular science magazineLa Nature, the critic insinuated that the photographs upon which Mach and Salcher's argument were ostensibly based must have been of such low quality that they did not allow any well-founded conclusion. The critic did not deny the phenomena Mach and Salcher (...) had presented in their article; he denied that the photographs taken in the course of the experiments could permit any observation of the phenomena. I take the resulting quarrel as a window into the actors’ ideas on the requirements of “good observations” and the role of technical devices in this case. In particular I enquire how the various arguments relate to Lorraine Daston's and Peter Galison's framing of photography as an emblem of “mechanical objectivity.” We will see that in the case under debate, actors considered naked-eye observation, observation by telescope and photography mainly with regard to the challenges of the particular research object. (shrink)

The superassertability theory of truth, inspired by Crispin Wright (1992, 2003), holds that a statement is true if and only if it is superassertable in the following sense: it possesses warrant that cannot be defeated by any improvement of our information. While initially promising, the superassertability theory of truth is vulnerable to a persistent difficulty highlighted by James Van Cleve (1996) and Terrence Horgan (1995) but not properly fleshed out: it is formally illegitimate in a similar sense that unsophisticated epistemic (...) theories of truth are widely acknowledged to be. Sustained analysis reveals that the unrestricted formal legitimacy argument is firmly grounded in first person conceivability evidence. (shrink)

Ample research demonstrates that parents’ experience-based mental representations of attachment—cognitive models of close relationships—relate to their children’s social-emotional development. However, no research to date has examined how parents’ attachment representations relate to another crucial domain of children’s development: brain development. The present study is the first to integrate the separate literatures on attachment and developmental social cognitive neuroscience to examine the link between mothers’ attachment representations and 3- to 8-year-old children’s brain structure. We hypothesized that mothers’ attachment representations would relate (...) to individual differences in children’s brain structures involved in stress regulation—specifically, amygdala and hippocampal volumes—in part via mothers’ responses to children’s distress. We assessed 52 mothers’ attachment representations and children’s brain structure. Mothers’ secure base script knowledge was significantly related to children’s smaller left amygdala volume but was unrelated to hippocampal volume; we found no indirect links via maternal responses to children’s distress. Exploratory analyses showed associations between mothers’ attachment representations and white matter and thalamus volumes. Together, these preliminary results suggest that mothers’ attachment representations may be linked to the development of children’s neural circuitry related to stress regulation. (shrink)

More intellectual modesty, but also conceptual clarity is urgently needed in AI, perhaps more than in many other disciplines. AI research has been coined by hypes and hubris since its early beginnings in the 1950s. For instance, the Nobel laureate Herbert Simon predicted after his participation in the Dartmouth workshop that “machines will be capable, within 20 years, of doing any work that a man can do”. And expectations are in some circles still high to overblown today. This paper addresses (...) the demand for conceptual clarity and introduces precise definitions of “strong AI”, “superintelligence”, the “technological singularity”, and “artificial general intelligence” which ground in the work by the computer scientist Judea Pearl and the psychologist Howard Gardner. These clarifications allow us to embed famous arguments from the philosophy of AI in a more analytic context. (shrink)

The Two Envelopes Problem is a beautiful and quite confusing problem in decision theory which is ca. 35 years old and has provoked at least 150 papers directly addressing the problem and displaying a surprising variety of different responses. This paper finds decisive progress in an approach of Priest and Restall in 2003, contends that the recent papers having appeared since did not really go beyond that paper, argues further that Priest’s and Restall’s solution is still not complete, and proposes (...) a completion of their solution. If the analysis is correct, this work has the potential of laying the Two Envelopes Problem at rest. (shrink)

Certain traits of the magnanimous man of the Nicomachean Ethics seem incompatible with gratitude and humility. Albert the Great and Thomas Aquinas are the first commentators of the Latin West who had access to the integral portrayal of magnanimity in the Nicomachean Ethics. Surprisingly, they welcomed the Aristotelian ideal of magnanimity without reservations. The paper summarizes Aristotle’s account of magnanimity, discusses briefly the transformation of this notion in Stoicism and early scholasticism, and analyzes Albert’s and Thomas’s interpretation of Aristotle. Thomas (...) is found to be a more faithful and ingenious interpreter than Albert. He addresses and solves a number of philosophical problems of Aristotle’s account that still puzzle contemporary interpreters. (shrink)

As far as immigration theory is concerned, the attempt to reconcile concern for all persons with the reality of state boundaries and exclusionary policies has proved difficult within the limits of normative liberal political philosophy. However, the realpolitik of migration in today's environment forces a major paradigm shift. We must move beyond standard debates between those who argue for more open borders and those who argue for more closed borders. This book aims to show that a realistic utopia of political (...) theory of immigration is possible, but argues that to do so we must focus on expanding the boundaries of what are familiar normative positions in political theory. Theorists must better inform themselves of the concrete challenges facing migration policies: statelessness, brain drain, migrant rights, asylum policies, migrant detention practices, climate refugees, etc. We must ask: what is the best we can and ought to wish for in the face of these difficult migration challenges. Blake, Carens, and Cole offer pieces that outline the major normative questions in the political theory of immigration. The positions these scholars outline are challenged by the pieces contributed by Lister, Ottonelli, Torresi, Sager, and Silverman. These latter pieces force the reformulation of the central positions in normative political theory of immigration. This book was originally published as a special issue of New Challenges in Immigration Theory. (shrink)

Das Novum Organum (1620), das zentrale Hauptwerk der berühmten Instauratio Magna (Große Erneuerung der Wissenschaften) Francis Bacons (1561-1626), markiert den radikalen Bruch der neuzeitlichen Wissenschaft mit den antiken und mittelalterlichen Traditionen des Denkens. Methodische "Forschung" sowie "Fortschritt" und soziale "Wohlfahrt" als Erkenntniszweck - das sind die Grundthemen, denen Bacon erstmals Bestimmtheit gab.

The Questions on Aristotle’s Metaphysics is Duns Scotus’s most important philosophical work. While Scotus’s obscurity is proverbial, that work adds additional layers of impenetrability, so much so that its fifteenth-century editor spoke of a chaos metaphysicum. In the last twenty-five years, scholars have brought a lot of clarity to this chaos, which is partly due to the difficulty of Scotus’s thought and writing style, and partly to the complicated textual tradition of this work. A further contribution to greater readability of (...) the Metaphysics commentary is being made by a research team under the direction of Olivier Boulnois, which is undertaking its French translation, enriched by valuable introductory material.... (shrink)

The article studies the reception of Aristotle’s treatments of voluntariness and decision (EN 3.1–5) in the first three Latin commentaries (two by Albert the Great, one by Thomas Aquinas) that are based on the integral text of the Nicomachean Ethics. In particular, my goal is to examine how Albert’s and Thomas’s non-Aristotelian concepts of the will as a faculty distinct from reason influences their explanations of the Aristotelian account. It is argued that the Dominican commentators emphasize the idea of freedom (...) more than Aristotle did. (shrink)

This article studies Walter Chatton 's account of the connection of the virtues and its relation to the teaching of Henry of Ghent and John Duns Scotus. Chatton 's position with regard to the connection of temperance, fortitude, and justice is influenced by Henry and yet importantly different from him. Chatton 's teaching on the connection between prudence and the moral virtues closely follows Scotus's view. Both Franciscans frame this problem in terms of the connection between intellect and will. They (...) both deny that having prudence implies possessing the moral virtues on account of the freedom of the will. Furthermore, they deny that prudence presupposes the moral virtues, because they consider it impossible that the will induce the intellect to err. (shrink)

My dissertation consists of three essays in the Metaphysics of Modality: In "A Puzzle about Truth and Singular Propositions," I consider two theses that seem to be true and then an argument for the conclusion that they form an inconsistent pair. One thesis is that a proposition that is singular with respect to a given object implies that the object exists. This is so because the proposition predicates something of the object. The other thesis is that some propositions are true (...) with respect to possible worlds in which they do not exist. An example is the negation of the proposition that Socrates is wise. This proposition is true with respect to possible worlds in which Socrates does not exist, but it does not exist in those worlds. ;In "Actualism, Ontological Dependence, and Possible Worlds," I consider Actualism, the doctrine that every possible object is an actual object. Plantinga has argued that the actualist is committed to the existence of unexemplified essences if he analyzes statements of modality by quantifying over possible worlds and over members of their domains. I argue that the actualist is committed to the existence of unexemplified essences even if he paraphrases statements of modality by quantifying only over possible worlds and actual objects. ;In "Possibilism and the Nature of Actuality," I consider Possibilism, the doctrine that there are possible objects that are not actual objects. Possibilism seems to be a coherent ontological doctrine. It is not Meinong's doctrine that there are objects of which it is true to say that there are no such objects. If one fails to distinguish between these two doctrines, then one's attempt to refute Possibilism might amount to an attack on a blatant contradiction. I illustrate this claim by arguing that the distinction between Possibilism and Meinong's doctrine has eluded Plantinga. I then consider the view that Possibilism is a consequence of Lewis's doctrine that 'actual' is an indexical term. I also argue that the sense in which Lewis said that 'actual' is indexical is an esoteric sense of the word, not a sense it ordinarily has. (shrink)

Many have argued that it is impossible to determine criteria to identify good arguments. In this contribution, we argue that it is at least possible to identify features of objectively bad arguments. Going beyond Blair and Johnson’s ARS criteria, which state that reasons must be acceptable, relevant, and sufficient, we develop a list of eight criteria with instructions for how to apply them to assess arguments. We conclude by presenting data from two empirical studies that show how frequently students violate (...) these criteria in lab conditions and “in the wild.”. (shrink)

Summary. This paper analyzes Frederik Stjernfelt’s recently published Diagrammatology in order to clarify the role of diagrammatic reasoning within an epistemology that focuses on the problem of learning and the growth of knowledge. To achieve this goal, I provide more precise definitions of Peirce’s concepts of “diagram” and “diagrammatic reasoning,” emphasizing in particular the necessity of consistent systems of representation as a precondition for both. The paper starts with a critique of two theses for which Stjernfelt argues based on some (...) remarks by Peirce: first, that it is possible to learn by observing icons and, second, that icons can be defined by similarity. (shrink)

Some “of the most influential and prominent scholars in the field of Peirce studies” were asked to answer five questions: 1) Why were you initially drawn to Peirce? 2) What do you consider your contribution to the field? 3) What is the proper role of Peirce’s work in relation to philosophy and other academic disciplines? 4) What do you consider the most important topics and/or contributions in the field of Peirce studies? 5) What are the most important open problems in (...) this field and what are the prospects/avenues for progress? (shrink)

External representations play a crucial role in learning. At the same time, cognitive load theory suggests that the possibility of learning depends on limited resources of the working memory and on cognitive load imposed by instructional design and representation tools. Both these observations motivate a critical look at Computer-Supported Argument Visualization tools that are supposed to facilitate learning. This paper uses cognitive load theory to compare the cognitive efficacy of RationaleTM 2 and AGORA.