Considerable hope surrounds the use of disease‐specific pluripotent stem cells to generate models of human disease allowing exploration of pathological mechanisms and search for new treatments. Disease‐specific human embryonic stem cells were the first to provide a useful source for studying certain disease states. The recent demonstration that human somatic cells, derived from readily accessible tissue such as skin or blood, can be converted to embryonic‐like induced pluripotent stem cells (hiPSCs) has opened new perspectives for modelling and understanding a larger (...) number of human pathologies. In this review, we examine the opportunities and challenges for the use of disease‐specific pluripotent stem cells in disease modelling and drug screening. Progress in these areas will substantially accelerate effective application of disease‐specific human pluripotent stem cells for drug screening. (shrink)

David Gauthier is one of the most outstanding and influential philosophers working in moral theory today, and his book Morals by Agreement has established him as a preeminent defender of contractarian moral theory. This volume brings together a selection of his best essays on contractarianism, many of which have become difficult to find.

This book provides a clear and helpful overview of the philosophical core of the thought of Emmanuel Levinas, one of the most significant and interesting philosophers of the late twentieth century.

Loudness is the magnitude of the auditory sensation that a listener experiences when exposed to a sound. Several sound attributes are reported to affect loudness, such as the sound pressure level at the listener's ears and the spectral content. In addition to these physical attributes of the stimulus, some subjective attributes also appear to affect loudness. When presented with a sound, a listener interacts with an auditory object and can focus on several aspects of the latter. Loudness appears to differ (...) depending on how listeners apprehend this object, notably whether they focus on the sound that reaches their ears or that is produced by the source. The way listeners focus on the auditory object may depend on the stimulus itself. For instance, they might be more likely to focus on the sound emitted by the source if the latter is visible. The instructions given by the experimenters can also explicitly direct the listener's focus on the sound reaching the ears or emitted by the source. The present review aims at understanding how listeners focus on the auditory object depending on the stimuli and instructions they are provided with, and to describe how loudness depends on this focus. (shrink)

Rousseau is often portrayed as an educational and social reformer whose aim was to increase individual freedom. In this volume David Gauthier examines Rousseau's evolving notion of freedom, where he focuses on a single quest: can freedom and the independent self be regained? Rousseau's first answer is given in Emile, where he seeks to create a self-sufficient individual, neither materially nor psychologically enslaved to others. His second is in the Social Contract, where he seeks to create a citizen who (...) identifies totally with his community, experiencing his dependence on it only as a dependence on himself. Rousseau implicitly recognized the failure of these solutions. His third answer is one of the main themes of the Confessions and Reveries, where he is made for a love that merges the selves of the lovers into a single, psychologically sufficient unity that makes each 'better than free'. But is this response a chimaera? (shrink)

Martin Buber is considered one of the 20th centuryes greatest thinkers and his contributions to philosophy, theology and education are testimony to this. His thought is founded on the idea that people are capable of two kinds of relations, namely I-Thou and I-It, emphasising the centrality of dialogue in all spheres of human life. For this reason, Buber is considered by many to be the philosopher of dialogue par excellence. After Buberes death the appreciation of his considerable legacy to the (...) various disciplines in which he had worked became rather muted, but was never completely forgotten. There is now a renewed and growing interest in Buberes thought, especially in his philosophy of education. This book brings together aspects of Buberes philosophy and educational practice, and explains their significance for peace dialogue and for conflict resolution, both between individuals and communities. Buber's philosophy of dialogue and views on education are pivotal in demonstrating the personal and social benefits of dialogical education as well as the dangers of non-dialogical education. The book will be valuable reading for academics, researchers and postgraduate students interested in Martin Buber, education, peace dialogue and conflict resolution. (shrink)

A new edition of this bestseller, the only book to cover this range of ethical issues with attention both to the roundedness and individual integrity of each religious tradition and to focused issues which are of contemporary interest. The format of the book has not changed. It provides for parallel study of the values held by different communities, exploring the ethical foundations of Hinduism, Buddhism, Sikhism, Judaism, Christianity, and Islam. Each section introduces a different religion and sets the wider context (...) within which more specific questions can be asked. Individual topics can be accessed and understood not only within a tradition as a whole but also across traditions through careful indexing. The following topics are then addressed as appropriate to the given traditions: Religious Identity and Authority Personal and Private? Marriage and Family Influence on and Use of Time and Money Quality and Value of Life Questions of Right and Wrong Equality and Difference National Divisions, War and Peace Global Issues Key features * Each section is written by a specialist in that religious tradition, who in some cases is also an 'insider' and in the other cases has worked closely and in a respected and respectful way with members of that tradition. * Individual topics can be accessed and understood not only within a tradition as a whole but also across traditions through careful indexing * Additions to the text include subsections on reproduction, vegetarianism, just war and terrorism; and new material on weapons of mass destruction and pre-emptive strikes and genetic modification. (shrink)

Through the personal stories of managers running global business, this book takes an inside look into the dilemmas of managers who are asked to make profits ethically according to the dictates of their company's ethics code. It examines what companies `think" they are doing to help managers in those situations and how those managers are actually affected. Thanks to the boost from the 1991 Sentencing Guidelines which minimizes penalties for companies with ethics codes caught in ethical wrongdoing, more than 85% (...) of US companies and two thirds of all Canadian companies and half of all European companies now have Codes of Ethics. Yet, over and over, we hear of stories of personal dilemmas and conflicts experienced by individual managers navigating those business waters in other cultures. "Eileen Morgan does an excellent job of mapping the course for navigating the previously uncharted global ethical waters. By identifying best practices, she leads the reader on a journey from Surviving, to Understanding to Knowing the ethical issues that frequently confront international business people. This is a must read for anyone who wants to successfully compete in world markets." -Michael J. Litwin, Executive Vice President, Chief Credit Officer, Heller Financial, Inc. "Eileen Morgan has combined the pragmatic concerns of the individual manager with the moral concerns that come from personal-life history, cultural roots, and corporate ethical culture …This book focuses on the constructive task of formulating and using an "ethical map," and is sure to be a tonic to conscientious managers who want to navigate cross-cultural commerce with integrity. It has done a superb job of creating order out of the complexity of cross-cultural moral experience by insisting that the complexity must be honored and appropriated rather than ignored or suppressed." -Dr. Richard Beauchamp, Professor of Ethics, Christopher Newport University "In this groundbreaking book, Eileen Morgan has provided scores of real-life examples and developed a framework for approaching ethical leadership in international business. This is mandatory reading for anyone involved in global management today...This is an important book on an important subject." -Stephen H. Rhinesmith, Ph.D. Author, A Manager's Guide to Globalization "Eileen Morgan provides us with a much needed roadmap for how to walk the path of ethical leadership with practical feet. She reminds us that ethical decision-making is a critical aspect of every day leadership, and that we can all choose to be 'ethical pioneers' in our companies and our communities. Every leader engaged in global business can benefit from the lessons and stories included in this book." -Christi A. Olson, Ph.D. Chair, Telecommunications Management Department, Golden Gate University "Eileen Morgan's thoughtful analysis of 'ethical capital' should be read by anyone who does business in a global environment…Morgan's book presents the issue clearly, comprehensively and compellingly, demonstrating that ethics is an indispensable aspect of individual leadership and organizational credibility. …It provides a clear roadmap for business leaders who need to communicate their commitment to integrity and accountability to their employees, their partners, and their customer, making their 'ethical capital' one of their most valuable assets." -Nell Minnow, Principal, Lens, The Corporate Governance Investors "Eileen Morgan gives excellent insight into ethical practices. She focuses on business but her insights have general application. This book also describes differences in ethical interpretation that can arise between diverse cultures. Ms. Morgan has made an excellent contribution to understanding the benefit of positive ethical practices." -David C. Lincoln, Sponsor, Lincoln Center for Applied Ethics, College of Business, Arizona State University President, Arizona Oxides, LLC · First in-depth look at how managers in global companies actually bridge the gap between their organizations and their daily decisions · Explains the need for internal and external ethical operations¦and how organizations often create confusion rather than clarity with the label of "ethics". (shrink)

Feminist critics of the stigmatization of prostitution such as Martha Nussbaum and Sybil Schwarzenbach argue that the features of the practice do not, or at least need not, differ essentially from those of other more respected sorts of labor. I argue that even the least degraded forms of the current practice of prostitution remain objectionable on feminist grounds because patrons demand a semblance of sexual self-expression that engages discriminatory beliefs about women's sexuality.

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Artificial Virtues and the Sensible Knave1 David Gauthier Hume's account in the Treatise ofthe artificial virtues, their obligation and motivation, resists easy interpretation. Two passages, taken from his discussion of promises, will introduce, the problems I propose to examine. First: No action can be requir'd of us as our duty, unless there be implanted in human nature some actuating passion or motive, capable of producing the action. This (...) motive cannot be the sense of duty. A sense of duty supposes an antecedent obligation: And where an action is not requir'd by any natural passion, it cannot be requir'd by any natural obligation; since it may be omitted without proving any defect or imperfection in the mind and temper, and consequently without any vice. Now 'tis evident we have no motive leading us to the performance of promises, distinct from a sense of duty. If we thought, that promises had no moral obligation, we never shou'd feel any inclination to observe them.... But as there is naturally no inclination to observe promises, distinct from a sense of their obligation; it follows, that fidelity is no natural virtue, and that promises have no force, antecedent to human conventions.2 Ignore for the present the last sentence quoted. Hume seems clearly to be claiming that (1) an action can be a duty only if there is some motive to perform it other than a sense of duty, and (2) there is no motive to perform an act of promise-keeping other than a sense of duty. From (1) and (2) we may infer that (3) an act of promise-keeping can not be a duty. But since the sense of duty motivates an action only ifit is apprehended to be a duty, then from (2) and (3) we may conclude that (4) there is no motive to perform an act of promise-keeping that does not involve the mistaken apprehension that it is a duty. And the second passage: Afterwards a sentiment of morals concurs with interest, and becomes a new obligation upon mankind.... The difficulties, Volume XVIII Number 2 401 DAVID GAUTHIER that occur to us, in supposing a moral obligation to attend promises, we either surmount or elude. For instance; the expression of a resolution is not commonly suppos'd to be obligatory; and we cannot readily conceive how the making use of a certain form of words shou'd be able to cause any material difference. Here, therefore, we feign a new act ofthe mind, which we call the willing an obligation; and on this we suppose the morality to depend. But we have prov'd already, that there is no such act of the mind, and consequently that promises impose no natural obligation. (T 523) This time, ignore for the present the first sentence. The remainder would seem to confirm my reading ofthe first passage. Hume claims that (5) there is no natural obligation to perform an act of promise-keeping, but (6) we feign the willing of such an obligation. If, as Hume has claimed in the previous passage, (2) there is no motivation to perform an act ofpromise-keeping other than a sense ofduty, and if obligation and duty may be taken as equivalent, then we may conclude as before that (4) there is no motive to perform an act of promise-keeping that does not involve the mistaken apprehension that it is a duty. In his theory of the artificial virtues and vices, Hume considers "the three fundamental laws ofnature, thatofthestabilityofpossession, of its transference by consent, and of the performance of promises" (T 526). It would seem, from the passages cited, that Hume must suppose that there is no real obligation to keep promises, but only a feigned obligation. And since the reasoning that Hume employs in the first ofthe passages that I have cited is explicitly identified with "that reasoning, which prov'd justice in general to be an artificial virtue" (T 518), it seems clear that he must also suppose that there is no real obligation to uphold stability of possession and its transference by consent—no real obligation to observe the other laws of justice or equity.3... (shrink)

Dans cet essai de cosmologie sauvage, je ne me suis pas adressé aux marquises et aux abbesses, comme le fit Fontenelle, mon lointain prédécesseur, en son temps. Mon public est profane et il refuse d'emblée la docte ignorance (docta ignorantia) des métaphysiciens et des mystiques, femmes savantes ou esprits crédules. Il se méfie aussi bien des mystifications dont se parent parfois les savants et les scientifiques, aussi bien que des fabulations des auteurs de science-fiction, mais il tend l'oreille souvent aux (...) poètes, écrivains et philosophes inquiets. La cosmologie ou théorie de l'univers est-elle possible et n'est-elle pas limitée par un horizon, l'horizon du visible ou de l'observable? Imaginer un au-delà de l'horizon est la tâche de la cosmologie spéculative qui a remplacé la métaphysique et qui prend alors la relève de la mythologie pour inventer la scène primitive d'une mer originelle. Cette eau originaire, que l'on retrouve chez Thalès dans la philosophie grecque présocratique, n'est pas si éloignée des fluctuations du vide quantique et le mythe de l'océan primitif peut être perçu comme la matrice de toutes les cosmogonies. Mais qui n'abordera jamais les rives de l'origine? La limite antérieure de l'origine rejoint la limite de l'horizon : toutes deux sont récessives et l'on ne peut concevoir l'univers que comme une sphère, ce qu'un autre penseur présocratique, Parménide, avait bien vu. C'est dans cette sphère que l'observateur local se tient et tient ensemble l'origine et l'horizon pour mesurer l'empan de l'univers, avec la Terre en son centre. (shrink)

The people's right to know and press rights to gather and publish information remain dominant justifications for controversial media activities. Yet, the power of the media to set the agenda for public discourse in our country warrants a careful analysis of these rights, their corresponding responsibilities, and their moral limits. This article examines the right to know and press freedom from the perspective of their shared purpose, facilitation of informed decision making. This article also demonstrates moral justification of limits on (...) right to know and press freedom based on traditional ethics theories and media impact on public discourse. (shrink)

This study explores gratitude as a multidimensional and work-specific construct. Utilizing a sample of 625 employees from a variety of positions in a medium-sized school district in the United States, we developed and evaluated a new measure, namely the Work Gratitude Scale, which encompasses recognized conative, cognitive, affective, and social aspects of gratitude. A systematic, six-phased approach through structural equation modeling was used to explore and confirm the factorial structure, internal consistency, measurement invariance, concurrent, convergent, and discriminant validity of the (...) WGS. The results supported a 10-item measure with three dimensions: “grateful appraisals”, “gratitude toward others”, and “intentional attitude of gratitude”. Thereafter, first-order, second-order, and bifactor confirmatory models were estimated and compared. Work gratitude was found to be best described by a second-order construct with three underlying first-order dimensions. Measurement invariance was supported in relation to gender. Concurrent validity was supported in relation to two existing dispositional gratitude scales, namely the Gratitude Questionnaire and the Gratitude, Resentment, and Appreciation Scale. Convergent validity was supported in relation to the Core Self-Evaluations Scale and the Psychological Capital Questionnaire. Discriminant validity was supported in relation to various demographic factors such as age, gender, occupation, and tenure. The findings support the WGS as a multidimensional measure that can be used in practice to measure overall work-related gratitude and to track the effectiveness of gratitude-related workplace interventions. (shrink)

Comment expliquer la persistance d’objets techniques ou scientifiques qui semblent en tout point dépassés? Cet article étudie ce problème, à travers un cas portant sur les modèles d’évaluation du passage de la radioactivité dans l’environnement. Ces modèles apparaissent dans les années 1950 et se fondent alors sur un coefficient unique. De nombreux problèmes conceptuels et pratiques concernant ce paramètre apparaissent et sont alors menés de nombreux travaux de développement d’alternatives à ces modèles qui semblent dépassés. Malgré cela, ceux-ci sont encore (...) aujourd’hui largement majoritaires. Nous expliquons cette situation a priori paradoxale par des raisons « pratiques » et avec des arguments fondés sur les fonctions des modèles et sur leurs usages. (shrink)

Comment expliquer la persistance d’objets techniques ou scientifiques qui semblent en tout point dépassés? Cet article étudie ce problème, à travers un cas portant sur les modèles d’évaluation du passage de la radioactivité dans l’environnement. Ces modèles apparaissent dans les années 1950 et se fondent alors sur un coefficient unique. De nombreux problèmes conceptuels et pratiques concernant ce paramètre apparaissent et sont alors menés de nombreux travaux de développement d’alternatives à ces modèles qui semblent dépassés. Malgré cela, ceux-ci sont encore (...) aujourd’hui largement majoritaires. Nous expliquons cette situation a priori paradoxale par des raisons « pratiques » (coûts techniques, structure sociale de l’expertise) et avec des arguments fondés sur les fonctions des modèles et sur leurs usages. (shrink)

My argument will proceed as follows. I will first sketch out the broad internalist case for pitching its normative account of sport in the abstract manner that following Dworkin’s lead in the philosophy of law its adherents insist upon. I will next show that the normative deficiencies in social conventions broad internalists uncover are indeed telling but misplaced since they hold only for what David Lewis famously called ‘coordinating’ conventions. I will then distinguish coordinating conventions from deep ones and make (...) my case not only for the normative salience of deep conventions but for their normative superiority over the abstract normative principles broad internalists champion. (shrink)

This paper examines the interpretation of Hobbes as a political formalist which is developed by F. S. McNeilly in The Anatomy of Leviathan. McNeilly argues that Hobbes's demonstration of the necessity of political society is independent of Hobbes's particular view of man as an egotist bent at all costs on his own preservation. The first part of the argument of the paper uses techniques of decision theory and game theory to show that this argument which McNeilly ascribes to Hobbes is (...) not valid. However, the argument which Hobbes is traditionally supposed to put forward is shown to be valid. The second part of the paper examines McNeilly's interpretation of the text of Leviathan and shows that he has insufficient grounds for supposing that Hobbes attempted to construct a purely formal science of politics. (shrink)

This book equips readers with a sound understanding of the value-base of mental health care and provides them with the skills and knowledge to demystify complex values in decision-making in order to reach outcomes which are focused on the needs of service users. Engaging case examples and exercises link theory and practice throughout.

The way many human rights advocates frame the international norm against child, early, and forced marriage (CEFM) has shifted in the past decade. While CEFM has historically been framed as driven by poverty and underdevelopment, advocates have more recently discussed the problem with a feminist sexuality frame. What leads advocates to change their framing about an international norm? We build an argument that stresses how (a) the nature of the frame, (b) the characteristics of the advocates, and (c) the characteristics (...) of the discursive environment interact to determine whether and to what extent advocates will adopt an alternative frame. We use a multi-methods approach (machine-learning text analysis, process tracing, and interviews) to examine the process of frame adoption around an international norm. Our theoretical understanding of international norms requires a better grasp on the role of framing, especially framing among the very norm entrepreneurs that are critical to international norm diffusion. (shrink)

Des millions d'années avant l'apparition de l'homme, la vie avait déjà inventé la roue, le moteur atomique, le sonar, le vol stationnaire, la capture de l'énergie solaire, l'éclairage électrique, le GPS et des myriades de techniques qui nous dépassent encore complètement : cicatrisation, reproduction, congélation suivie de réanimation, et des cerveaux dont chacun des milliards de neurones est un univers informatique. Pour le comprendre, il a fallu attendre que nos propres technologies atteignent les profondeurs moléculaires du vivant, nous révélant que (...) les inventions de la nature étaient infiniment plus complexes que les nôtres. " Le service Recherche et Développement de la nature a 3,8 milliards d'années d'avance sur ceux de nos entreprises ", aime dire Janine Benyus, la naturaliste américaine qui a inventé le concept de biomimétisme. " Il s'agit de nous en inspirer pour pousser plus loin nos propres inventions, mais surtout pour corriger le tir de ces dernières, qui nous ont conduits dans les impasses écologiques que l'on sait. " Il existe trois niveaux de biomimétisme. Le premier consiste à imiter les formes de la nature. Le second, de plus en plus prisé des industriels, repose sur l'imitation des matériaux et des processus naturels. La vraie révolution repose cependant sur le troisième niveau, qui consiste à imiter les stratégies du vivant, sa philosophie. Ce troisième niveau a des implications fascinantes. Ainsi, contrairement à l'image que nous nous faisons de la " loi de la jungle ", la nature ne pratique la compétition que dans 10 % des rapports entre organismes. Les 90 % restants sont fondés sur la coexistence, le mutualisme, la coopération, le commensalisme, le parasitisme et la symbiose. A imiter absolument! (shrink)

Questions about the function of consciousness have long been central to discussions of consciousness in philosophy and psychology. Intuitively, consciousness has an important role to play in the control of many everyday behaviors. However, this view has recently come under attack. In particular, it is becoming increasingly common for scientists and philosophers to argue that a significant body of data emerging from cognitive science shows that conscious states are not involved in the control of behavior. According to these theorists, nonconscious (...) states control most everyday behaviors. Andy Clark does an admirable job of summarizing and defending the most important data thought to support this view. In this paper, I argue that the evidence available does not in fact threaten the view that conscious states play an important and intimate role in the control of much everyday behavior. I thereby defend a philosophically intuitive view about the functions of conscious states in action. (shrink)

In this paper a new resolution to the gamer’s dilemma is presented. The first part of the paper is devoted to strictly formulating the dilemma, and the second to establishing its resolution. The proposed resolution, the grave resolution, aims to resolve not only the gamer’s dilemma, but also a wider set of analogous paradoxes – which together make up the paradox of treating wrongdoing lightly.

ABSTRACT: It is argued that the equivalence, which is usually postulated to hold between infinite descent and transfinite induction in the foundations of arithmetic uses the law of excluded middle through the use of a double negation on the infinite set of natural numbers and therefore cannot be admitted in intuitionistic logic and mathematics, and a fortiori in more radical constructivist foundational schemes. Moreover it is shown that the infinite descent used in Dedekind-Peano arithmetic does not correspond to the infinite (...) descent of classical Fermatian arithmetic or number theory. However, from the point of view of classical logic, the principles of complete induction and transfinite induction, the least number principle and infinite descent are all equivalent. We find here a focal point for a foundational critique that aims for a a clarification of philosophical options in the foundations of logic and mathematics. (shrink)

The principle of respect for autonomy is increasingly under siege as a valuable component of healthcare ethics. Its critics charge that it has been elevated to a position out of proportion to its contribution, so that the individual's wishes and rights have come to dominate healthcare decisionmaking, while obligations and responsibilities are ignored or devalued. If we are to salvage respect for autonomy we must find a way to reconnect the individual and the community, rights and responsibilities, in the way (...) we think about, discuss, and make healthcare decisions. (shrink)

Although recent research suggests that women are underrepresented in philosophy after initial philosophy courses, there have been relatively few empirical investigations into the factors that lead to this early drop-off in women’s representation. In this paper, we present the results of empirical investigations at a large American public university that explore various factors contributing to women’s underrepresentation in philosophy at the undergraduate level. We administered climate surveys to hundreds of students completing their Introduction to Philosophy course and examined differences in (...) women’s and men’s feelings of belonging, comfort, and confidence in the philosophy classroom. We present findings suggesting various factors that contribute to women’s lower willingness to continue in philosophy compared to men’s, including perceptions about intuition-based methods in philosophy, the usefulness of the philosophy major, philosophy as a male discipline, and philosophical abilities as innate talents. We conclude by providing some suggestions for improving undergraduate philosophy courses in ways that would increase women’s willingness to continue in philosophy and may improve the courses for all students. (shrink)

Most people agree that murder is wrong. Yet, within computer games virtual murder scarcely raises an eyebrow. In one respect this is hardly surprising, as no one is actually murdered within a computer game. A virtual murder, some might argue, is no more unethical than taking a pawn in a game of chess. However, if no actual children are abused in acts of virtual paedophilia (life-like simulations of the actual practice), does that mean we should disregard these acts with the (...) same abandon we do virtual murder? In this paper I shall outline several arguments which attempt to permit virtual murder, whilst prohibiting virtual paedophilia. (shrink)