© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 23 (2003) 147-148 [Access article in PDF] Buddhists and Christians: Praying for Peace in the World Archbishop Michael L. Fitzgerald Pontifical Council for Interreligious Dialogue Dear Buddhist Friends:As the new president of the Pontifical Council for Interreligious Dialogue, the office of His Holiness the Pope for relations with people of different religious traditions, I wish to greet you and send this congratulatory message on the occasion (...) of the feast of Vesakh. This gesture of friendship, initiated in 1995 by my predecessor Cardinal Francis Arinze, has almost become a tradition. I wish to continue this good tradition and express my hearty congratulations to each and every one of you.In this message, I would like to invite you, my dear Buddhist friends, to join in prayer for the cause of peace in the world. Observing the current international situation, we cannot but be aware of the acuteness of the question of peace in our world. Since the beginning of this new millennium, marked by the dramatic events of September 11, 2001, we witness every day fresh scenes of bloodshed, violence, confrontation, and crisis in almost all parts of the world. In the midst of this grave situation, we cannot lead our lives without committing ourselves to advancing the cause of peace in the world.We Christians and Buddhists are convinced that the origin of all conflict is ultimately located in human hearts characterized by selfish desire, specifically by desire for power, domination, and wealth, often at the expense of others. It is also our common conviction that peace must inhabit people's hearts before it can become a social reality. For us, therefore, the most fundamental and efficient way to advance peace is to do our best to see that the deep-rooted selfishness of human hearts is overcome, so that people may be transformed into true artisans of peace.Pope John Paul II has proclaimed the year from October 2002 to October 2003 the Year of the Rosary of the Virgin Mary. He has earnestly encouraged the frequent recitation of the Rosary in order to pray for peace in the world. His wish to revive the practice of the Rosary is closely connected with the present historical circumstances, which need more than ever-constant supplication for the great gift of peace.My Buddhist friends, is it not a wonderful coincidence that you also have a lengthy tradition of using the Mala for prayer? The Rosary for Catholics and the [End Page 147] Mala for Buddhists are simple yet profound and meaningful prayer, despite essential differences in their form and content, based on our distinct doctrines and practices. For Catholics, the Rosary represents a most effective means of fostering contemplation of Jesus Christ. For Buddhists, the Mala is used to overcome the 108 Sinful Desires in order to reach the state of Nirvana. By virtue of their meditative character, these two prayers have in common a calming effect on those who pray them; they lead them to experience and to work for peace, and they produce fruits of love. For Catholics, the repetition and meditation of the holy names of the Persons of the Blessed Trinity and the Virgin Mary in the recitation of the Rosary makes us more willing to assimilate their love and compassion for others, especially for the poor and afflicted. In your Buddhist tradition, praying the Mala helps one to become a peacemaker.Dear Buddhist friends, these are the thoughts I wish to share with you this year. I am convinced that by persevering in prayer we will contribute to advancing peace in the world both now and in the future. May this peace be with you and your families on the feast of Vesakh and at all times.Archbishop Michael L. Fitzgerald, President © by Michael L. Fitzgerald. Reprinted by permission.... (shrink)

Alexis de Tocqueville asserted that America had no truly great literature, and that American writers merely mimicked the British and European traditions of the eighteenth and nineteenth centuries. This new edited collection masterfully refutes Tocqueville's monocultural myopia and reveals the distinctive role American poetry and prose have played in reflecting and passing judgment upon the core values of American democracy. The essays, profiling the work of Mark Twain, F. Scott Fitzgerald, John Updike, Edith Wharton, Walt Whitman, Henry James, Willa (...) Cather, Walker Percy, and Tom Wolfe, reveal how America's greatest writers have acted as society's most ardent cheerleaders and its most penetrating critics. Christine Dunn Henderson's exciting new work offers literature as a portal through which to view the philosophical principles that animate America's political order and the mores which either reinforce or undermine them. (shrink)

This book offers a defence of mathematical fictionalism, according to which we have no reason to believe that there are any mathematical objects. Perhaps the most pressing challenge to mathematical fictionalism is the indispensability argument for the truth of our mathematical theories (and therefore for the existence of the mathematical objects posited by those theories). According to this argument, if we have reason to believe anything, we have reason to believe that the claims of our best empirical theories are (at (...) least approximately) true. But since claims whose truth would require the existence of mathematical objects are indispensable in formulating our best empirical theories, it follows that we have good reason to believe in the mathematical objects posited by those mathematical theories used in empirical science, and therefore to believe that the mathematical theories utilized in empirical science are true. Previous responses to the indispensability argument have focused on arguing that mathematical assumptions can be dispensed with in formulating our empirical theories. This book, by contrast, offers an account of the role of mathematics in empirical science according to which the successful use of mathematics in formulating our empirical theories need not rely on the truth of the mathematics utilized. (shrink)

We all know that speech can be harmful. But how? Mary Kate McGowan argues that speech constitutes harm when it enacts a norm that prescribes that harm. She investigates such harms as oppression, subordination, and discrimination in such forms of speech as sexist remarks, racist hate speech, pornography, verbal triggers, and micro-aggressions.

Philosophers have traditionally concentrated on the qualities that make human beings different from other species. In _Beast and Man_ Mary Midgley, one of our foremost intellectuals, stresses continuities. What makes people tick? Largely, she asserts, the same things as animals. She tells us humans are rather more like other animals than we previously allowed ourselves to believe, and reminds us just how primitive we are in comparison to the sophistication of many animals. A veritable classic for our age, _Beast (...) and Man_ has helped change the way we think about ourselves and the world in which we live. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Scandal of White Complicity in US Hyper-Incarceration: A Nonviolent Spirituality of White Resistance by Alex Mikulich, Laurie Cassidy, and Margaret PfeilNancy M. RourkeThe Scandal of White Complicity in US Hyper-Incarceration: A Nonviolent Spirituality of White Resistance Alex Mikulich, Laurie Cassidy, and Margaret Pfeil new york: palgrave macmillan, 2013. 203 pp. $90.00As a white American Catholic ethicist, I often envy my Protestant counterparts’ legacy of acknowledging and fighting (...) racism. Catholic moral theology lacks Protestantism’s bodies of literature, activism, and bold ecclesial statements addressing racism in the United States. (For more on this, see Bryan Massingale’s Racial Justice and the Catholic Church.) The Scandal of White Complicity in US Hyper-Incarceration demonstrates how Catholicism might approach American racism using several elements of Catholic theology.The book opens with series editor Mary Jo Iozzo’s introduction to the Content and Context in Theological Ethics series, of which this is the fifth book. A personal and reflective foreword by Sr. Helen Prejean follows. Then the book’s argument begins with a description of the United States’ practice of mass incarceration and brief discussions of what is meant by “whiteness” and “complicity.” This book employs a phenomenological understanding of race and of whiteness, taking whiteness as habitus. The literature about this approach to race and to identity is enormous, but familiarity with that literature is not necessary to follow this book’s presentation, argument, or use of the idea.Each of the book’s three authors has written a two-chapter section. Alex Mikulich’s explanation of white habitus speaks on levels of social thought and of the individual’s experience. Laurie Cassidy’s section looks at the culture of hyperincarceration and the development of the “dangerous black man” myth, and Margaret Pfeil’s section on spirituality works from the beatitudes, John of the Cross, and a wide array of other sources to describe a political spirituality of resistance for white Christians.This book would be most useful to masters-level graduate students in theological ethics or anyone preparing to begin teaching in areas of ethics related to racism or criminal justice (particularly in Catholic institutional settings). Rather than drawing exclusively on Catholic social teaching to talk about white participation in racism, these authors more satisfyingly put many Catholic traditions into action. For example, the book demonstrates careful use of the concepts of complicity, responsibility, participation, and intention; it considers specific [End Page 195] actions while maintaining focus on systems’ structures; and it uses a wide range of Catholic thinkers, including Metz, Copeland, Soelle, Gutiérrez, Carmelite Sr. Constance FitzGerald, Lonergan, Day, and John of the Cross.This book assumes and asserts that racism still exists, that whiteness exists and aims to make itself invisible, and that racism is kept alive through social structures that flow from white habitus. However, the book does not assume the reader’s agreement with any of these. Instead, the book first makes the case that these things are true and then takes next steps toward responsive practices of resistance. Rhetorically tinged homiletic shortcuts are not used to bolster this argument. For example, in similar works, the question of moral culpability for racist social structures is sometimes managed only with a discussion of how such structures distribute benefits and harms unequally. In this book, that argument is not used alone but in tandem with a careful look at the intention of one’s participation in such structures.Minor problems exist. The book would have benefited from one more round of editing to eliminate minor punctuation and writing problems, and the Catholic moral concept of “scandal” receives little systematic attention despite its presence in the title. Otherwise, the book demonstrates well what Catholic moral theology could do if applied to American white racism. Here’s hoping that this is just the beginning of more such scholarship.Nancy M. RourkeCanisius CollegeCopyright © 2015 Society of Christian Ethics... (shrink)

This 1997 book was the first English translation of all of Kant's writings on moral and political philosophy collected in a single volume. No other collection competes with the comprehensiveness of this one. As well as Kant's most famous moral and political writings, the Groundwork of the Metaphysics of Morals, the Critique of Practical Reason, the Metaphysics of Morals, and Toward Perpetual Peace, the volume includes shorter essays and reviews, some of which have never been translated before. The volume has (...) been furnished with a substantial editorial apparatus including translator's introductions and explanatory notes to each text by Mary Gregor, and a general introduction to Kant's moral and political philosophy by Allen Wood. There is also an English-German and German-English glossary of key terms. (shrink)

Mary Midgley argues in her powerful new book that far from being the opposite of science, myth is a central part of it. In brilliant prose, she claims that myths are neither lies nor mere stories but a network of powerful symbols that suggest particular ways of interpreting the world.

Plato famously promised to complement the Sophist and the Statesman with another work on a third sort of expert, the philosopher--but we do not have this final dialogue. Mary Louise Gill argues that Plato promised the Philosopher, but did not write it, in order to stimulate his audience and encourage his readers to work out, for themselves, the portrait it would have contained. The Sophist and Statesman are themselves members of a larger series starting with the Theaetetus, Plato's investigation (...) of knowledge, and the whole series relies on the Parmenides, the second part of which presents a philosophical exercise, introduced as the first step in a larger philosophical program. Gill contends that the dialogues leading up to the missing Philosopher, though they reach some substantive conclusions, are philosophical exercises of various sorts designed to train students in dialectic, the philosopher's method; and that a second version of the Parmenides exercise, closely patterned on it, spans parts of the Theaetetus and Sophist and brings the philosopher into view. This is the exercise about being, the subject-matter studied by Plato's philosopher. Plato hides the pieces of the puzzle and its solution in plain sight, forcing his students (and modern readers) to dig out the pieces and reconstruct the project. Gill reveals how, in finding the philosopher through the exercise, the student becomes a philosopher by mastering his methods. She shows that the target of Plato's exercise is internally related to its pedagogical purpose. (shrink)

The concept of self-motion is not only fundamental in Aristotle's argument for the Prime Mover and in ancient and medieval theories of nature, but it is also central to many theories of human agency and moral responsibility. In this collection of mostly new essays, scholars of classical, Hellenistic, medieval, and early modern philosophy and science explore the question of whether or not there are such things as self-movers, and if so, what their self-motion consists in. They trace the development of (...) the concept of self-motion from its formulation in Aristotle's metaphysics, cosmology, and philosophy of nature through two millennia of philosophical, religious, and scientific thought. This volume contains "Self-Movers" (David Furley), "Aristotle on Self-Motion" (Mary Louise Gill), "Aristotle on Perception, Appetition, and Self-Motion" (Cynthia Freeland), "Self-Movement and External Causation" (Susan Sauvé Meyer), "Aristotle on the Mind's Self-Motion" (Michael Wedin), "Mind and Motion in Aristotle" (Christopher Shields), "Aristotle's Prime Mover" (Aryeh Kosman), "The Transcendence of the Prime Mover" (Lindsay Judson), "Self-Motion in Stoic Philosophy" (David Hahm), "Duns Scotus on the Reality of Self-Change" (Peter King), "Ockham, Self-Motion, and the Will" (Calvin Normore), and "Natural Motion and Its Causes: Newton on the 'Vis Insita' of Bodies" (J. E. McGuire). Originally published in 1994. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

Renowned philosopher Mary Midgley explores the remarkable gap that has opened up between our own understanding of our sense of our self and today's scientific orthodoxy that claims the self to be nothing more than an elaborate illusion. Bringing her formidable acuity and analytic skills to bear, she exposes some very odd claims and muddled thinking on the part of cognitive scientists and psychologists when it comes to talk about the self. Well-known philosophical problems in causality, subjectivity, empiricism, free (...) will and determinsim are shown to have been glossed over by scientists claiming that the self is no more than a jumble of brain-cells. Midgley argues powerfully and persuasively that the rich variety of our imaginative life cannot be contained in the narrow bounds of a highly puritanical materialism that equates brain and self. The denial of the self has been sustained by the belief that physical science requires it, but there is not just one such pattern of thought but many others which all help to explain the different kinds of problems that arise in our life, argues Midgley. Physics' amazing contemporary successes spring from attacking problems that arise within physics, not from outside. It is no more sensible to give a physical answer to a moral problem than it is to give political answers to physical ones. 'Are you an Illusion?' is an impassioned defence of the importance of our own experiences - the subjective sources of thought - which are every bit as necessary for the world as the objective ones such as brain cells. (shrink)

In this new book, Mary Lynne Ellis and Noreen O'Connor move to the heart of 21st century intertwining of psychoanalytical and philosophical critical reflections ...

For many philosophers not automatically inclined to Platonism, the indispensability argument for the existence of mathematical objectshas provided the best (and perhaps only) evidence for mathematicalrealism. Recently, however, this argument has been subject to attack, most notably by Penelope Maddy (1992, 1997),on the grounds that its conclusions do not sit well with mathematical practice. I offer a diagnosis of what has gone wrong with the indispensability argument (I claim that mathematics is indispensable in the wrong way), and, taking my cue (...) from Mark Colyvan''s (1998) attempt to provide a Quinean account of unapplied mathematics as `recreational'', suggest that, if one approaches the problem from a Quinean naturalist starting point, one must conclude that all mathematics is recreational in this way. (shrink)

This 1997 book was the first English translation of all of Kant's writings on moral and political philosophy collected in a single volume. No other collection competes with the comprehensiveness of this one. As well as Kant's most famous moral and political writings, the Groundwork of the Metaphysics of Morals, the Critique of Practical Reason, the Metaphysics of Morals, and Toward Perpetual Peace, the volume includes shorter essays and reviews, some of which have never been translated before. The volume has (...) been furnished with a substantial editorial apparatus including translator's introductions and explanatory notes to each text by Mary Gregor, and a general introduction to Kant's moral and political philosophy by Allen Wood. There is also an English-German and German-English glossary of key terms. (shrink)

Published in 1982, Carol Gilligan's _In a Different Voice_ proposed a new model of moral reasoning based on care, arguing that it better described the moral life of women. ____An Ethic of Care__ is the first volume to bring together key contributions to the extensive debate engaging Gilligan's work. It provides the highlights of the often impassioned discussion of the ethic of care, drawing on the literature of the wide range of disciplines that have entered into the debate. _Contributors:_ Annette (...) Baier, Diana Baumrind, Lawrence A. Blum, Mary Brabeck, John Broughton, Owen Flanagan, Marilyn Friedman, Carol Gilligan, Catherine G. Greeno, Catherine Jackson, Linda K. Kerber, Mary Jeanne Larrabee, Zella Luria, Eleanor E. Maccoby, Linda Nicholson, Bill Puka, Carol B. Stack, Joan C. Tronto, Lawrence Walker, Gertrud Nunner-Winkler. (shrink)

This book explores a fundamental tension in Aristotle's metaphysics: how can an entity such as a living organisma composite generated through the imposition of form on preexisting matterhave the conceptual unity that Aristotle demands of primary substances? Mary Louise Gill bases her treatment of the problem of unity, and of Aristotle's solution, on a fresh interpretation of the relation between matter and form. Challenging the traditional understanding of Aristotelian matter, she argues that material substances are subverted by matter and (...) maintained by form that controls the matter to serve a positive end. The unity of material substances thus involves a dynamic relation between resistant materials and directive ends. Aristotle on Substance offers both a general account of matter, form, and substantial unity and a specific assessment of particular Aristotelian arguments. At every point, Gill engages Aristotle on his own philosophical ground through the detailed analysis of central, and often controversial, texts from the Metaphysics, Physics, On Generation and Corruption, De Anima, De Caelo, and the biological works. The result is a coherent, firmly grounded rethinking of Aristotle's central metaphysical concepts and of his struggle toward a fully consistent theory of material substances. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Kennedy Institute of Ethics Journal 14.4 (2004) 411-425 [Access article in PDF] Vulnerability, Vulnerable Populations, and Policy Mary C. Ruof "Special justification is required for inviting vulnerable individuals to serve as research subjects and, if they are selected, the means of protecting their rights and welfare must be strictly applied."Guideline 13: Research Involving Vulnerable Persons International Ethical Guidelines for Biomedical Research Involving Human Subjects Council for International Organizations (...) of Medical Sciences (CIOMS) and World Health Organization (WHO) Geneva, Switzerland, 2002 Within medical research and healthcare certain groups are afforded special protections and services because of their designation as vulnerable. The vulnerable require special justification to participate in human subject research in order to eliminate potential human rights abuses. The Nuremberg Code of 1947 was written in response to the extreme human subject abuses that occurred under the Nazi regime, and, although the intent of the 1947 Code was to protect human rights, rigid voluntary consent requirements deprived some individuals of the right to participate in clinical trials. Recent human research guidelines, such as the CIOMS/WHO guidelines referenced above and the guidelines referenced in Section V of this Scope Note, attempt to balance both protection from abuse in research and access to new, experimental treatments for the vulnerable.Although various protective guidelines stipulate special protections for vulnerable populations, the concept of vulnerability and consequently the criteria designating vulnerable populations remain vague. Precisely who are the vulnerable? The word "vulnerability" stems from the Latin vulnerare, "to wound." (Oxford Encyclopedic English Dictionary 1995). In clinical research, the term [End Page 411] vulnerable generally is applied to individuals who are unable to give informed consent or who are susceptible to coercion. The Common Rule (45 CFR 46, Subpart A) includes as vulnerable research subjects: children, prisoners, pregnant women, and persons who are handicapped, mentally disabled, economically disadvantaged, or educationally disadvantaged. Although the Common Rule specifies certain vulnerable categories, the guidelines were not intended to be exclusive, leaving open the interpretation of vulnerability.In medical research and health policy, vulnerability is an abstract concept that has concrete effects both for those labeled vulnerable and for those not. Clinical researchers, healthcare workers, ethical reviewers, and policymakers must be able to identify vulnerable subjects to establish how healthcare resources will be allocated and who will qualify for special protections and socialized benefits. Attempts to quantify vulnerability in clear, measurable ways have met little if any consensus. As Alexander Morawa (II, 2003, p. 150) states, "There is no single approach to definition of vulnerability. In fact, there is no purposeful categorisation at all."Difficulties in defining vulnerability have prompted discourse surrounding its utility as a qualifying factor in the allocation of health resources and its appropriateness as a guiding principle in bioethics. Some of the authors cited in this Scope Note argue against the labeling and categorization of vulnerable individuals and populations. "Labeling individuals as 'vulnerable' risks viewing vulnerable individuals as 'others' worthy of pity, a view rarely appreciated" (III, Danis and Patrick 2002, p. 320). The categories of vulnerable groups listed under the Common Rule have been the source of controversy, "for example, many find the suggestion that pregnant women are vulnerable to be quite sexist" (IV, DeBruin 2001, p. 7). Instead of creating categories of vulnerable populations, would it not be better to derive an account of just treatment from a just social policy at large that encompasses human vulnerabilities (II, Brock 2002, p. 283).For some of the authors listed here, the concept of vulnerability is essential to bioethics. Robert Goodin (I, 1985, p. 107) writes that the vulnerability of other human beings is the source of our special responsibilities to them. In contrast to the four American principles of biomedical ethics—autonomy, nonmaleficence, beneficence, and justice—the four principles of European bioethics and biolaw include vulnerability along with autonomy, dignity, and integrity. According to, Jacob Dahl Rendtorff and Peter Kemp (I, 2000, p. 274) "the principle of vulnerability is ontologically prior to the other [European] principles, it expresses better than all of the other ethical principles... the finitude of the human condition."Some of the... (shrink)

Crude materialism, reduction of mind to body, extreme individualism. All products of a 17th century scientific inheritance which looks at the parts of our existence at the expense of the whole. Cutting through myths of scientific omnipotence, Mary Midgley explores how this inheritance has so powerfully shaped the way we are, and the problems it has brought with it. She argues that poetry and the arts can help reconcile these problems, and counteract generations of 'one-eyed specialists', unable and unwilling (...) to look beyond their own scientific or literary sphere. Dawkins, Atkins, Bacon and Descartes all come under fire as Midgely sears through contemporary debate, from Gaia to memes, and organic food to greenhouse gases. After years of unquestioned imperialism, science is finally forced to take a step back and acknowledge the arts. (shrink)

In this book, Mary Midgely turns a spotlight on the fashionable view that we no longer need or use moral judgements. She shows how the question of whether or not we can make moral judgements must inevitably affect our attitudes to the law and its institutions, but also to events that occur in our daily lives.

Published in 1785, Immanuel Kant's Groundwork of the Metaphysics of Morals ranks alongside Plato's Republic and Aristotle's Nicomachean Ethics as one of the most profound and influential works in moral philosophy ever written. In Kant's own words, its aim is to identify and corroborate the supreme principle of morality, the categorical imperative. He argues that human beings are ends in themselves, never to be used by anyone merely as a means, and that universal and unconditional obligations must be understood as (...) an expression of the human capacity for autonomy and self-governance. As such, they are laws of freedom. This volume contains Mary Gregor's acclaimed translation of the text into English, revised by Jens Timmermann, and an accessible, updated introduction by Christine Korsgaard. (shrink)

Background:Clinical investigation is a growing field employing increasing numbers of nurses. This has created a new specialty practice defined by aspects unique to nursing in a clinical research context: the objectives, setting, and nature of the nurse–participant relationship. The clinical research nurse role may give rise to feelings of ethical conflict between aspects of protocol implementation and the duty of patient advocacy, a primary nursing responsibility. Little is known about whether research nurses experience unique ethical challenges distinct from those experienced (...) by nurses in traditional patient-care settings.Research objectives:The purpose of the study was to describe the nature of ethical challenges experienced by clinical research nurses within the context of their practice.Research design:The study utilized a qualitative descriptive design with individual interviews.Participants and research context:Participating nurses self-identified as having experienced ethical challenges during screening. The majority were Caucasian, female, and worked in outpatient settings. Approximately 50% had > 10 years of research experience.Ethical considerations:The human subjects review board approved the study. Written informed consent was obtained.Findings:Predominant themes were revealed: the inability to provide a probable good, or/do no harm, and dual obligations. The following patterns and subthemes emerged: conflicted allegiances between protocol implementation, needs of the participant, desire to advance science, and tension between the nurse–patient therapeutic relationship versus the research relationship.Discussion:Participants described ethical challenges specific to the research role. The issues are central to the nurse–participant relationship, patient advocacy, the nurse’s role in implementing protocols, and/or advancing science.Conclusion:Ethical challenges related to the specialized role of clinical research nurses were identified. More research is warranted to fully understand their nature and frequency and to identify support systems for resolution. (shrink)

A phenomenological approach to mathematical practice is sketched out, and some problems with this sort of approach are considered. The approach outlined takes mathematical practices as its data, and seeks to provide an empirically adequate philosophy of mathematics based on observation of these practices. Some observations are presented, based on two case studies of some research into the classification of C*-algebras. It is suggested that an anti-realist account of mathematics could be developed on the basis of these and other studies, (...) locating the substance of mathematics in the various informal argument methods used by mathematicians. (shrink)

In _The Ethical Primate_, Mary Midgley, 'one of the sharpest critical pens in the West' according to the _Times Literary Supplement_, addresses the fundamental question of human freedom. Scientists and philosophers have found it difficult to understand how each human-being can be a living part of the natural world and still be free. Midgley explores their responses to this seeming paradox and argues that our evolutionary origin explains both why and how human freedom and morality have come about.

To look into the darkness of the human soul is a frightening venture. Here Mary Midgley does so, with her customary brilliance and clarity. Midgley's analysis proves that the capacity for real wickedness is an inevitable part of human nature. This is not however a blanket acceptance of evil. Out of this dark journey she returns with an offering to us: an understanding of human nature that enhances our very humanity.

This article revisits the account of magnanimity offered by Thomas Aquinas, in his Commentary on the Nicomachean Ethics of Aristotle and especially in his Summa Theologiae. Recent scholarship has viewed Aquinas' magnanimity as essentially Aristotle's, complemented by the addition of charity and humility to the classical moral horizon. By contrast, I read Aquinas as offering a subtle yet far-reaching critique of important aspects of Aristotelian magnanimity, a critique with roots in Aquinas' theology, yet also comprising a significant philosophic reappraisal of (...) Aristotle's account of human excellence. Against contentions that Aquinas' ethical revisionism is antithetical to civic common sense, the requirements of statesmanship, and the rational foundations of social science, I argue that Aquinas' theory is politically salutary and theoretically enlightening. Moreover, I suggest that recent dissident reflection on twentieth-century totalitarian experience underscores both the humanity and the nobility of a humility-informed magnanimity, such as that advocated by Thomas Aquinas. (shrink)

The second half of the twentieth century inaugurated another historically contextualized shift in theological anthropology, which can be characterized by four interconnected turns to historical consciousness, to socially contextualized ethical norms and decisions, to human subjectivity, and to the inclusion of foundational faith convictions. Feminist ethicists have participated in and advanced this current re-formulation of theological anthropologies both by their critique and by their reconstruction of theological anthropologies inclusive of women’s experience. In these feminist contributions, five recurring dimensions emerge: relationality, (...) human embodiment, social location, difference, and subjectivity. Taken together these elements provide the building blocks toward an adequate anthropology. In part, this author’s conviction is supported by the integral connection of these elements to the essential dimensions of the human person in the personalist anthropology of Louis Janssens. Consequently, this inquiry will use these five elements as a lens through which to examine the theological anthropologies present in the documents of Catholic Social Teachings for points of intersection with developing feminist anthropologies. This research into Catholic Social Teachings concludes that the anthropologies in the documents both provide: 1) a foundationally different approach to authentic human living and 2) some points of intersection with a feminist perspective of authentic human living inclusive of women. This reading of Catholic Social Teachings argues that what is said particularly about the constitutive dimensions of social bodies sheds light on the constitutive dimensions of authentic human living; as such it contains a dynamic potential for future development. (shrink)