Genetic testing can be used to determine if unexplained fractures in children could have resulted from a predisposition to bone fractures, e.g., osteogenesis imperfecta. However, uncertainty is introduced if a variant of unknown significance is identified. Proper interpretation of VUS in these situations is critical because of its influence on clinical care and in court rulings. This study sought to understand how VUS are interpreted and used by practitioners when there is a differential diagnosis including both osteogenesis imperfecta and non-accidental (...) injury.A 15-question survey was emailed to physicians who requested analysis of two genes, COL1A1 and COL1A2, from the University of Washington from 2005-2013 for patient cases involving suspicion of child abuse.Among the 89 participants, responses differed about when genetic testing should be ordered for osteogenesis imperfecta, who should be consulted about utilization of VUS test results, follow-up procedures, and who should receive the VUS results.There are no clear guidelines for how to interpret and follow up on VUS. In the legal setting, misinterpreted VUS could lead to unintended consequences and deleterious ramifications for family members. The need for better practice guidelines to help promote more equitable handling of these sensitive legal cases is clear. (shrink)

Attribution theorists assume that character information informs judgments of blame. But there is disagreement over why. One camp holds that character information is a fundamental determinant of blame. Another camp holds that character information merely provides evidence about the mental states and processes that determine responsibility. We argue for a two-channel view, where character simultaneously has fundamental and evidential effects on blame. In two large factorial studies (n = 495), participants rate whether someone is blameworthy when he makes a mistake (...) (burns a cake or misses a bus stop). Although mental state inferences predict blame judgments, character information does not. Using mediation analyses, we find that character information influences responsibility via two channels (Studies 3–4; n = 447), which are sensitive to different kinds of information (Study 5; n = 149). On the one hand, forgetfulness increases judgments of responsibility, because mental lapses manifest an objectionable character flaw. On the other hand, forgetfulness decreases judgments of state control, which in turn decreases responsibility judgments. These two channels cancel out, which is why we find no aggregate effect of forgetfulness on responsibility. Our results challenge several fundamental assumptions about the role of character information in moral judgment, including that good character typically mitigates blame. (shrink)

It is argued, on the basis of ideas derived from Wittgenstein's Tractatus and Husserl's Logical Investigations, that the formal comprehends more than the logical. More specifically: that there exist certain formal-ontological constants (part, whole, overlapping, etc.) which do not fall within the province of logic. A two-dimensional directly depicting language is developed for the representation of the constants of formal ontology, and means are provided for the extension of this language to enable the representation of certain materially necessary relations. The (...) paper concludes with a discussion of the relationship between formal logic, formal ontology, and mathematics. (shrink)

Many maintain that petitionary prayer is pointless. I argue that the theist can defend petitionary prayer by giving a general account of how divine and creaturely causation can be compatible and complementary, based on the claim that the goodness of something depends on its cause. I use Thomas Aquinas’s metaphysical framework to give an account that explains why a world with creaturely causation better reflects God’s goodness than a world in which God brought all things about immediately. In such a (...) world, prayer could allow us to cause good things in a distinctive way: by asking God for them. (shrink)

In this second of a 2-part survey of Aristotle’s epistemology, I present an overview of Aristotle’s views on technē (craft or excellent productive reason) and phronēsis (practical wisdom or excellent practical reason). For Aristotle, attaining the truth in practical matters involves actually doing the right action. While technē and phronēsis are rational excellences, for Aristotle they are not as excellent or true as epistēmē or nous because the kinds of truth that they grasp are imperfect and because they are excellent (...) states for humans, not simply speaking. I then discuss why Aristotle takes sophia (wisdom), understanding and scientific knowledge of the best things, to be its own excellence. While this is the best cognitive state for human beings, I argue that Aristotle thinks divine cognitive activity is different in kind and more perfect than any human activity. (shrink)

To adequately model mathematical arguments the analyst must be able to represent the mathematical objects under discussion and the relationships between them, as well as inferences drawn about these objects and relationships as the discourse unfolds. We introduce a framework with these properties, which has been used to analyse mathematical dialogues and expository texts. The framework can recover salient elements of discourse at, and within, the sentence level, as well as the way mathematical content connects to form larger argumentative structures. (...) We show how the framework might be used to support computational reasoning, and argue that it provides a more natural way to examine the process of proving theorems than do Lamport’s structured proofs. (shrink)

I lay out and examine two sharply conflicting interpretations of Aristotle's claims about nous in the De Anima (DA). On the human separability approach, Aristotle is taken to have identified reasons for thinking that the intellect can, in some way, exist on its own. On the naturalist approach, the soul, including intellectual soul, is inseparable from the body of which it is the form. I discuss how proponents of each approach deal with the key texts from the DA, focusing on (...) four of the most important and interesting topics in this area. Two of these topics concern the activity of understanding (noêsis): first, what does Aristotle mean when he claims that the intellect cannot have a bodily organ and, secondly, what role does Aristotle think phantasmata (“images” or “representations”) play in understanding something? Two of the topics concern DA 3.5, one of the most difficult passages in Aristotle's corpus: first, what is the nature and role of the productive intellect (nous poiêtikos) introduced there and, secondly, what are this chapter's implications for the question of whether the intellect or intellectual soul can exist apart from the body? I conclude by identifying areas where further research is necessary. (shrink)

I critically respond to Scott A. Davison, Petitionary Prayer: A Philosophical Investigation. I attack his Contrastive Reasons Account of what it takes for a request to be answered and provide an alternative account on which a request is answered as long as it has deliberative weight for the person asked. I also raise issues with Davison’s dismissive treatment of direct divine communication. I then emphasize the importance of value theory for addressing the puzzles of petitionary prayer. Whether a defense of (...) petitionary prayer is successful depends on whether it can support the sort of requests that are central to the theological practices of the religion in question, explaining how they could be known to be effective, and this depends on the value theory of the theology in question. As an example, I show the relevance the traditional distinction between temporal and spiritual goods could have for knowing whether one’s prayers have been answered. How prayers could make a difference also depends on the theology in question, raising issues of ecclesiology and collective action that demand further attention. (shrink)

We consider connections between number sense—the ability to judge number—and the interpretation of natural language quantifiers. In particular, we present empirical evidence concerning the neuroanatomical underpinnings of number sense and quantifier interpretation. We show, further, that impairment of number sense in patients can result in the impairment of the ability to interpret sentences containing quantifiers. This result demonstrates that number sense supports some aspects of the language faculty.

Amidst expanding interest in local food and agriculture, food banks and allied organizations across the United States have increasingly engaged in diverse gleaning, gardening, and farming activities. Some of these programs reinforce food banks’ traditional role in distributing surplus commodities, and most extend food banks’ reliance on middle class volunteers and charitable donations. But some gleaning and especially gardening and farming programs seek to build poor people’s and communities’ capacity to meet more of their own food needs, signaling new roles (...) for some food banks in promoting community food security and food justice. This article reports the results of a national survey and in-depth case studies of the ways in which food banks are engaging in and with local agriculture and how this influences food banks’ roles in community and regional food systems. The patterns it reveals reflect broader tensions in debates about hunger relief and food security. (shrink)

When deciding what disorders to screen newborns for, we should be guided by evidence of real effectiveness, take opportunity cost into account, distribute costs and benefits fairly, and respect human rights. Current newborn screening policy does not meet these requirements.

This paper introduces Richard Rorty’s notion of the liberal ironist and his vision of a liberal utopia and explores the implications of these for philosophical questions concerning morality, as well as morality in general. Rorty’s assertions of the contingency of language, society and self are explored. Under the contingency of language, the figure of the ironist is defined, and Rorty’s conception of vocabularies is discussed. Under the contingency of society, Rorty’s definition of liberalism, his opposition of literary culture to materialist (...) and metaphysical culture, and his notions concerning utopian politics are discussed. Under the contingency of self, Rorty’s critique of Kantian and his appropriations of Deweyan and Freudian conceptions of morality are presented. Other key factors discussed are Rorty’s theory of the separation of the private and public spheres of life and his ideas concerning cruelty and human solidarity. In this way, a critical analysis of Rorty’s proposed balance between private, ironic doubt and public, liberal social hope is presented and assessed in terms of its merit as a system of thought suited to the needs of post-metaphysical, liberal societies. (shrink)

More than any other thinker, Giorgio Agamben shows us that philosophy is also a matter of style and politics a matter of poetics. This book explores the unexpected and illuminating paths that his work traces across the territories of law and literature, linguistics, dance or cinema, in search of a new idea and practice of the community. It offers an irreplaceable introduction to one of the most fascinating thinkers of our time.'Jacques RanciereGathering some of the most important established and emerging (...) scholars to examine his body of work, this collection of essays seeks to explore Agamben's thought from these broader philosophical and literary concerns, underpinning its place within larger debates in continental philosophy. Including a contribution by Agamben himself, it is essential reading for anyone interested in his work.In the past five years, Giorgio Agamben has emerged as one of the most important continental philosophers. This burgeoning popularity of his work has largely been confined to a study of the homo sacer series. Yet these later 'political' works have their foundation in Agamben's earlier works on the philosophy of language, aesthetics and literature. From a philosophy of language and linguistics that leads to a broader theory of representation, Agamben develops a critical theory that attempts to explore the hiatuses and paradoxes that govern discursive practice across a broad range of disciplines. (shrink)

This book contains a collection of the essential readings treating both classic and contemporary issues in philosophy of religion.

Kenneth Goodpaster has criticized ethicists like Feinberg and Frankena for too narrowly circumscribing the range of moral considerability, urging instead that “nothing short of the condition of being alive” is a satisfactory criterion. Goodpaster overlooks at least one crucial objection: that his own “condition of being alive” may aIso be too narrow a criterion of moral considerability, since “being in existence” is at least as plausible and nonarbitrary a criterion as is Goodpaster’s. I show that each of the arguments that (...) Goodpaster musters in support of his criterion can be used equally weIl to bolster “being in existence” as a test of moral considerability. Moreover, I argue that “being in existence” appears to be a stronger criterion overall, since it is broader. Until or unless a fuller justification is forthcoming of “being alive” as a satisfactory criterion of moral considerability-a justification which must demonstrate that “mere things,” included under the condition of “being in existence,” do not deserve moral consideration--Goodpaster’sthesis is confronted with a serious problem. (shrink)

Philosophy Compass, Volume 17, Issue 1, January 2022.

We examine the emergence of the ‘postfeminist’ sensibility from feminist theory and praxis, and its relation and relevance to education. Analytical frameworks such as postfeminism and intersectionality have given equal weight to recognition-based struggles, such as those based on sexual, racial, class-based, gender-related identities. We follow Nancy Fraser’s argument that these identity-based movements have been co-opted by neoliberal politicians and bureaucratic policy-makers, and become a divide and rule strategy, neglecting the subjugating power of capital. Beginning with third-wave feminism’s emphasis on (...) individual identity, women’s struggles have been become a part of the greater parisitic neoliberal project. We consider the implications of this docile and domesticated feminism for the education of women. (shrink)

Prospective memory (PM) enables people to remember to complete important tasks in the future. Failing to do so can result in consequences of varying severity. Here, we investigated how PM error-consequence severity impacts the neural processing of relevant cues for triggering PM and the ramification of that processing on the associated prospective task performance. Participants role-played a cafeteria worker serving lunches to fictitious students and had to remember to deliver an alternative lunch to students (as PM cues) who would otherwise (...) experience a moderate or severe aversive reaction. Scalp-recorded, event-related potential (ERP) measures showed that the early-latency frontal positivity, reflecting the perception-based neural responses to previously learned stimuli, did not differ between the severe versus moderate PM cues. In contrast, the longer-latency parietal positivity, thought to reflect full PM cue recognition and post retrieval processes, was elicited earlier by the severe than the moderate PM cues. This faster instantiation of the parietal positivity to the severe-consequence PM cues was then followed by faster and more accurate behavioral responses. These findings indicate how the relative importance of a PM can be neurally instantiated in the form of enhanced and faster PM cue recognition and processing and culminate into better PM. (shrink)

Most philosophers of science nowadays hold a network or postulational view of the meaning of theoretical words. However, there are many nuances to this view, and after explicitly separating them, we show what we take to be wrong with each one. While we reject the postulational view we do not defend its traditional alternatives either; rather we show the pointlessness of insisting on a single source for the meaning of theoretical words. We also point out the shortcomings of Carnap's newest (...) meaning criterion which depends upon a network view. But, again, we suggest not only that this new rendition of the criterion is faulty but also that there is something misguided about any search at all for such a criterion. (shrink)

This book provides a major review of the state of international theory. It is focused around the issue of whether the positivist phase of international theory is now over, or whether the subject remains mainly positivistic. Leading scholars analyse the traditional theoretical approaches in the discipline, then examine the issues and groups which are marginalised by mainstream theory, before turning to four important new developments in international theory (historical sociology, post-structuralism, feminism, and critical theory). The book concludes with five chapters (...) which look at the future of the subject and the practice of international relations. This survey brings together key figures who have made leading contributions to the development of mainstream and alternative theory, and will be a valuable text for both students and scholars of international relations. (shrink)

“Ontario and its Universities” embodies the views, on several central issues in higher education in Ontario, of members of a seminar which met regularly in the autumn of 1973 and early winter of 1974. The seminar was initiated by a group of professors from the University of Toronto and York University. They invited a number of their academic colleagues and several interested and informed persons from the wider public to discuss with them the responsibilities and essential requirements of the contemporary (...) university in Ontario. (shrink)

Equality is a fundamental but contested facet of justice. There are competing views about how the basic egalitarian character of justice should be conceptualized and about what practical implications ideals of equality have for the evaluation of political institutions, laws, and social practices. This volume brings together the reflections of some of today's leading political philosophers on the basic character and practical significance of equality as an ideal of justice. The topics explored are diverse and the essays offer challenging new (...) perspectives on recent work about justice and equality. The collection features new essays by Elizabeth Anderson, Richard Arneson, Michael Blake, Colin Macleod, Sophia Moreau, Debra Satz and Kok-Chor Tan. The essays provide an excellent indication of the richness and diversity of contemporary egalitarian theory. (shrink)

RésuméDans ce dialogue, deux personnages principaux, Philopolis et Éleuthérios, proposent la position communautarienne et la position contractualiste libérale comme fondements de la théorie politique. Le débat se déroule, comme tout bon débat devrait lefaire, autour d'une bouteille de Chardonnay.

There is a nationwide resurgence of tuberculosis in the country’s urban centers; New York City stands at the forefront of this resurgence. The root causes are increased homelessness, drug addiction and poverty, all symbols of deteriorating social and economic conditions in the city. The inadequate level of public health resources devoted to TB has also contributed to its spread. Still, even with these factors, it is questionable whether the escalating number of TB cases in this country would have occurred without (...) the reservoir of immunosuppressed persons, who are less resistant to the disease, created by the AIDS epidemic. The fear and urgency of this public health crisis, which has been emerging since the beginning of the last decade, are fueled by the rise of TB strains resistant to the first-line drugs and by the disease’s contagiousness. (shrink)

There is a nationwide resurgence of tuberculosis in the country’s urban centers; New York City stands at the forefront of this resurgence. The root causes are increased homelessness, drug addiction and poverty, all symbols of deteriorating social and economic conditions in the city. The inadequate level of public health resources devoted to TB has also contributed to its spread. Still, even with these factors, it is questionable whether the escalating number of TB cases in this country would have occurred without (...) the reservoir of immunosuppressed persons, who are less resistant to the disease, created by the AIDS epidemic. The fear and urgency of this public health crisis, which has been emerging since the beginning of the last decade, are fueled by the rise of TB strains resistant to the first-line drugs and by the disease’s contagiousness. (shrink)

Eliciting negative stereotypes about ageing commonly results in worse performance on many physical, memory, and cognitive tasks in adults aged over 65. The current studies explored the potential effect of this “stereotype threat” phenomenon on older adults’ emotion recognition, a cognitive ability that has been demonstrated to decline with age. In Study 1, stereotypes about emotion recognition ability across the lifespan were established. In Study 2, these stereotypes were utilised in a stereotype threat manipulation that framed an emotion recognition task (...) as assessing either cognitive ability, social ability, or general abilities. Participants then completed an emotion recognition task in which they labelled dynamic expressions of negative and positive emotions. Self-reported threat concerns were also measured. Framing an emotion recognition task as assessing cognitive ability significantly heightened older adults’ reports of stereotype threat concerns. Despite this, older adults’ emotion recognition performance was unaffected. Unlike other cognitive abilities, recognising facially expressed emotions may be unaffected by stereotype threat, possibly because emotion recognition is automatic, making it less susceptible to the cognitive load that stereotype threat produces. (shrink)

The dual-deficit model of visual hallucinations (Collerton et al. target article) is compared with the dual-deficit model of auditory hallucinations (Waters et al., in press). Differences in cognitive mechanisms described may be superficial. Similarities between these models may provide the basis for a general model of complex hallucinations extended across disorders and modalities, involving shared (overlapping) cognitive processes.

The authors respond to a letter by Mitchell Berger in the March‐April 2024 issue of the Hastings Center Report concerning their essay “Securing the Trustworthiness of the FDA to Build Public Trust in Vaccines.”.

_K. al-Manām_ by Ibn Abī al-Dunyā is a compendium of 350 Muslim dream narratives in Arabic. The English introduction examines the function of dreams in classical Arabic literature with a focus on dreams as a means of edification.

By reflecting on a variety of cartoon representations of teachers and their work, this paper outlines a semiotic approach to undertaking research on teachers ' professional cultures.

What is the relationship between detailed critical analysis and the background assumptions made by a given theory of film spectatorship? In this article, I approach this question by looking at Vittorio Gallese and Michele Guerra's The Empathic Screen in the light of the method of triangulation—the coordination and integration of phenomenological, psychological, and neuroscientific evidence, as set out in my Film, Art, and the Third Culture. In particular, I examine Gallese and Guerra's arguments concerning the role of camera movement in (...) prompting immersive, embodied simulation, as well as critiques of these arguments from David Bordwell and Malcolm Turvey. I focus on the special, irreducible role of critical analysis in these arguments. Detailed analysis of film form and style plays an essential role, I argue, in demonstrating the plausibility (or otherwise) of the thesis advanced by Gallese and Guerra. Such analysis is where the rubber of theoretical assumptions meets the road of the material work. (shrink)

The vast majority of health research resources are used to study conditions that affect a small, advantaged portion of the global population. This distribution has been widely criticized as inequitable and threatens to exacerbate health disparities. However, there has been little systematic work on what individual health research funders ought to do in response. In this article, we analyze the general and special duties of research funders to the different populations that might benefit from health research. We assess how these (...) duties apply to governmental, multilateral, nonprofit, and for-profit organizations. We thereby derive a framework for how different types of funders should take the beneficiaries of research into account when they allocate scarce research resources. (shrink)

The research we fund today will improve the health of people who will live tomorrow. But future people will not all benefit equally: decisions we make about what research to prioritize will predictably affect when and how much different people benefit from research. Organizations that fund health research should thus fairly account for the health needs of future populations when setting priorities. To this end, some research funders aim to allocate research resources in accordance with disease burden, prioritizing illnesses that (...) cause more morbidity and mortality. In this article, I defend research funders' practice of aligning research funding with disease burden but argue that funders should aim to align research funding with future—rather than present—disease burden. I suggest that research funders should allocate research funding in proportion to aggregated estimates of disease burden over the period when research could plausibly start to yield benefits until indefinitely into the future. (shrink)