Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

IN the heroic Latin hexameter, after the essential alternation of long and short syllables, by far the most important feature is unquestionably the caesura. Nevertheless, ancient writers on metre dismiss it with the most cursory notice; all we get from them is that the chief caesura is the penthemimeral, the trochaic and hephthemimeral coming next; the fourth trochaic and the bucolic are usually rejected, and the trihemimeral is mentioned only by Ausonius, Modern writers, among whom are Müller and Winbolt, deal (...) with the question at greater length, but do not agree even on fundamental points, and often base their statements on an insufficient analysis of the extant remains of Latin hexameter verse. The purpose of the following paper is to attempt a more complete analysis, at least in the case of Virgil, the acknowledged master of the Latin hexameter. But before we proceed further there are two preliminaries which must be settled—what are the main types of caesura, and how many caesurae are admissible in one verse? (shrink)

Nature of the problem: Testimony from scientists. Reflex action and theism (1881) by W. James. The organization of thought (1916) by A.N. Whitehead. The changing scientific scene 1900-1950 (1952) by J.B. Conant. A note on methods of analysis (1943) by H.J. Muller. The way things are (1959) by P.W. Bridgman. A definition of style (1948) by J.R. Oppenheimer.--Consequences of the problem: Testimony from artists and writers. Existentialism (1947) by J.-P. Sartre. The testimony of modern art (1957) by W. Barrett. (...) Parts of speech and punctuation (1935) by G. Stein. The waves (1931) by V. Woolf. The imperfect paradise, by W. Stevens. A note on style and the limits of language, by W. Gibson. (shrink)

Gert H. Müller The growth of the number of publications in almost all scientific areas,· as in the area of (mathematical) logic, is taken as a sign of our scientifically minded culture, but it also has a terrifying aspect. In addition, given the rapidly growing sophistica tion, specialization and hence subdivision of logic, researchers, students and teachers may have a hard time getting an overview ofthe existing literature, partic ularly if they do not have an extensive library available in their (...) neighbourhood: they simply do not even know what to ask for! More specifically, if someone vaguely knows that something vaguely connected with his interests exists some where in the literature, he may not be able to find it even by searching through the publications scattered in the review journals. Answering this challenge was and is the central motivation for compiling this Bibliography. The Bibliography comprises (presently) the following six volumes (listed with the corresponding Editors): I. Classical Logic W. Rautenberg II. Non-c1assical Logics W. Rautenberg IH. Model Theory H. -D. Ebbinghaus IV. Recursion Theory P. G. Hinman V. Set Theory A. R. Blass VI. ProofTheory; Constructive Mathematics J. E. Kister; D. van Dalen & A. S. Troelstra. (shrink)

`Folk Psychology' - our everyday talk of beliefs, desires and mental events - has long been compared with the technical language of `Cognitive Science'. Does folk psychology provide a correct account of the mental causes of our behaviour, or must our everyday terms ultimately be replaced by a language developed from computational models and neurobiology? This broad-ranging book addresses these questions, which lie at the heart of psychology and philosophy. Providing a critical overview of the key literature in the field, (...) including the seminal work of Fodor and Churchland, the author explores the classic `Frame Problem' and assesses the future prospects of cognitive science. The scope of the frame problem, touching on connec. (shrink)

Mill's feminism has been attacked as being logically incoherent. The general verdict has been that Mill can easily be defended from the charge. However, both sides in the debate have ignored the fact that his feminism is part of a broader theory of liberal empiricism. Placing The Subjection of Women in this context re–opens the question of its logical credentials and reveals a basic weakness in Millian feminism.

This volume contains papers that represent Leibniz’s early thoughts on the problem of evil, centering on a dialogue, the Confessio philosophi, in which he formulates a general account of God’s relation to sin and evil that becomes a fixture in his thinking. How can God be understood to be the ultimate cause, asks Leibniz, without God being considered as the author of sin, a conclusion incompatible with God’s holiness? Leibniz’s attempts to justify the way of God to humans lead him (...) to deep discussion of related topics: the nature of free choice, the problems of necessitarianism and fatalism, the nature of divine justice and holiness. All but one of the writings presented here are available in English for the first time. (shrink)

My discussion of this theme falls into two parts. In the first part, starting from the assumption that we do in fact tend to respond favourably to the idea, vague though it may be, that “persons are to be respected, simply as persons”, I endeavour to clear my mind a little about our warrant for speaking in this way; and to do this is at the same time to clarify in some measure our understanding of what such language means. But (...) of course, since it is the language of practical principle, or precept, there can be no full understanding of its meaning without a grasp of its “working value”, of its significance as a clue to the proper directing and assessing of conduct. The second, and briefer, part of the discussion, accordingly, which is reserved for a subsequent article, is devoted to the question of the practical import of the principle of respect, the sort of guidance that it may provide in the actual business of life. (shrink)

G. W. F. Hegel is an immensely important yet difficult philosopher. Philosophy of Mind is the third part of Hegel's Encyclopaedia of the Philosophical Sciences, in which he summarizes his philosophical system. It is one of the main pillars of his thought. Michael Inwood presents this central work to the modern reader in an intelligible and accurate new translation---the first into English since 1894---that loses nothing of the style of Hegel's thought. In his editorial introduction Inwood offers a philosophically sophisticated (...) evaluation of Hegel's ideas which includes a survey of the whole of Hegel's thought and detailed analysis of the terminology he used. (shrink)