The differentiation of mammalian neurons during development is a highly complex process involving regulation and coordination of gene expression at multiple steps. The P19 mouse embryonal carcinoma cell line is a suitable model system with which to analyze regulation of neuronal differentiation. These multipotential cells can be maintained and propagated in tissue culture in an undifferentiated state. Exposure of aggregated P19 cells to retinoic acid results in the differentiation of cells with many fundamental phenotypes of mammalian neurons. Undifferentiated P19 cells (...) are amenable to genetic manipulations such as transfection and establishment of stable clonal cell lines expressing introduced genes. Proteins that play a key role in the neuronal differentiation of P19 cells are beginning to be identified. These include retinoic acid receptors, the epidermal growth factor receptor and the transcription factors Oct‐3 and Brn‐2. The biological and technical advantages of this system should facilitate deeper analysis of the activities of proteins that play a role in neuronal differentiation. (shrink)

This paper elaborates on conceptual, empirical and practical arguments why corporations need to focus on their social dimensions, in order to further enhance organizational performance. The paper starts with an introduction on the general trend towards inclusiveness and connectedness. It then elaborates on the phase-wise development of cultures and organizational structures. Managing corporate improvement by building cultures of trust is the central focus of this contribution. By showing the cultural dimensions of Great Places to Work and their workplace practices, worthwhile (...) experiences leading to organizational improvement and superior financial performance are demonstrated. (shrink)

For organizational development that is future-oriented, enterprises increasingly need qualified, motivated and efficient workers who are able and willing to contribute actively to technical and organizational innovations. Furthermore, customers and consumers are increasingly interested in healthy products and services. Therefore, health has become a (potential) business value of strategic importance. In interaction with all relevant stakeholders, an approach was developed for companies that want to manage their health impact in a proactive and preventive manner. The approach was termed Integral Health (...) Management (IHM). IHM forms a strategic approach for reducing the costs of sickness absence and working disability, while the productivity and resilience of the company and its employees are increased. This brings the company direct economic benefits. Finally, it is of prime interest for employees to remain physically and mentally healthy and employable. The IHM approach distinguishes seven lines of development: (1) health as a strategic company interest; (2) the realization of a healthy primary process; (3) a safe and sound physical (work) environment; (4) an inspiring social (work) environment; (5) vital people; (6) a sound relationship with the immediate organizational environment and local community, and (7) healthy products and/or services. The inter-relationships between the seven development lines are essential for combining an improvement of the business impact on health with a strategic interest of companies and organizations. The seven lines of IHM development can easily be linked to the European Foundation for Quality Management''s European Excellence Model. (shrink)

The unpleasantness of pain motivates action. Hence many philosophers have doubted that it can be accounted for purely in terms of pain’s possession of indicative representational content. Instead, they have explained it in terms of subjects’ inclinations to stop their pains, or in terms of pain’s imperative content. I claim that such “noncognitivist” accounts fail to accommodate unpleasant pain’s reason-giving force. What is needed, I argue, is a view on which pains are unpleasant, motivate, and provide reasons in virtue of (...) possessing content that is indeed indicative, but also, crucially, evaluative. (shrink)

Accounts of the nature of unpleasant pain have proliferated over the past decade, but there has been little systematic investigation of which of them can accommodate its badness. This paper is such a study. In its sights are two targets: those who deny the non-instrumental disvalue of pain's unpleasantness; and those who allow it but deny that it can be accommodated by the view—advanced by me and others—that unpleasant pains are interoceptive experiences with evaluative content. Against the former, I argue (...) that pain's unpleasantness does indeed have noninstrumental disvalue; against the latter I argue both that my critics’ own desire-theoretic accounts of pain's unpleasantness cannot accommodate such disvalue, and that my evaluativist view can—either by appealing to “anti-unpleasantness” desires or by exploiting pain's perceptuality. (shrink)

Pain asymbolia is a rare condition caused by brain damage, usually in adulthood. Asymbolics feel pain but appear indifferent to it, and indifferent also to visual and verbal threats. How should we make sense of this? Nikola Grahek thinks asymbolics’ pains are abnormal, lacking a component that make normal pains unpleasant and motivating. Colin Klein thinks that what is abnormal is not asymbolics’ pains, but asymbolics: they have a psychological deficit making them unresponsive to unpleasant pain. I argue that an (...) illuminating account requires elements of both views. Asymbolic pains are indeed abnormal, but they are abnormal because asymbolics are. I agree with Klein that asymbolics are incapable of caring about their bodily integrity; but I argue against him that, if this is to explain not only their indifference to visual and verbal threat, but also their indifference to pain, we must do the following: (i) take asymbolics’ lack of bodily care not as an alternative to, but as an explanation of their pains’ missing a component, and (ii) claim that the missing component consists in evaluative content. Asymbolia, I conclude, reveals not only that unpleasant pain is composite, but that its ‘hedomotive component’ is evaluative. (shrink)

Reading Galileo: Scribal Technologies and The Two New Sciences, by Renée Raphael, Baltimore, Johns Hopkins University Press, 2017, ix + 265 pp., figs., bibl., index, £40.50 (cloth), ISBN 9781421421...

This paper notes the apparent ineffectiveness of the critical response to competence-based education and training (CBET) and suggests that this results from a failure to correctly isolate CBET's unique, identifying features. It is argued that the prevailing tendency to identify CBET with ‘competence’ is fundamentally mistaken and that the competence approach is more properly characterised in terms of its philosophically naïve methodological strategy. It is suggested that this strategy is based upon untenable assumptions relating to the semantic status of statements (...) of outcome and the epistemological and ontological constructs to which such statements are intended to correspond. (shrink)

The popular and successful rhetorical textbooks produced by the 18th century Scottish philosophical tradition, such as George Campbell's The Philosophy of Rhetoric, Hugh Blair’s Lectures on Rhetoric and Belles Lettres, and Alexander Bain’s English Composition and Rhetoric have been widely accorded a role in the trajectories of 19th and 20th century literary theory. Scholars have generally overlooked them, however, as philosophical works. The selected writings chosen for this volume show how these rhetorical textbooks were a practical extension of the (...) philosophy of language developed by 18th century Scottish philosophers. Francis Hutcheson, Adam Smith, Thomas Reid, Adam Ferguson, Alexander Gerard, and Henry Home, Lord Kames, advanced a radically new paradigm of language as an inherently mediated practice, directed simultaneously to personal and social, moral and aesthetic uses. This Scottish philosophy of rhetoric powerfully influenced the teaching of language and literacy as tools for social and educational innovation. This volume — the first of its kind — offers a wide variety of writings on rhetoric and rhetorical theory, selected in a way that reveals their intimate connection with the Scottish philosophical tradition. (shrink)

Pain may appear to undermine the radically intentionalist view that the phenomenal character of any experience is entirely constituted by its representational content. That appearance is illusory. After categorizing versions of pain intentionalism along two dimensions, I argue that an 'objectivist' and 'non-mentalist' version is the most promising, if it can withstand two objections concerning what we say when in pain, and the distinctiveness of pain. I rebut these objections, in a way available to both opponents of and adherents to (...) the view that experiential content is entirely conceptual. (shrink)

Evaluativism is best thought of as a way of enriching a perceptual view of pain to account for pain’s unpleasantness or painfulness. Once it was common for philosophers to contrast pains with perceptual experiences (McGinn 1982; Rorty 1980). It was thought that perceptual experiences were intentional (or content-bearing, or about something), whereas pains were representationally blank. But today many of us reject this contrast. For us, your having a pain in your toe is a matter not of your sensing “pain-ly” (...) or encountering a sense-datum, but of your having an interoceptive experience representing (accurately or inaccurately) that your toe is in a particular experience-independent condition, such as undergoing a certain “disturbance” or being damaged or in danger (Armstrong 1962; Tye 1995). But even if such representational content makes an experience a pain, a further ingredient seems required to make the pain unpleasant. According to evaluativism, the further ingredient is the experience’s possession of evaluative content: its representing the bodily condition as bad for the subject. In this chapter, I elaborate evaluativism, locate it among alternatives, and explain its attractions and challenges. (shrink)

Pain, crucially, is unpleasant and motivational. It can be awful; and it drives us to action, e.g. to take our weight off a sprained ankle. But what is the relationship between pain and those two features? And in virtue of what does pain have them? Addressing these questions, Colin Klein and Richard J. Hall have recently developed the idea that pains are, at least partly, experiential commands—to stop placing your weight on your ankle, for example. In this paper, I reject (...) their accounts. Against Klein, I use dissociation cases to argue that possession of ‘imperative content’ cannot wholly constitute pain. Against them both, I further claim that possession of such content cannot even constitute pain’s unpleasant, motivational aspect. For, even if it were possible to specify the relevant imperative content—which is far from clear—the idea of a command cannot bear the explanatory weight Klein and Hall place on it. (shrink)

Radical Ontic Structural Realism (ROSR) claims that structure exists independently of objects that may instantiate it. Critics of ROSR contend that this claim is conceptually incoherent, insofar as, (i) it entails there can be relations without relata, and (ii) there is a conceptual dependence between relations and relata. In this essay I suggest that (ii) is motivated by a set-theoretic formulation of structure, and that adopting a category-theoretic formulation may provide ROSR with more support. In particular, I consider how a (...) category-theoretic formulation of structure can be developed that denies (ii), and can be made to do work in the context of formulating theories in physics. Keywords: structural realism, category theory, general relativity.. (shrink)

Perceptualists say that having a pain in a body part consists in perceiving the part as instantiating some property. I argue that perceptualism makes better sense of the connections between pain location and the experiences undergone by people in pain than three alternative accounts that dispense with perception. Turning to fellow perceptualists, I also reject ways in which David Armstrong and Michael Tye understand and motivate perceptualism, and I propose an alternative interpretation, one that vitiates a pair of objections—due to (...) John Hyman—concerning the meaning of ‘Amy has a pain in her foot’ and the idea of bodily sensitivity. Perceptualism, I conclude, remains our best account of the location of pains. (shrink)

In this book the author intends to present a careful analysis of the Stoic teaching on human action and to apply it to the moral doctrine of mainly Zeno and Chrysippus. The work is divided into two parts: the first deals with the structure of human action, whereas the second applies the result of the performed analysis to the moral theory, especially to the teaching on passions and the ethical evolution of an individual from a pre-moral to a moral stage. (...) In the first chapter the author draws the attention to the Aristotelian background of the Stoic theory: the notion of phantasia, being the faculty which provides images of sensible reality and interprets them, plays an important part in both doctrines. In his analysis of action Aristotle uses logical and linguistic concepts and the Stoics proceed in the same way. According to Zeno, the founder of the Stoic school, human soul comprises eight parts, one of them being the hegemonikon or the mind. Within the mind four powers are distinguished: presentation, assent, impulse and reason; they are enduring and stable entities and they govern the activities corresponding to them. So they exist even when they are not being exercised, they are dispositions of the pneuma of the mind. In spite of their determinism the Stoics were anxious to preserve man's responsibility: therefore they stressed particularly the importance of assent, which causes impulse, whereas impulse produces action. Assent is an internal factor: man is a responsible being because his actions are the result of a personal assent. In this respect man differs from mere animals, which are unable to produce such an act; as a matter of fact assent is not given to a presentation as such, but to the meaning or content of a presentation. Since mere animals are unable to form lekta, they do not have the capacity of performing an act of assent. However mere animals may have something similar, which is called yielding. According to the Stoics no human action is performed without an act of assent, even when the agent is not aware of it: in these cases the assent is implicitly present in the action. This factor does not coincide with the Aristotelian bouleusis: within the Stoic theory of action there is no room for deliberation. The assent is the internal cause of an impulse, which is directed at a predicate, related to an imperative: in this way impulse is the immediate cause of action. (shrink)

Compare your pain when immersing your hand in freezing water and your pleasure when you taste your favourite wine. The relationship seems obvious. Your pain experience is unpleasant, aversive, negative, and bad. Your experience of the wine is pleasant, attractive, positive, and good. Pain and pleasure are straightforwardly opposites. Or that, at any rate, can seem beyond doubt, and to leave little more to be said. But, in fact, it is not beyond doubt. And, true or false, it leaves a (...) good deal more to be said: about the nature of sensory affect; its relations to perception, motivation, and rationality; its value; and the mechanisms underlying it. Much is said about these matters in the contributions that follow. Here, in this introductory essay, we map the dialectical landscape and locate our contributors’ papers within it. (shrink)

This article offers a new theory about how using lotteries to distribute scarce benefits satisfies beneficiaries' claims. In the first section of the article I criticize John Broome's view and on the basis of these criticisms set out four desiderata for a philosophically adequate account of claim satisfaction by lottery. In section II I propose and defend a new view called the dual structure view, so called because it posits that claimants have two types of claims in the relevant scarce (...) benefit distribution cases under discussion. This view meets all the desiderata set out in section I. Section III draws out the practical implications of my view for a variety of temporally extended cases, including the distribution of corneas to patients who have suffered corneal degeneration. (shrink)

It is sometimes said that there has been a ‘paradigm shift’ in the field of assessment over the last two or three decades: a new preoccupation with what learners can do, what they know or what they have achieved. It is suggested in this article that this change has precipitated a need to distinguish two conceptually and logically distinct methodological approaches to assessment that have hitherto gone unacknowledged. The upshot, it is argued, is that there appears to be a fundamental (...) confusion at the heart of current policy, a confusion occasioned by the demand to know what learners know and compounded by a failure to recognise what this properly entails for assessment methodology. (shrink)

(1) What may be gained by applying concepts generalised from economics to methodological problems? The perspective of cost-benefit analysis ('CBA' for short) may help the researcher to see what sorts of questions he should take into account when dealing with particular methodological problems. This claim is supported by applying generalised CBA-thinking to two standard problems of methodology. (2) In the practice of research the handling of basic statements does not normally constitute any problem, and no conscious decision is involved. In (...) the methodological reconstruction the key questions are: 'How can a particular basic statement be criticised?' and 'What are the costs of defending a statement that is "problematic"?' The problem of the empirical 'base' is an investment problem: whether or not to invest time and effort into processing a particular basic statement into a falsifying hypothesis for the theory we wish to test. The valuation of the costs of rejecting or, as the case may be, of defending a basic statement, are objective. (3) With respect to theories, in basic science, the issue is not one of acceptance or rejection of a single theory, but rather of theory preference. Both the rational response to a falsification and rational theory preference are governed by CBA-considerations. The option for one of two competing theories is based upon a CBA where the valuation of benefits and costs is objective. Theory change is an objective process, at least in those fields, where theorising is closely controlled by empirical testing: the better theory drives out the less good theory. The costs of defending a theory that is less good than its competitor are mainly epistemic resources forgone. The use of CBA in methodology not only is compatible with Popper's position, but it may pay to view Popper's methodology as an application of CBA to epistemic situations. (shrink)

It is possible to predict future life forms? In this paper it is argued that the answer to this question may well be positive. As a basis for predictions a rationale is used that is derived from historical data, e.g. from a hierarchical classification that ranks all building block systems, that have evolved so far. This classification is based on specific emergent properties that allow stepwise transitions, from low level building blocks to higher level ones. This paper shows how this (...) hierarchy can be used for predicting future life forms.The extrapolations suggest several future neural network organisms. Major aspects of the structures of these organisms are predicted. The results can be considered of fundamental importance for several reasons. Firstly, assuming that the operator hierarchy is a proper basis for predictions, the result yields insight into the structure of future organisms. Secondly, the predictions are not extrapolations of presently observed trends, but are fully integrated with all historical system transitions in evolution. Thirdly, the extrapolations suggest the structures of intelligences that, one day, will possess more powerful brains than human beings.This study ends with a discussion of possibilities for falsification of the present theory, the implications of the present predictions in relation to recent developments in artificial intelligence and the philosophical implications of the role of humanity in evolution with regard to the creation of future neural network organisms. (shrink)

La pensée de Jean-Jacques Rousseau est essentiellement une pensée politique, qui oscille entre un pôle transpolitique, que le citoyen de Genève incarne, par exemple, dans les personnages du législateur, du pédagogue et du sage, et un pôle prépolitique, où figurent l'homme naturel, le marginal et l'homme sensible. C'est en examinant quelques pages de trois grandes oeuvres de Rousseau: l'« Emile », « Du contrat social » et « Julie ou la Nouvelle Héloïse », que je tenterai d'éclaircir brièvement ces points. (...) Ainsi sera manifestée l'actualité des paradoxes rousseauistes.Rousseau's thought is essentially a political thought that swings from a transpolitical pole, presented through the figures of the legislator, the pedagogue and the wise man, and a prepolitical pole, where we meet natural man, the outsider and the man of exquisite sensibility. This theme is brought to light through a partial analysis of three of Rousseau's major works : " Emile ", " Du contrat social " and the "Nouvelle Héloïse". In this way, it is hoped that Rousseau's paradoxes will be shown to have meaning for our contemporaries. (shrink)

This paper presents the algebraic and Kripke modelsoundness and completeness ofa logic over Boolean monoids. An additional axiom added to thelogic will cause the resulting monoid models to be representable as monoidsof relations. A star operator, interpreted as reflexive, transitiveclosure, is conservatively added to the logic. The star operator isa relative modal operator, i.e., one that is defined in terms ofanother modal operator. A further example, relative possibility,of this type of operator is given. A separate axiom,antilogism, added to the logic (...) causes the Kripke models to support acollection of abstract topological uniformities which become concretewhen the Kripke models are dual to monoids of relations. The machineryfor the star operator is shownto be a recasting of Scott-Montague neighborhood models. An interpretationof the Kripke frames and properties thereof is presented in terms ofcertain CMOS transister networks and some circuit transformation equivalences.The worlds of the Kripke frame are wires and the Kripke relation is a specializedCMOS pass transistor network. (shrink)

We have now celebrated the centenary of J. J. Thomson’s famous paper (1897) on the electron and have examined one hundred years of the history of our first fundamental particle. What should philosophers of science learn from this history? To some, the fundamental moral is already suggested by the rapid pace of this history. Thomson’s concern in 1897 was to demonstrate that cathode rays are electrified particles and not aetherial vibrations, the latter being the “almost unanimous opinion of German physicists” (...) (p. 293) But were these German physicists so easily vanquished? De Broglie proposed in 1923 that electrons are a wave phenomenon after all and his proposal was soon multiply vindicated, even by the detection of the diffraction of the electron waves. Should we not learn from such a reversal? Should we not dispense with the simple-minded idea that Thomson discovered our first fundamental particle and admit that the very notion of discovery might well be ill-suited to science? (shrink)

In this volume his object is to fully examine his friend's writings and characters and draws upon his own personal recollections to do so.

I argue that political philosopher Charles W. Mills’ twin concepts of ‘the epistemology of ignorance’ and ‘white ignorance’ are useful tools for thinking through racial injustice in the British education system. While anti-racist work in British education has a long history, racism persists in British primary, secondary and tertiary education. For Mills, the production and reproduction of racism relies crucially on cognitive and epistemological processes that produce ignorance, and which promote various ways of ignoring the histories and legacies of European (...) colonialism and imperialism, as well as the testimonies and scholarship of those who experience racism in their everyday lives. I survey these concepts within Mills’ work then marshal evidence in support of my claim that ‘the epistemology of ignorance’ and ‘white ignorance’ provide a useful framework for thinking through problems of racial injustice in British education. (shrink)

As concerns heighten over links between biomass production and land grabs in the global south, attention is turning to understanding the role of governance of biofuels systems, whereby decision-making and conduct are not solely determined through government regulations but increasingly shaped by non-state actors, including multi-stakeholder initiatives. Launched in 2005, Bonsucro is the principal MSI that focuses on sustainability standards for sugar and sugarcane ethanol production. Bonsucro claims that because it is free from government interference and draws on scientific metrics, (...) their standards transcend localized, political–economic contexts. In this paper, we illustrate how the local context shapes the prospects for Bonsucro sustainably certified biofuel production in relation to land and water grabs. To accomplish this, our case focuses on Colombia, which has used a range of national policy mandates to establish itself as one of the larger producers of agrofuels in Latin America. We draw on interviews with stakeholders in the sugar and ethanol industries, paired with an examination of Bonsucro principles on land rights and water use, to illustrate how the sugar industry is framing their participation in Bonsucro, and the effects of the increasing intensification of sugarcane for ethanol production on land and water access for communities. We find that within the context of Colombia, efforts such as Bonsucro provide a veil of legitimacy and authority to a system that is premised on deeply entrenched historical patterns of inequitable land ownership patterns and access to natural resources. (shrink)

In this article we examine Kant’s understanding of toleration by including a study of all instances in which he directly uses the language of toleration and related concepts. We use this study to resolve several key areas of interpretative dispute concerning Kant’s views on toleration. We argue that Kant offers a nuanced and largely unappreciated approach to thinking about toleration, and related concepts, across three normative spheres: the political, the interpersonal and the personal. We examine shortcomings in earlier interpretations and (...) conclude by arguing that the theme of toleration in Kant’s work, while coherent and important, is neither as central nor as peripheral as suggested by previous interpretations. Further, while Kant is critical of the arrogance of toleration in the political sphere, he is more positive toward the role of toleration in the interpersonal and personal spheres since it promotes virtue. (shrink)

It can seem natural to say that, when in pain, we undergo experiences which present to us certain experience-dependent particulars, namely pains. As part of his wider approach to mind and world, John McDowell has elaborated an interesting but neglected version of this account of pain. Here I set out McDowell’s account at length, and place it in context. I argue that his subjectivist conception of the objects of pain experience is incompatible with his requirement that such experience be presentational, (...) rationalizing, and classificatory. (shrink)

This essay considers the prospects of modeling spacetime as a phenomenon that emerges in the low-energy limit of a quantum liquid. It evaluates three examples of spacetime analogues in condensed matter systems that have appeared in the recent physics literature, indicating the extent to which they are viable, and considers what they suggest about the nature of spacetime.

Classical theories of truth are monistic, since they fundamentally search for the essence of truth. The correspondence theory of truth is the most representative in this regard. There are several difficulties with the essentialist theories of truth, which led to the emergence of several alternatives. The purpose of this article is to critically evaluate three of them: the pragmatic theory of truth, the deflationary theory and the pluralistic approach. I argue for overcoming monism and for accepting pluralism in our understanding (...) of truth. At the same time, I argue – from a wittgensteinian point of view – for abandoning the attempt to build a general philosophical theory of truth. I plead for limiting the philosopher’s role to the clarification of the specific ways in which the concept of truth is used in various forms of life and areas of scientific investigation. Multiple uses of the concept of truth in different thematic areas cannot be synthesized, properly speaking, through a particular philosophical theory. (shrink)

This paper elaborates on conceptual, empirical and practical arguments why corporations need to focus on their social dimensions, in order to further enhance organizational performance. The paper starts with an introduction on the general trend towards inclusiveness and connectedness. It then elaborates on the phase-wise development of cultures and organizational structures. Managing corporate improvement by building cultures of trust is the central focus of this contribution. By showing the cultural dimensions of Great Places to Work and their workplace practices, worthwhile (...) experiences leading to organizational improvement and superior financial performance are demonstrated. (shrink)