Short-term limb immobilization results in skeletal muscle decline, but the underlying mechanisms are incompletely understood. This study aimed to determine the neurophysiologic basis of immobilization-induced skeletal muscle decline, and whether repetitive Transcranial Magnetic Stimulation could prevent any decline. Twenty-four healthy young males underwent unilateral limb immobilization for 72 h. Subjects were randomized between daily rTMS using six 20 Hz pulse trains of 1.5 s duration with a 60 s inter-train-interval delivered at 90% resting Motor Threshold, or Sham rTMS throughout immobilization. (...) Maximal grip strength, EMG activity, arm volume, and composition were determined at 0 and 72 h. Motor Evoked Potentials were determined daily throughout immobilization to index motor excitability. Immobilization induced a significant reduction in motor excitability across time. The rTMS intervention increased motor excitability at 0 h. Despite daily rTMS treatment, there was still a significant reduction in motor excitability, loss in EMG activity, and a loss of maximal grip strength after immobilization. Interestingly, the increase in biceps and posterior forearm skinfold thickness with immobilization in Sham treatment was not observed following rTMS treatment. Reduced MEPs drive the loss of strength with immobilization. Repetitive Transcranial Magnetic Stimulation cannot prevent this loss of strength but further investigation and optimization of neuroplasticity protocols may have therapeutic benefit. (shrink)

It is commonly maintained that neuroplastic mechanisms in the brain provide empirical support for the hypothesis of multiple realizability. We show in various case studies that neuroplasticity stems from preexisting mechanisms and processes inherent in the neural structure of the brain. We argue that not only does neuroplasticity fail to provide empirical evidence of multiple realization, its inability to do so strengthens the mind-body identity theory. Finally, we argue that a recently proposed identity theory called Flat Physicalism can be enlisted (...) to explain the current state of the mind-body problem more adequately. (shrink)

Aristotle bequeathed to us a powerful metaphysical picture, of substances in which properties inhere. The picture has turned out to be highly problematic in many ways; but it is nevertheless a picture not easy to dislodge. Less obvious are the normative tones implicit in the picture and the way these permeate our system of values, especially when thinking of ourselves and our ambitions, hopes and fears. These have proved, if anything, even harder to dislodge than the metaphysical picture which supports (...) them. This paper first draws out the ethics suggested by a conception of being as individual substances, and finds both inner tensions among these values—expressed in divergent characteristics in the history of philosophy—and a neglect of a significant set of values. Substance metaphysics prefers freedom, independence and autonomy over relational and reciprocal values, which can even be regarded as existentially threatening. A prominent attempt to accommodate both sorts of values without eschewing substantialist metaphysics is briefly considered, before turning to examine an alternative metaphysics and the values it implies. A metaphysics which takes being as becoming, it is argued, supports an ethics centred on relational values, and their associated virtues of care. (shrink)

Many philosophers think that we can identify, e.g., a weather expert by checking if she has a track record of making accurate weather predictions but that there isn’t an analogous way for laypeople to verify the judgement of a putative moral expert. The weather is an independent check for weather expertise but there is no independent check for moral expertise, and the only way for laypeople to identify moral experts is to engage in first-order moral reasoning of one’s own. But (...) if one can do that, one would not need to rely on a moral expert in the first place. This paper provides an account of Feedback as an independent check for moral expertise in the form of certain positive and negative changes in the lives of advisees after they started acting in accordance with an advisor’s advice whilst nothing else of significance changed in their lives in that period. Given our folk background theories, and some specific information about the advisee’s situation, Feedback suggests that the advisor’s advice was correct. Laypeople would identify moral experts by inferring that the best explanation of the correctness of the advisor’s advice in a high proportion of cases in which she dispensed advice is that the advisor had moral knowledge. Identifying moral experts in this way involves the use of some moral reasoning of one’s own but it is too elementary to make moral experts redundant. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 25.1 (2001) 75-86 [Access article in PDF] Defending Logocentrism Clive Stroud-Drinkwater Postmodernists sometimes seem to think that they can find,support for their antirationalism and anti-objectivism in the work of Wittgenstein, Davidson, and Kuhn. 1 Even opponents of postmodernism occasionally see its central assumptions as allied somehow to the ideas of these three philosophers. 2 Given the revolutionary character and general difficulty of the thought of (...) these three philosophers, it would be hard to prove that all postmodern readings of their works are ungrounded. Davidson 3 does claim that the concept of reference is merely a "theoretical construct" and, at best, an "inscrutable" one within a holistic Tarski-style theory of a language. Wittgenstein 4 does suggest that rules are not like rails that guide us, but rather that they are holistic constructs out of rule-following action. And Kuhn 5 does argue that revolutionary changes in scientific outlook are not determined by rational scientific method.Elsewhere 6 I have expressed doubt about some of these specific views, but in this paper I shall not be directly concerned with either the validity of these ideas themselves, or the possible support such views offer for postmodern attacks on reason and objectivity. My concern will be to show that other, quite central ideas of these thinkers are directly inimical to the postmodern campaign against reason and objectivity. Since postmodernism accords with the poststructuralist assimilation of all language to literature, I shall begin with some remarks on literary criticism itself, setting out the foundation for a Wittgensteinean perspective on traditional issues in the field. [End Page 75] I The New Critics wished to regard a literary text as an object with secondary qualities in it. This theoretical assumption was regarded by some metacritics as hopelessly naïve, partly because different readers find different secondary qualities in the same text, and because it was thought that relativity to a subject is incompatible with externality. However, Einstein's theory of the relativity to a point of view of the primary properties of mass and length, which are clearly external properties, shows that externality and relativity are not necessarily incompatible properties. That purely logical point helps to prepare the conceptual ground for a theory of the externality of certain secondary qualities that exist only relative to a subject. Once the general logical compatibility of externality and relativity is established, what is then needed is a reason for thinking that the relevant secondary qualities in certain texts not only could be but also actually are outside us.Elsewhere 7 I have argued in favor of the externality of the secondary qualia of color by appealing to Grice's causal theory of perception, 8 but my argument there also appeals to the phenomenological givenness of the qualia of color, and hence it would not apply to the aesthetic secondary qualities that concern literary critics. There is, however, another sort of reason to suppose that certain aesthetic qualities not only could be but actually are outside us and in texts. The argument is Wittgensteinean; I believe that it supplies for certain aesthetic qualities that which my argument supplies for certain phenomenological qualities. Very roughly, my argument says that the qualia of color are in objects because that is where the causal story of their existence locates them, and therefore there is no better place to locate them; and, very roughly, the Wittgensteinean argument says that an aesthetic quality such as beauty is in a text because that is where the language game of literary criticism locates it, and there is no better place. For example, we say things like "There is dramatic irony in chapter 4," or "Line 37 is particularly lovely," and if a metaphysician asked, "Where is the loveliness or the irony really?," with special emphasis on the words "really" and "where," then we should answer, "I have already said--it is in chapter 4 and in line 37." If the metaphysician then said, "But different readers find different qualities in the same work--how can there be different aesthetic or literary qualities in the same text?", then we should... (shrink)

This study investigated relationships between inter-class variations in paranormal experience and executive functions. A sample of 516 adults completed self-report measures assessing personal encounter-based paranormal occurrences, executive functions together with Emotion Regulation and Belief in the Paranormal. Paranormal belief served as a measure of convergent validity for experience-based phenomena. Latent profile analysis combined experience-based indices into four classes based on sample subpopulation scores. Multivariate analysis of variance then examined interclass differences. Results revealed that breadth of paranormal experience was associated with (...) higher levels of executive functioning difficulties for General Executive Function, Working Memory, Decision Making, and Belief in the Paranormal. On the Everyday Memory Questionnaire, scores differed on Attention Tracking and Factor 3, but not Retrieval. In the case of the Emotion Regulation Scale, class scores varied on Expressive Suppression, however, no difference was evident on Cognitive Reappraisal. Overall, inter-class comparisons identified subtle differences in executive functions related to experience. Since the present study was exploratory, sampled only a limited subset of executive functions, and used subjective, self-report measures, further research is necessary to confirm these outcomes. This should employ objective tests and include a broader range of executive functions. (shrink)

We analyze the environmental implications of basic income programs through literature review, government documents, pilot studies, and interviews eliciting expert knowledge. We consider existing knowledge and then use a grounded approach to produce theory on the relationship between a basic income guarantee and environmental protection/damage. We find that very little empirical or theoretical work has been done on this relationship and that theoretical arguments can be made for both positive and negative environmental impacts. Ultimately, this implies, the environmental impact of (...) a basic income program will be dependent on program design. These insights allow us to generate a toolkit of policy proposals to assist in the development of green basic income programs via either conditions, additions, or complements. (shrink)

Microbiome science asserts humans are made up of more microbial cells and genes than human ones, and that each person harbors their own unique microbial population. Human microbiome studies gesture toward the post-racial aspirations of personalized medicine—characterizing states of human health and illness microbially. By viewing humans as “supraorganisms” made up of millions of microbial partners, some microbiome science seems to disrupt binding historical categories often grounded in racist biology, allowing interspeciality to supersede race. But inevitably, unexamined categories of race (...) and ethnicity surface in a myriad of studies on microbiota. This paper approaches race as a ghost variable across microbiome research and asks, what is race doing in studies of the microbiome? Why is it there, and how is it functioning? I examine this research to argue that social scientists must work with biological scientists to help put microbial differences into perspective—to investigate how microbiomes and race are entangled embodiments of the social, environmental, and biological. Ultimately, transdisciplinary collaboration is required to address racial health disparities in microbiome research without reifying race as a straightforward biological or social designation. (shrink)

A survey was conducted on the advertising practitioners in Taiwan concerning their experiences of ethical challenges at work. Among 120 respondents, while 32.5 percent responded that ethical problems did not exist, 67.5 percent admitted that ethical problem was a commonplace at work. According to these respondents, the most frequently mentioned ethical problems area representing unethical products or services, the message of advertisements, agency-client relationship, the creditability of research, undertable rebate, and the quality of service. Suggestions for international advertising managers were (...) also provided by comparing the finding from the present study with earlier studies in the United States. However, due to its preliminary nature, the present study should be considered exploratory and descriptive rather than conclusive, with the hope to inspire more research on advertising ethics in Taiwan as well as in other countries in the world. (shrink)

SummarySurely, we think, in some cases it is determinate which rules we follow . But what in the world could determine a rule for us in any case? First 1 consider five common, perfectly natural, but utterly inadequate sorts of answer to this question. Then I consider an account which would avoid the usual inadequacies but would leave rules radically indeterminate, a position which is utterly counter‐intuitive. Thus painted into a corner, I then step out with a prima facie queer, (...) but adequate and ultimately not terribly counter‐intuitive, solution to the puzzle: a sort of picture‐theory of understanding rules . Finally 1 show that the picture‐theory undermines the sorts of anti‐realism which would, if they were valid, undermine the picture‐theory.RésuméNous pensons que, dans certains cas, les règies que nous suivons sont sûrement déterminées. Mais qu'est‐ce au monde qui pourrait déterminer pour nous une règie dans tous les cas? Je considère d'abord cinq réponses communes à cette question, réponses très naturelles, mais absolument inadéquates. Ensuite, j'examine une réponse qui serait plus adéquate, mais laisserait les règies radicalement indéterminées, ce qui est très contraire a l'intuition. Je propose alors une solution qui paraît au premier abord saugrenue, mais qui est adéquate et pas tellement contraire à l'intuition: une sorte de theorie des images pour comprendre les régies . Finalement, je montre que cette théorie des images désarme les types d'antiréalisme qui, s'ils étaient valables, s'opposeraient à cette théorie des images.ZusammenfassungWir denken, dass in einigen Fällen bestimmt ist, wetche Regeln wir befolgen . Was aber in der Welt könnte eine Regel in einem beliebigen Fall bestimmen? Ich betrachte zunächst fünf gewöhnliche durch‐aus natürliche, aber völlig inadäquate Arten von Antworten auf diese Frage. Dann betrachte ich eine Behandlung , die die üblichen Mängel vermeidet, die jedoch Regeln radikal unbestimmt lässt, was unserer Intuition zuwiderläuft. So in die Enge getrieben suche ich einen Ausweg in einer Lösung, die prima facie zwar befremdlich erscheinen mag, die aber adäquat ist und nicht stark gegen die Intuition verstösst: eine Art von Bildtheorie des Verstehens von Regeln . Schliesslich weise ich nach, dass die Bildtheorie die Arten von Antirealismus unterminiert, die die Bildtheorie zerstören würden, wenn sie güitig waren. (shrink)

SummaryWe can find a relation in the world between perceivable objects like rabbits and uses of expressions, so we can define a determinate semantic relation between an expression and such an object. . The relation which we find in the world is such that some philosophers may say that we should not define any semantic relation in terms of it; but the dispute here is really verbal. We can admit that the relation in question is at all significant only because (...) other facts of a sort more familiar to philosophers of language obtain, without giving up the idea that the relation is significant.RésuméOn peut, quoi qu'en dise Quine, découvrir une relation dans le monde entre des objets tels que des lapins et l'usage de certaines expressions, et ainsi définir une relation sémantique entre une expression et un tel objet. La relation que nous découvrons dans le monde est telle que certains philosophes peuvent prétendre qu'elle ne permet pas de définir une quelconque relation semantique, mais la querelle est vraiment verbale. On peut admettre que la relation en question n'est véritablement signifiante que parce que se produisent d'autres faits qui appartiennent à un domaine plus familier aux pbilosophes du langage, sans cependant renoncer à l'idée que la relation est signifiante.ZusammenfassungWir können in der Welt eine Beziehung zwischen wahrnehmbaren Objekten wie Kaninchen und Verwendungen von Ausdrücken finden; wir können deshalb entgegen Quine — eine bestimmte semantische Relation zwischen einem Ausdruck und einem solchen Objekt definieren. Die Relation, die wir in der Welt finden, ist so geartet, dass einige Philosophen behauptet haben, dass wir keine semantische Relation vermittefst von ihr definieren sollten; der Streit ist jedoch in Wirklichkeit verbaler Natur. Wir können annehmen, die fragliche Relation sei überhaupt sinn‐voll, nur weil an deren Tatsachen einer den Sprachphilosophen vertrauteren Art bestehen, ohne die Aussicht, die Relation sei sinnvoll, aufzugeben. (shrink)

New agrifood technologies are often difficult to grasp for the public, which may lead to resistance or even rejection. Insight into which technology features determine public acceptability of the technology could offer guidelines for responsible technology development. This paper systematically assesses the relative importance of specific technology features for consumer response in the agrifood domain in two consecutive studies. Prominent technology features were selected from expert judgment and literature. The effects of these features on consumer evaluation were tested in a (...) consumer study. Fictitious technologies were used to avoid any uncontrollable contextual influences that existing new technologies may evoke. Results show that technologies that were seen as more natural and newer were perceived less risky, more beneficial, and were evaluated more positively. Technologies applied to food were judged to be more beneficial, but also more risky than those applied to non-food. Technologies used in the production process were perceived to be less risky and evaluated more positively than those used in the product. Technologies owned by the market leader were perceived to be more beneficial, and evaluated more positively than those that were freely available. In a next study, effects of the technology features on consumer response were tested for existing new agrifood technologies. This study replicated the results for perceived naturalness, perceived newness, and place in the production process where the technology is applied. However, in contrast to the first study, we did not find an effect of application area and technology ownership. (shrink)

Despite advances in feminism, the "law of the father" remains the dominant model of Western psychological and cultural analysis, and the law of the mother continues to exist as an underdeveloped and marginal concept. In her radical rereading of the Greek myth, _Oresteia_, Amber Jacobs hopes to rectify the occlusion of the mother and reinforce her role as an active agent in the laws that determine and reinforce our cultural organization. According to Greek myth, Metis, Athena's mother, was Zeus's (...) first wife. Zeus swallowed Metis to prevent her from bearing children who would overthrow him. Nevertheless, Metis bore Zeus a child-Athena-who sprang forth fully formed from his head. In Aeschylus's _Oresteia_, Athena's motherless status functions as a crucial justification for absolving Orestes of the crime of matricide. In his defense of Orestes, Zeus argues that the father is more important than the mother, using Athena's "motherless" birth as an example. Conducting a close reading of critical works on Aeschylus's text, Jacobs reveals that psychoanalytic theorists have unwittingly reproduced the denial of Metis in their own critiques. This repression, which can be found in the work of Sigmund Freud and Melanie Klein as well as in the work of more contemporary theorists such as André Green and Luce Irigaray, has resulted in both an incomplete analysis of Oresteia and an inability to account for the fantasies and unconscious processes that fall outside the oedipal/patricidal paradigm. By bringing the story of Athena's mother, Metis, to the forefront, Jacobs challenges the primacy of the Oedipus myth in Western culture and psychoanalysis and introduces a bold new theory of matricide and maternal law. She finds that the Metis myth exists in cryptic forms within Aeschylus's text, uncovering what she terms the "latent content of the Oresteian myth," and argues that the occlusion of the law of the mother is proof of the patriarchal structures underlying our contemporary social and psychic realities. Jacobs's work not only provides new insight into the Oresteian trilogy but also advances a postpatriarchal model of the symbolic order that has strong ramifications for psychoanalysis, feminism, and theories of representation, as well as for clinical practice and epistemology. (shrink)

The increasing demand for transparency in AI has recently come under scrutiny. The question is often posted in terms of “epistemic double standards”, and whether the standards for transparency in AI ought to be higher than, or equivalent to, our standards for ordinary human reasoners. I agree that the push for increased transparency in AI deserves closer examination, and that comparing these standards to our standards of transparency for other opaque systems is an appropriate starting point. I suggest that a (...) more fruitful exploration of this question will involve a different comparison class. We routinely treat judgments made by highly trained experts in specialized fields as fair or well-grounded even though—by the nature of expert/layperson division of epistemic labor—an expert will not be able to provide an explanation of the reasoning behind these judgments that makes sense to most other people. Regardless, laypeople are thought to be acting reasonably—and ethically—in deferring to the judgments of experts that concern their areas of specialization. I suggest that we reframe our question regarding the appropriate standards of transparency in AI as one that asks when, why, and to what degree it would be ethical to accept opacity in AI. I argue that our epistemic relation to certain opaque AI technology may be relevantly similar to the layperson’s epistemic relation to the expert in certain respects, such that the successful expert/layperson division of epistemic labor can serve as a blueprint for the ethical use of opaque AI. (shrink)

This article uses recent work in philosophy of science and social epistemology to argue for a shift in analytic philosophy of religion from a knowledge-centric epistemology to an epistemology centered on understanding. Not only can an understanding-centered approach open up new avenues for the exploration of largely neglected aspects of the religious life, it can also shed light on how religious participation might be epistemically valuable in ways that knowledge-centered approaches fail to capture. Further, it can create new opportunities for (...) interaction with neighboring disciplines and can help us revitalize and transform stagnant debates in philosophy of religion, while simultaneously allowing for the introduction and recovery of marginalized voices and traditions. (shrink)

Several of the most compelling anti-materialist arguments are motivated by the supposed existence of an unbridgeable epistemic gap between first-person subjective knowledge about one’s own conscious experience and third-personally acquired knowledge. The two with which this paper is concerned are Frank Jackson’s ‘knowledge argument’ and David Chalmers’s ‘modal argument’. The knowledge argument and the modal argument are often taken to function as ‘two sides of the same coin … in principle each succeeds on its own, but in practice they work (...) best in tandem’. This paper disagrees with the above claim, and argues that when considered together the knowledge argument and modal arguments illuminate each other’s weaknesses. These weaknesses become apparent when we acknowledge the epistemic richness of the cognitive aspect of perceptual experience, and question the epistemic role that any non-cognitive aspect might play. Closer examination of judgments about what it’s like to have a perceptual experience reveals fundamental problems with the knowledge argument, and when these problems are exposed, the two arguments can no longer ‘buttress each other where help is needed’. It becomes clear that neither is likely to succeed on its own, and when taken together both are destabilized. (shrink)

Medieval and early modern devotional works rarely receive serious treatment from philosophers, even those working in the subfields of philosophy of religion or the history of ideas. In this article, I examine one medieval devotional work in particular—the Middle High German image- and verse-program, Christus und die minnende Seele —and I argue that it can plausibly be viewed as a form of medieval public philosophy, one that both exhibited and encouraged philosophical innovation. I address a few objections to my proposal—namely, (...) that CMS is neither public enough nor that it counts as proper philosophy—and I attempt to defend CMS’s public philosophical credentials in light of these objections. I conclude with a brief discussion of how devotional texts like CMS can help us do innovative public philosophy today. (shrink)

Infants are sensitive to statistical regularities (i.e., transitional probabilities, or TPs) relevant to segmenting words in fluent speech. However, there is debate about whether tracking TPs results in representations of possible words. Infants show preferential learning of sequences with high TPs (HTPs) as object labels relative to those with low TPs (LTPs). Such findings could mean that only the HTP sequences have a word‐like status, and they are more readily mapped to a referent for that reason. But these findings could (...) also suggest that HTP sequences are easier to encode, just like any other predictable sequence. Here we aimed to distinguish between these explanations. To do so, we built on findings that infants become resistant to learning labels that are not typical of their native language as they approach 2 years of age and add words to their lexicons. If tracking TPs in speech results in identifying candidate words, at this age TPs may have reduced power to confer lexical status when they yield a unit that is very dissimilar to word forms that are typical of infants’ native language. Indeed, we found that at 20 months, English‐learning infants with relatively small vocabularies learned HTP Italian words (but not LTP words) as object labels, while infants with larger vocabularies resisted learning HTP Italian words. These findings suggest that the HTP sequences may be represented as candidate words, and more broadly, that TP statistics are relevant to word learning. (shrink)

Moral understanding is a species of knowledge. Understanding why an action is wrong, for example, amounts to knowing why the action is wrong. The claim that moral understanding is immune to luck while moral knowledge is not does not withstand scrutiny; nor does the idea that there is something deep about understanding for there are different degrees of understanding. It is also mistaken to suppose that grasping is a distinct psychological state that accompanies understanding. To understand why something is the (...) case is to grasp or see why something is the case and grasping and seeing are ways of knowing. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 26.2 (2002) 346-353 [Access article in PDF] Stevens after Davidson on Metaphor Clive Stroud-Drinkwater IN "NOTES TOWARD A SUPREME FICTION" 1 Wallace Stevens suggests that the absolute as we imagine that an angel would experience it constitutes the supreme fiction. We conceive the experience of the angel only in a fantasy, but it is our fantasy, and therefore the experience of the angel and its (...) absolute are things that we comprehend in our imagination. Thus, in imagination we can apprehend that which we may at first suppose only angels can apprehend, since "the lapis-haunted air" of the angel's absolute is a creature of our own imagination and nothing more. When Stevens asks, "Is it he or is it I that experience this?," the question is rhetorical, since the angel's "experience" exists only within the poet's imagination. In "Sunday Morning," likewise, Stevens suggests that the concept of paradise is defined only within the limits of human imagination. It is a construct which people can comprehend only in the terms of their essentially finite "passions," "moods," "grievings," "elations," "remembrance" and "desire;" it is a construct which people create in "a chant of paradise, / Out of their blood, returning to the sky." Abstracting from our ordinary feelings will not leave us with a transcendent conception of paradise; on the contrary, it will deprive us of our sense of value. The image of the inhuman god ("Jove in the clouds" with "his inhuman birth") is sterile, remote from all human concern. For Stevens, "The ultimate value is reality." 2 [End Page 346]It is possible to regard this as a sad and resigned affirmation that we have at most this world and its parochial values, since God is "dead" and we cannot really have paradise at all, 3 but it is also possible to regard it as an affirmation of the genuine value of the ordinary and the human. On this interpretation of Stevens, "Sunday Morning" calls us from the shadows of a self-defeating attempt to transcend our own values to a consideration of the place of ordinary values in our conception of paradise: Shall she not find in comforts of the sun, In pungent fruit and bright, green wings, or else In any balm or beauty of the earth, Things to be cherished like the thought of heaven? The question, which is already rhetorical, is answered flatly in another poem, "The Rock"; the imagination can indeed find paradise in reality: In this plenty, the poem makes meanings of the rock, Of such mixed motion and such imagery That its barrenness becomes a thousand things And so exists no more. This is the cure Of leaves and of the ground and of ourselves. In this "cure" we imagine the world as paradise, or the rock as meaningful, or barrenness as a thousand things. There is, however, an unresolved tension between imagining one thing as another and recognizing that the things are, in fact, different. Max Black regards this tension as the greatest weakness in his "interaction" theory of metaphor. 4 In "Notes" Stevens addresses this problem: Fat girl, terrestrial, my summer, my night, How is it I find you in difference, see you there In a moving contour, a change not quite completed? The problem here is the general problem of metaphor: metaphors seem to constitute an "evasion" 5 since they are usually literally false. 6 For example, the "fat girl" is presumably not literally summer or night, and may not even be fat or a girl, metaphors being what they are. To the "fat girl," the poet says, [End Page 347] You remain the more than natural figure. You Become the soft-footed phantom, the irrational Distortion, however fragrant, however dear. His metaphors disguise the object; the object is represented in them as "more than natural"—in other words, not natural, not the thing as it is. "The very thing and nothing else" ("Credences") that Stevens, the poet of the real world, wishes to see thus becomes "obscure," a thing in "an obscure world / Of things that would... (shrink)

Recent studies of the low abundant signaling lipid, phosphatidylinositol 3,5‐bisphosphate (PI(3,5)P2), reveal an intriguingly diverse list of downstream pathways, the intertwined relationship between PI(3,5)P2 and PI5P, as well as links to neurodegenerative diseases. Derived from the structural lipid phosphatidylinositol, PI(3,5)P2 is dynamically generated on multiple cellular compartments where interactions with an increasing list of effectors regulate many cellular pathways. A complex of proteins that includes Fab1/PIKfyve, Vac14, and Fig4/Sac3 mediates the biosynthesis of PI(3,5)P2, and mutations that disrupt complex function and/or (...) formation cause profound consequences in cells. Surprisingly, mutations in this pathway are linked with neurological diseases, including Charcot‐Marie‐Tooth syndrome and amyotrophic lateral sclerosis. Future studies of PI(3,5)P2 and PI5P are likely to expand the roles of these lipids in regulation of cellular functions, as well as provide new approaches for treatment of some neurological diseases. (shrink)

It seems an odd claim that knowing could be itself of intrinsic worth. Knowledge appears heavily, perhaps entirely reliant for its worth on the value of the objects known and the value of the ends...

The author introduces the existential psychology of the Austrian psychiatrist and Holocaust survivor Viktor Frankl. The article describes several theoretical ideas and perceptual metaphors derived from Frankl’s scholarship that make it useful as a philosophical and historical underpinning for the practice of autoethnography. Frankl asserted that each individual’s disposition, situation, and position work together to create a uniquely valuable and incommutable individual perspective. This incommutability suggests that the value of autoethnographic social science is based on the opportunities derived from the (...) particular, not the general. Frankl’s work also demonstrates that transsubjectivity is best facilitated when several autoethnographers take advantage of their unique combinations of disposition, situation and position rather than when a single autoethnographer tries to move into multiple positions simultaneously. Psychologists who publish autoethnography may find Frankl’s ideas and metaphors useful for conceptualizing and defending their own scholarship. (shrink)

Sustainable development is a concern for countries, businesses and organizations sensitive to excess in terms of utilized resources. This is evident in international initiatives which aim to establish guiding principles for institutions to follow regarding what is considered to be socially responsible behavior, allowing for assessment and the identification of objectives. As higher education institutions, colleges and universities have a public responsibility to generate and transmit knowledge to society as a whole, as well as an economic and social responsibility regarding (...) resource management; hence the importance of specifically analyzing their socially responsible behavior. This paper introduces an initiative which has been implemented in the United States and Canada; one of its aims is to identify best practices in this field and obtain knowledge that allows for the creation and development of a guide to social responsibility adapted specifically to higher education institutions. The Sustainability Tracking, Assessment & Rating System (STARS) is an innovative initiative developed by the Association for the Advancement of Sustainability in Higher Education (AASHE), in which all higher education institutions in the United States and Canada are welcome to participate. Their analysis will allow us to determine which measurable aspects will become a part of the sustainability culture that is developing in the higher education institutions that participate in this initiative. Furthermore, it will allow us to highlight the ethical values that are being promoted among its special interest groups. (shrink)

This article proposes potential strategies to address gun violence in communities of color while identifying the harms associated with a policing-centered, criminal legal approach. In addition to highlighting the dangers associated with the United States' current criminal legal tactics to reduce gun violence in these communities, the authors advocate for community-endorsed strategies that give those impacted by this issue the resources to take on gun violence in their own communities. Specifically, they identify, describe, and endorse a series of violence prevention (...) programs that rely on community relations to detect and prevent incidents of gun violence and that view gun violence as a public health rather than criminal legal issue. (shrink)

Noninvasive prenatal testing promises to enhance women's reproductive autonomy by providing genetic information about the fetus, especially in the detection of genetic impairments like Down syndrome. In practice, however, NIPT provides opportunities for intensified manipulation and control over women's reproductive decisions. Applying Miranda Fricker's concept of epistemic injustice to prenatal screening, this article analyzes how medical professionals impair reproductive decision-making by perpetuating testimonial injustice. They do so by discrediting positive parental testimony about what it is like to raise a child (...) with DS. We argue that this testimonial injustice constitutes a twofold harm: people with DS and their family members who claim that parenting a child with DS may be a rewarding and joyous experience are harmed when they are systematically silenced, disbelieved, and/or denied epistemic credibility by medical professionals, and pregnant women are harmed since they might make poorly informed choices without access to all relevant information. The broader implication of the analysis is that epistemic justice is a precondition of reproductive autonomy. We conclude by calling for federal oversight of the acquisition and dissemination of information that prospective parents receive following a positive diagnosis of DS to ensure that it is comprehensive and up to date. (shrink)

"This is an important contribution to the serious, detailed philosophical discussion of Buddhist ideas, an approach to the study of Buddhism that is still relatively young and undeveloped. The arguments for and against various Buddhist views are presented in an accessible and clear way, but without shying away from the inevitable conundrums and complexities. The study is well supported by a wide range of primary sources and references to recent scholarly discussions." - David Burton, Canterbury Christ Church University The first (...) introductory survey of Indian Buddhist philosophy available in the English language. Organised in broadly chronological terms, this book presents the philosophical arguments of the great Indian Buddhist philosophers of the fifth century BCE to the eighth century CE. Each chapter examines their core ethical, metaphysical and epistemological views as well as the distinctive area of Buddhist ethics that we call today moral psychology. Throughout, the book follows three key themes that both tie the tradition together and are the focus for most critical dialogue: the idea of anatman or no-self, the appearance/reality distinction and the moral aim, or ideal. Indian Buddhist philosophy is shown to be a remarkably rich tradition that deserves much wider engagement from European philosophy. Carpenter shows that while we should recognise the differences and distances between Indian and European philosophy, its driving questions and key conceptions, we must resist the temptation to find in Indian Buddhist philosophy, some Other, something foreign, self-contained and quite detached from anything familiar. Indian Buddhism is shown to be a way of looking at the world that shares many of the features of European philosophy and considers themes central to philosophy understood in the European tradition. (shrink)

Democritus’ atomism aims to respond to threats of Parmenidean monism. In so doing, it deploys a familiar epistemological distinction between what is known by the senses and what is known by the mind. This turns out to be a risky strategy, however, leading to inadvertent skepticism with only diffuse and contrary ethical implications. Vasubandhu’s more explicitly metaphysical atomism, by contrast, relies on a different principle to get to its results, and aims to address different concerns. It leaves us with a (...) view that positively implies a concrete mode of practical engagement, and resources for a critical stance. Even if certain atoms end up proven incoherent, there is no danger of slipping into the morally fatal indifference of inadvertent skepticism. For the ethical implications, it matters how one arrives at one’s atomism. (shrink)

More than two decades after the passage of the Americans with Disabilities Act , people with disabilities continue to live at the margins of American democracy and capitalist society. This persistent exclusion poses a conundrum to political theorists committed to disability rights, multiculturalism, and social justice. Drawing from feminist insights, specifically the work of Nancy Fraser, among others, I examine the necessary conditions for meaningful inclusion to be realized within a deliberative democracy. Using Fraser's concept of “participatory parity” as a (...) proxy for inclusion, I strategize how to overcome informal barriers—economic inequality and misrecognition—that persist even after disabled people are granted the legal right to participate. The analysis concludes that a truly inclusionary and multicultural democracy requires the redistribution of wealth and a more expansive model of political deliberation, one that can recognize unconventional modes of communication through practices of translation. (shrink)

In 2010, pitcher Armando Galarraga was denied a perfect game when umpire Jim Joyce called Jason Donald safe at first with two outs in the bottom of the 9th. In the numerous media discussions that followed, Joyce’s ‘blown’ call was commonly referred to as ‘mistaken’, ‘wrong’, or otherwise erroneous. However, this use of language makes some not uncontroversial ontological assumptions. It claims that the fact that a runner is safe or out has nothing to do with the ruling of the (...) umpire himself, but rather with some state of the universe that does not depend on the umpire for its existence. In this paper, I recast the problem as a version of Plato’s Euthyphro Dilemma and argue that the view implied by the above assertions is actually misguided. Instead, I hope to show that an alternative view – what I call ‘restricted umpire voluntarism’ – is actually more in line with the spirit of the game of baseball and is not as counterintuitive as it may appear.. (shrink)

Given that many people with disabilities have been excluded from political deliberation and subjected to infantilizing and degrading treatment from others, many members of the disability rights movement are understandably critical of policies and practices that speak on behalf of people with disabilities and presume to know what is really in their best interest. Yet, this analysis argues that a general principle of anti-paternalism is not desirable for disability politics. In particular, people with cognitive disabilities are sometimes unable to make (...) important decisions by themselves, and may require assistance from family members or more cognitively able and verbally fluent citizens to make their political voices and choices heard. Drawing from John Locke and Alasdair MacIntyre, this article reconsiders the relationship between paternalism and autonomy, suggesting that autonomous decisionmaking and expression are best thought of as collaborative processes undertaken between people with a range of capacities. (shrink)

ABSTRACTThroughout his published work, Michel Henry expresses a deep appreciation for the writings of Kierkegaard, using them as an inspirational foundation for much of his own thought. However, Henry claims to be far more Kierkegaardian than he really is. Henry’s peers have identified several philosophical and theological deficiencies in Henry’s thought. These places of weakness also happen to be his most obvious points of departure from Kierkegaard. A Kierkegaardian confrontation with Henry demands a retrieval of the Infinite Qualitative Difference between (...) God and man as key to exploring the structure of the self. Kierkegaard’s texts correct Henry’s assumption that the ontological difference established in the act of creation would separate the self from God. They suggest instead that the IQD provides the necessary conditions for the truly theological self to emerge. (shrink)

In this paper we argue that to adequately capture the complicated relationship between Descartes' work and late medieval thought, philosophers need to think not only about his ideas but also about his presentation and choice of genre. Reading the Meditations as a mere discursive treatise containing a progressive and consistent set of arguments intended to establish a particular philosophical position fails to appreciate the eponymous genre that Descartes explicitly chose to employ in writing them. Instead, we argue that reading the (...) text in light of the long tradition of contemplative meditative literature opens up a radically new way of interpreting the Meditations as a “mystagogical” project of spiritual edification and epistemic and volitional transformation. During such a transformation, the meditator undergoes a series of revelatory experiences structurally similar to those we find in various so-called “mystical” or “mystagogical”literature, in the Christian West. We show how paying attention to these mystagogical aspects of the Meditations can open up new avenues for understanding the connection between the theoretical, practical, and theological aspects of Descartes' thought. Such a reading resolves a number of seemingly glaring problems and peculiarities in the Meditations including the Cartesian circle, and the tension in the Cartesian notion of the freedom of the will. We also argue that the odd detours the meditator takes in the Sixth Meditation through physiology are not mere digressions but rather mark an often overlooked aspect of the mystagogical story – the return to embodiment as a transformed self. Indeed, the overly intellectualist emphasis of contemporary scholars on both the contemplative aspects of mystagogical literature and the epistemological focus of Descartes' project in the Meditations have caused them to largely overlook the ways in which the aim of both medieval and Cartesian meditation involves a transformative re-orientation of the whole person and their understanding of the world – one which has practical, moral, and social consequences that have gone underexplored in discussions of these texts. (shrink)

Medieval and early modern devotional works rarely receive serious treatment from philosophers, even those working in the subfields of philosophy of religion or the history of ideas. In this article, I examine one medieval devotional work in particular—the Middle High German image- and verse-program, Christus und die minnende Seele (CMS)—and I argue that it can plausibly be viewed as a form of medieval public philosophy, one that both exhibited and encouraged philosophical innovation. I address a few objections to my proposal—namely, (...) that CMS is neither public enough nor that it counts as proper philosophy—and I attempt to defend CMS’s public philosophical credentials in light of these objections. I conclude with a brief discussion of how devotional texts like CMS can help us do innovative public philosophy today. (shrink)

Development of Buddhist thought in India; 1. The Buddha’s suffering; 2. Practice and theory of no-self; 3. Kleśas and compassion; 4. The second Buddha’s greater vehicle; 5. Karmic questions; 6. Irresponsible selves, responsible non-selves; 7. The third turning: Yogācāra; 8. The long sixth to seventh century: epistemology as ethics; I. Perception and conception: the changing face ofultimate reality; II. Evaluating reasons: Naiyāyikas and Diṅnāga. III. Madhyamaka response to Yogācāra IV. Percepts and concepts: Apoha 1 ; V. Efficacy: Apoha 2 ; (...) VI. The path of the Bodhisattva; Epilogue; Background information; Appendix 1: The languages of Buddhism; Appendix 2: Intellectual context; Appendix 3: The Abhidharma. (shrink)