Short-term limb immobilization results in skeletal muscle decline, but the underlying mechanisms are incompletely understood. This study aimed to determine the neurophysiologic basis of immobilization-induced skeletal muscle decline, and whether repetitive Transcranial Magnetic Stimulation could prevent any decline. Twenty-four healthy young males underwent unilateral limb immobilization for 72 h. Subjects were randomized between daily rTMS using six 20 Hz pulse trains of 1.5 s duration with a 60 s inter-train-interval delivered at 90% resting Motor Threshold, or Sham rTMS throughout immobilization. (...) Maximal grip strength, EMG activity, arm volume, and composition were determined at 0 and 72 h. Motor Evoked Potentials were determined daily throughout immobilization to index motor excitability. Immobilization induced a significant reduction in motor excitability across time. The rTMS intervention increased motor excitability at 0 h. Despite daily rTMS treatment, there was still a significant reduction in motor excitability, loss in EMG activity, and a loss of maximal grip strength after immobilization. Interestingly, the increase in biceps and posterior forearm skinfold thickness with immobilization in Sham treatment was not observed following rTMS treatment. Reduced MEPs drive the loss of strength with immobilization. Repetitive Transcranial Magnetic Stimulation cannot prevent this loss of strength but further investigation and optimization of neuroplasticity protocols may have therapeutic benefit. (shrink)

Cascades of Grace was formed within the United Reformed Church through Global and Intercultural Ministries to network and empower Black, Asian and Minority Ethnic women in the churches. In the article, two of the founding members describe the formation of the group, and their own experiences in URC and other churches, and in candidating for ministry.

ABSTRACT:Determining the biological function of phenomenal consciousness appears necessary to explain its origin: evolution by natural selection operates on organisms’ traits based on the biological functions they fulfill. But identifying the function of phenomenal consciousness has proven difficult. Some have proposed that the function of phenomenal consciousness is to facilitate mental processes such as reasoning or learning. But mental processes such as reasoning and learning seem to be possible in the absence of phenomenal consciousness. It is difficult to pinpoint in (...) what way phenomenal consciousness enhances these processes or others like them. In this paper, we explore a possibility that has been neglected to date. Perhaps phenomenal consciousness has no function of its own because it is either a by-product of other traits or a (functionless) accident. If so, then phenomenal consciousness has an evolutionary explanation even though it fulfills no biological function. (shrink)

Explainable artificial intelligence (XAI) is an emerging, multidisciplinary field of research that seeks to develop methods and tools for making AI systems more explainable or interpretable. XAI researchers increasingly recognise explainability as a context-, audience- and purpose-sensitive phenomenon, rather than a single well-defined property that can be directly measured and optimised. However, since there is currently no overarching definition of explainability, this poses a risk of miscommunication between the many different researchers within this multidisciplinary space. This is the problem we (...) seek to address in this paper. We outline a framework, called Explanatory Pragmatism, which we argue has two attractive features. First, it allows us to conceptualise explainability in explicitly context-, audience- and purpose-relative terms, while retaining a unified underlying definition of explainability. Second, it makes visible any normative disagreements that may underpin conflicting claims about explainability regarding the purposes for which explanations are sought. Third, it allows us to distinguish several dimensions of AI explainability. We illustrate this framework by applying it to a case study involving a machine learning model for predicting whether patients suffering disorders of consciousness were likely to recover consciousness. (shrink)

According to ‘Excluders’, descriptive uncertainty – but not normative uncertainty – matters to what we ought to do. Recently, several authors have argued that those wishing to treat normative uncertainty differently from descriptive uncertainty face a dependence problem because one's descriptive uncertainty can depend on one's normative uncertainty. The aim of this paper is to determine whether the phenomenon of dependence poses a decisive problem for Excluders. I argue that existing arguments fail to show this, and that, while stronger ones (...) can be found, Excluders can escape them. (shrink)

I came to utopia by accident, having painted myself into a corner with an idea for a trilogy: three science fiction novels consisting of an after-the-fall novel, a dystopia, and a utopia, all set in the same place and about the same distance into the future. The idea came to me in 1972, and I didn’t know how to write a novel then, so the plan needed brooding on. Some sixteen years later, the time came for the utopia. I had (...) written the after-the-fall novel, The Wild Shore, and the dystopia, The Gold Coast. The utopia was the only one left.By that time many aspects of it had been determined by the previous two books. I needed it to be in Orange County, California; I needed it to be fifty years in the future; and I.. (shrink)

It is a standard feature of modern philosophy, at least from Locke, to tie together the questions of how we perceive the world and what we have reason to think the world is like in itself. This is a natural connection, because the questions of how we perceive it, and what kind of conception of it we can best form on the basis of that mode of perception, are obviously intimately linked. Part I of this volume defends the sense-datum theory (...) of perception against its opponents, and argues that the sense-datum theory is much closer to a form of direct realism than is normally thought: we directly perceive the world in the form that it naturally manifests itself to creatures like us. This leaves open the question of what it is like in itself, and Part II tries to show that a Berkeleian interpretation—that the world is a nomological structure in the mind of God—is the most plausible option. Arguments with roots in Berkeley, in modern philosophers such as John Foster, and in modern science, are drawn on to support this conclusion. (shrink)

In proof-theoretic semantics, model-theoretic validity is replaced by proof-theoretic validity. Validity of formulae is defined inductively from a base giving the validity of atoms using inductive clauses derived from proof-theoretic rules. A key aim is to show completeness of the proof rules without any requirement for formal models. Establishing this for propositional intuitionistic logic raises some technical and conceptual issues. We relate Sandqvist’s (complete) base-extension semantics of intuitionistic propositional logic to categorical proof theory in presheaves, reconstructing categorically the soundness and (...) completeness arguments, thereby demonstrating the naturality of Sandqvist’s constructions. This naturality includes Sandqvist’s treatment of disjunction that is based on its second-order or elimination-rule presentation. These constructions embody not just validity, but certain forms of objects of justifications. This analysis is taken a step further by showing that from the perspective of validity, Sandqvist’s semantics can also be viewed as the natural disjunction in a category of sheaves. (shrink)

According to epiphenomenalism, our behavior is caused by events in our brains that also cause our mentality. This resulting mentality reflects our brains¿ organization, but does not in turn cause anything. This book defends an epiphenomenalist account of philosophy of mind. It builds on the author¿s previous work by moving beyond a discussion of sensations to apply an epiphenomenalist outlook to other aspects of mental causation such as beliefs, desires, pleasure, and displeasure. The first four chapters of the book argue (...) for a dualistic theory of sensations and develop an epiphenomenalist version of dualism. The remaining chapters discuss propositional attitudes and valence. The author also responds to potential objections to epiphenomenalism by considering how sensations, intelligence, or understanding might be built into a robot. This book will be of interest to scholars and students in philosophy of mind who are interested in consciousness, mental causation, and how our mentality is situated in the world. (shrink)

As technologies of ocean exploitation emerged during the late 1960s, science policy and diplomacy were formed in response to anticipated capabilities that did not match the realities of extracting deep-sea minerals and of resource exploitation in the deep ocean at the time. Promoters of ocean exploitation in the late 1960s envisaged wonders such as rare mineral extraction and the stationing of divers in underwater habitats from which they would operate seabed machinery not connected to the turbulent surface waters. Their promises (...) coincided with others' fears that nuclear weaponry would be placed on the seabed. Those who lacked the technological capability to extract minerals from the seabed also had concerns that other nations would exploit their resources. Scientific imaginaries caused uncertainty in the international community—especially in the “Global South.” The UN called the “Law of the Sea” conferences to mediate emerging geopolitical tensions caused by these imaginaries of exploitation of ocean resources. These conferences became a site where lawmakers projected futures rather than merely responding to past or present dilemmas. Diplomats' negotiations, with their basis in anticipation of the future uses of science and technology, reveal the role of scientific imaginaries within complex negotiations. Here, we see the impact of the distinction (or blurring) of the real and the imagined on the balance of relations between Global North and South increasing global imbalances of resources and power. This article's analysis of such scientific diplomacy provides a valuable example of the power of scientific imaginaries to have a global impact. (shrink)

: Experiential acquaintance is an alleged relation between ourselves and our experiences that has sometimes been hypothesized as necessary for knowledge of our experiences. This paper begins with a clarification of ‘acquaintance’ and an explanation of ‘experience’ that focuses attention on a famous, but flawed, argument by G. E. Moore. It goes on to critically examine several recent arguments concerning experiential acquaintance and to show how internalist foundationalism can respond to a famous Sellarsian dilemma without appeal to a relation of (...) acquaintance with our experiences. It concludes that we can dispense with experiential acquaintance. (shrink)

This article will review reasons why it is argued that the law on abortion on the grounds of disability is discriminatory, as well as recent unsuccessful attempts to address this discrimination in the law. These attempts include ones which would have moderately restricted access to abortion in certain limited cases, and another that might have opened to door to a number of different possibilities, including both to options that could have restricted access to abortion, and to other options that might (...) have increased access. Finally, this article will also examine reasons why some of the most important challenges surrounding disability equality cannot be sufficiently addressed through legal change alone. While there are strong reasons to support some form of change in the law, a more foundational change in values is necessary if we want to live in a more ethical society that is truly capable of welcoming disabled children. (shrink)

This article will review reasons why it is argued that the law on abortion on the grounds of disability is discriminatory, as well as recent unsuccessful attempts to address this discrimination in the law. These attempts include ones which would have moderately restricted access to abortion in certain limited cases, and another that might have opened to door to a number of different possibilities, including both to options that could have restricted access to abortion, and to other options that might (...) have increased access. Finally, this article will also examine reasons why some of the most important challenges surrounding disability equality cannot be sufficiently addressed through legal change alone. While there are strong reasons to support some form of change in the law, a more foundational change in values is necessary if we want to live in a more ethical society that is truly capable of welcoming disabled children. (shrink)

Philosophical dialogue has the power to improve interdisciplinary scientific research. The Toolbox Dialogue Initiative (TDI) conducts workshops that foster philosophical dialogue among interdisciplinary researchers. This chapter focuses on 20 of these workshops, all of which used the Toolbox STEM (Science, Technology, Engineering, and Mathematics) instrument and were conducted with interdisciplinary research teams of scientists. We analyze data from some of these workshops and demonstrate that philosophical dialogues conducted using the Toolbox method have two salutary effects. First, they lead to a (...) significant increase in belief formation about philosophical topics relevant to interdisciplinary science. Scientists sometimes do not have preconceived commitments on issues in philosophy of science, and Toolbox workshops tend to prompt them to adopt views on these topics. Second, these philosophical …. (shrink)

This book offers students a philosophical introduction to the ethical foundations of business management. It combines lessons from Kant with virtue ethics and also touches upon additional approaches such as utilitarianism. At the core of the book lies the concept of the nexus of imperfect managerial duty: building and reinforcing the virtuous managerial team, engaging in reasoned discourse among all stakeholders, and diligently pursuing business responsibilities, including the creative efforts necessary for modern organizations. Case illustrations of these applications are presented (...) throughout the book, including chapter appendices. Ancillary videos, test and answer banks and sample syllabi are available online via the author’s website. (shrink)

Research integrating the perspectives of different disciplines, or interdisciplinary research, has become increasingly common in academia and is considered important for its ability to address complex questions and problems. This mode of research aims to leverage differences among disciplines in generating a more complex understanding of the research landscape. To interact successfully with other disciplines, researchers must appreciate their differences, and this requires recognizing how the research landscape looks from the perspective of other disciplines. One central aspect of these disciplinary (...) perspectives involves values, and more specifically, the roles that values do, may, and should play in research practice. It is reasonable to think that disciplines differ in part because of the different views that their practitioners have on these roles. This paper represents a step in the direction of evaluating this thought. Operating at the level of academic branches, which comprise relevantly similar disciplines (e.g. social and behavioral sciences), this paper uses quantitative techniques to investigate whether academic branches differ in terms of views on the impact of values on research. Somewhat surprisingly, we find very little relation between differences in these views and differences in academic branch. We discuss these findings from a philosophical perspective to conclude the paper. (shrink)

According to the most popular versions of the flicker defense, Frankfurt-style cases fail to undermine the Principle of Alternative Possibilities (PAP) because agents in these cases are (directly) morally responsible not for making the decisions they make but for making these decisions on their own, which is something they could have avoided doing. Frankfurt defenders have primarily focused on trying to show that the alternative possibility of refraining from making the relevant decisions on their own is not a robust alternative, (...) while generally granting that this alternative cannot easily be eliminated from successful cases of this sort. In a recent issue of this journal, Stockdale (2022) attempts to sidestep the debate concerning robustness and develops a novel kind of Frankfurt-style case in which agents are unable to avoid making the relevant decisions on their own. The fundamental problem with Stockdale’s argument is that it hinges on an implausible conception of acting on one’s own. I help clarify the pertinent sense of what it means to do a thing on one’s own in this context and show that these new cases are unable to overcome the targeted versions of the flicker defense of PAP. (shrink)

This paper presents a case for a feminist care ethics approach to thinking about ethics and justice in the context of the COVID-19 pandemic. Much of the existing commentary has been focused on arri...

Vision consists of four essays: “Seeing distance,” “Size,” “Perceptual inference,” and “A Gibsonian alternative?” The continuous thread is the Berkeleian treatment of the perception of spatial properties, particularly in connection with what is and is not “immediately perceived.” The first two essays are closely connected with specific Berkeleian arguments and modern responses to them. The second two essays deal more generally with modern discussions by psychologists of whether visual perception is “direct” or “indirect.” The claims on the cover that the (...) book is “unique in its blend of philosophical and historical perspectives on contemporary issues in vision studies” and that it is “clearly written” and suitable “for an interdisciplinary readership in philosophy of mind, philosophy of science, cognitive psychology and history of science” are all entirely justified. (shrink)

Experiential acquaintance is an alleged relation between ourselves and our experiences that has sometimes been hypothesised as necessary for knowledge of our experiences. This paper begins with a clarification of ‘acquaintance’ and an explanation of ‘experience’ that focuses attention on a famous, but flawed, argument by G. E. Moore. It goes on to critically examine several recent arguments concerning experiential acquaintance and to show how internalist foundationalism can respond to a famous Sellarsian dilemma without appeal to a relation of acquaintance (...) with our experiences. It concludes that we can dispense with experiential acquaintance. (shrink)

It is a cliché of self-help advice that there are no problems, only opportunities. The rationale and actions of the BSHS in creating its Global Digital History of Science Festival may be a rare genuine confirmation of this mantra. The global COVID-19 pandemic of 2020 meant that the society's usual annual conference – like everyone else's – had to be cancelled. Once the society decided to go digital, we had a hundred days to organize and deliver our first online festival. (...) In the hope that this will help, inspire and warn colleagues around the world who are also trying to move online, we here detail the considerations, conversations and thinking behind the organizing team's decisions. (shrink)

'Thick neural event' is introduced to mean an event that requires firings of more than one neuron and a substantive (i.e. additional to merely temporal and spatial) relation among them. It is shown that some well regarded theories (e.g. by Lamme, Koch, etc.) strongly suggest that neural correlates of consciousness (NCCs) are thick neural events. It is then shown that thin (= not thick) neural events provide sufficient causation for neural events leading to behaviour, and that there are good reasons (...) to reject overdetermination by thick events. Thus, any physicalism that recognizes legitimacy of a search for NCCs must either reject theories that embrace thickness of NCCs, or accept the epiphenomenalistic view that the properties in virtue of which we are conscious are not properties in virtue of which events causally contribute to our behaviour. (shrink)

Peace is a hallmark of human societies. However, certain ant species engage in long-term intergroup resource sharing, which is remarkably similar to peace among human groups. We discuss how individual and group payoff distributions are affected by kinship, dispersal, and age structure; the challenges of diagnosing peace; and the benefits of comparing convergent complex behaviours in disparate taxa.

This chapter contains sections titled: Introduction The Argument for Predicate Dualism Why Predicate Dualism leads to Dualism Proper Is the Talk of “Perspectives” Legitimate? A Surprising Ally The Optionality of Non‐basic Levels and the Unavoidability of Psychology Why Bundle Dualism Will Not Do Two Reflections on this Conclusion An Objection Conclusion.

Through an engagement with Sylvia Wynter, this article explores how black feminist critiques of the human can inform critical genealogies of religion. Specifically, the article develops a theoretical framework to interrogate how the modern construction of religion and the secular also produces racial identities and hierarchies. To draw attention to the global dimensions of this project, the article foregrounds the seminal work of Jason Ā. Josephson-Storm in his book, The Invention of Religion in Japan. The article argues that studies like (...) Josephson-Storm's show how religion helps transform existing forms of social organization within a bio-evolutionary conception of the nation, and is used by the state to differentiate between who can be considered fully human and who cannot. In this process “superstition” or “irrationality” is rewritten as a biological threat to the health and well-being of “the people,” and political domination is represented as a struggle to purify the nation. (shrink)

In my feature article, ‘Pregnancy and superior moral status: a proposal for two thresholds of personhood’,1 I argue that there are reasons to recognise that pregnant women have a superior moral status. This is a new argument on personhood in philosophy, and I am not surprised that it has generated some discussion. While I am grateful that many authors have engaged with my ideas, I have not identified from the six commentaries any aspect in my approach that would need to (...) be revised. I will do my best here, in the space available, to address the main points raised. Gibson starts off by correctly noting that my proposal rests on a starting assumption (which I do not defend) that we follow a first threshold of personhood, but then seems to leave this aside in the rest of his critique.2 He says I have not justified why humanity’s survival is important, and that I have assumed that the existence of human persons matters. My response is that yes, I have, and that the first threshold already recognises the high moral value of human persons. If alternatively babies are harms themselves, or are harmed from being born, then perhaps we will see pregnant women as pest-making or victim-making entities. I …. (shrink)

One way to defend the Principle of Alternative Possibilities (PAP) against Frankfurt‐style cases is to challenge the claim that agents in these scenarios are genuinely morally responsible for what they do. Alternatively, one can grant that agents are morally responsible for what they do in these cases but resist the idea that they could not have done otherwise. This latter strategy is known as the flicker defense of PAP. In an argument he calls the W‐Defense, David Widerker adopts the former (...) approach. I argue that, while Widerker's argument does a poor job showing that these agents are not morally responsible for what they do, it does a very good job highlighting the alternative possibilities that remain open to agents in these cases and illustrating their moral significance (or robustness). In doing so, my aim is to co‐opt Widerker's argument to bolster the most promising versions of the flicker defense. (shrink)

Humility is a paradoxical virtue. This should come as no great surprise. It doesn’t take much explanation for one to realize that if someone is boasting about how humble he is, then he probably is not humble. In fact, as we shall see, the paradoxical nature of humility has a long history, going back to at least Thomas Aquinas in the thirteenth century. While it may not be a novel claim that there exists an apparent paradox of humility, I will (...) argue that there is more than one humility paradox, perhaps as many as five: the epistemic paradox, the paradox of self-attribution, the inculcation paradox, the agentic paradox, and the axiological paradox. All these paradoxes are distinct, yet seemingly intertwined. Upon examining them each in turn, we will be left with a Gordian knot of humility paradoxes. (shrink)

Most academic philosophers and intellectual historians are familiar with the major historical figures and intellectual movements coming out of Scotland in the 18 th Century. These scholars are also familiar with the works of Immanuel Kant and his influence on Western thought. But with the exception of discussion examining David Hume’s influence on Kant’s epistemology, metaphysics, and moral theory, little attention has been paid to the influence of the Scottish Enlightenment thinkers on Kant’s philosophy. _Kant and The Scottish Enlightenment_ aims (...) to fill this perceived gap in the literature and provides a starting point for future discussions looking at the influence of Hume, Thomas Reid, Adam Smith, Francis Hutcheson, and other Scottish Enlightenment thinkers on Kant’s philosophy. The chapters are laid out according to a natural progression of ideas beginning with the influence of Scottish Enlightenment thinkers on Kant’s moral thought, including the role of feelings, reason, and religion. From there, the discussion moves to an examination of the relationship between truth, freedom, and responsibility in the texts coming out of the Scottish Enlightenment and its connection to Kant’s metaphysics and aesthetics. The volume concludes with a discussion of the influence of Scottish Enlightenment thinkers on Kant’s anthropology. This book will be of interest to Kant scholars as well as philosophers and intellectual historians working in the history of eighteenth-century philosophy. (shrink)

According to the most popular versions of the flicker defense, Frankfurt-style cases fail to undermine the Principle of Alternative Possibilities (PAP) because agents in these cases are (directly) morally responsible not for making the decisions they make but for making these decisions on their own, which is something they could have avoided doing. Frankfurt defenders have primarily focused on trying to show that the alternative possibility of refraining from making the relevant decisions on their own is not a robust alternative, (...) while generally granting that this alternative cannot easily be eliminated from successful cases of this sort. In a recent issue of this journal, Stockdale (2022) attempts to sidestep the debate concerning robustness and develops a novel kind of Frankfurt-style case in which agents are unable to avoid making the relevant decisions on their own. The fundamental problem with Stockdale’s argument is that it hinges on an implausible conception of acting on one’s own. I help clarify the pertinent sense of what it means to do a thing on one’s own in this context and show that these new cases are unable to overcome the targeted versions of the flicker defense of PAP. (shrink)

This special issue of The New Bioethics follows on from a conference that took place at St Stephen's House, University of Oxford, in March 2022, on ‘Prenatal Testing, Disability, and the Ethical So...

Le mode infini immédiat de l’étendue (MIIE) est l’un des éléments les plus mystérieux de l’ontologie de Spinoza. Malgré son importance pour le système métaphysique de Spinoza, ce dernier nous dit très peu à propos de ce mode. Dans un effort pour faire progresser l’étude de cette question, j’examine trois hypothèses bien acceptées qui traitent de l’identité de ce mode : l’interprétation de la force, l’interprétation nomique et l’interprétation cinétique. J’affirme premièrement que l’interprétation de la force et l’interprétation nomique doivent (...) faire face à de sérieuses objections. Deuxièmement, je soutiens que malgré les affirmations contraires des spécialistes, l’interprétation cinétique du MIIE est une option valable. (shrink)

Adequate ideas are the fundamental element of Spinoza’s epistemological program. However, a recurrent worry among scholars is that Spinoza’s account of adequate ideas is inconsistent with any finite being ever having one. As I frame it, the problem is that for Spinoza an idea is adequate in a mind only if all its causal antecedents lie within the mind as well. However, it seems there can be no finite mind for which this is true; finite minds come to be and (...) exist within a deterministic causal nexus, and the causal antecedents of every idea in a mind will ultimately stretch far beyond it. I call this the External Cause Objection. I argue that Spinoza appreciated and explicitly answered this concern. According to this reply, adequate ideas do not have causes external to the mind because they do not fall into the category of what Spinoza calls “singular things.” In addition to showing that this coheres with his more specific claims about adequate ideas and his firm belief that finite minds are parts of nature, I argue that the resolution to this problem sheds light on Spinoza’s understanding of what I call absolute agency. Published on 2022-03-23 11:07:32. (shrink)