Schistosoma mansoni is one of several species of trematode helminths responsible for schistosomiasis, a major parasitic infection of man. Genetic analysis in mice has revealed that the protective immunity induced against this parasite by an attenuated larval vaccine is strongly influenced by genes regulating the activation of macrophage effector cells. The latter finding suggests that the induction of cell‐mediated immunity may be a successful strategy for a non‐living vaccine against the human infection.

The present crisis of truth, the "post-truth" crisis, puts the philosophy of truth in a new light. It calls for a reexamination of the tasks of the philosophy of truth and sets a new adequacy condition on this philosophy. One of the central roles of the philosophy of truth is to explain the importance of truth for human life and civilization. Among other things, it has to explain what is, or will be, lost in a post-truth era. Clearly, the deflationist (...) answer that the role of truth is to serve as a tool of generalization and oblique endorsement will not do. My account of truth in this paper addresses this task. Truth, I argue, is first and foremost a human value. Its importance to our life/civilization lies, not exclusively, but principally, in the centrality of this value to our humanity. I investigate the ramifications of this answer to the issues discussed in the contemporary philosophy of truth, and I end with a comparison of the substantivist and deflationist approaches to truth in light of this new perspective. (shrink)

In this new edition of his acclaimed autobiography — long out of print and rare until now — Alan Watts tracks his spiritual and philosophical evolution from a child of religious conservatives in rural England to a freewheeling spiritual teacher who challenged Westerners to defy convention and think for themselves. From early in this intellectual life, Watts shows himself to be a philosophical renegade and wide-ranging autodidact who came to Buddhism through the teachings of Christmas Humphreys and D. T. (...) Suzuki. Told in a nonlinear style, In My Own Way wonderfully combines Watts’ own brand of unconventional philosophy and often hilarious accounts of gurus, celebrities, psychedelic drug experiences, and wry observations of Western culture. A charming foreword written by Watts’ father sets the tone of this warm, funny, and beautifully written story of a compelling figure who encouraged readers to “follow your own weird” — something he always did himself, as his remarkable account of his life shows. (shrink)

In his 1936 paper,On the Concept of Logical Consequence, Tarski introduced the celebrated definition oflogical consequence: “The sentenceσfollows logicallyfrom the sentences of the class Γ if and only if every model of the class Γ is also a model of the sentenceσ.” [55, p. 417] This definition, Tarski said, is based on two very basic intuitions, “essential for the proper concept of consequence” [55, p. 415] and reflecting common linguistic usage: “Consider any class Γ of sentences and a sentence which (...) follows from the sentences of this class. From an intuitive standpoint it can never happen that both the class Γ consists only of true sentences and the sentenceσis false. Moreover, … we are concerned here with the concept of logical, i.e.,formal, consequence.” [55, p. 414] Tarski believed his definition of logical consequence captured the intuitive notion: “It seems to me that everyone who understands the content of the above definition must admit that it agrees quite well with common usage. … In particular, it can be proved, on the basis of this definition, that every consequence of true sentences must be true.” [55, p. 417] The formality of Tarskian consequences can also be proven. Tarski's definition of logical consequence had a key role in the development of the model-theoretic semantics of modern logic and has stayed at its center ever since. (shrink)

Evolutionary developmental biology (Evo-devo) is a loose conglomeration of research programs in the life sciences with two main axes: (a) the evolution of development, or inquiry into the pattern and processes of how ontogeny varies and changes over time; and, (b) the developmental basis of evolution, or inquiry into the causal impact of ontogenetic processes on evolutionary trajectories—both in terms of constraint and facilitation. Philosophical issues are found along both axes surrounding concepts such as evolvability, novelty, and modularity. The developmental (...) basis of evolution has garnered much attention because it speaks to the possibility of revising a standard construal of evolutionary theory, but the evolution of development harbors its own conceptual questions. This article addresses the heterogeneity of Evo-devo’s conglomerate structure (including disagreements over its individuation), as well as the concepts and controversies of philosophical interest pertaining to the evolution of development and the developmental basis of evolution. Future research will benefit from a shift away from global theorizing toward the scientific practices of Evo-devo. (shrink)

This paper offers a response to William’s Hanson’s criticism of Sher’s formal-structural conception of logical consequence and logical constants.

This is a critique of Michael P. Lynch’s functional pluralism with respect to truth. The paper is sympathetic to Lynch’s overall approach to truth, but is critical of (i) his platitudinous characterization of the general principles of truth, (ii) his excessive pluralism with respect to the “realizers” of truth, (iii) his treatment of atomic truth, and (iv) his analysis of “mixed” logical inferences. The paper concludes with a proposal for a functional pluralism that puts greater emphasis on the unity of (...) truth. For example: while Lynch regards truth as based on correspondence principles in some domains and on coherence principles in others, the current proposal regards truth as based on correspondence principles in all domains, restricting the plurality of truth to a plurality of correspondence principles. (shrink)

Co-published with the University of Queensland Press. HPC holds rights in North America and U. S. Dependencies. Since its first publication in 1976, Alan Chalmers's highly regarded and widely read work--translated into eighteen languages--has become a classic introduction to the scientific method, known for its accessibility to beginners and its value as a resource for advanced students and scholars. In addition to overall improvements and updates inspired by Chalmers's experience as a teacher, comments from his readers, and recent developments (...) in the field, this fourth edition features an extensive chapter-long postscript that draws on his research into the history of atomism to illustrate important themes in the philosophy of science. Identifying the qualitative difference between knowledge of atoms as it figures in contemporary science and metaphysical speculations about atoms common in philosophy since the time of Democritus offers a revealing and instructive way to address the question at the heart of this groundbreaking work: What is this thing called science? (shrink)

White searches for the subtler side of Nietzsche beyond his ambiguous support for violence and oppression. He looks at the `yes saying teachings' articulated with the `voice of beauty'.

Since its first publication in 1976, Alan Chalmers's highly regarded and widely read work--translated into eighteen languages--has become a classic introduction to the scientific method, known for its accessibility to beginners and its value as a resource for advanced students and scholars. -- Amazon.com.

This review essay discusses Matt King’s recent book Simply Responsible, in which he defends a unifying account of responsibility that spans not only moral responsibility, but also prudential and epistemic responsibility, among other forms. The first half of the essay summarizes the three key elements of King’s account--his treatment of basic responsibility, basic blame, and basic desert--while the second half takes a more critical look at each element.

'O men, serve your Lord who created you and those before you, so that you may guard against evil. Deals with Allah, Prophet Muhammad PBUH, Hazrat Mirza Ghulam Ahmad Sahib -- What are the signs of the appearance of the promised messiah? and do these signs appear in the being of Hazrat Mirza Sahib?

Following Henkin’s discovery of partially-ordered (branching) quantification (POQ) with standard quantifiers in 1959, philosophers of language have attempted to extend his definition to POQ with generalized quantifiers. In this paper I propose a general definition of POQ with 1-place generalized quantifiers of the simplest kind: namely, predicative, or “cardinality” quantifiers, e.g., “most”, “few”, “finitely many”, “exactly α ”, where α is any cardinal, etc. The definition is obtained in a series of generalizations, extending the original, Henkin definition first to a (...) general definition of monotone-increasing (M↑) POQ and then to a general definition of generalized POQ, regardless of monotonicity. The extension is based on (i) Barwise’s 1979 analysis of the basic case of M↑ POQ and (ii) my 1990 analysis of the basic case of generalized POQ. POQ is a non-compositional 1st-order structure, hence the problem of extending the definition of the basic case to a general definition is not trivial. The paper concludes with a sample of applications to natural and mathematical languages. (shrink)

Including significant passages from The Prince, The Discourses, The Art of War and History of Florence, this illuminating book explores the influence of Machiavelli, who was often reviled as a teacher of evil, on the modern state.

This compilation offers a unique synthesis of the traditional branches of Eastern thought by drawing upon their historical connections and common foundations in mystical experience.

Featuring the edited transcripts of eight lectures delivered by Alan Watts from 1960 to 1973. The Tao of Philosophy offers a rich introduction to the wit and wisdom of one of the foremost philosophers of the twentieth century.

“Life exists only at this very moment, and in this moment it is infinite and eternal. For the present moment is infinitely small; before we can measure it, it has gone, and yet it exists forever…. You may believe yourself out of harmony with life and its eternal Now; but you cannot be, for you are life and exist Now.”–from Become What You Are In this collection of writings, including nine new chapters never before available in book form, Watts displays (...) the intelligence, playfulness of thought, and simplicity of language that has made him so perennially popular as an interpreter of Eastern thought for Westerners. He draws on a variety of religious traditions, and covers topics such as the challenge of seeing one’s life “just as it is,” the Taoist approach to harmonious living, the limits of language in the face of ineffable spiritual truth, and the psychological symbolism of Christian thought. (shrink)

Physicians have a sacred commitment to dedicate themselves through their art and through science to the improvement of the human condition. They have the solemn responsibility to focus on both the prevention and the cure of disease. The human genome project, a 15-year effort to draw the first detailed map in human DNA, will inevitably lead to the widespread implementation of human-gene therapy for the treatment and prevention of disease. We are on the verge of nothing less than a biomedical (...) revolution, the likes of which have not been encountered before. The human genome project will lead to profound changes in the ability to manipulate genes. It will change the way we are born, how we live, how we die, and how we view ourselves in relation to our destiny. Before us lies a difficult transition. (shrink)

An explanation is given of why it is in the nature of inquiry into whether or not p that its aim is fully achieved only if one comes to know that p or to know that not-p and, further, comes to know how one knows, either way. In the absence of the latter one is in no position to take the inquiry to be successfully completed or to vouch for the truth of the matter in hand. An upshot is that (...) although knowledge matters because truth matters this should not be understood to mean that knowledge matters because true belief matters. (shrink)

In order to come to your senses, Alan Watts often said, you sometimes need to go out of your mind. Perhaps more than any other teacher in the West, this celebrated author, former Anglican priest, and self-described spiritual entertainer was responsible for igniting the passion of countless wisdom seekers to the spiritual and philosophical delights of India, China, and Japan. With Out of Your Mind, you are invited to immerse yourself in six of this legendary thinker's most engaging teachings (...) on how to break through the limits of the rational mind and expand your awareness and appreciation for the great game unfolding all around us. Distilled from Alan Watts’s pinnacle lectures, Out of Your Mind brings you an inspiring new resource that captures the true scope of this brilliant teacher in action. For those both new and familiar with Watts, this book invites us to delve into his favorite pathways out of the trap of conventional awareness, including: • The art of the “controlled accident”—what happens when you stop taking your life so seriously and start enjoying it with complete sincerity • How we come to believe “the myth of myself”—that we are skin-encapsulated egos separate from the world around us—and how to transcend that illusion • Why we must fully embrace chaos and the void to find our deepest purpose • Unconventional and refreshing insights into the deeper principles of Buddhism, Hinduism, Western philosophy, Christianity, and much more. (shrink)

In his newly updated version of The Anatomy of a Constitutional Law Case, Alan F. Westin provides a documentary portrait of historically important constitutional law case, 'Youngstown Sheet & Tube Co. v. Sawyer, ' from its rise in a bargaining dispute in the steel industry during 1952 to the aftermath of its decision by the United States Supreme Court. Westin has added to his classic book additional materials and personal commentaries collected since the work was first published. The new (...) information covers what went on within the Truman administration, what went on within the Supreme Court when analyzing and resolving issues that come before it. Westin includes selections from transcripts, briefs and other official proceedings, adds notes describing each phase of the constitutional process, and a section of commentary and questions relating this case to others. (shrink)

To be responsible for their acts, agents must both perform those acts voluntarily and in some sense know what they are doing. Of these requirements, the voluntariness condition has been much discussed, but the epistemic condition has received far less attention. In Who Knew? George Sher seeks to rectify that imbalance. The book is divided in two halves, the first of which criticizes a popular but inadequate way of understanding the epistemic condition, while the second seeks to develop a (...) more adequate alternative. It is often assumed that agents are responsible only for what they are aware of doing or bringing about--that their responsibility extends only as far as the searchlight of their consciousness. The book criticizes this "searchlight view" on two main grounds: first, that it is inconsistent with our attributions of responsibility to a broad range of agents who should but do not realize that they are acting wrongly or foolishly, and, second, that the view is not independently defensible. The book's positive view construes the crucial relation between an agent and his failure to recognize the wrongness or foolishness of what he is doing in causal terms: the agent is responsible when, and because, his failure to respond to his reasons for believing that he is acting wrongly or foolishly has its origins in the same constitutive psychology that generally does render him reason-responsive. (shrink)

In spite of a powerful tradition, more than two thousand years old, that in a valid argument the premises must be relevant to the conclusion, twentieth-century logicians neglected the concept of relevance until the publication of Volume I of this monumental work. Since that time relevance logic has achieved an important place in the field of philosophy: Volume II of Entailment brings to a conclusion a powerful and authoritative presentation of the subject by most of the top people working in (...) the area. Originally the aim of Volume II was simply to cover certain topics not treated in the first volume--quantification, for example--or to extend the coverage of certain topics, such as semantics. However, because of the technical progress that has occurred since the publication of the first volume, Volume II now includes other material. The book contains the work of Alasdair Urquhart, who has shown that the principal sentential systems of relevance logic are undecidable, and of Kit Fine, who has demonstrated that, although the first-order systems are incomplete with respect to the conjectured constant domain semantics, they are still complete with respect to a semantics based on "arbitrary objects." Also presented is important work by the other contributing authors, who are Daniel Cohen, Steven Giambrone, Dorothy L. Grover, Anil Gupta, Glen Helman, Errol P. Martin, Michael A. McRobbie, and Stuart Shapiro. Robert G. Wolf's bibliography of 3000 items is a valuable addition to the volume. (shrink)

abstractThis paper addresses the relation between morality and private thought. It is widely agreed that government and society have no business trying to control our thoughts—that, as long as we d...

All this is tightly reasoned, the argument is packed, but the language is clear."—Christian Century "The man value of this book seems to me to be that it ...

Drawing upon ancient Hindu philosophy, the author explores the human psyche and the importance of personal identity.

Many philosophers are baffled by necessity. Humeans, in particular, are deeply disturbed by the idea of necessary laws of nature. In this paper I offer a systematic yet down to earth explanation of necessity and laws in terms of invariance. The type of invariance I employ for this purpose generalizes an invariance used in meta-logic. The main idea is that properties and relations in general have certain degrees of invariance, and some properties/relations have a stronger degree of invariance than others. (...) The degrees of invariance of highly-invariant properties are associated with high degrees of necessity of laws governing/describing these properties, and this explains the necessity of such laws both in logic and in science. This non-mysterious explanation has rich ramifications for both fields, including the formality of logic and mathematics, the apparent conflict between the contingency of science and the necessity of its laws, the difference between logical-mathematical, physical, and biological laws/principles, the abstract character of laws, the applicability of logic and mathematics to science, scientific realism, and logical-mathematical realism. (shrink)

Two central themes of Douglas Edwards’s The Metaphysics of Truth are anti-deflationism and substantial pluralism. In Part I of this paper I discuss Edwards’s grounds for rejecting deflationism and suggest a few additional grounds. In Part II I discuss Edward's truth-pluralism and respond to his criticism of my correspondence-pluralism. While these pluralisms share significant features, their differences also raise several important questions.

The Bounds of Logic presents a new philosophical theory of the scope and nature of logic based on critical analysis of the principles underlying modern Tarskian logic and inspired by mathematical and linguistic development. Extracting central philosophical ideas from Tarski’s early work in semantics, Sher questions whether these are fully realized by the standard first-order system. The answer lays the foundation for a new, broader conception of logic. By generally characterizing logical terms, Sher establishes a fundamental result in (...) semantics. Her development of the notion of logicality for quantifiers and her work on branching are of great importance for linguistics. Sher outlines the boundaries of the new logic and points out some of the philosophical ramifications of the new view of logic for such issues as the logicist thesis, ontological commitment, the role of mathematics in logic, and the metaphysical underpinning of logic. She proposes a constructive definition of logical terms, reexamines and extends the notion of branching quantification, and discusses various linguistic issues and applications. (shrink)

This paper is a critical discussion of the recent tendency to moralize various aspects of life that were previously viewed as private and discretionary. The paper takes as its starting point six recently unearthed moral prohibitions, and it examines the prospects for defending each as an extension of some familiar moral requirement. Its conclusion is not only that none of the extended prohibitions are defensible, but also that each impedes morality's function by limiting the ability of those whose lives it (...) governs to pursue their own aims as they see fit. (shrink)

'Working Memory, Thought, and Action' is the magnum opus of one of the most influential cognitive psychologists of the past 50 years. This new volume on the model he created discusses the developments that have occurred within the model in the past twenty years, and places it within a broader context.

Gila Sher approaches knowledge from the perspective of the basic human epistemic situation—the situation of limited yet resourceful beings, living in a complex world and aspiring to know it in its full complexity. What principles should guide them? Two fundamental principles of knowledge are epistemic friction and freedom. Knowledge must be substantially constrained by the world (friction), but without active participation of the knower in accessing the world (freedom) theoretical knowledge is impossible. This requires a grounding of all knowledge, (...) empirical and abstract, in both mind and world, but the fall of traditional foundationalism has led many to doubt the viability of this ‘classical’ project. Sher challenges this skepticism, charting a new foundational methodology, foundational holism, that differs from others in being holistic, world-oriented, and universal (i.e., applicable to all fields of knowledge). Using this methodology, Epistemic Friction develops an integrated theory of knowledge, truth, and logic. This includes (i) a dynamic model of knowledge, incorporating some of Quine’s revolutionary ideas while rejecting his narrow empiricism, (ii) a substantivist, non-traditional correspondence theory of truth, and (iii) an outline of a joint grounding of logic in mind and world. The model of knowledge subjects all disciplines to demanding norms of both veridicality and conceptualization. The correspondence theory is robust and universal yet not simplistic or naive, admitting diverse forms of correspondence. Logic’s grounding in the world brings it in line with other disciplines while preserving, and explaining, its strong formality, necessity, generality, and normativity. (shrink)

Blame is an unpopular and neglected notion: it goes against the grain of a therapeutically-oriented culture and has been far less discussed by philosophers than such related notions as responsibility and punishment. This book seeks to show that neither the opposition nor the neglect is justified. The book's most important conclusion is that blame is inseperable from morality itself - that any considerations that justify us in accepting a set of moral principles must also call for the condemnation of those (...) who violate the principles. Properly understood, blame and morality must stand or fall together. (shrink)