Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

We provide a retrospective of 25 years of the International Conference on AI and Law, which was first held in 1987. Fifty papers have been selected from the thirteen conferences and each of them is described in a short subsection individually written by one of the 24 authors. These subsections attempt to place the paper discussed in the context of the development of AI and Law, while often offering some personal reactions and reflections. As a whole, the subsections build into (...) a history of the last quarter century of the field, and provide some insights into where it has come from, where it is now, and where it might go. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Mindfulness and compassion meditation are thought to cultivate prosocial behavior. However, the lack of diverse representation within both scientific and participant populations in contemplative neuroscience may limit generalizability and translation of prior findings. To address these issues, we propose a research framework calledIntersectional Neurosciencewhich adapts research procedures to be more inclusive of under-represented groups. Intersectional Neuroscience builds inclusive processes into research design using two main approaches: 1) community engagement with diverse participants, and 2) individualized multivariate neuroscience methods to accommodate neural (...) diversity. We tested the feasibility of this framework in partnership with a diverse U.S. meditation center (East Bay Meditation Center, Oakland, CA). Using focus group and community feedback, we adapted functional magnetic resonance imaging (fMRI) screening and recruitment procedures to be inclusive of participants from various under-represented groups, including racial and ethnic minorities, gender and sexual minorities, people with disabilities, neuropsychiatric disorders, and/or lower income. Using person-centered screening and study materials, we recruited and scanned 15 diverse meditators (80% racial/ethnic minorities, 53% gender and sexual minorities). The participants completed the EMBODY task – which applies individualized machine learning algorithms to fMRI data – to identify mental states during breath-focused meditation, a basic skill that stabilizes attention to support interoception and compassion. All 15 meditators’ unique brain patterns were recognized by machine learning algorithms significantly above chance levels. These individualized brain patterns were used to decode the internal focus of attention throughout a 10-min breath-focused meditation period, specific to each meditator. These data were used to compile individual-level attention profiles during meditation, such as the percentage time attending to the breath, mind wandering, or engaging in self-referential processing. This study provides feasibility of employing an intersectional neuroscience approach to include diverse participants and develop individualized neural metrics of meditation practice. Through inclusion of more under-represented groups while developing reciprocal partnerships, intersectional neuroscience turns the research process into an embodied form of social action. (shrink)

It would be good to have a Bayesian decision theory that assesses our decisions and thinking according to everyday standards of rationality — standards that do not require logical omniscience (Garber 1983, Hacking 1967). To that end we develop a “fragmented” decision theory in which a single state of mind is represented by a family of credence functions, each associated with a distinct choice condition (Lewis 1982, Stalnaker 1984). The theory imposes a local coherence assumption guaranteeing that as an (...) agent's attention shifts, successive batches of "obvious" logical information become available to her. A rule of expected utility maximization can then be applied to the decision of what to attend to next during a train of thought. On the resulting theory, rationality requires ordinary agents to be logically competent and to often engage in trains of thought that increase the unification of their states of mind. But rationality does not require ordinary agents to be logically omniscient. (shrink)

The 'best-system' analysis of lawhood [Lewis 1994] faces the 'zero-fit problem': that many systems of laws say that the chance of history going actually as it goes--the degree to which the theory 'fits' the actual course of history--is zero. Neither an appeal to infinitesimal probabilities nor a patch using standard measure theory avoids the difficulty. But there is a way to avoid it: replace the notion of 'fit' with the notion of a world being typical with respect to a (...) theory. (shrink)

In a letter to Wlodek Rabinowicz, David Lewis introduced a decision scenario that he described as “much more problematic for decision theory than the Newcomb Problems”. This scenario, which involves an agent with foreknowledge of the outcome of some chance process, has received little subsequent attention. However, in one of the small number of discussions of such cases, Huw Price's Causation, Chance and the Rational Significance of Supernatural Evidence it has been argued that cases of this sort pose serious (...) problems for causal decision theory. In this paper, I will argue that these problems can be overcome: scenarios of this sort do not pose fatal problems for this theory as there are versions of CDT that reason appropriately in these cases. However, I will also argue that such cases push us toward a particular version of CDT developed by Wlodek Rabinowicz. (shrink)

In “Radical Interpretation” (1974), David Lewis asked: by what constraints, and to what extent, do the non-intentional, physical facts about Karl determine the intentional facts about him? There are two popular approaches: the reductive externalist program and the phenomenal intentionality program. I argue against both approaches. Then I sketch an alternative multistage account incorporating ideas from both camps. If we start with Karl's conscious experiences, we can appeal to Lewisian ideas to explain his other intentional states. This account develops (...) the multistage Lewisian approach presented at the end of my earlier "Does Phenomenology Ground Mental Content?" (2013). (shrink)

I develop several new arguments against claims about "cognitive phenomenology" and its alleged role in grounding thought content. My arguments concern "absent cognitive qualia cases", "altered cognitive qualia cases", and "disembodied cognitive qualia cases". However, at the end, I sketch a positive theory of the role of phenomenology in grounding content, drawing on David Lewis's work on intentionality. I suggest that within Lewis's theory the subject's total evidence plays the central role in fixing mental content and ruling out (...) deviant interpretations. However I point out a huge unnoticed problem, the problem of evidence: Lewis really has no theory of sensory content and hence no theory of what fixes evidence. I suggest a way of plugging this hole in Lewis's theory. On the resulting theory, which I call " phenomenal functionalism", there is a sense in which sensory phenomenology is the source of all determinate intentionality. Phenomenal functionalism has similarities to the theories of Chalmers and Schwitzgebel. (shrink)

Smith proposes an account of how languages developed. He did so not as historian, but as a philosopher with a special concern about how a nominalist could account for general terms. Names for individuals are taken as fairly unproblematic – say ‘Thames’ and ‘Avon’ for each of the respective rivers. But whence the word ‘river,’ applicable to more than one, if all that exist are particular objects? Smith’s view is not the usual one, according to which people deploy a powerful (...) ability to abstract mentally, and subsequently affix a label to a general concept. He resisted this because he granted that such robust mental processes themselves presuppose the use of words. Rather, what holds the class together is the word itself, a “single appellation.”. (shrink)

In "Counterfactual Dependence and Time's Arrow", David Lewis defends an analysis of counterfactuals intended to yield the asymmetry of counterfactual dependence: that later affairs depend counterfactually on earlier ones, and not the other way around. I argue that careful attention to the dynamical properties of thermodynamically irreversible processes shows that in many ordinary cases, Lewis's analysis fails to yield this asymmetry. Furthermore, the analysis fails in an instructive way: it teaches us something about the connection between the asymmetry (...) of overdetermination and the asymmetry of entropy. (shrink)

The Significance Argument (SA) for the irreducibility of consciousness is based on a series of new puzzle-cases that I call multiple candidate cases. In these cases, there is a multiplicity of physical-functional properties or relations that are candidates to be identified with the sensible qualities and our consciousness of them, where those candidates are not significantly different. I will argue that these cases show that reductive materialists cannot accommodate the various ways in which consciousness is significant and must allow massive (...) vagueness in conscious experience. I also will argue that a nonreductive theory of the conscious-of relation can easily provide a very satisfying, unified explanation of the ways in which this relation is significant. (shrink)

This is a chapter from my introductory book *Perception* covering the representational view of experience. I use the Ramsey-Lewis method to define the theoretical term "experiential representation". I clarify and discuss various questions for representationalists, for instance, "how rich is the content of experience?" and "is the content of visual experience singular or general?" Finally, I address some objections to representationalism - in particular, that it cannot explain perceptual presence (John Campbell), and that it cannot explain the "laws of (...) appearance" (constraints on how things can appear). (shrink)

Given his hostility to intensional locutions, it is not surprising that Quine was suspicious of the subjunctive conditional. Although he admitted its usefulness as a heuristic device, in order to introduce dispositional terms, he held that it had no place in a finished scientific theory. In this paper I argue in support of something like Quine’s position. Many contemporary philosophers are unreflectively realist about subjunctives, regarding them as having objective truth values. I contest this. “Moderate realist” theorists, such as (...) class='Hi'>Lewis and Stalnaker, admit that subjunctives are context-relative and often indeterminate; I argue, using some examples from the contemporary literature on conditionals, that these features are deeper and more widespread than they think. “Ultra-realist” theories, which deny any indeterminacy, are not credible. Hence subjunctives are unsuitable for certain purposes, in particular the description of mind-independent reality. (shrink)

The computable Lipschitz reducibility was introduced by Downey, Hirschfeldt and LaForte under the name of strong weak truth-table reducibility [6]). This reducibility measures both the relative randomness and the relative computational power of real numbers. This paper proves that the computable Lipschitz degrees of computably enumerable sets are not dense. An immediate corollary is that the Solovay degrees of strongly c.e. reals are not dense. There are similarities to Barmpalias and Lewis’ proof that the identity bounded Turing degrees of (...) c.e. sets are not dense [2]), however the problem for the computable Lipschitz degrees is more complex. (shrink)

I relate plural quantification, and predicate logic where predicates do not need a fixed number of argument places, to the part-whole relation. For more on these themes see later work by Boolos, Lewis, and Oliver & Smiley.

Arian Lewis provides a comprehensive overview of how the United Kingdom’s medicolegal context manages challenges to determining death by neurologic criteria (DNC) and suggests that a well-crafted s...

The aim of this article is to draw attention to the breadth and importance of Mumford's philosophical outlook by exploring his critical appropriation of the theories of Marx and Jung which he employed to create a penetrating, visionary collection of works that offer us a powerful and timely insight into the ills besetting our current technological civilization. Mumford partially accepted Marx's matter–psyche dynamic but expanded it to include architecture, technology and urban planning. He surpassed the one-way process of Marxist historical-economic (...) teleology to form a conception of historical process based upon a dialectic interaction between mind and material conditions. He constructed a Jungian model of mind and explored its formative effect on material conditions. At the same time he criticized Jung's failure to engage with the external world, namely with those material conditions in urgent need of transformation. Like Jung he was concerned by the exclusion of religion from the modern scientific idolum, the dominant ideological presence, yet unlike Jung he extended his analysis further, considering not only the effect of religion on the individual but also its effect on the community. His theory of the dialectic interaction of material conditions and psyche is partly drawn from these two thinkers but transcends both by refusing to commit wholly to either. His incorporation, modification and rejection of elements of both Marx and Jung contributed more significantly than has so far been noted to his own critique of the present civilization and vision for the future. This vision involved a deeper awareness of the human personality, liberation from automatism and increased sensitivity to others and the natural world. This, according to the Mumfordian project, would be inexorably followed by a gradual withdrawal from the consumerism of the current technological civilization, the construction of a more personal and organic ideology and the subsequent regeneration of material conditions to nurture human nature. I therefore argue that it is essential to our understanding of Lewis Mumford that we witness his critical engagement with Marx and Jung and see the ways in which they inform and inspire this project. (shrink)

The twenty-sixth volume in the highly acclaimed Library of Living Philosophers series is devoted to the work of British philosopher of logic and metaphysician, P. F. Strawson. Following the Library of Living Philosophers series format, the volume contains an intellectual autobiography, twenty critical and descriptive essays by leading philosophers from around the world, Strawson's replies to the essays, and a bibliography of Strawson's works. Born in 1919, Strawson was a leading proponent of ordinary language philosophy. He is the author of (...) the early and extremely influential paper "On Referring" in which he criticized Russell's theory of definite descriptions. His most influential book, Individuals, helped to raise the status of metaphysics as a philosophical enterprise. Themes first addressed in this book continued to be of concern to him in his later work, including the possibility of objective knowledge, the subject-predicate distinction, the ontological status of persons, and the problem of individuation. Contributors to the book include: Ruth Garrett Millikan, Susan Haack, E. M. Adams, Panayot Butchvarov, Richard Behling, John McDowell, Simon Blackburn, Tadeusz Szubka, David Frederick Haight, Joseph S. Wu, Andrew G. Black, David Pears, Robert Boyd, Hilary Putnam, Paul F. Snowdon, Arindam Chakrabarti, Wenceslao J. Gonzalez, Ernest Sosa, Chung-M. Tse, John R. Searle, P. F. Strawson. (shrink)

I address the question of whether phenomenology is "prior to" all intentionality. I also sketch a version of David Lewis's interpretationism in which phenomenal intentionality plays the role of source intentionality.

I discuss the intelligibility of belief in God, presenting a neo-positivist view. It is aimed at a non-professional audience.

In an economy that increasingly trades in electronic information products, the copy assumes a new reversibility, as a figure at once valued for its rapid exchangeability and vilified for of its associations with counterfeit and fraud. The incorporation of confidence measures into the design of electronic information products is symptomatic of a primary crisis of belief installed within empiricist epistemologies, of which anti-circumvention technologies and knock-off economies are merely the incorrigible children. The aesthetic strategies practiced by Albert Oehlen and N.E. (...) Thing Co., which mirror the information hiding techniques employed by steganography software and technologies of trust as well as the circumvention tactics employed to defeat them, register an emergent preoccupation in contemporary visual culture with structures of belief. They also disclose a Humean attention to processes of devivification, which figures in these artists’ work as an effect of the multiplication of the same. The trope of the ‘false bottom’ deployed in the 1930s novels of British artist and author Wyndham Lewis serves as intertext in this genealogical investigation of the politics of circumvention. (shrink)

In his superb book, The Metaphysics of Representation, Williams sketches biconditional reductive definitions of representational states in non-representational terms. The central idea is an extremely innovative variety of interpretationism about belief and desire. Williams is inspired by David Lewis but departs significantly from him. I am sympathetic to interpretationism for some basic beliefs and desires. However, I will raise three worries for Williams’s version (§2–4). It neglects the role of conscious experience, it makes beliefs and desire too dependent on (...) "hidden facts", and it commits to the unmotivated and problematic claim that mental content is always explanatorily prior to linguistic content. Then, I will suggest a modified version of interpretationism that avoids these problems (§5). I will conclude with a general question (§6). -/- . (shrink)

The aim of the paper is to show that W. V. O. Quine's animadversions against modal logic did not get the same attention that is considered to be the case nowadays. The community of logicians focused solely on the technical aspects of C. I. Lewis’ systems and did not take Quine's arguments and remarks seriously—or at least seriously enough to respond. In order to assess Quine's place in the history, however, his relation to Carnap is considered since their notorious (...) break was about the status of extensionality and modal logic. Since much of the works about the history of analytic philosophy is centered on the relationship of Quine and Carnap, their break about modality deserves much more attention—it also sheds some light on why should anyone wonder about Quine's early arguments against modal logic. The paper ends with some further considerations regarding the early formation of modal logic and hitherto unconsidered problematic issues. (shrink)

ABSTRACT Drawing inspiration from Fred Dretske, L. S. Carrier, John A. Barker, and Robert Nozick, we develop a tracking analysis of knowing according to which a true belief constitutes knowledge if and only if it is based on reasons that are sensitive to the fact that makes it true, that is, reasons that wouldn’t obtain if the belief weren’t true. We show that our sensitivity analysis handles numerous Gettier-type cases and lottery problems, blocks pathways leading to skepticism, and validates the (...) epistemic closure thesis that correct inferences from known premises yield knowledge of the conclusions. We discuss the plausible views of Ted Warfield and Branden Fitelson regarding cases of knowledge acquired via inference from false premises, and we show how our sensitivity analysis can account for such cases. We present arguments designed to discredit putative counterexamples to sensitivity analyses recently proffered by Tristan Haze, John Williams and Neil Sinhababu, which involve true statements made by untrustworthy informants and strange clocks that sometimes display the correct time while running backwards. Finally, we show that in virtue of employing the paradox-free subjunctive conditionals codified by Relevance Logic theorists instead of the paradox-laden subjunctive conditionals codified by Robert Stalnaker and David Lewis. (shrink)

1. IntroductionIn this superb book, Williams sets a very ambitious goal for himself: to sketch biconditionals that define representational conditions in non-representational terms (p. xvii). Representation is not a spooky, primitive capacity of the mind; it is built from more basic ingredients. At the centre is his radical interpretation theory of belief and desire, inspired by the work of David Lewis. To a first approximation: Basic radical interpretation theory. The correct assignment of beliefs and desires to an agent is (...) the most rationalizing assignment given her perceptual evidence and dispositions to act. (pp. 16, 97ff)Williams does not give a master argument for this account of belief and desire over rival accounts in which constitutive rationality plays no role. Rather, his main goal is the laudatory one of theory-building. In this respect, his book hearkens back to the decade or so from the early 80s to the early 90s that was the heyday for developing grand theories of representation. In particular, his main aim is to develop the details of the basic radical interpretation theory – something Lewis never fully did. The result is a unique, multi-stage theory of representation that departs importantly from Lewis in many places. (shrink)

Hardin argues that Reflectance Physicalism about color fails because it cannot accommodate color structure. David Lewis and others have replied that the Reflectance Physicalist may explain color structure in terms of color experience. I argue that this reply fails.

v. 1. Essays on ethics by the Earl of Shaftesbury, Frances Hutcheson ; Samuel Butler ; Adam Smith ; Jeremy Bentham - v. 2. Essays by Samuel Clarke ; John Balguy ; Richard Price ; John Brown ; John Clarke ; Ralph Cudworth ; John Gay ; Thomas Hobbes ; Henry Home Kames ; John Locke ; John Mandeville ; William Paley ; William Wollaston.

This paper begins with a problem stemming from Hume regarding credences about credences. Suppose one has a credence of .95 in p, and suppose one assesses the credence to be such. But suppose one’s second-order credence in this assessment is less than 1. Then, by a standard conditionalization rule, one’s credence in p becomes less than .95. Moreover, such “erosion” can iterate by considering one’s, third-, fourth-, fifth-order credences, etc. (In light of this, some have rejected higher-order credences; however, it (...) is argued that Lewis’ “Principal Principle” forbids this.) The paper then offers a partial solution by describing circumstances under which a person has reason to assign credence 1 to a first-order credence. The solution takes the form of a “transparency” view of self-knowledge from Parent (2017, chapter 8). Briefly, it is argued that when one “reflex-like” utters a sentence “The probability of p is n”, then as a matter of psychological law, the utterance is an expression of one’s own judgment. The Principal Principle then necessitates that one’s credence in p is n, assuming one is being rational. Roughly, upon perceiving such an utterance, one can thereby have a reason to assign a second-order credence of 1. (shrink)

Relativized Metaphysical Modality (RMM: Murray and Wilson, 'Relativized metaphysical modality', Oxford Studies in Metaphysics, 2012; Murray, Perspectives on Modal Metaphysics, 2017) exploits 'two-dimensionalist' resources to metaphysical, rather than epistemological, ends: the second dimension offers perspective-dependence without contingency, diverting attacks on 'Classical' analyses of modals (in effect, analyses validating S5 and the Barcan Formulae). Here, we extend the RMM program in two directions. First, we harvest resources for RMM from Lewis's 1980 'Context--Index' (CI) framework: (a) the ban in CI on (...) binding into context-arguments (akin to Kaplan's 'monstrosity' ban) projects a bright line between perspective-dependence and contingency; and (b) CI-postulated connections among meaning, content, truth, argument-structure, context, and modality collectively generate a 'Generalized Humphrey Problem' for any non-Classical analysis (examples covered include appeals to accessibility, contingent domains, and counterpart relations). Second, we sharpen the tools of RMM-based metaphysical analysis, and extend their domain of coverage across familiar anomalies for Classical modals: we revisit earlier RMM-based bulwarks for S5 (against 'Chisholm's Paradox' for moderate flexibility of essence, and nomological necessitarianism); and we now similarly shore up the Barcan Formulae (against the apparent contingency of existence and nonexistence). (shrink)