BackgroundThe use of human embryonic stem cells (ES cells) for the development of medical therapies is surrounded with moral concerns. The aim of this study was to assess the public’s attitudes toward the use of ES cells for treatment of Parkinson’s disease (PD) and other diseases, what factors are most important to consider when using ES cells for drug development, and if there is an association between religious beliefs and attitudes toward using ES cells for medical treatment.MethodsA randomly selected sample (...) of the Swedish public, aged 18–87-years-old, completed an online survey (n = 467). The survey assessed socio-demographics, religious views, perceived moral status of the embryo, and attitudes toward using ES cells for medical treatment of PD and other diseases. Adjusted odds ratios (ORs) and 95% confidence intervals (CI) for positive vs. negative attitude toward using ES cells for drug development were computed using logistic regression.ResultsThe respondents were positive about using ES for treatment; specifically, 70% totally agreed that it is acceptable to use ES cells for treatment of PD, while 40% totally agreed that it is acceptable to use ES cells for treatment but induced pluripotent cells is just as efficient. Religion being of little importance in one’s life was associated with a positive attitude toward using ES cells for treatment of PD (adjusted OR 6.39, 95% CI 2.78–14.71). The importance of being able “to access new, effective treatments against diseases that do not have any treatment available” was ranked as the most important factor to consider when using ES cells for drug development.ConclusionMost respondents are positive about using ES cells for drug development, and making effective treatments accessible to those who do not have any. However, these attitudes are influenced by the specific disorder that the drug development is intended for, as well as the religious views and perceived moral status of the early embryo. (shrink)

BackgroundHuman embryonic stem cells as a source for the development of advanced therapy medicinal products are considered for treatment of Parkinson’s disease. Research has shown promising results and opened an avenue of great importance for patients who currently lack a disease modifying therapy. The use of hESC has given rise to moral concerns and been the focus of often heated debates on the moral status of human embryos. Approval for marketing is still pending.ObjectiveTo Investigate the perspectives and concerns of patients (...) with PD, patients being the directly concerned stakeholders in the ethical discussion.MethodsQualitative semi-structured interviews related to this new therapy in seventeen patients from two Swedish cities.ResultsThe participants expressed various interests related to the use of human embryos for development of medicinal therapies; however, overall, they were positive towards the use of hESC for treatment of PD. It was deemed important that the donating woman or couple made the choice to donate embryos voluntarily. Furthermore, there were concerns that the industry does not always prioritise the patient over profit; thus, transparency was seen as important. (shrink)

BackgroundNew disease-modifying ways to treat Parkinson’s disease (PD) may soon become a reality with intracerebral transplantation of cell products produced from human embryonic stem cells (hESCs). The aim of this study was to assess what factors influence preferences of patients with PD regarding stem-cell based therapies to treat PD in the future.MethodsPatients with PD were invited to complete a web-based discrete choice experiment to assess the importance of the following attributes: (i) type of treatment, (ii) aim of treatment, (iii) available (...) knowledge of the different types of treatments, (iv) effect on symptoms, and (v) risk for severe side effects. Latent class conditional logistic regression models were used to determine preference estimates and heterogeneity in respondents’ preferences.ResultsA substantial difference in respondents’ preferences was observed in three latent preference patterns (classes). “Effect on symptoms” was the most important attribute in class 1, closely followed by “type of treatment,” with medications as preferred to other treatment alternatives. Effect on symptoms was also the most important attribute in class 2, with treatment with hESCs preferred over other treatment alternatives. Likewise for class 3, that mainly focused on “type of treatment” in the decision-making. Respondents’ class membership was influenced by their experience in treatment, side effects, and advanced treatment therapy as well as religious beliefs.ConclusionsMost of the respondents would accept a treatment with products emanating from hESCs, regardless of views on the moral status of embryos. Preferences of patients with PD may provide guidance in clinical decision-making regarding treatments deriving from stem cells. (shrink)

ABSTRACT:The ethics of high frequency trading are obscure, due in part to the complexity of the practice. This article contributes to the existing literature of ethics in financial markets by examining a recent trend in regulation in high frequency trading, the prohibition of deception. We argue that in the financial markets almost any regulation, other than the most basic, tends to create a moral hazard and increase information asymmetry. Since the market’s job is, at least in part, price discovery, we (...) argue that simplicity of regulation and restraint in regulation are virtues to a greater extent than in other areas of finance. This article proposes criteria for determining which high-frequency trading strategies should be regulated. (shrink)

All of finance is now automated, most notably high frequency trading. This paper examines the ethical implications of this fact. As automation is an interdisciplinary endeavor, we argue that the interfaces between the respective disciplines can lead to conflicting ethical perspectives; we also argue that existing disciplinary standards do not pay enough attention to the ethical problems automation generates. Conflicting perspectives undermine the protection those who rely on trading should have. Ethics in finance can be expanded to include organizational and (...) industry-wide responsibilities to external market participants and society. As a starting point, quality management techniques can provide a foundation for a new cross-disciplinary ethical standard in the age of automation. (shrink)

The comparison of Ernst Cassirer’s philosophy of symbolic forms and Levi-Strauss’ structural anthropology requires a clarification of their definitions of morphology, transformation and translatability. We will expose the morphological field where Cassirer’s aesthetics emerges in relation to Goethe, who represents an important source for Levi-Strauss as well. Defining the concept of transformation is supposed to follow his modifications of the key ideas of the German poet and biologist, by taking account of the new point of view provided by the theory (...) of groups of transformation which the mathematician Felix Klein developed in the »circle of Erlangen «. Then we will show how Edgar Wind, a brilliant student of Cassirer, invents a kind of morphological aesthetics to provide art history with a methodology, and we will give some examples for the application of the concept of building series of pictures in the field of art history. We will examine the global function of the tables of Aby Warburg’s Atlas Mnemosyne, Erwin Panofsky’s wellknown iconological interpretation of Durer’s Melencolia I and then, by contrast, the creation of a virtual series of masks through an imaginative variation which Levi-Strauss creates to give sense to a particular Ameridian mask found during his investigations. Finally, we will investigate the problems appearing by the definition of transformation as translatability in both Cassirer’s and Levi-Strauss’ semiologies. We will ask for their uses of the model of translation in linguistics to compare different forms of structural homologies. (shrink)

The paper reviews Cassirer's recent reception in France and takes two international meetings in Rennes and Paris as an opportunity to determine current research interests in this area. A striking feature of French concern is the stress on art historical contextualization of Cassirer's thought (Riegl, Wolfflin, Panofsky).

L'anthropologie de l'art est une discipline relativement récente, qui naît au carrefour de plusieurs sciences humaines à la fin du XIXe siècle et qui se développe au XXe siècle jusqu'à connaître sa floraison actuelle. On entend par ce terme les études qui traitent de l'art par le prisme de la diversité des cultures, donc constamment tourné vers d'autres formes telles que le langage, le rituel, la technique et la science avec lesquelles il interagit. Cet ouvrage aborde des œuvres qui ont (...) un caractère esthétique, mais également une signification culturelle et des fonctions techniques, cognitives, sociales et politiques diverses. Au travers d'un panorama qui ne se prétend pas exhaustif, ce sont les conditions de son émergence que nous voudrions analyser ici avec les figures pionnières qui ont accompagné son avènement et le déploiement qu'en offrent quelques-unes des principales figures plus contemporaines pour mieux en saisir la diversité et la richesse"--Page 4 of cover. (shrink)

This article responds to Srinivas Aravamudan's call to revisit the notion of the trace from the standpoint of the Anthropocene. A Derridean understanding of the trace shows how postcolonial difference challenges the humanist distinction between human and nature by questioning the distinction between life and death that is central to metaphysics. This discussion thus reframes the prospect of extinction signaled by the Anthropocene by means of a return to a Marxist, feminist, psychoanalytic and deconstructive trajectory within postcolonial thought.

Bien au-delà de la seule philosophie, le débat à Davos en 1929 entre Cassirer et Heidegger a marqué l'histoire des idées. Il a même donné naissance à des récits passablement légendaires qui négligeaient le contexte historique précis. Un nouveau regard s'impose, à la lumière des œuvres publiées depuis lors. Les vingt-cinq tomes de l'édition allemande de référence de Cassirer ne sont disponibles que depuis 2007.0S'y s'ajoutent les dix-sept tomes du Nachlass depuis 2017. Des 102 volumes de la Gesamtausgabe de Heidegger, (...) édition de référence mais sans garantie scientifique, moins d'une dizaine reste programmée, mais d'ores et déjà la publication des cinq premiers volumes des Cahiers noirs a permis d'engager une relecture critique de l'ensemble. C'est donc à présent seulement que l'on peut véritablement évaluer les projets contrastés des deux auteurs.0Leurs enjeux intéressent notamment le statut de la rationalité et des sciences, en particulier celles de la culture, aussi bien que le statut de la technique parmi les formes symboliques. Et tout autant, l'opposition entre la démocratie et la théologie politique ; entre la légitimité du cosmopolitisme et l'ontologie identitaire ; enfin, entre la possibilité même d'une éthique ou son rejet de principe.0Tous ces thèmes contradictoires exigent aujourd'hui une révision critique, non seulement rétrospective, mais aussi ancrée dans le présent. Car au-delà même de la philosophie, des courants de pensée et des forces politiques en Europe et dans le monde poursuivent ces deux voies qui s'opposent aujourd'hui. (shrink)

An increasing number of transcription factors both from prokaryotic and eukaryotic sources are found to bend the DNA upon binding to their recognition site. Bending can easily be detected by the anomalous electrophoretic behaviour of the DNA‐protein complex or by increased cyclization of DNA fragments containing the protein‐induced bend. Induction of DNA bending by transcription factors could regulate transcription in various ways. Bending may bring distantly bound transcription factors closer together by facilitating DNA‐looping or it could mediate the interaction between (...) transcription factors and the general transcription machinery by formation of large nucleoprotein structures in which the DNA is wrapped around the protein complex. Alternatively, the energy stored in a protein‐induced bend could be used to favour formation of an open transcription complex or to dissociate the RNA polymerase in the transition from initiation to elongation. Modification of the bend angles and bending centers, caused by homodimerization or heterodimerization of transcription factors, may well turn out to be an important way to enlarge the range of interactions required for regulation of gene expression. (shrink)

Die Festschrift Gnostica et Manichaica ehrt den am 13. Juli 1952 geborenen Religionshistoriker, Turkologen, Iranisten und Wissenschaftsgeschichtler Alois van Tongerloo. Sein vielseitiges und vielgestaltiges Wirken spiegelt sich in den 19 Beitragen von Kollegen, Freunden und Schulern, die so unterschiedliche Felder wie Religionsgeschichte, Manichaologie, Kirchengeschichte, Wissenschaftsgeschichte, Turkologie, Sinologie und Iranistik abdecken.Aus dem Inhalt : L. Cirillo, Mani: Apostle of Jesus Christ and Paraclete, in the Manichean primitive tradition and in the criticism of St. AugustinePaul Mirecki, Manichaeism, scribal magic and Papyrus Kellis (...) 35Zekine Ozertural, Uber eine orthographische Besonderheit der manichaisch-uigurischen TexteAntonio Panaino, The three Magi, the Stone of Christ and the Christian origin of the Mazdeam fire cultRomolo Perrotta, Wie entsteht eine "Haresie"? Eine phanomenologische PerspektiveCardinal Julien Ries, Le Manicheisme - une religion dualiste, gnostique et syncretisteJurgen Tubach, Die manichaische Hierarchie: die Zahlen 12, 72 und 360Roland van Vliet, Adoptianismus in der manichaischen Christologi. (shrink)

Metaphysicians speak of laws of nature in terms of necessity and universality; scientists, in terms of symmetry and invariance. In this book van Fraassen argues that no metaphysical account of laws can succeed. He analyzes and rejects the arguments that there are laws of nature, or that we must believe there are, and argues that we should disregard the idea of law as an adequate clue to science. After exploring what this means for general epistemology, the author develops the empiricist (...) view of science as a construction of models to represent the phenomena. (shrink)

What is empiricism and what could it be? Bas . van Fraassen, one of the world’s foremost contributors to philosophical logic and the philosophy of science, here undertakes a fresh consideration of these questions and offers a program for renewal of the empiricist tradition. The empiricist tradition is not and could not be defined by common doctrines, but embodies a certain stance in philosophy, van Fraassen says. This stance is displayed first of all in a searing, recurrent critique of metaphysics, (...) and secondly in a focus on experience that requires a voluntarist view of belief and opinion. Van Fraassen focuses on the philosophical problems of scientific and conceptual revolutions and on the not unrelated ruptures between religious and secular ways of seeing or conceiving of ourselves. He explores what it is to be or not be secular and points the way toward a new relationship between secularism and science within philosophy. (shrink)

What is empiricism and what could it be? Bas C. van Fraassen, one of the world’s foremost contributors to philosophical logic and the philosophy of science, here undertakes a fresh consideration of these questions and offers a program for renewal of the empiricist tradition. The empiricist tradition is not and could not be defined by common doctrines, but embodies a certain stance in philosophy, van Fraassen says. This stance is displayed first of all in a searing, recurrent critique of metaphysics, (...) and second in a focus on experience that requires a voluntarist view of belief and opinion._ _Van Fraassen focuses on the philosophical problems of scientific and conceptual revolutions and on the not unrelated ruptures between religious and secular ways of seeing or conceiving of ourselves. He explores what it is to be or not be secular and points the way toward a new relationship between secularism and science within philosophy. (shrink)

The fundamental texts of the great classical period in modern logic, some of them never before available in English translation, are here gathered together for ...

This essay argues that there are theoretical benefits to keeping distinct—more pervasively than the literature has done so far—the psychological states of imagining that p versus believing that in-the-story p, when it comes to cognition of fiction and other forms of narrative. Positing both in the minds of a story’s audience helps explain the full range of reactions characteristic of story consumption. This distinction also has interesting conceptual and explanatory dimensions that haven’t been carefully observed, and the two mental state (...) types make distinct contributions to generating emotional responses to stories. Finally, the differences between the mental states illuminate how a given story can be both shared with others and at the same time experienced as personal. (shrink)

Organizations such as the EU High-Level Expert Group on AI and the IEEE have recently formulated ethical principles and (moral) values that should be adhered to in the design and deployment of artificial intelligence (AI). These include respect for autonomy, non-maleficence, fairness, transparency, explainability, and accountability. But how can we ensure and verify that an AI system actually respects these values? To help answer this question, I propose an account for determining when an AI system can be said to embody (...) certain values. This account understands embodied values as the result of design activities intended to embed those values in such systems. AI systems are here understood as a special kind of sociotechnical system that, like traditional sociotechnical systems, are composed of technical artifacts, human agents, and institutions but—in addition—contain artificial agents and certain technical norms that regulate interactions between artificial agents and other elements of the system. The specific challenges and opportunities of embedding values in AI systems are discussed, and some lessons for better embedding values in AI systems are drawn. (shrink)

Bryan W. Van Norden lambastes academic philosophy for its Eurocentrism and insularity and challenges educational institutions to live up to their cosmopolitan ideals. Taking Back Philosophy is at once a manifesto for multicultural education, an accessible introduction to Confucian and Buddhist philosophy, and a defense of the value of philosophy.

Metaethics: A Contemporary Introduction provides a solid foundation in metaethics for advanced undergraduates by introducing a series of puzzles that most metaethical theories address. These puzzles involve moral disagreement, reference, moral epistemology, metaphysics, and moral psychology. From there, author Mark van Roojen discusses the many positions in metaethics that people will take in reaction to these puzzles. Van Roojen asks several essential questions of his readers, namely: What is metaethics? Why study it? How does one discuss metaethics, given its inherently (...) controversial nature? Each chapter closes with questions, both for reading comprehension and further discussion, and annotated suggestions for further reading. (shrink)

This text gives examples of how a different kind of human experience may be explored, and how the methods used for investigating phenomena may contribute to the process of human understanding.