The Greeks could never have asked, "Why is there something; why not nothing?" Parmenides and Plato both held Absolute Non-Being to be inconceivable, and Aristotle's emphasis on the priority of the actual also excluded this question. The ex nihilo nihil fit of classical metaphysics may be taken as an implicit rejection of the why of Being. To say that nothing can come from nothing is to deny any priority for, or any ontological status to, Nothing.

Within each of these negational ranges two general facets of negation may be distinguished for analysis. I shall call them "free" and "bound." Negation, however, is never completely free nor completely bound, so "free" and "bound" shall refer to negation in a relative sense.

Nihilism, American style -- The quest for evil -- The negative zone : suburban familial malaise in American beauty, Revolutionary road, and Mad men -- Normal nihilism as comic : Seinfeld, Trainspotting, and Pulp fiction -- Romanticism and nihilism -- Defense against the dark arts : from Se7en to the Dark knight and Harry Potter -- God got involved : sacred quests and overcoming nihilism -- Feels like the movies.

Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

Russell Hardin produced a body of work of great breadth and richness on essential subjects of the social sciences and political and moral philosophy: collective action, trust, utilitarian ethics, groups and conflict, institutions, and knowledge. The volume of output, the engagement with cross-cutting fields of scholarship and myriad subjects, and his at-times conversational mode of analysis make a succinct encapsulation difficult. In this introduction, we give a brief account of three main areas of Hardin’s work: his distinctive take on the (...) moral and political philosophy of utilitarianism, his accounts of collective action and the nature of social life, and his account of the fundamental idea of trust and social capital. (shrink)

Thomas Friedman’s best-selling The World is Flat has exerted much influence in the west by providing both an accessible analysis of globalisation and its economic and social effects, and a powerful cultural metaphor for globalisation. In this review, we more closely examine Friedman’s notion of the social contract, the moral centre of his hopeful vision of a globalised world. While Friedman’s social contract holds a more generous view of social and state obligation than his neoliberal economic analysis might otherwise (...) allow, his fallacious assumptions about education rest on poorly argued claims about the nature of human beings, the proper aims of schooling, and meanings of justice in a globalised world. (shrink)

The presence and role of microbes in human cancers has come full circle in the last century. Tumors are no longer considered aseptic, but implications for cancer biology and oncology remain underappreciated. Opportunities to identify and build translational diagnostics, prognostics, and therapeutics that exploit cancer's second genome—the metagenome—are manifold, but require careful consideration of microbial experimental idiosyncrasies that are distinct from host‐centric methods. Furthermore, the discoveries of intracellular and intra‐metastatic cancer bacteria necessitate fundamental changes in describing clonal evolution and selection, (...) reflecting bidirectional interactions with non‐human residents. Reconsidering cancer clonality as a multispecies process similarly holds key implications for understanding metastasis and prognosing therapeutic resistance while providing rational guidance for the next generation of bacterial cancer therapies. Guided by these new findings and challenges, this Review describes opportunities to exploit cancer's metagenome in oncology and proposes an evolutionary framework as a first step towards modeling multispecies cancer clonality. Also see the video abstract here: https://youtu.be/-WDtIRJYZSs. (shrink)

In 1905 William James wrote an essay in McClure's Magazine recalling the importance to his own work of the Scottish-born philosopher Thomas Davidson. In the essay, James states that Davidson was "essentially a teacher." What is interesting when one looks at Davidson's life and work is that, for Davidson, teaching does seem to be an essential feature of what it means to be a philosopher. Here, I develop how Davidson construes this linking of philosophy and teaching with a concluding (...) emphasis on the two schools he established: Glenmore, a summer philosophy program in the Adirondacks and the "Breadwinners' College," an open school he began for working persons in New York City. I offer this as a discussion paper so that James's recollection of Davidson's importance to his own work may provoke us to consider how we presently understand the linking of teaching and philosophy. This seems especially appropriate for an academic culture such as ours in which much of our time is spent teaching and in which we are often primarily evaluated by a separate category of professional "research." The American tradition has "lost" any number of its important.. (shrink)

The unexpected roles of the microbiota in cancer challenge explanations of carcinogenesis that focus on tumor-intrinsic properties. Most tumors contain bacteria and viruses, and the host’s proximal and distal microbiota influence both cancer incidence and therapeutic responsiveness. Continuing the history of cancer–microbe research, these findings raise a key question: to what extent is the microbiota relevant for clinical oncology? We approach this by critically evaluating three issues: how the microbiota provides a predictive biomarker of cancer growth and therapeutic responsiveness, the (...) microbiota’s causal role(s) in cancer development, and how therapeutic manipulations of the microbiota improve patient outcomes in cancer. Clarifying the conceptual and empirical aspects of the cancer-associated microbiota can orient future research and guide its implementation in clinical oncology. (shrink)

Gordon Knight recently challenged my assumption, which I made for the purpose of organizing and classifying certain theological disputes, that a specific set of three propositions is logically inconsistent . In this brief rejoinder, I explain Knight’s objection and show why it rests upon a misunderstanding.

This essay explores the relation between Living-Together and Living-Alone by analysing the overlap between two figures sketched out in Comment vivre ensemble: Autarky and Enclosure. Barthes's ambivalence towards enclosure and self-sufficiency — ideologically negative, existentially and neurotically positive — is traced backwards through a number of 1950s essays to his 1947 proto-mythology Esquisse d’une société sanatoriale. On the basis of Barthes's analysis there of the excessive socialization that serves to repress the reality of illness and death, I move forward again (...) to his own autobiographical return to the sanatorium in Roland Barthes by Roland Barthes, in interviews and — via Thomas Mann's The Magic Mountain — in Comment vivre ensemble. Finally, some passages of The Magic Mountain are read through Barthes's figures Enclosure and Cause. (shrink)

Galton and subsequent investigators find wide divergences in people's subjective reports of mental imagery. Such individual differences might be taken to explain the peculiarly irreconcilable disputes over the nature and cognitive significance of imagery which have periodically broken out among psychologists and philosophers. However, to so explain these disputes is itself to take a substantive and questionable position on the cognitive role of imagery. This article distinguishes three separable issues over which people can be "for" or "against" mental images. Conflation (...) of these issues can lead to theoretical differences being mistaken for experiential differences, even by theorists themselves. This is applied to the case of John B. Watson, who inaugurated a half-century of neglect of image psychology. Watson originally claimed to have vivid imagery; by 1913 he was denying the existence of images. This strange reversal, which made his behaviorism possible, is explicable as a "creative misconstrual" of Dunlap's "motor" theory of imagination. (shrink)

Romantic sensibility and political necessity led Humphry Davy, Britain's most prominent scientist in the first quarter of the nineteenth century, to pantheism: nature worship, involving for him a fervent belief in the immortality of the soul. Rapt with a vision of sublimity, from mountain tops or balloons, men of science in succeeding generations also found in pantheism a reason for their vocation and a way of making sense of their world. It should be seen as an alternative both to active (...) participation in church life (like Faraday's) and to a gritty agnosticism (like Huxley's), indicating again how subtle and complex relationships were between science and religion in the nineteenth century. (shrink)

Luck egalitarianism is a family of egalitarian theories of distributive justice that give a special place to luck, choice, and responsibility. These theories can be understood as responding to perceived weaknesses in influential earlier theories of both the left – in particular Rawls’ liberal egalitarianism (1971) – and the right – Nozick’s libertarianism (1974) stands out here. Rawls put great emphasis on the continuity of his theory with the great social contract theories of modern political thought, particularly emphasising its Kantian (...) character, while Nozick overtly develops his theory as an elaboration of John Locke’s account of property. By contrast, how luck egalitarianism is related to the history of political thought or philosophy more generally has been left unexplored by its proponents. Perhaps this is because they see luck egalitarianism, with its focus on individual choice and association with such contemporary concerns as equality of opportunity, as without significant predecessors in the canon. My purpose in this chapter is to make the tentative first steps towards identifying some historical antecedents of luck egalitarianism among the main works of Western political thought, in particular Aristotle, Machiavelli, and Locke. (shrink)

This compelling and distinctive volume advances Aristotelianism by bringing its traditional virtue ethics to bear upon characteristically modern issues, such as the politics of economic power and egalitarian dispute. This volume bridges the gap between Aristotle's philosophy and the multitude of contemporary Aristotelian theories that have been formulated in the twentieth and twenty-first centuries. Part I draws on Aristotle's texts and Thomas Aquinas' Aristotelianism to examine the Aristotelian tradition of virtues, with a chapter by Alasdair MacIntyre contextualising the different (...) readings of Aristotle's philosophy. Part II offers a critical engagement with MacIntyrean Aristotelianism, while Part III demonstrates the ongoing influence of Aristotelianism in contemporary theoretical debates on governance and politics. Extensive in its historical scope, this is a valuable collection relating the tradition of virtue to modernity, which will be of interest to all working in virtue ethics and contemporary Aristotelian politics. (shrink)

This compelling and distinctive volume advances Aristotelianism by bringing its traditional virtue ethics to bear upon characteristically modern issues, such as the politics of economic power and egalitarian dispute. Clearly divided into three parts and featuring a contribution from Alasdair MacIntyre, this volume bridges the gap between Aristotle's philosophy and the multitude of contemporary Aristotelian theories that have been formulated in the twentieth and twenty-first centuries. Part I draws on Aristotle's texts and Thomas Aquinas' Aristotelianism to examine the Aristotelian (...) tradition of virtues, with a chapter by Alasdair MacIntyre contextualising the different readings of Aristotle's philosophy. Part II offers a critical engagement with MacIntyrean Aristotelianism, assessing MacIntyre's development of Aristotelian themes and revealing their conflict with modernity. Firmly establishing the relevance of Aristotle's thought today, Part III demonstrates the ongoing influence of Aristotelianism in contemporary theoretical debates on governance and politics. Extensive in its historical scope, this is a valuable collection relating the tradition of virtue to modernity, which will be of interest to all working in virtue ethics and contemporary Aristotelian politics. (shrink)

SummaryIn Part One of this essay, I linked Marion’s concept of infinite distance to Aquinas’s doctrine of relation.

Thomas Talbott has recently argued in this journal that the three propositions 1) God wills universal salvation 2) God has the power to produce universal salvation and 3) some persons are not saved are inconsistent. I contend that this claim is only true if God has no overriding purposes that would place restrictions on the means God uses to achieve God’s ends. One possible example of such an overriding purpose would be God’s aim to produce the most good. I (...) end by suggesting that while God’s purpose of universal salvation does render the achievement of this end probable, it is by no means necessary. (shrink)

Batman is allied with modern natural law in the way he relies upon reason to bring about his vision of ‘true justice’, operating as a force external to law. This vision of justice is a protective one, with Batman existing as a guardian—a force for resistance against the corruption of the state and the failures of the legal system. But alongside his rational means, Batman also employs violence as he moves beyond the boundaries of the civilised state into the dark (...) and violent world outside law’s protection. He thus sacrifices his own safety to ensure the safety of others—he is a Dark Knight, a sentinel, fighting the nasty and brutish underworld of criminality in his effort to bring rational order to the world and protect the people of Gotham from criminal harm. This fight for justice is fuelled by a deeply private trauma: the murder of Bruce Wayne’s parents: a private desire for vengeance that Batman transcends. In navigating Batman’s jurisprudential dimensions, we are ultimately reminded that private desires and motivations are enfolded within the public structures of justice. (shrink)

‘Read until you hear the voices’; so the maxim goes for those who would engage with the Victorians. Let us try with Thomas Henry Huxley:A great chapter in the history of the world is written in the chalk. Few passages in the history of man can be supported by such an overwhelming mass of direct and indirect evidence as that which testifies to the truth of the fragment of the history of the globe, which I hope to enable you (...) to read, with your own eyes, tonight. Let me add, that few chapters of human history have a more profound significance for ourselves. I weigh my words well when I assert, that the man who should know the true history of the bit of chalk which every carpenter carries about in his breeches-pocket, though ignorant of all other history, is likely, if he will think his knowledge out to its ultimate results, to have a truer, and therefore a better, conception of this wonderful universe, and man's relation to it, than the most learned student who is deep-read in the records of humanity and ignorant of those of Nature. (shrink)

Honor, fearlessness, calm, decisive action, strategic thinking, and martial prowess have been the hallmarks of the Japanese samurai culture through the ages. Their ethos is known as bushido, or the way of the warrior-knight. Here is an insider’s view of the samurai—their moral and psychological development, the ethical standards they strive to uphold, their training in both martial arts and strategy, and the enormous role that the traditions of Shintoism, Buddhism, Confucianism, and Taoism had in influencing their ideals. (...) class='Hi'>Thomas Cleary has collected writings on bushido by warriors, scholars, political advisors, and educators from the fifteenth through the nineteenth centuries that provide a comprehensive, historically rich view of samurai life and education. The selections deal with a broad range of subjects—from military strategy and political science to personal discipline and character development. Cleary includes an introduction to each piece, putting it into historical context and presenting biographical information about the authors. This is an essential read for martial artists and anyone interested in samurai history, but it will also appeal to readers in the fields of government, military, religion, and education. (shrink)

This book contains the text of Thomas Kuhn's unfinished book, The Plurality of Worlds: An Evolutionary Theory of Scientific Development, which Kuhn himself described as "a return to the central claims of The Structure of Scientific Revolutions, and the problems that it raised but did not resolve." The Plurality of Worlds is preceded by two related texts that Kuhn publicly delivered but never published in English: his paper "Scientific Knowledge as a Historical Product" and his Shearman Memorial Lectures, "The (...) Presence of Past Science." The book opens with an introduction by the editor that describes the origins and structure of The Plurality of Worlds, and sheds light on its central philosophical problems. Kuhn's aims in his last writings are bold. He sets out to develop an empirically grounded theory of meaning that would allow him to make sense of both the possibility of historical understanding and the inevitability of incommensurability between past and present science. Moreover, he intends to show that incommensurability is fully compatible with a robust notion of a real world that science investigates, with the rationality of scientific belief change, and with the idea that scientific development is progressive. This is a must-read follow-up to The Structure of Scientific Revolutions, one of the most important books of the twentieth century. (shrink)

Thomas S. Kuhn's classic book is now available with a new index.

The significance of the plurality of the Copernican Revolution is the main thrust of this undergraduate text In this study of the Copernican Revolution, the ...

A highly condensed account of the author's present view of some philosophical problems unresolved in The Structure of Scientific Revolutions. The concept of incommensurability, now considerably developed, remains at center stage, but the evolutionary metaphor, introduced in the final pages of the book, now also plays a principal role.

Divided into three parts, this work is a record of the direction Kuhn was taking during the last two decades of his life. It consists of essays in which he refines the basic concepts set forth in "Structure"--Paradigm shifts, incommensurability, and the nature of scientific progress.

This paper discusses ethnomethodology's program in relation to the phenomenological life-world analysis of Alfred Schutz. A recent publication of Garfinkel's early writings sheds new light on how he made use of phenomenological reflections in order to create a new sociological approach. Garfinkel used Schutz's life-world analysis as a source of inspiration, called for 'misreading' in the sense of an alternate reading and developed a new, empirical approach to the analysis of social order which he called 'ethnomethodology'. Ethnomethodologists usually acknowledge the (...) historical importance of Schutz but emphasize that Garfinkel succeeded to overcome the limitations of phenomenological analyses and moved beyond. This view has spread above all in the Anglosaxon countries. In German sociology, Schutz's life-world analysis still has a much stronger standing than ethnomethodology and is interpreted as a systematic whole. Following Luckmann, it is discussed as a protosociological foundation of the methodology of social sciences or, following Srubar, as a philosophical anthropology with two poles: a subjective and a social, pragmatic pole. Both versions claim to analyze the meaningful constitution of the social world, to serve as a foundation of sociological methodology and to provide guidelines for an `adequate' sociology. While Garfinkel used phenomenological concepts for sociological analysis, Luckmann clearly distinguishes the two: you either do phenomenology (protosociology) or you do sociology (a theoretically guided, empirical sociology of knowledge). This paper describes the present-day debate in German sociology and compares ethnomethodology's program with these interpretations of Schutz's life-world analysis. (shrink)