Antibiotic allergies are commonly reported among patients, but most do not experience reactions on rechallenge with the same agents. These reported allergies complicate management of infections in patients labelled as having penicillin allergy, including serious infections where penicillin-based antibiotics are the first-line (most effective and least toxic) treatment option. Allergy labels are rarely questioned in clinical practice, with many clinicians opting for inferior second-line antibiotics to avoid a perceived risk of allergy. Reported allergies thereby can have significant impacts on patients (...) and public health, and present major ethical challenges. Antibiotic allergy testing has been described as a strategy to circumvent this dilemma, but it carries limitations that often make it less feasible in patients with acute infections or in community settings that lack access to allergy testing. This article provides an empirically informed ethical analysis of key considerations in this clinical dilemma, usingStaphylococcus aureusbacteraemia in patients with penicillin allergies as a case study. We argue that prescribing first-line penicillin-based antibiotics to patients with reported allergies may often present a more favourable ratio of benefits to risks, and may therefore be more ethically appropriate than using second-line drugs. We recommend changes to policy-making, clinical research and medical education, in order to promote more ethically acceptable responses to antibiotic allergies than the status quo. (shrink)

Although every emerging infectious disease occurs in a unique context, the behaviour of previous pandemics offers an insight into the medium- and long-term outcomes of the current threat. Where an informative historical analogue exists, epidemiologists and policymakers should consider how the insights of the past can inform current forecasts and responses.

Human infection challenge studies have been proposed as a means to accelerate SARS-CoV2 vaccine development and thereby help to mitigate a prolonged global public health crisis. A key criterion for the ethical acceptability of SARS-CoV2 HCS is that potential benefits outweigh risks. Although the assessment of risks and benefits is meant to be a standard part of research ethics review, systematic comparisons are particularly important in the context of SARS-CoV2 HCS in light of the significant potential benefits and harms at (...) stake as well as the need to preserve public trust in research and vaccines. In this paper we explore several considerations that should inform systematic assessment of SARS-CoV-2 HCS. First, we detail key potential benefits of SARS-CoV-2 HCS including, but not limited to, those related to the acceleration of vaccine development. Second, we identify where modelling is needed to inform risk-benefit assessments. Modelling will be particularly useful in comparing potential benefits and risks of HCS with those of vaccine field trials under different epidemiological conditions and estimating marginal risks to HCS participants in light of the background probabilities of infection in their local community. We highlight interactions between public health policy and research priorities, including situations in which research ethics assessments may need to strike a balance between competing considerations. (shrink)

The public health benefits of herd immunity are often used as the justification for coercive vaccine policies. Yet, ‘herd immunity’ as a term has multiple referents, which can result in ambiguity, including regarding its role in ethical arguments. The term ‘herd immunity’ can refer to (1) the herd immunity threshold, at which models predict the decline of an epidemic; (2) the percentage of a population with immunity, whether it exceeds a given threshold or not; and/or (3) the indirect benefit afforded (...) by collective immunity to those who are less immune. Moreover, the accumulation of immune individuals in a population can lead to two different outcomes: elimination (for measles, smallpox, etc) or endemic equilibrium (for COVID-19, influenza, etc). We argue that the strength of a moral obligation for individuals to contribute to herd immunity through vaccination, and by extension the acceptability of coercion, will depend on how ‘herd immunity’ is interpreted as well as facts about a given disease or vaccine. Among other things, not all uses of ‘herd immunity’ are equally valid for all pathogens. The optimal conditions for herd immunity threshold effects, as illustrated by measles, notably do not apply to the many pathogens for which reinfections are ubiquitous (due to waning immunity and/or antigenic variation). For such pathogens, including SARS-CoV-2, mass vaccination can only be expected to delay rather than prevent new infections, in which case the obligation to contribute to herd immunity is much weaker, and coercive policies less justifiable. (shrink)

This fourth edition of one of the classic logic textbooks has been thoroughly revised by John Burgess. The aim is to increase the pedagogical value of the book for the core market of students of philosophy and for students of mathematics and computer science as well. This book has become a classic because of its accessibility to students without a mathematical background, and because it covers not simply the staple topics of an intermediate logic course such as Godel's Incompleteness Theorems, (...) but also a large number of optional topics from Turing's theory of computability to Ramsey's theorem. John Burgess has now enhanced the book by adding a selection of problems at the end of each chapter, and by reorganising and rewriting chapters to make them more independent of each other and thus to increase the range of options available to instructors as to what to cover and what to defer. (shrink)

George Boolos was one of the most prominent and influential logician-philosophers of recent times. This collection, nearly all chosen by Boolos himself shortly before his death, includes thirty papers on set theory, second-order logic, and plural quantifiers; on Frege, Dedekind, Cantor, and Russell; and on miscellaneous topics in logic and proof theory, including three papers on various aspects of the Gödel theorems. Boolos is universally recognized as the leader in the renewed interest in studies of Frege's work on logic (...) and the philosophy of mathematics. John Burgess has provided introductions to each of the three parts of the volume, and also an afterword on Boolos's technical work in provability logic, which is beyond the scope of this volume. (shrink)

George S. Counts was a_ _major figure in American education for almost fifty years. Republication of this early work draws special attention to Counts’s role as a social and political activist. Three particular themes make the book noteworthy because of their importance in Counts’s plan for change as well as for their continuing contem­porary importance: _ _Counts’s crit­icism of child-centered progressives; _ _the role Counts assigns to teachers in achieving educational and social re­form; and Counts’s idea for the re­form (...) of the American economy. (shrink)

A number of commentators on the work of berkeley have maintained that berkeleyan minds are related to ideas by the relation of inherence. Thus, Ideas are taken to inhere in minds in something like the way that accidents were supposed to inhere in substances for the aristotelian. This inherence account, As I call it, Is spelled out in detail and critically evaluated. Ultimately it is rejected despite its considerable initial plausibility.

Since the dawn of Romanticism, artists and intellectuals in Germany have maintained an abiding interest in the gods and myths of antiquity while calling for a new mythology suitable to the modern age. In this study, George S. Williamson examines the factors that gave rise to this distinct and profound longing for myth. In doing so, he demonstrates the entanglement of aesthetic and philosophical ambitions in Germany with some of the major religious conflicts of the nineteenth century. Through readings (...) of key intellectuals ranging from Herder and Schelling to Wagner and Nietzsche, Williamson highlights three crucial factors in the emergence of the German engagement with myth: the tradition of Philhellenist neohumanism, a critique of contemporary aesthetic and public life as dominated by private interests, and a rejection of the Bible by many Protestant scholars as the product of a foreign, "Oriental" culture. According to Williamson, the discourse on myth in Germany remained bound up with problems of Protestant theology and confessional conflict through the nineteenth century and beyond. A compelling adventure in intellectual history, this study uncovers the foundations of Germany's fascination with myth and its enduring cultural legacy. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Abstract General Ideas in Hume George S. Pappas Hume followed Berkeley in rejecting abstract general ideas; that is, both of these philosophers rejected the view that one could engage in the operation or activity ofabstraction — a kind ofmental separation ofentities that are inseparable in reality —as well as the view that the alleged products of such an activity — ideas which are intrinsically general — really exist. (...) What has not been clear to commentators on either of these two philosophers has been why they each were so opposed to abstraction and abstract general ideas. The provision of an answer to this question is the main thrust of this paper. The nature of the question should be clarified at the outset. I am notasking the psychological question, whatwere BerkeleyandHume's actual intentions when they were moved to reject abstraction and abstract general ideas. Though I regard this question as one of great interest and importance, I am presently aiming to answer a somewhat different one, viz., what role, what philosophical role, does the rejection of abstraction and abstract general ideas play in the philosophies ofBerkeley and Hume? The answer to this latter question is apt to have some bearing on the right way to answer the first question; but, for present purposes, it is important to keep the two questions distinct. The maincontentionofthe paperis thattherejectionofabstraction and abstract general ideas lies at the very heart of the philosophy of Berkeley, and that pretty much the same may be said for Hume. Berkeley's defense ofa kind ofidealism stands or falls with the success ofhis attack on abstract general ideas, and Hume's critique ofinfinite divisibility in matters pertaining to space and time, along with his destructive critique ofvarious metaphysical notions, crucially depends on the successful denial of abstract general ideas. I. Berkeleyan Idealism Berkeley's most extended treatment of abstract ideas comes in the introduction to the Principles ofHuman Knowledge, first published in 1710. However, since he does not take up the topic in any systematic way later in the same book, nor in the Three Dialogues Between Hylas and Phihnous (1713), it has seemed to many commentators that Berkeley's attack on abstract ideas is a local matter, one having only to do with issues concerning language use and a somewhat isolated criticism of Locke. That this is the wrong way to look at things is Volume XV Number 2 339 GEORGE S. PAPPAS perhaps best indicated by a couple of passages from the Principles. In section 5 ofthat work Berkeley says: If we thoroughly examine this tenet it will, perhaps, be found at bottom to depend on the doctrine of abstract ideas. For can there be a nicer strain of abstraction than to distinguish the existence of sensible objects from there being perceived, so as to conceive them existing unperceived? The tenet Berkeley is here referring to is to the effect that sensible objects such as trees and chairs exist independently ofperception. This allusion is made clear when we notice that in the immediately preceding passage Berkeley says: It is indeed an opinion strangely prevailing among men that houses, mountains, rivers, and in a word all sensible objects, have an existence, natural or real, distinct from their being perceived by the understanding. But, with how great an assurance and acquiescence soever this Principle may be entertained... whoever shall find in his heart to call it in question may... perceive it to involve a manifest contradiction. For, what are the aforementioned objects but the things we perceive by sense? and what do we perceive besides our own ideas or sensations? and is it not plainly repugnant that any one of these, or any combination of them, should exist unperceived? (Principles 4) The claim that sensible objects exist independently ofall perception is the very denial of Berkeley's esse is percipi thesis regarding such objects. For the latter thesis holds that each sensible object is such that it exists if and only if it is perceived. So, in the first-quoted passage from Principles 5, Berkeley is saying that the denial of esse is percipi 'depends on' the doctrine of abstract ideas. Surely, the esse is percipi thesis is part ofthe core ofBerkeley's... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:17. HUME AND ABSTRACT GENERAL IDEAS In his discussion of abstract ideas in the Treatise, Hume offers what "...may... be thought... a plain dilemma, that decides concerning the nature of those abstract ideas..." He states the dilemma in these words: The abstract idea of a man represents men of all sizes and all qualities; which 'tis concluded it cannot do, but either by representing at once all possible sizes (...) and all possible qualities, or by representing no particular one at all. Now it having been esteemed absurd to defend the former proposition, as implying an infinite capacity in the mind, it has been commonly infer'd in favour of the latter; and our abstract ideas have been suppos'd to represent no particular degree either of quality or quantity. (T, 1,1,7,?.18) However, with respect to this dilemma, Hume says: But that this inference is erroneous, I shall endeavor to make appear, first, by proving, that 'tis utterly impossible to conceive any quantity or quality, without forming a precise notion of its degrees: And secondly by showing, that tho' the capacity of the mind be not infinite, yet we can at once form a notion of all possible degrees of quantity and quality, in such a manner at least, as, however imperfect, may serve all the purposes of reflexion and conversation. (T, 1,1,7, p. 18) The second item Hume claims he is about to prove is aimed at the first disjunct of the above-stated dilemma; more specifically, it is aimed at the claim that (1) An abstract idea (e.g., of a man) represents all possible degrees of quantity and quality (in men) only if the human mind is infinite in capacity. To show that (1) is false, Hume offers his own positive account of how ideas which are particular in nature may nevertheless be general in representation, even though the mind's capacity is finite. The first item Hume sets out to prove is aimed at the second disjunct, and conclusion, of the dilemma; it is aimed, that is, at 18. (2)Abstract ideas represent no particular degree of either quantity or quality. In this paper I will be concerned solely with Hume's attack on (2); it is this attack in which Hume says I "place my chief confidence." (T, I, I, 7, p. 24) I_ As stated, (2) is ambiguous, since it might be taken to mean that abstract ideas fail to represent altogether, or that they fail to represent any quantity or quality however construed. But, I believe, Hume means neither of these; he means, instead, that (2a) Abstract ideas represent non-particular, indeterminate degrees of quantity or quality. Now recall that Hume tries to refute (2a) by establishing, as he says, that (3)It is impossible to conceive any quantity or quality without forming a precise notion of its degrees. But how, by establishing (3), would Hume thereby refute or aid in the refutation of (2a)? And, for that matter, how does he support (3)? Hume's case for (3) consists of three arguments, the respective conclusions of which are most pertinent here. He concludes his first argument by saying that (4)...the general idea of a line...has in its appearance in the mind a precise degree of quantity and quality. (T, 1,1,7, p. 19) The conclusion of the second argument is this : (5)An idea is a weaker impression; and as a strong impression must necessarily have a determinate quantity and quality, the case must be the same with its copy or representative.(T, 1,1,7, p. 19) 19. and of the third it is this: (6)Abstract ideas are therefore in themselves individual, however they may become general in their representation. The image in the mind is only that of a particular object, tho' the application of it in our reasoning be the same, as if it were universal.(T, 1,1,7, p. 20) Construed in a fully general way, these conclusions assert that (7)Each idea is determinate with respect to öegree of) quantity and quality. But notice that (7) is not equivalent to, and does not obviously imply, (3). Hence, Hume... (shrink)

This chapter reviews four books published in 2018 which are not readily categorized as works in ‘modern European philosophy’: Gurminder K. Bhambra, Kerem Nişancloğlu, and Dalia Gebrial’s edited volume Decolonising the University, Chantal Mouffe’s For a Left Populism, Cinzia Arruzza, Tithi Bhattacharya, and Nancy Fraser’s Feminism for the 99%, and Andreas Malm’s The Progress of this Storm. Yet their uneasy relationship to this philosophy is precisely the reason they constitute a significant contribution to it. The philosophical originality and critical purchase (...) of these books proceed from the fact that each is a singular case of philosophy’s dependence on ‘non-philosophy’; each exposes the impossibility of viewing philosophy as a self-sufficient discipline. In particular, they are a timely reminder that the best political philosophy is produced through actually existing social movements to change (which ecologically now means simply saving) the world. The chapter is divided into six sections: 1. Introduction; 2. Decolonizing Philosophy: Decolonising the University; 3. Anti-Post-Politics: For a Left Populism; 4. Anti-Post-Marxism: Feminism for the 99%; 5. Anti-Postmodernism: The Progress of This Storm; 6. Conclusion. (shrink)

This chapter picks up on what Heidegger in his 1949 ‘Letter on ‘Humanism’’ calls ‘the historical in being’, that dimension of being within which, for Heidegger, a ‘productive dialogue’ between phenomenology and existentialism, on the one hand, and Marxism, on the other, ‘first becomes possible.’ It introduces the possibility of this dialogue through a particular, and particularly revealing, problem with The German Ideology: namely, Marx and Engels offer no analysis of the relationship between time, temporality and their materialist concept of (...) history. (shrink)

Philosophical accounts of perception in the tradition of Kant and Reid have generally supposed that an event of making a judgment is a key element in every perceptual experience. An alternative very austere view regards perception as an event containing nothing judgmental, nor anything conceptual. This account of perception as nonconceptual is discussed first historically as found in the philosophies of Locke and (briefly) Berkeley, and then examined in the contemporary work of Chisholm and Alston.

In this essay, the author analyses Berkeley’s conformity and inference argument against Locke’s theory of percep tion. Both arguments are not as decisive as traditionally has been perceived and fail to engage in Locke’s actual position. The main reason for this is that Berkeley does not see that Locke’s position is compatible with the non-inferential nature of perceptual knowledge.

In this essay, the author analyses Berkeley’s conformity and inference argument against Locke’s theory of percep tion. Both arguments are not as decisive as traditionally has been perceived and fail to engage in Locke’s actual position. The main reason for this is that Berkeley does not see that Locke’s position is compatible with the non-inferential nature of perceptual knowledge.

Central-state materialism is a very strong, but also very exciting theory of mind according to which each mental state is identical with a state of the central nervous system. CSM thus goes considerably beyond early versions of the identity theory of mind, since those early accounts held only that sensations are to be identified with neural events. CSM, by contrast, is a thesis about all mental states; every mental state is held to be a state of the central nervous system. (...) In fact, as we will see shortly, CSM is an even more sweeping thesis than this formulation of it suggests, since it is not concerned simply with mental states.One prominent defender of CSM, David Armstrong, has maintained that CSM can be established by means of a two-step argument. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:167. ON McRAE' S HUME Professor McRae's interesting paper may be rather naturally divided into two parts. In the first part he explains what he takes Hume's account of time to be; in the second he advances the bold thesis that Hume's account of time, or perhaps of duration, provides a basis or foundation for his more widely discussed remarks on identity, substance, the self, the necessary connections. In (...) what follows I first reconstruct Professor McRae' s paper, and then I raise some problems, perhaps puzzles, about Hume's view on duration, time and fictions. According to McRae, some philosophers (Descartes, Spinoza, Leibniz) distinguish between time and duration, both of which are taken to be perfectly legitimate notions. Hume, by contrast, takes time and duration to be the same, viz., a succession of moments. What philosophers and the vulgar call 'duration' is something quite different, namely a single unbroken stretch of time which is not composed of successive parts. Of duration taken in this latter way, McRae says, Hume has four things to say, all of them negative: (1) we have no idea of duration; (2) no object has duration; (3) there is no such thing as duration; and (4) duration is a fiction. Properly understood as a succession of moments, however, time certainly exists and is thus not a fiction. Moreover, we have the or at least an idea of time, despite the fact that it is obtained without derivation from a precedent impression. And, while no object can be said to have time, Hume will nonetheless allow that objects exist at certain times and perhaps across a time span. In the second part of his paper, Professor McRae distinguishes two types of Humean fictions. The first arises when one idea is confused with another and mis-applied to some object. The second arises when the imagination creates an "idea" in the attempt to resolve a 168. contradiction which comes up when the first fiction is applied to an object. What I have called McRae' s "bold thesis" in the second part of his paper can now be stated. Duration, or the putative idea thereof, is a fiction of the first type, one that is attributed to what Hume calls "steadfast objects." However, such an object can be considered in two ways. One might consider the object at two stages of this duration and, McRae says, "...this will give us the idea of number" (p. 126); or, one might consider in turn a series of objects, each of them supposedly "steadfast," all along supposing that though time is changing, the objects are not, and "...in this way- we get the idea of unity" (Ibid.). But no object is both a unity and a multiplicity. So, to reconcile these conflicting considerations, the "idea" or fiction of identity is invented. As McRae says: "The idea of identity is a pure product of the imagination invented to mediate between unity and number" (Ibid. ). This invented "idea" is then mis-applied (a fiction of type one) to interrupted appearances of an object. To reconcile the supposed identity of an object with successive appearances of it, the fiction of substance is invented. Quoting both McRae and Hume, In order to reconcile the contradiction between identity and diversity, the imagination is apt to feign something unknown and invisible, which it supposes to continue the same under all these variations ; 2 and this unintelligible something it calls a substance... (p. 128). Related needs to resolve contradictions, on McRae' s account, lead to the fictions of the self (p. 128) and of necessary connections (p. 130), though the latter fiction is of type one. Hence, McRae' s "bold thesis" amounts to this: Duration is a fiction. In the attempt to apply this fiction, one is led to, logically led to, most, if not all, of the other famous Humean fictions. And, if we allow that there are mental acts, for Hume, as well as impressions and ideas, "...then a fictitious duration will be attributed to 169. objects and by a progressive compounding of fictitious mental actions will give the world the ontological structure which it has for the vulgar belief we all share. It... (shrink)

Quantitative utilitarianism demands equal treatment of human and nonhuman animals where there are no relevant differences between them. A difference is relevant only if it excludes the animal from suffering evil if it is treated differently. Quantitative utilitarianism cannot, however, resolve conflicts of interest nor prove that painless killing of animals is morally wrong. For this we need a higher qualitativegood. I suggest Care, as Heidegger understands it, is such a good, and that it is the essence not only of (...) human, but of nonhuman animaI Dasein as well. Because animals care, we are morally obliged to desist from killing them, even painlessly. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Perception of the Self George S. Pappas Differences of detail aside, we may think ofboth Locke and Berkeley as accepting the same view of the mind. They agree that there are minds, and that each mind is a simple, immaterial substance. Sometimes the word 'soul' is used instead of'mind'; but in this context, the different terminology is not consequential. Moreover, Locke and Berkeley employ essentially the same argument (...) for their shared view about minds. More exactly, they use the same argument for the limited thesis that there is something distinct from perceptions and from ideas perceived, and that this somethingis aperceiver, or that which perceives. The argument, given in more detail below, claims that we are aware ofour own minds in, or while we are engaged in, perception. The kind ofawareness is said to be or to involve a reflex act, a concept we associate with Berkeley, though I think it is one he appropriated from Locke. Hume, ofcourse, rejects the view ofLocke and Berkeley. He rejects the very notion of an immaterial mind or soul, finding it to be meaningless. And he rejects as well the limited thesis that there is something which perceives and which is distinct from all perceptions. In this paper I will restrict attention to Hume's arguments for rejecting the limited thesis. 1. Rejection ofthe limited thesis Hume investigates the limited thesis of Locke and Berkeley in the well-known section ofthe Treatise which deals with personal identity (Treatise 1.4.6). Here is how he expresses the view of "some philosophers": Theke are some philosophers, who imagine we are every moment intimately conscious of what we call our SELF; that we feel its existence and continuance in existence; and are certain, beyond the evidence of a demonstration, both of its perfect identity and simplicity. The strongest sensation, the most violent passion, say they, instead of distracting us from this view, only fix it the more intensely, and make us consider their influence on selfeither by their pain or pleasure.1 Thus, Hume represents the argumentofthosehe opposes as containing two premises: Volume XVIII Number 2 275 GEORGE S. PAPPAS (1)In perception, one is aware ofone's self, and aware ofthe simplicity of the self. (2)In being thus aware of the self and its simplicity one gains an idea of a simple self. These premises, in turn, support a double conclusion: (3)There are simple selves (minds). (4)We have an idea of a simple self(mind). Hume does not take the trouble to cite the second premise given here in the passage I have quoted, butitis clear that he has it in mind, since he proceeds directly to a criticism of it. The criticism is quite familiar inform, encapsulatingwhat I call aderivabilityargument. Here is what Hume says: all these positive assertions are contrary to that very experience, which is pleaded for them, nor have we any idea of self, after the manner it is here explain'd. For from what impression cou'd this idea be deriv'd?... It must be some one impression, that givesrise toeveryreal idea. But selfor person is not any one impression, but that to which our severahmpressionsandideas are suppos'd to have areference. Ifany impression gives rise to the idea ofself, that impression must continue invariably the same, thro' the whole course of our lives; since self is suppos'd to exist after that manner. (T 251) He is also sharply critical ofthe first premise. Hume says: when I enter most intimately into what I call myself, I always stumble on some particularperception orother, ofheatorcold, light or shade, love or hatred, pain or pleasure. I never can catch myselfat any time without a perception, and never can observe any thing but the perception. (T 252) So, minimally, Hume's arguments amount to this: (1) is false; hence, we have nogroundforclaiming(3). Similarly, (2) is false, so that we have no ground for claiming (4). Actually, of course, Hume asserts stronger claims, maintaining that (3) and (4) arefalse, and not merely that we lack adequate support forthem. Buttoshowtheirfalsityrequires additional argumentbeyond whatis providedin the above-quoted passages. Here I will not consider those additional arguments, except to note... (shrink)

The natural sciences are sometimes called "hard" sciences in contrast to the social sciences , which are thought to represent "soft" sciences. L. V. Hedges made an important effort to determine the empirical cumulativeness of various scientific research programs, with an eye toward assessing if this criterion is related to a discipline's "hardness" or "softness." This article discusses another criterion, a research program's predictive accuracy, that might also be considered along with a program's empirical cumulativeness. Finally, recent improvements in the (...) predictive accuracy of multifaceted psychological theories are discussed. 2012 APA, all rights reserved). (shrink)

Northern Ireland physicist John Stewart Bell's possible understanding of quantum theory.