The analogy between sequences of behavior and sequences of words is examined in detail and found to be both logically and empirically defensible. Linguistic distinctions are shown to be applicable to other forms of behavior. A behavioral grammar framework is developed and applied to the study of conversational behavior. The framework is shown to be superior to simpler finite state, associative models and the formal limits of the latter are discussed.

In contrast to the great majority of mycobacterial species that are harmless saprophytes, Mycobacterium tuberculosis and other closely related tubercle bacilli have evolved to be among the most important human and animal pathogens. The need to develop new strategies in the fight against tuberculosis (TB) and related diseases has fuelled research into the evolutionary success of the M. tuberculosis complex members. Amongst the various disciplines, genomics and functional genomics have been instrumental in improving our understanding of these organisms. In this (...) review we will present some of the recent key findings on molecular determinants of mycobacterial pathogenicity and attenuation, the evolution of M. tuberculosis, genome dynamics, antigen mining for improved diagnostic and subunit antigens, and finally the identification of novel drug targets. The genomics revolution has changed the landscape of TB research, and now underpins our renewed efforts to defeat this deadly pathogen. (shrink)

Resisting Corporate Corruption teaches business ethics in a manner very different from the philosophical and legal frameworks that dominate graduate schools. The book offers twenty-eight case studies and nine essays that cover a full range of business practice, controls and ethics issues. The essays discuss the nature of sound financial controls, root causes of the Financial Crisis, and the evolving nature of whistleblower protections. The cases are framed to instruct students in early identification of ethics problems and how to work (...) such issues within corporate organizations. They also provide would-be whistleblowers with instruction on the challenges they’d face, plus information on the legal protections, and outside supports available should they embark on that course. Some of the cases illustrate how ‘The Young are the Most Vulnerable,’ i.e. short service employees are most at risk of being sacrificed by an unethical firm. Other cases show the ethical dilemmas facing well-known CEOs and the alternatives they can employ to better combine ethical conduct and sound business strategy. Through these case studies, students should emerge with a practical toolkit that better enables them to follow their moral compass. Finally, the cases provide an in depth look at how a corporation becomes progressively corrupted (Enron), how the Financial Crisis was rooted in ethical decay at institutions as diverse as Countrywide, Goldman Sacks, Citigroup, Fannie Mae and Moody’s, and at the ethical challenges that persist in the post-Crisis, post-Dodd-Frank environment. (shrink)

This paper publishes a gold ring until recently in private hands in the United States. The former owners, private persons with no scholarly background, brought the ring to the present writer's attention upon learning that he had some knowledge of Greek inscriptions. The one deplorable fact is that this ring was removed from its context, so that much of its scientific value is forever lost to us. Nonetheless, the damage was done by others years ago, and its owners deserve praise (...) for making the ring available for study. The dedicatory inscription on it is an invaluable example of early Argive script. The details of acquisition are unclear. I have been able to ascertain only that the ring was acquired in ancient Mycenae from some Greeks who claimed to have dug it up in the area. As will be seen, in all probability it comes from the Argive Heraion. (shrink)

The fire beacon in the opening scenes of the Agamemnon commands attention and creates the positive image of light from darkness. In the immediate context the light of the beacon relieves the watchman of his toil and brings joy to Argos. The image, however, is not totally positive. The fire signal announces both the fall of Troy and the return of Agamemnon to Clytemnestra. The negative aspect, furthermore, is emphasised at the opening — the watchman's joy at seeing the beacon (...) gives way at line 36 to foreboding . For the original audience of 458 b.c. I suggest that this fire beacon proclaiming victory must have conveyed other negative overtones. In brief, it will have recalled to them vividly the signals used by the Persian commanders during the great invasion of 480 to announce Athens' capture to an expectant Persian court. (shrink)

Opioid use disorder rarely presents as a unitary psychiatric condition, and the comorbid symptoms likely depend upon the diverse risk factors and mechanisms by which OUD can arise. These factors are heterogeneous and include genetic predisposition, exposure to prescription opioids, and environmental risks. Crucially, one key environmental risk factor for OUD is early life adversity. OUD and other substance use disorders are widely considered to derive in part from abnormal reward circuit function, which is likely also implicated in comorbid mental (...) illnesses such as depression, bipolar disorder, and schizophrenia. ELA may disrupt reward circuit development and function in a manner predisposing to these disorders. Here, we describe new findings addressing the effects of ELA on reward circuitry that lead to OUD and comorbid disorders, potentially via shared neural mechanisms. We discuss some of these OUD-related problems in both humans and animals. We also highlight the increasingly apparent, crucial contribution of biological sex in mediating the range of ELA-induced disruptions of reward circuitry which may confer risk for the development of OUD and comorbid neuropsychiatric disorders. (shrink)

Motivation: There is an ongoing search for definitive and reliable biomarkers to forecast or predict imminent seizure onset, but to date most research has been limited to EEG with sampling rates <1,000 Hz. High-frequency oscillations have gained acceptance as an indicator of epileptic tissue, but few have investigated the temporal properties of HFOs or their potential role as a predictor in seizure prediction. Here we evaluate time-varying trends in preictal HFO rates as a potential biomarker of seizure prediction.Methods: HFOs were (...) identified for all interictal and preictal periods with a validated automated detector in 27 patients who underwent intracranial EEG monitoring. We used LASSO logistic regression with several features of the HFO rate to distinguish preictal from interictal periods in each individual. We then tested these models with held-out data and evaluated their performance with the area-under-the-curve of their receiver-operating curve. Finally, we assessed the significance of these results using non-parametric statistical tests.Results: There was variability in the ability of HFOs to discern preictal from interictal states across our cohort. We identified a subset of 10 patients in whom the presence of the preictal state could be successfully predicted better than chance. For some of these individuals, average AUC in the held-out data reached higher than 0.80, which suggests that HFO rates can significantly differentiate preictal and interictal periods for certain patients.Significance: These findings show that temporal trends in HFO rate can predict the preictal state better than random chance in some individuals. Such promising results indicate that future prediction efforts would benefit from the inclusion of high-frequency information in their predictive models and technological architecture. (shrink)

We defend two theses: (1) Knowledge how and knowledge that are two distinct forms of knowledge, and; (2) Stanley-style intellectualism is neuro-psychologically implausible. Our naturalistic argument for the distinction between knowledge how and knowledge that is based on a consideration of the nature of slips and basic activities. We further argue that Stanley’s brand of intellectualism has certain ontological consequences that go against modern cognitive neuroscience and psychology. We tie up our line of thought by showing that input from cognitive (...) neuroscience and psychology, on multiple levels of analysis, cohere in supporting the distinction between two separate forms of knowledge. The upshot is a neuro-psychologically plausible understanding of knowledge. (shrink)

For several centuries, the Russians have been famous for the number of transactions they conduct through unofficial channels. This book, the first sustained attempt to explain and analyze Russian society's reliance on unofficial "give-and-take," focuses especially on two key practices: bribery (the use of public office for private gain) and blat (the informal exchange of favors). It brings together specialists from a wide range of disciplines.

For quite some time, cognitive science has offered philosophy an opportunity to address central problems with an arsenal of relevant theories and empirical data. However, even among those naturalistically inclined, it has been hard to find a universally accepted way to do so. In this article, we offer a case study of how cognitive-science input can elucidate an epistemological issue that has caused extensive debate. We explore Jason Stanley’s idea of the practical grasp of a propositional truth and present naturalistic (...) arguments against his reductive approach to knowledge. We argue that a plausible interpretation of cognitive-science input concerning knowledge—even if one accepts that knowledge how is partly propositional—must involve an element of knowing how to act correctly upon the proposition; and this element of knowing how to act correctly cannot itself be propositional. (shrink)

This paper draws from the fields of history, sociology, psychology, moral philosophy, and organizational theory to establish a theoretical connection between a social/organizational influence (ethical work climate) and an individual cognitive element of moral behavior (moral awareness). The research was designed to help to fill a gap in the existing literature by providing empirical evidence of the connection between organizational influences and individual moral awareness and subsequent ethical choices, which has heretofore largely been merely assumed. Results of the study provide (...) evidence that ethical work climate (EWC) is a primary predictor of individual moral awareness, and that the influence of social factors often overrides the effects of individual differences in a work group setting. Implications for future research are provided. (shrink)

The choroid plexuses (CPs) are involved in the most-basic aspects of neural function including maintaining the extracellular milieu of the brain by actively modulating chemical exchange between the CSF and brain parenchyma, surveying the chemical and immunological status of the brain, detoxifying the brain, secreting a nutritive “cocktail” of polypeptides and participating in repair processes following trauma. This diversity of functions may mean that even modest changes in the CP can have far-reaching effects. Indeed, changes in the anatomy and physiology (...) of the CP have been linked to aging and several CNS diseases. It is also possible that replacing diseased or transplanting healthy CP might be useful for treating acute and chronic brain diseases. This review focuses on the wide-ranging and under-appreciated functions of the CP, alterations of these functions in aging and neurodegeneration, and recent demonstrations of the therapeutic potential of transplanted CP for neural trauma. BioEssays 27:262–274, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

For any choice of initial state and weak assumptions about the Hamiltonian, large isolated quantum systems undergoing Schrödinger evolution spend most of their time in macroscopic superposition states. The result follows from von Neumann’s 1929 Quantum Ergodic Theorem. As a specific example, we consider a box containing a solid ball and some gas molecules. Regardless of the initial state, the system will evolve into a quantum superposition of states with the ball in macroscopically different positions. Thus, despite their seeming fragility, (...) macroscopic superposition states are ubiquitous consequences of quantum evolution. We discuss the connection to many worlds quantum mechanics. (shrink)

Christian miller invites further clarification about the relationship between accountability and autonomy. Whereas embracing accountability to others for one’s responsibilities in those relationships emphasizes relationality, autonomy accents the individual’s own capacities to exhibit agency in enacting one’s decisions. Accordingly, we theorize that relational capacities for empathic concern and perspective-taking are especially important in the virtue of accountability. The capacity for self-regulation may serve both one’s autonomous pursuits and accountability for carrying out one’s responsibilities...

Since at least Hume and Kant, philosophers working on the nature of aesthetic judgment have generally agreed that common sense does not treat aesthetic judgments in the same way as typical expressions of subjective preferences—rather, it endows them with intersubjective validity, the property of being right or wrong regardless of disagreement. Moreover, this apparent intersubjective validity has been taken to constitute one of the main explananda for philosophical accounts of aesthetic judgment. But is it really the case that most people (...) spontaneously treat aesthetic judgments as having intersubjective validity? In this paper, we report the results of a cross‐cultural study with over 2,000 respondents spanning 19 countries. Despite significant geographical variations, these results suggest that most people do not treat their own aesthetic judgments as having intersubjective validity. We conclude by discussing the implications of our findings for theories of aesthetic judgment and the purpose of aesthetics in general. (shrink)

A comprehensive, in-depth study of Roe v. Wade and Doe v. Bolton, the 1973 U.S. Supreme Court decisions which legalized abortion. The author closely analyzes the opinions, and contends that the Court made significant errors in its understanding of the many aspects surrounding abortion.

We share with Anderson & Lebiere (A&L) (and with Newell before them) the goal of developing a domain-general framework for modeling cognition, and we take seriously the issue of evaluation criteria. We advocate a more focused approach than the one reflected in Newell's criteria, based on analysis of failures as well as successes of models brought into close contact with experimental data. A&L attribute the shortcomings of our parallel-distributed processing framework to a failure to acknowledge a symbolic level of thought. (...) Our framework does acknowledge a symbolic level, contrary to their claim. What we deny is that the symbolic level is the level at which the principles of cognitive processing should be formulated. Models cast at a symbolic level are sometimes useful as high-level approximations of the underlying mechanisms of thought. The adequacy of this approximation will continue to increase as symbolic modelers continue to incorporate principles of parallel distributed processing. (shrink)

v. 1. The collective use and evolution of concepts.

In its comprehensive overview of Alain Locke's pragmatist philosophy this book captures the radical implications of Locke's approach within pragmatism, the critical temper embedded in Locke's works, the central role of power and empowerment of the oppressed and the concept of broad democracy Locke employed.

Recent accounts of pretense have been underdescribed in a number of ways. In this paper, we present a much more explicit cognitive account of pretense. We begin by describing a number of real examples of pretense in children and adults. These examples bring out several features of pretense that any adequate theory of pretense must accommodate, and we use these features to develop our theory of pretense. On our theory, pretense representations are contained in a separate mental workspace, a Possible (...) World Box which is part of the basic architecture of the human mind. The representations in the Possible World Box can have the same content as beliefs. Indeed, we suggest that pretense representations are in the same representational ``code'' as beliefs and that the representations in the Possible World Box are processed by the same inference and UpDating mechanisms that operate over real beliefs. Our model also posits a Script Elaborator which is implicated in the embellishment that occurs in pretense. Finally, we claim that the behavior that is seen in pretend play is motivated not from a ``pretend desire'', but from a real desire to act in a way that ®ts the description being constructed in the Possible World Box. We maintain that this account can accommodate the central features of pretense exhibited in the examples of pretense, and we argue that the alternative accounts either can't accommodate or fail to address entirely some of the central features of pretense. q 2000 Elsevier Science B.V. All rights reserved. (shrink)

Lists of species underpin many fields of human endeavour, but there are currently no universally accepted principles for deciding which biological species should be accepted when there are alternative taxonomic treatments (and, by extension, which scientific names should be applied to those species). As improvements in information technology make it easier to communicate, access, and aggregate biodiversity information, there is a need for a framework that helps taxonomists and the users of taxonomy decide which taxa and names should be used (...) by society whilst continuing to encourage taxonomic research that leads to new species discoveries, new knowledge of species relationships, and the refinement of existing species concepts. Here, we present 10 principles that can underpin such a governance framework, namely (i) the species list must be based on science and free from nontaxonomic considerations and interference, (ii) governance of the species list must aim for community support and use, (iii) all decisions about list composition must be transparent, (iv) the governance of validated lists of species is separate from the governance of the names of taxa, (v) governance of lists of accepted species must not constrain academic freedom, (vi) the set of criteria considered sufficient to recognise species boundaries may appropriately vary between different taxonomic groups but should be consistent when possible, (vii) a global list must balance conflicting needs for currency and stability by having archived versions, (viii) contributors need appropriate recognition, (ix) list content should be traceable, and (x) a global listing process needs both to encompass global diversity and to accommodate local knowledge of that diversity. We conclude by outlining issues that must be resolved if such a system of taxonomic list governance and a unified list of accepted scientific names generated are to be universally adopted. (shrink)

The field of neuroimaging has reached a watershed. Brain imaging research has been the source of many advances in cognitive neuroscience and cognitive science over the last decade, but recent critiques and emerging trends are raising foundational issues of methodology, measurement, and theory. Indeed, concerns over interpretation of brain maps have created serious controversies in social neuroscience, and, more important, point to a larger set of issues that lie at the heart of the entire brain mapping enterprise. In this volume, (...) leading scholars -- neuroimagers and philosophers of mind -- reexamine these central issues and explore current controversies that have arisen in cognitive science, cognitive neuroscience, computer science, and signal processing. The contributors address both statistical and dynamical analysis and modeling of neuroimaging data and interpretation, discussing localization, modularity, and neuroimagers' tacit assumptions about how these two phenomena are related; controversies over correlation of fMRI data and social attributions ; and the standard inferential design approach in neuroimaging. Finally, the contributors take a more philosophical perspective, considering the nature of measurement in brain imaging, and offer a framework for novel neuroimaging data structures. Contributors: William Bechtel, Bharat Biswal, Matthew Brett, Martin Bunzl, Max Coltheart, Karl J. Friston, Joy J. Geng, Clark Glymour, Kalanit Grill-Spector, Stephen José Hanson, Trevor Harley, Gilbert Harman, James V. Haxby, Rik N. Henson, Nancy Kanwisher, Colin Klein, Richard Loosemore, Sébastien Meriaux, Chris Mole, Jeanette A. Mumford, Russell A. Poldrack, Jean-Baptiste Poline, Richard C. Richardson, Alexis Roche, Adina L. Roskies, Pia Rotshtein, Rebecca Saxe, Philipp Sterzer, Bertrand Thirion, Edward Vul The hardcover edition does not include a dust jacket. (shrink)

I offer a new theory of faultless disagreement, according to which truth is absolute (non-relative) but can still be non-objective. What's relative is truth-aptness: a sentence like ‘Vegemite is tasty’ (V) can be truth-accessible and bivalent in one context but not in another. Within a context in which V fails to be bivalent, we can affirm that there is no issue of truth or falsity about V, still disputants, affirming and denying V, were not at fault, since, in their context (...) of assertion V was bivalent. This theory requires a theory of assertion that is a form of cognitive expressivism. (shrink)

Geoengineering – roughly “the intentional manipulation of the planetary systems at a global scale” (Keith 2000) – to combat climate change is often introduced as a “plan B”: an alternative solution in case “plan A”, reducing emissions, fails. This framing is typically deployed as part of an argument that research and development is necessary in case robust conventional mitigation is not forthcoming, or proves insufficient to prevent dangerous climate impacts. Since coming to prominence with the release of the Royal Society (...) report in 2009 (Shepherd et al. 2009, v), the Plan B framing has proved popular with scientists, in policy circles, and in the news media (see Nerlich and Jaspal 2012; Luokkanen, Huttunen, and Hilden 2014). Though sometimes used to refer to geoengineering as a whole, it is associated particularly strongly with stratospheric sulfate injection (SSI) techniques. Consequently, these will be our focus here. We argue that the plan B framing is particularly ill-suited to the integrative assessment of options within climate policy, because it oversimplifies a complex issue in a misleading and deceptive way. For instance, it highlights extreme positions, presents SSI as an alternative independent from mainstream policies, ignores the multiplicity of options available, and neglects threats of morally indecent SSI in a context of ongoing political inertia. We are particularly concerned about the way ‘Plan B’ risks conveying an implicit hyper-optimism about SSI, and so obscures the need for ethical standards. (shrink)

This was one of SCSS President Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns that appeared during 2015 in Crisismagazine.com and The Wanderer and at his blog site. It discusses the U.S. Supreme Court’s landmark 2015 decision on same-sex “marriage,” Obergefell v. Hodges, and its likely implications for religious liberty, true marriage, and children. He says it is the latest expression of concocted rights under the Court’s “substantive-due-process” doctrine. He suggests ways to respond to the decision politically (...) and legally—by citizens, organizations, and the use of executive power by a sound president in the near future, and by the Church. (shrink)

Hegel, Derrida, and Restricted Economy: The Case of Mechanical Memory STEPHEN HOULGA'FE A GLANCE AT THE TEXTS OF Jacques Derrida and at the texts and lectures of G. W. F. Hegel indicates that Hegel and Derrida are extraordi- narily different thinkers. Hegel is clearly what Derrida would regard as a philosopher of presence, working toward the point "where knowledge no longer needs to go beyond itself, where knowledge finds itself," where con- sciousness is present to itself as it is (...) in itself. 1 Derrida, on the other hand, suggests that everything that is present, here, now, at this moment, bears within it, as constitutive features of itself, the marks or traces of what is irredeemably past, and that, consequently, we can never talk of entities such as ourselves being simply or wholly present to themselves. ~ Derrida claims in Positions that he tries hard to distinguish "diff6rance" from tlegelian "differ- ence," indeed that "diff~rance" might well be defined precisely as "the inter- ruption, the destruction of Hegelian sublation [relive] wherever it operates"; and, to judge at least from the look of his texts, he would seem to have G. W. F. Hegel, Werke in zwamag B~inden, edited by E. Moldenhauer and K. M. Michel, 20 vols. and Index, Ill [Phi~nomenologie des Geistes], 74. For the English translation, see Hegel, Phenomenolog) of Spirit, translated by A. V. Miller, with analysis of the... (shrink)

Punishment and Reparations are sometimes held to express retaliatory emotions whose object is to strike back against a victimizer. I begin by examining a version of this idea in Mill's writings about natural resentment and the sense of justice in Chapter V of Utilitarianism. Mill's view is that the ?natural? sentiment of resentment or ?vengeance? that is at the heart of the concept of justice is essentially retaliatory, therefore has ?nothing moral in it,? and so must be disciplined or moralized (...) from without by the desire to promote the general welfare. I argue to the contrary that if ?reactive attitudes? like resentment and moral blame are understood as Strawson analyzed them, as essentially ?interpersonal? or ?second personal?, they have a different content and function. They implicitly demand respect in a way that also expresses respect for the victimizer as a member of mutually accountable community of moral equals. Some implications of this idea are discussed for the ?expressive theory of punishment? and ?civil recourse? theories of torts. (shrink)