Recent publications by several leading philosophers of chemistry have focused on the definition, scope, utility, and nomenclature of issues dealing with acidity and basicity. In this paper, molecular orbital theory is used to explain all acid–base reactions, concluding that the interaction of the highest occupied molecular orbital (HOMO) of one substrate, “the base,” with the lowest unoccupied molecular orbital (LUMO) of a second substrate, “the acid,” determines the reactivity of such systems. This paradigm provides an understanding of all acid–base reactions (...) as well as other reactions which, on the surface, may not seem like acid–base reactions but which have fundamental underpinnings of that kind of chemistry. Rather than being unable to determine a unified understanding of acidity and basicity as suggested in the philosophy of chemistry literature, we propose that acidity and basicity fit securely in a classification of many other reactions that, using classical chemistry knowledge, pre-quantum chemistry, would not be possible. We strongly support the use of all scientific knowledge and experience in the development of the ideas in the philosophy science. We further suggest increased interactions between philosophers of science and scientists, so that all scholars benefit from the values, knowledge, and perspectives of other disciplines. (shrink)

In this article, we discuss a hypothesis to explain the preferential synthesis of the superoxide sensitive form of aconitase in mitochondria and the phenotype observed in manganese superoxide dismutase mutant mice, which show a gross over accumulation of stored fat in liver. The model proposes that intermediary metabolism is redox regulated by mitochondrial superoxide generated during mitochondrial respiration. This regulates the level of reducing equivalents (NADH) entering the electron transport chain (ETC) through the reversible inactivation of mitochondrial aconitase. This control (...) mechanism has a dual function; firstly, it regulates levels of superoxide generated by the ETC and, secondly, it fine‐tunes metabolism by channeling citrate either for the production of NADH for energy metabolism or diverting it for the synthesis of fats. In this setting, the mitochondrial redox state influences metabolic decisions via a superoxide–aconitase rheostat. BioEssays 26:894–900, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Robert Hopkins _Picture, Image, and Experience_ Cambridge: Cambridge University Press, 1998 ISBN 0521-58259-8 (hbk) 205 pp.

The lambda model provides a physiologically grounded terminology for describing muscle function and emphasizes the important influence of environmental and reflex-mediated effects on final states. However, lambda itself is only a convenient point on the length-tension curve; its importance should not be overemphasized. Ascribing movement to changes in a lambda-based frame of reference is generally valid, but it leaves unanswered a number of questions concerning mechanisms.

Oxford Studies in Metaphysics is the forum for the best new work in this flourishing field. Much of the most interesting work in philosophy today is metaphysical in character: this new series is a much-needed focus for it. OSM offers a broad view of the subject, featuring not only the traditionally central topics such as existence, identity, modality, time, and causation, but also the rich clusters of metaphysical questions in neighbouring fields, such as philosophy of mind and philosophy of science. (...) Besides independent essays, volumes will often contain a critical essay on a recent book, or a symposium that allows participants to respond to one another's criticisms and questions. Anyone who wants to know what's happening in metaphysics can start here. Volume Two begins with a major paper on consciousness by Ned Block. Block examines 'Max Black's Objection to Mind-Body Identity', an argument for a dualism of physical and phenomenal properties, closely related to Jackson's 'knowledge argument'. His extensive exploration of this family of arguments for property dualism includes considerable discussion of John Perry and Stephen White; their responses to Block's paper complete the section on the metaphysics of consciousness.Three papers consider the thesis that the future is, in some sense, 'open'. Eli Hirsch elaborates a view according to which contingent statements about the future can be indeterminate in truth-value, while preserving 'straight logic', including a principle of bivalence. Peter Forrest defends a sort of 'growing block' theory of the passage of time, emphasizing the way such a metaphysics, combined with a truth-maker principle, can provide an analysis of natural necessity. Trenton Merricks presents a trenchant and original criticism of the 'growing block' theory of time.The volume continues with a group of papers on problems of ontology. Thomas Hofweber's paper, defending nominalism from the objection that there are 'inexpressible' properties and propositions, won the first annual Oxford Studies in Metaphysics Younger Scholar Prize. The papers by Phillip Bricker and Michael Loux examine a couple of deep divides within ontology. John Hawthorne's paper raises some extremely puzzling questions about the nature of persons, given the ontology needed for Timothy Williamson's theory of vagueness. Hawthorne uses these problems to motivate an alternative style of epistemicism. The final three papers take up several issues in the metaphysics of traditional theism. Michael Bergmann and Jeffrey Brower raise objections to combining a Platonic conception of universals with the doctrine of divine aseity; while Brian Leftow defends a non-Platonic theory of universals - a kind of divine-concept nominalism. Hud Hudson suggests that contemplation of the possibility of higher dimensions opens up new avenues in theodicy. (shrink)

To the Editor: It was with great interest that our Canadian Palliative Sedation Therapy Guideline working group read Jeffrey Berger's recent article ("Rethinking Guidelines for the Use of Palliative Sedation," May-June 2010). Given our own group's efforts to develop national guidelines, we have rethought the issue of palliative sedation therapy several times over the past year.The use of clear and concise definitions is fundamental to the development of any consensus guidelines on this topic. In the article, the term "palliative (...) sedation to unconsciousness," or PSU, implies the concerning assumption that sedation will knowingly be to unconsciousness in the palliative case under consideration. This conflicts with .. (shrink)

Although the doctrine of divine simplicity has faced substantial criticism in recent years, Jeffrey Brower has recently offered a novel defense of the view by appealing to contemporary truthmaker theory. In this paper, I will argue that Brower’s defense of divine simplicity requires an implausible account of how truthmaking works for essential intrinsic predications. I will first argue that, unless Brower is willing to make an ad hoc exception for how truthmaking works in God’s case, he is committed to (...) saying that essential intrinsic predications about any object are made true by that object alone, not by its having essential properties. I will then argue that reflecting on cases where distinct essential intrinsic predications about an object have different causal explanations behind them shows that this general view of truthmaking is implausible. (shrink)

‘Molinism’, in contemporary usage, is the name for a theory about the workings of divine providence. Its defenders include some of the most prominent contemporary Protestant and Catholic philosophical theologians.¹ Molinism is often said to be the only way to steer a middle..

Direct neurological and especially imaging-driven investigations into the structures essential to naturally occurring cognitive systems in their development and operation have motivated broadening interest in the potential for artificial consciousness modeled on these systems. This first paper in a series of three begins with a brief review of Boltuc’s (2009) “brain-based” thesis on the prospect of artificial consciousness, focusing on his formulation of h-consciousness. We then explore some of the implications of brain research on the structure of consciousness, finding limitations (...) in biological approaches to the study of consciousness. Looking past these limitations, we introduce research in artificial consciousness designed to test for the emergence of consciousness, a phenomenon beyond the purview of the study of existing biological systems. (shrink)

Jeffrey T. Dean Getting a Good View of Depiction _Film-Philosophy_, vol. 3 no. 26, June 1999.

This third paper locates the synthetic neurorobotics research reviewed in the second paper in terms of themes introduced in the first paper. It begins with biological non-reductionism as understood by Searle. It emphasizes the role of synthetic neurorobotics studies in accessing the dynamic structure essential to consciousness with a focus on system criticality and self, develops a distinction between simulated and formal consciousness based on this emphasis, reviews Tani and colleagues' work in light of this distinction, and ends by forecasting (...) the increasing importance of synthetic neurorobotics studies for cognitive science and philosophy of mind going forward, finally in regards to most- and myth-consciousness. (shrink)

Discoverability: the urgent need of an ecology of human creativity from the prolific Lorenzo Magnani is worthy of direct attention. The message may be of special interest to philosophers, ethicists and organizing scientists involved in the development of AI and related technologies which are increasingly directed at reinforcing conditions against which Magnani directly warns, namely the “overcomputationalization” of life marked by the gradual encroachment of technologically “locked strategies” into everyday decision-making until “freedom, responsibility, and ownership of our destinies” are ceded (...) and we, in parallel, build a future fit for artifacts over human beings. Professional educators - teachers and administrators serious about teaching - and policy-makers including the concerned public, parents and social activists concerned about the effects of technologies on development and well-being may benefit, as well. (shrink)

Predictive processing accounts of neural function view the brain as a kind of prediction machine that forms models of its environment in order to anticipate the upcoming stream of sensory stimulation. These models are then continuously updated in light of incoming error signals. Predictive processing has offered a powerful new perspective on cognition, action, and perception. In this chapter we apply the insights from predictive processing to the study of emotions. The upshot is a picture of emotion as inseparable from (...) perception and cognition, and a key feature of the embodied mind. (shrink)

Property dualism is enjoying a slight resurgence in popularity, these days; substance dualism, not so much. But it is not as easy as one might think to be a property dualist and a substance materialist. The reasons for being a property dualist support the idea that some phenomenal properties (or qualia) are as fundamental as the most basic physical properties; but what material objects could be the bearers of the qualia? If even some qualia require an adverbial construal (if they (...) are modifications of the thing that is conscious because of them, not properties of something else to which the subject of consciousness is related), then the property dualist can be driven to speculative forms of materialism none of which, at this point, looks more likely to be true than the more modest versions of emergent dualism defended by contemporary substance dualists. (shrink)

The phenomenon of altruism extends from the biological realm to the human sociocultural realm. This article sketches a coherent outline of multiple types of altruism of progressively increasing scope that span these two realms and are grounded in an ever-expanding sense of “self.” Discussion of this framework notes difficulties associated with altruism at different levels. It links scientific ideas about the evolution of cooperation and about hierarchical order to perennial philosophical and religious concerns. It offers a conceptual background for inquiry (...) into societal challenges that call for altruistic behavior, especially the challenge of environmental and social sustainability. (shrink)

Shows that the very same asymmetries that arise for intentionally also arise from deciding, desiring, in favor of, opposed to, and advocating. It seems that the phenomenon is not due to anything about the concept of intentional action in particular. Rather, the effects observed for the concept of intentional action should be regarded as just one manifestation of the pervasive impact of moral judgment.

Our purpose in this article is to identify and suggest resolution for two core problematics of grounded theory. First, while grounded theory provides transparency to one part of the conceptualization process, where codes emerge directly from the data, it provides no such systematic or transparent way for gaining insight into the conceptual relationships between discovered codes. Producing a grounded theory depends not only on the definition of conceptual pieces, but the delineation of a relationship between at least two of those (...) pieces. Second, the conceptualization process of grounded theory is done in hierarchical fashion, where individual codes emerge from the data but then are used to generate insight into more general concepts and thematic statements. But various works on grounded theory have failed to provide any systematic way of using data specific levels of scale (the codes) to gain insight into more macro levels of scale (concepts and themes). We offer fractal concept analysis as a means of resolving both of these issues. By using a logic structure generator, fractal concept analysis delineates self-similar conceptual frameworks at various levels of abstraction, yielding a method for linking concepts together within and between levels of scale encountered in the grounded theory coding and categorization process. We conclude that this fractal analytic technique can bolster the aims of grounded theory as a formalized and systematic process for generating theory from empirical data. (shrink)

In this classic analysis of travel and sightseeing, author Dean MacCannell brings social scientific understandings to bear on tourism in the postindustrial age, during which the middle class has acquired leisure time for international travel. In _The Tourist_—now with a new introduction framing it as part of a broader contemporary social and cultural analysis—the author examines notions of authenticity, high and low culture, and the construction of social reality around tourism.

Selective scientific realists disagree on which theoretical posits should be regarded as essential to the empirical success of a scientific theory. A satisfactory account of essentialness will show that the (approximate) truth of the selected posits adequately explains the success of the theory. Therefore, (a) the essential elements must be discernible prospectively; (b) there cannot be a priori criteria regarding which type of posit is essential; and (c) the overall success of a theory, or ‘cluster’ of propositions, not only individual (...) derivations, should be explicable. Given these desiderata, I propose a “unification criterion” for identifying essential elements. (shrink)

Wattles offers a comprehensive survey of the history of the golden rule, "Do unto others as you want others to do unto you". He traces the rule's history in contexts as diverse as the writings of Confucius and the Greek philosophers, the Bible, modern theology and philosophy, and the American "self-help" context. He concludes by offering his own synthesis of these varied understandings.

This study provides an evaluation of ethical business perception of busIness students from three countries: Australia, Taiwan and the United States. Although statistically significant differences do exist there is significant agreement with the way students perceive ethical/unethical practices in business. The findings of this paper indicate a universality of business ethical perceptions.

Some theories of goodness are descriptively rich: they have much to say about what makes things good. Neo-Aristotelian accounts, for instance, detail the various features that make a human being, a dog, a bee good relative to facts about those forms of life. Famously, such theories of relative goodness tend to be comparatively poor: they have little or nothing to say about what makes one kind of being better than another kind. Other theories of goodness—those that take there to be (...) absolute goodness—are comparatively rich: they offer grounds for judging some types of things better than others because they have more absolute goodness. Moorean accounts, for example, can tell us that humans and human experiences are superior to bees and blades of grass. But such theories tend to be descriptively poor: they struggle to tell us in virtue of what this is so. In this essay we motivate and flesh out a view that splits the difference between accounts of goodness as relative and accounts of goodness as absolute. Such a view holds promise only if the mechanics of this kind of metaphysics of goodness can be worked out. Here we present a view on which the paradigm for absolute goodness is God and the paradigm for each kind of relative goodness is a divine idea. (shrink)

It is a natural thought that understanding language consists in possessing knowledge—to understand a word is to know what it means. It is also natural to suppose that this knowledge is propositional knowledge—to know what a word means is to know that it means such-and-such. Thus it is prima facie plausible to suppose that understanding a bit of language consists in possessing propositional knowledge of its meaning. I refer to this as the epistemic view of understanding language. The theoretical appeal (...) of this view for the philosophy of language is that it provides for an attractive account of the project of the theory of meaning. If understanding language consists in possessing propositional knowledge of the meanings of expressions, then a meaning theory amounts to a theory of what speakers know in virtue of understanding language. In this paper I argue that, despite its intuitive and theoretical appeal, the epistemic view is false. Propositional knowledge is not necessary for understanding language, not even tacit knowledge. Unlike knowledge, I argue, linguistic understanding does not fail in Gettier cases, does not require epistemic warrant and does not even require belief. The intuitions about knowledge that have been central to epistemology do not seem to hold for linguistic understanding. So unless epistemologists have been radically mistaken about what knowledge requires, knowledge is unnecessary for understanding language. (shrink)

This chapter presents the main formalism of the book, which is used in subsequent chapters to describe a variety of concepts in Husserlian phenomenology, and thereby unify them. A dynamical systems approach to Husserl is introduced, and several dynamical laws of Husserlian phenomenology are described. The first is an expectation rule according to which expectations are determined by what a person knows, sees, and does. The second is a learning rule according to which background knowledge is updated in a specific (...) way when experiences fulfill or frustrate prior expectations. In addition to these rules, a “supervenience function” is described, which associates how a thing is seen with a “trail set,” the set ways that thing is expected to look, relative to all possible ways of moving around it. This function further illustrates the explanatory dimension of phenomenology described in Chap. 2, whereby how we immanently experience things is determined by how we expect them to look relative to counterfactual movement patterns. (shrink)

"Justice as the Living Good offers a comprehensive reading of Hegel's social and political philosophy. Two hundred years after the publication of his Philosophy of Right, Hegel's theory of justice remains a viable alternative to the social contract tradition in modern political theory. Hegel's Value shows that underlying Hegel's claims about freedom and history is a theory of value grounded in our dual nature as living and self-conscious beings. While Hegel follows the modern tradition in basing his theory on the (...) free will, he departs from the tradition in emphasizing the expression of the will in valuable action. Hegel's Value argues for the expressive validity of practical inferences as the key to understanding the connection between value and a system of right. Through a close reading of key episodes in the Phenomenology of Spirit and of the entire Philosophy of Right, this study show how Hegel develops his account of justice through an inferentialist conception of reason. Hegel's Value traces the development of right from the basic conception of property rights to an inclusive conception that he calls simply the Good, and finally to a system of just institutions structured by "living" inferential relations. The result is an institutional system governed by a moral ideal but realized through concrete economic and political processes"--. (shrink)

We argue that companion friendship is not importantly marked by self-disclosure as understood in either of these two ways. One's close friends need not be markedly similar to oneself, as is claimed by the mirror account, nor is the role of private information in establishing and maintaining intimacy important in the way claimed by the secrets view. Our claim will be that the mirror and secrets views not only fail to identify features that are in part constitutive of close or (...) companion friendship, but that they miss the mark quite broadly and fail to capture anything significant and distinctive about the ways in which friendship has an impact on the self. The article will proceed as follows. In the first section we outline our account of the self in friendship. In the next two sections we examine the mirror and secrets views and develop our own view in counterpoint to these. In the final section we defend our own account by showing how it provides the governing conditions which do distinguish friendship from other kinds of relations between persons. (shrink)

Reliabilism—the view that a belief is justified iff it is produced by a reliable process—is often characterized as a form of consequentialism. Recently, critics of reliabilism have suggested that since it is a form of consequentialism, reliabilism condones a variety of problematic trade-offs involving cases where someone forms an epistemically deficient belief now that will lead her to more epistemic value later. In the present paper, we argue that the relevant argument against reliabilism fails because it equivocates. While there is (...) a sense in which reliabilism is a kind of consequentialism, it is not of a kind on which we should expect problematic trade-offs. (shrink)

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The paper has two parts: First, I describe a relatively popular thesis in the philosophy of propositional attitudes, worthy of the name ‘taking tense seriously’; and I distinguish it from a family of views in the metaphysics of time, namely, the A-theories (or what are sometimes called ‘tensed theories of time’). Once the distinction is in focus, a skeptical worry arises. Some A-theorists maintain that the difference between past, present, and future, is to be drawn in terms of what exists: (...) growing-block theorists eschew ontological commitment to future entities; presentists, to future and past entities. Others think of themselves as A-theorists but exclude no past or future things from their ontology. The metaphysical skeptic suspects that their attempt to articulate an ‘eternalist’ version of the A-theory collapses into merely ‘taking tense seriously’– a thesis that does not imply the A-theory. The second half of the paper is the search for a stable eternalist A-theory. It includes discussion of temporary intrinsics, temporal parts, and truth. (shrink)

A simple tool is provided to assist researchers in assessing contributions to a scientific publication, for ease in evaluating which contributors qualify for authorship, and in what order the authors should be listed. The tool identifies four phases of activity leading to a publication—Conception and Design, Data Acquisition, Analysis and Interpretation, and Manuscript Preparation. By comparing a project participant’s contribution in a given phase to several specified thresholds, a score of up to five points can be assigned; the contributor’s scores (...) in all four phases are summed to yield a total “contribution score”, which is compared to a threshold to determine which contributors merit authorship. This tool may be useful in a variety of contexts in which a systematic approach to authorial credit is desired. (shrink)

In order to formulate hypotheses about the evolutionary underpinnings that preceded the first glimmerings of language, mother-infant gestural and vocal interactions are compared in chimpanzees and humans and used to model those of early hominins. These data, along with paleoanthropological evidence, suggest that prelinguistic vocal substrates for protolanguage that had prosodic features similar to contemporary motherese evolved as the trend for enlarging brains in late australopithecines/early Homo progressively increased the difficulty of parturition, thus causing a selective shift toward females that (...) gave birth to relatively undeveloped neonates. It is hypothesized that hominin mothers adopted new foraging strategies that entailed maternal silencing, reassuring, and controlling of the behaviors of physically removed infants (i.e., that shared human babies' inability to cling to their mothers' bodies). As mothers increasingly used prosodic and gestural markings to encourage juveniles to behave and to follow, the meanings of certain utterances (words) became conventionalized. This hypothesis is based on the premises that hominin mothers that attended vigilantly to infants were strongly selected for, and that such mothers had genetically based potentials for consciously modifying vocalizations and gestures to control infants, both of which receive support from the literature. Key Words: bipedalism; brain size; chimpanzees; foraging; gestures; hominins; infant riding; motherese; prosody; protolanguage. (shrink)

Let us say that an extended object is “composed wholly of simples” just in case it is an aggregate of absolutely unextended parts spread throughout an extended region—that is, just in case there is a set S such that: every member is a point-sized part of the object, and for every x, x is part of the object if and only if it has a part in common with some member of S. Could a truly extended substance be composed entirely (...) of unextended parts? Reflection upon the fact that it must be at least possible for extended objects to touch one another suggests that the answer to this question is: No. (shrink)

How do we know what other speakers say? Perhaps the most natural view is that we hear a speaker's utterance and infer what was said, drawing on our competence in the syntax and semantics of the language. An alternative view that has emerged in the literature is that native speakers have a non-inferential capacity to perceive the content of speech. Call this the perceptual view. The disagreement here is best understood as an epistemological one about whether our knowledge of what (...) speakers say is epistemically mediated by our linguistic competence. The present paper takes up the question of how we should go about settling this issue. Arguments for the perceptual view generally appeal to the phenomenology of speech comprehension. The present paper develops a line of argument for the perceptual view that draws on evidence from empirical psychology. The evidence suggests that a speaker's core syntactic and semantic competence is typically deployed sub-personally. The point is not just that the competence is tacit or unconscious, but that the person is not the locus of the competence. I argue that standing competence can enter into the grounds for knowledge only if it is subject to a certain sort of epistemic assessment, an assessment that is appropriate only if the person is the locus of that competence. If the person is not the locus of a speaker's core linguistic competence, as the psychological evidence suggests, then that competence does not enter into the grounds for our knowledge of what speakers say. If this line of argument is right, it has implications for the epistemology of perception and for our understanding of how empirical psychology bears on epistemology generally. (shrink)