In lieu of an abstract, here is a brief excerpt of the content:Surprised DivideAnonymous OneAnonymous OneNot long after our daughter was born, my wife and I were expecting a son. We were busy new parents, so her pregnancy with our second child went by quickly and without a lot of the fuss that a first pregnancy brings. To our surprise, our son was born a few weeks early but aside from a little jaundice he was a happy, healthy baby.My parents (...) were caring for our daughter while we were at the hospital. After my son's birth, we were excited for them to bring our daughter up to the hospital to visit her new baby brother. The hospital photographer came by and took photos of our two kids together and photos of our son swaddled and sleeping soundly in a basket. Other family members stopped by to meet the new baby as well. It was a happy time.Little did we know that a couple of hours later we would be faced with a communication breakdown. My wife and I usually pride ourselves on how well we are able to communicate and plan our future.I grew up heavily Catholic, attending parochial schools through high school graduation. Meanwhile, my wife's family are Unitarian Universalists. You could not have two more polar opposite religions! We are used to having different points of view. We have always talked through many of life's choices and have both had to make compromises in order to have a successful relationship. It was on that happy day of my son's birth that we discovered we forgot to discuss one important topic.As our family was gathered in my wife's hospital room, joyfully celebrating the newest addition, the doctor entered the room to check on my wife and said it was time to do the circumcision if we wanted.Without hesitation, I responded in the affirmative, then the doctor and I looked over at my wife, who was staring at us with saddened, conflicted eyes. I was confused. Didn't she want the same thing for our son that I did? Surprisingly we never discussed this decision, at least not that I remember. I don't recall her ever telling me she was against it.My wife stated that she wasn't prepared to make a decision because she didn't know what our son would want and she was worried about him experiencing pain. She worked hard for 9 months to grow this baby boy, and he was so little. I understood her anguish in the thought of letting someone alter his tiny body.I am circumcised myself. My background provided me guidance and an expectation that this would be happening, so it was a nonissue for me. I never considered a scenario in which my son would not be circumcised. In truth, it felt ridiculous to even contemplate not circumcising him. My words of reassurance that it would be fine and my explanation to my wife that this was just one of the many decisions we would need to make for him and our other child did little to settle her.It was clear that no one (including me) had discussed this with my wife prior to this point, which was unfortunate. The doctor described the process and tried to reassure my wife that it was a safe and minor procedure. This still left my wife in a conflicted state. The other men in my family there visiting at the time chimed in to reassure my wife that this is what our son would want. She reluctantly agreed to the circumcision, giving in to peer pressure I suppose. I'm confident that an alliance of circumcised men telling her that our son would also want to be circumcised is what swayed her. Frankly, I'm glad they happened to be there when the doctor stopped by to help back up my position.But while our son was out of the room undergoing his procedure, my wife remained conflicted and saddened. We were both surprised at each other's response. My opinion on this was coming from the position of expectation and tradition, while she was worried about not knowing... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Second GuessingAnonymous OneThis is difficult for me to write because I have tremendous respect for every doctor that has been involved in my son’s care. I firmly believe that they chose and administered the highest level of care that they assessed as appropriate; that they cared for him both personally and professionally as if he were their own child; and that he was in the care of acknowledged giants (...) in their fields. I write this knowing that I will share this narrative with these doctors, in order that they can better understand the decisions I was faced with and the guilt I must live with feeling that I may not have made the best possible informed choice for my son, because of this trust and relationship.Let me describe my oncologist. I say “my” instead of my son’s whose doctor he really is, because he is mine too in every sense of the word. He cares passionately about his work and about my son specifically; he engenders my trust because he is compassionate, brilliant, and available to me for concerns both great and small. His accomplishments have saved lives and will continue to impact his field. He became the narrow bridge I walk, that is the only thing between me and dangerous water and rocks waiting below; the balancing bar on the tightrope that is the only thing that stands to keep me from falling into the abyss and breaking my neck. And this made it difficult for me to disagree with him and seek a second opinion. Because his unspoken words were, “Don’t you trust me that I will do the best for your child?” and I could not answer then what I would answer now, “Nobody is infallible and sometimes we may miss something that someone else can see despite how much we know or care.”It is ironic, I think, that sometimes a layperson, because of her limited knowledge, can see more clearly where a professional may not.My son was diagnosed at age six with Grade II ependymoma in 2006. He was treated with surgery, a complete resection, and then 33 rounds of conformal radiation. He recurred in 2012, and was diagnosed with anaplastic ependymoma Grade III. He had another surgery, with the same surgeons, who pronounced it another successful total resection. This is where my story begins.The MRI taken the next day showed a sliver of something there. My oncologist, much sought after for his diagnostic abilities in reading MRI’s showed slight concern that it may be residual tumor, but both the surgeons and the MRI report came back negative, identifying the sliver as inflammation. Six [End Page 9] weeks later, 3 days before we were scheduled to leave out of town to receive proton beam radiation, I insisted on another MRI. The sliver was enlarged from the post–op MRI. My oncologist said it was tumor; one surgeon said it was inflammation and the other surgeon abstained from speculation. The MRI report stated it appeared to be recurrent tumor.Now here was my dilemma as a parent. The prognosis today of radiation on residual tumor for ependymomas is very bad, especially with a residual tumor of his size. On the other hand, my oncologist felt that going in for surgery with no guarantee of a total resection anyway, was incurring a risk of damage to my child that may impact severely on his quality of life.My oncologist felt that for many medical reasons, inherent risks of surgery, uncertainty about status of the scan reading, quality versus quantity of life, and—I think—an understandably pessimistic view of the possibility of cure for recurrent anaplastic grade III ependymoma, he was against another surgery, and opted to continue with radiation with the tumor as is.I am part of two support groups on line, one for parents of children with any type of brain tumor and the other specific for ependymoma parents. The clinical and anecdotal knowledge of these groups as a whole is phenomenal because, unfortunately, we have parents who have experienced and researched almost everything about this illness, in all its stages. When I was faced... (shrink)

When naming certain hand-held, man-made tools, American Sign Language signers exhibit either of two iconic strategies: a handling strategy, where the hands show holding or grasping an imagined object in action, or an instrument strategy, where the hands represent the shape or a dimension of the object in a typical action. The same strategies are also observed in the gestures of hearing nonsigners identifying pictures of the same set of tools. In this paper, we compare spontaneously created gestures from hearing (...) nonsigning participants to commonly used lexical signs in ASL. Signers and gesturers were asked to respond to pictures of tools and to video vignettes of actions involving the same tools. Nonsigning gesturers overwhelmingly prefer the handling strategy for both the Picture and Video conditions. Nevertheless, they use more instrument forms when identifying tools in pictures, and more handling forms when identifying actions with tools. We found that ASL signers generally favor the instrument strategy when naming tools, but when describing tools being used by an actor, they are significantly more likely to use more handling forms. The finding that both gesturers and signers are more likely to alternate strategies when the stimuli are pictures or video suggests a common cognitive basis for differentiating objects from actions. Furthermore, the presence of a systematic handling/instrument iconic pattern in a sign language demonstrates that a conventionalized sign language exploits the distinction for grammatical purpose, to distinguish nouns and verbs related to tool use. (shrink)

It would be very desirable to have an account of the relation between mind and world that sustained the integrity of each. In this paper, we will argue that a theory of cognition which is broadly Thomistic can do just that. Many commentators recognize that cognitio is Aquinas’s basic epistemic concept, and that it designates knowledge in the broadest and most basic sense, as distinguished from scientia, or knowledge in the paradigmatic sense. There are several important consequences of this distinction (...) which are relevant to a proper understanding of the way in which a theory of knowledge which is in the Aristotelian-Thomistic tradition approaches the issue of the relation between the mind and the world. First and foremost, knowledge cannot be construed as a univocal concept in the A/t context. There are different senses of knowledge and we should not expect there to be a theory which supplies necessary and sufficient conditions for “S knows that p” that satisfies all the different senses of knowledge. It is perplexing that the contemporary discussion seems to miss this point, for the same sort of systematic ambiguity of the term ‘knowledge’ seems to hold in English. Second, the A/t theory of knowledge is not an epistemological theory in the modern sense, if by “epistemological” we mean one which is clearly demarcated from a metaphysical, psychological, or even semantical theory. The A/t theory is a metaphysics of knowledge. Third, a Thomistic theory of knowledge begins with a theory of cognition which provides the grounds of knowledge across the board, including even that of scientia. (shrink)

More and more these days it is asked whether aesthetics is still possible. A question that, given the context and phrasing, seems to direct us towards its answer. Conferences and meetings, books and journal specials examine the issue of aesthetics, talk about rediscovery or return of aesthetics. Well known philosophers and aestheticians underscore the need to reconsider the foundations of aesthetics and set new directions for aesthetics today (Berleant, 2004) or attempt to expand aesthetics beyond aesthetics–like Welsch, for example who (...) tries to extend aesthetics beyond art to society and the life-world (Welsch, 1997). Others underline the need to revisit the aesthetic experience (Shusterman, 1999; Iseminger, 2002, Fenner, 1996) and examine the relevance or irrelevance of the aesthetic with art (Carroll, 2001). It seems that it is strongly recommended to turn to aesthetics on the condition however to carefully re-approach the meaning and import of the term in the present situation. The aesthetic that Passmore condemned as “dreary”(Passmore, 1954), the one Sparshott considered a formless conception, vague and loose in application (Sparshott, 1982), the same that Danto emphatically argues that has nothing to do with the definition of art or arts in general (Danto, 1981) returns to claim its rightful place in the fields of philosophy and critical theory (Levine, 1994, Michaud, 1999), as well as artistic creation. And one cannot but wonder: what does this return mean? What was the degree of aesthetics decline that we need to discuss about recovery or for new implementations of aesthetics? (shrink)

Dr. Vukov analyzing patients with disorders of consciousness, proposed that medical well-regarded policy recommendations cannot be justified by looking solely to patients’ actual levels of consciousness (minimally conscious state – MCS versus vegetative state – VS), but that they can be justified by looking to patients’ potential for consciousness. One objective way to estimate this potential (actual physical possibility) is to consider a neurophysiologically informed strategy. Ideally such strategy would utilize objective brain activity markers of consciousness/unconsciousness. The Operational Architectonics (OA) (...) theory of brain-mind functioning is an example of such a strategy. Besides being mathematically simple, neurophysiologically accurate, and compatible with the cognitive/phenomenal perspectives on consciousness, application of OA strategy to quantitative EEG analysis of patients in VS and MCS revealed that the absence of consciousness in VS is paralleled by impairment of overall EEG operational architecture. Specifically, neuronal assemblies become smaller, their life span shortened, and they became highly unstable and functionally disconnected (desynchronized). At the same time, fluctuating (minimal) awareness in patients in MCS was paralleled by partial restoration of EEG operational architecture (increased size, life span, and stability of neuronal assemblies, together with an increased number and strength of functional connections among them), approaching the level found in healthy fully conscious participants. Moreover OA strategy to EEG analysis allowed predicting the emergence of consciousness in VS patients after six years following the brain trauma. Therefore, the OA methodology could reliably predict which patients may regain consciousness, and thus determine which patients may have the potential for consciousness. (shrink)

Scientists of the Human Genome Project tend to rely on three metaphors to describe their work, each of which implicitly tells much the same story. Whether they claim to interpret the ultimate "book," to fix a flawed "machine," or to map a mysterious "wilderness," they invariably cast the researcher as one who dominates and exploits the Other. This essay, which explores the ways such a story conflicts with feminist values, proposes an alternative.

Miriam solomon resuscitates a famous proposal of George Engel's to classify normal grief as a medical disorder. She has two main arguments justifying such a reclassification, one based on Engel's "wound analogy" and another a "Humpty Dumpty"-type argument that 'disorder' is a technical term that we can redefine any way we please. I consider them in turn.Solomon says: "I suggest that we allow a concept of "psychological injury" that is analogous to the concept of physical injury." Of course, we already (...) have a whole chapter of the Diagnostic and Statistical Manual of Mental Disorders devoted to psychological injuries in the form of "trauma- and stressor-related disorders" (this is where the new... (shrink)

We consider the following signaling game. Nature plays first from the set {1, 2}. Player 1 (the Sender) sees this and plays from the set {A, B}. Player 2 (the Receiver) sees only Player 1’s play and plays from the set {1, 2}. Both players win if Player 2’s play equals Nature’s play and lose otherwise. Players are told whether they have won or lost, and the game is repeated. An urn scheme for learning coordination in this game is as (...) follows. Each node of the desicion tree for Players 1 and 2 contains an urn with balls of two colors for the two possible decisions. Players make decisions by drawing from the appropriate urns. After a win, each ball that was drawn is reinforced by adding another of the same color to the urn. A number of equilibria are possible for this game other than the optimal ones. However, we show that the urn scheme achieves asymptotically optimal coordination. (shrink)

I argue that, contrary to how he is often read, Spinoza did not believe that the mind and the body were numerically identical. This means that we must find some alternative reading for his claims that they are 'one and the same thing'.

The way, in which quantum information can unify quantum mechanics (and therefore the standard model) and general relativity, is investigated. Quantum information is defined as the generalization of the concept of information as to the choice among infinite sets of alternatives. Relevantly, the axiom of choice is necessary in general. The unit of quantum information, a qubit is interpreted as a relevant elementary choice among an infinite set of alternatives generalizing that of a bit. The invariance to the axiom of (...) choice shared by quantum mechanics is introduced: It constitutes quantum information as the relation of any state unorderable in principle (e.g. any coherent quantum state before measurement) and the same state already well-ordered (e.g. the well-ordered statistical ensemble of the measurement of the quantum system at issue). This allows of equating the classical and quantum time correspondingly as the well-ordering of any physical quantity or quantities and their coherent superposition. That equating is interpretable as the isomorphism of Minkowski space and Hilbert space. Quantum information is the structure interpretable in both ways and thus underlying their unification. Its deformation is representable correspondingly as gravitation in the deformed pseudo-Riemannian space of general relativity and the entanglement of two or more quantum systems. The standard model studies a single quantum system and thus privileges a single reference frame turning out to be inertial for the generalized symmetry [U(1)]X[SU(2)]X[SU(3)] “gauging” the standard model. As the standard model refers to a single quantum system, it is necessarily linear and thus the corresponding privileged reference frame is necessary inertial. The Higgs mechanism U(1) → [U(1)]X[SU(2)] confirmed enough already experimentally describes exactly the choice of the initial position of a privileged reference frame as the corresponding breaking of the symmetry. The standard model defines ‘mass at rest’ linearly and absolutely, but general relativity non-linearly and relatively. The “Big Bang” hypothesis is additional interpreting that position as that of the “Big Bang”. It serves also in order to reconcile the linear standard model in the singularity of the “Big Bang” with the observed nonlinearity of the further expansion of the universe described very well by general relativity. Quantum information links the standard model and general relativity in another way by mediation of entanglement. The linearity and absoluteness of the former and the nonlinearity and relativeness of the latter can be considered as the relation of a whole and the same whole divided into parts entangled in general. (shrink)

Ennead VI.4-5, originally written as a single treatise, contains Plotinus' most general and sustained exposition of the relationship between the intelligible and the sensible realms, addressing and coalescing two central issues in Platonism: the nature of the soul-body relationship and the nature of participation. Its main question is, How can soul animate bodies without sharing their extension? The treatise seems to have had considerable impact: it is much reflected in Porphyry's important work, Sententiae, and the doctrine of reception according to (...) the capacity of the recipient, for which this treatise is the main source, resonated in medieval thinkers. (shrink)

En trabajos anteriores he tratado de mostrar que la lectura que hemos de hacer de la ciencia natural de Leibniz ha de ser una lectura holística, esto es, un recorrido transversal por todos los niveles ontológicos del ser y por todos los caminos epistémicos del pensar, de manera que puede argumentarse de unos a otros con perfecta legitimidad siempre que, guiados por la forma lógica de la razón, podamos encontrar alguna estructura común que los anude. En este escrito ofrezco un (...) primer ejemplo de este modo de razonar. En el prefacio de los NE Leibniz reconstruye todo su sistema científico y metafísico a partir de las “petites perceptions” (GP V, 46-53). El texto principal de mi escrito será el discurso de Leibniz, que comentaré en notas a pie de página. (shrink)

Philosophers often talk about the things we say, or believe, or think, or mean. The things are often called ‘propositions’. A proposition is what one believes, or thinks, or means when one believes, thinks, or means something. Talk about propositions is ubiquitous when philosophers turn their gaze to language, meaning and thought. But what are propositions? Is there a single class of things that serve as the objects of belief, the bearers of truth, and the meanings of utterances? How do (...) our utterances express propositions? Under what conditions do two speakers say the same thing, and what (if anything) does this tell us about the nature of propositions? There is no consensus on these questions—or even on whether propositions should be treated as things at all. During the second Propositions and Same-Saying workshop, which took place on July 19–21 2010 at the University of Sydney, philosophers debated these (and related) questions. The workshop covered topics in the philosophy of language, perception, and metaphysics. The present volume contains revised and expanded versions of the papers presented at the workshop. (shrink)

Many countries throughout the globe function in a system that allows the usage of more than one language. Such a multilingual social reality’s construction, especially in societies like the one in which I am living, is perceived in many different ways: attempting thus to provide for the process of differentiating identity’s oneness and sameness into various cultural subcategories, which already represent new realities. Due to newly created social realities, semiotics naturally discusses the differences and/or oppositions that can contribute (...) to various cultures’ mutual exclusivity or inclusivity, in terms of various heterogeneous “transformations,” which would thus overcome dualities, and be viewed as single acts of signs, or as a result of a process of singularization of their constituent components. I shall also attempt using a semiotic style that may enact a semiotics of action, grounded on the semiotics of passions, through a way of producing semantic taxonomies as pride versus humiliation, hegemony versus subordination, etc., obtainable due to disjunctive and/or conjunctive semiotic relations such as contextualization versus de-contextualization. (shrink)

The COVID-19 pandemic is a man-made disaster, caused by undue interference in the ecological balance and the lives of multiple species. Paradoxically, the contagion has resulted in increased use of technology and digital mediation, as well as enhanced hopes for vaccines and biomedical solutions. It has thereby intensified humans’ reliance on the very high-tech economy of cognitive capitalism that caused the problems in the first place. This combination of ambivalent elements in relation to the Fourth Industrial revolution and the Sixth (...) Extinction is the trademark of the posthuman condition. This essay explores this condition further, offering both critical and affirmative propositions for moving forward. (shrink)

I argue that we should rethink the nature and scope of Spinoza’s “one and the same” relation. Contrary to the standard reading, the nature of this relation is not identity but a union, and its scope includes all idea-object pairs, even God and the idea of God. A crucial reason we should adopt this dual picture is that the idea of God must be one and the same as something found when Nature is conceived under each of the other attributes. (...) If “one and the same” is interpreted as a relation of identity, this requirement cannot be met. However, maintaining that God and the idea of God are one and the same not only fulfills this requirement, but also is independently motivated. I also briefly consider how the thesis that God and the idea of God are one and the same affords us with positive insights concerning the nature of this relation. (shrink)

I hope to open a wider dialogue between process philosophy and feminist spirituality. Process philosophy can help us to articulate the philosophical implications of feminist revisionings of divine power. Feminist spirituality can help us to understand the wider implications of process philosophy's rethinking of finitude, relationship, the body, and nature.

Lest the conjunction seduce readers into supposing that the two are of a piece, we point out that analyses made at the superset level concerning intelligence do not readily align with or outperform the scientific advances made via investigations of reasoning, which at best can be viewed as a subset of intelligent behaviour.

What is truth? Michael Lynch defends a bold new answer to this question. Traditional theories of truth hold that truth has only a single uniform nature. All truths are true in the same way. More recent deflationary theories claim that truth has no nature at all; the concept of truth is of no real philosophical importance. In this concise and clearly written book, Lynch argues that we should reject both these extremes and hold that truth is a functional property. To (...) understand truth we must understand what it does, its function in our cognitive economy. Once we understand that, we'll see that this function can be performed in more than one way. And that in turn opens the door to an appealing pluralism: beliefs about the concrete physical world needn't be true in the same way as our thoughts about matters -- like morality -- where the human stain is deepest. (shrink)

In this paper I examine the concept of cross-temporal personal identity (diachronicity). This particular form of identity has vexed theorists for centuries -- e.g.,how can a person maintain a belief in the sameness of self over time in the face of continual psychological and physical change? I first discuss various forms of the sameness relation and the criteria that justify their application. I then examine philosophical and psychological treatments of personal diachronicity(for example,Locke's psychological connectedness theory; the role of (...) episodic memory) and find each lacking on logical grounds, empirical grounds, or both. I conclude that to achieve a successful resolution of the issue of the self as a temporal continuant we need to draw a sharp distinction between the feeling of the sameness of one's self and the evidence marshaled in support of that feeling. (shrink)

Abstract:This essay develops a dialogue between Zhu Xi's thirteenth-century Neo-Confucian thought and Levinas' twentieth-century Western philosophy, around the notion of interrelatedness between individuals, between self and other. Despite the fact that Zhu Xi and Levinas belong to diff erent cultural universes and to diff erent philosophical spiritualities, and lived in diff erent historical times, they share the same interest in exploring, interpreting, and building interrelatedness, and therefore in ethics and ethical relationships. Through an intertextual and hermeneutical approach, the essay builds (...) a dialogue between diff erent cultural presuppositions underlying the essence of ethics and of ethical relationship: otherness and sameness. This dialogue allows one to become aware of the existence of transcultural concepts such as interrelatedness, and of their diff erent, cross-cultural meanings (e.g., interrelatedness is grounded in "sameness" in Zhu Xi's Confucian context and in "otherness" in Levinas' thought). (shrink)

Recent advances in stem cell research suggest that in the future it may be possible to create eggs and sperm from human stem cells through a process that we term in vitro gametogenesis (IVG). IVG would allow treatment of some currently untreatable forms of infertility. It may also allow same-sex couples to have genetically-related children. For example, cells taken from one man could potentially be used to create an egg, which could then be fertilised using naturally produced sperm from another (...) man to create a genetically-related child with half of its DNA from each of the men. In this chapter, we consider whether this technology could justifiably be denied to same-sex couples if it were made available as a fertility treatment to different-sex couples. We argue that it could not. (shrink)

This article engages the views of PRC Confucian scholars who responded to the United States Supreme Court Justice Anthony Kennedy's citing of Confucius in his majority opinion on same-sex marriage in 2015. It questions their separation of tolerance for homosexuality from legalization of same-sex marriage and argue that tolerance is not enough. The arguments in the mainland Confucian discourse about same-sex marriage highlights the historical and persistent entanglement of Confucianism with patriarchy. Instead of reviving traditional patriarchal society, further entrenching and (...) increasing gender inequality, contemporary Confucianism could shape its own unique modern society that aspires to (and hopefully one day achieving) gender equality together with sexual inclusivity by deconstructing the patriarchal Confucian family and reconstructing a different Confucian family ideal. Accepting same-sex marriage would lend weight to the latter, and there are Confucian reasons for legalizing same-sex marriage and recognizing its ethical value. (shrink)

Background: Existing ethical guidelines recommend that, all else equal, past receipt of a medical resource (e.g. a scarce organ) should not be considered in current allocation decisions (e.g. a repeat transplantation).DiscussionOne stated reason for this ethical consensus is that formal theories of ethics and justice do not persuasively accept or reject repeated access to the same medical resources. Another is that restricting attention to past receipt of a particular medical resource seems arbitrary: why couldn't one just as well, it is (...) argued, consider receipt of other goods such as income or education? In consequence, simple allocation by lottery or first-come-first-served without consideration of any past receipt is thought to best afford equal opportunity, conditional on equal medical need. There are three issues with this view that need to be addressed. First, public views and patient preferences are less ambiguous than formal theories of ethics. Empirical work shows strong preferences for fairness in health care that have not been taken into account: repeated accessto resources has been perceived as unfair. Second, while difficult to consider receipt of many other prior resources including non-medical resources, this should not be used a motive for ignoring the receipt of any and all goods including the focal resource in question. Third, when all claimants to a scarce resource are equally deserving, then use of random allocation seems warranted. However, the converse is not true: mere use of a randomizer does not by itself make the merits of all claimants equal.SummaryMy conclusion is that not ignoring prior receipt of the same medical resource, and prioritizing those who have not previously had access to the medical resource in question, may be perceived as fairer and more equitable by society. (shrink)

Occasions of Identity is an exploration of timeless philosophical issues about persistence, change, time, and sameness. Andre Gallois offers a critical survey of various rival views about the nature of identity and change, and puts forward his own original theory. He supports the idea of occasional identities, arguing that it is coherent and helpful to suppose that things can be identical at one time but distinct at another. Gallois defends this view, demonstrating how it can solve puzzles about persistence (...) dating back to the Ancient Greeks, and investigates the metaphysical consequences of rejecting the necessity and eternity of identities. (shrink)

Molecular vibrations and quantum tunneling may link ligand binding to the function of pharmacological receptors. The well‐established lock‐and‐key model explains a ligand's binding and recognition by a receptor; however, a general mechanism by which receptors translate binding into activation, inactivation, or modulation remains elusive. The Vibration Theory of Olfaction was proposed in the 1930s to explain this subset of receptor‐mediated phenomena by correlating odorant molecular vibrations to smell, but a mechanism was lacking. In the 1990s, inelastic electron tunneling was proposed (...) as a plausible mechanism for translating molecular vibration to odorant physiology. More recently, studies of ligands’ vibrational spectra and the use of deuterated ligand analogs have provided helpful information to study this admittedly controversial hypothesis in metabotropic receptors other than olfactory receptors. In the present work, based in part on published experiments from our laboratory using planarians as an experimental organism, I will present a rationale and possible experimental approach for extending this idea to ligand‐gated ion channels. (shrink)

There are certain traits that make us good human beings by enabling us to realize our natural ends. From the perspective of such a naturalized virtue ethics, there is nothing obviously unethical or imprudent about the capacity for same-sex love. Moreover, given the resources of this theory, such questions are empirical ones. If the capacity for same-sex love is a trait the possession of which makes one a good human being, then the just state will promote and encourage it, or (...) at least not stand in its way. It can do so by allowing same-sex marriage. (shrink)

Explores the development of Chinese thought, highlighting its concern with questions of coherence. Providing a bracing expansion of horizons, this book displays the unsuspected range of human thinking on the most basic categories of experience. The way in which early Chinese thinkers approached concepts such as one and many, sameness and difference, self and other, and internal and external stand in stark contrast to the way parallel concepts entrenched in much of modern thinking developed in Greek and European thought. (...) Brook Ziporyn traces the distinctive and surprising philosophical journeys found in the works of the formative Confucian and Daoist thinkers back to a prevailing set of assumptions that tends to see questions of identity, value, and knowledge—the subject matter of ontology, ethics, and epistemology in other traditions—as all ultimately relating to questions about coherence in one form or another. Mere awareness of how many different ways human beings can think and have thought about these categories is itself a game changer for our own attitudes toward what is thinkable for us. The actual inhabitation and mastery of these alternative modes of thinking is an even greater adventure in intellectual and experiential expansion. Brook Ziporyn is Professor of Chinese Philosophy, Religion, and Comparative Thought at the University of Chicago Divinity School and Visiting Professor of Philosophy at the National University of Singapore. His books include The Penumbra Unbound: The Neo-Taoist Philosophy of Guo Xiang, also published by SUNY Press. (shrink)

Supporters of Justificatory Liberalism (JL)—such as John Rawls and Gerard Gaus—typically maintain that the state may not coerce its citizens on matters of constitutional essentials unless it can provide public justification that the coerced citizens would be irrational in rejecting. The state, in other words, may not coerce citizens whose rejection of the coercion is based on their reasonable comprehensive doctrines (i.e., worldviews). Proponents of the legal recognition of same-sex marriage (SSM) usually offer some version of JL as the most (...) fundmental reason why laws that recognize marriage only if it is a union between one man and one woman are unjust. In this article I argue that the application of JL in support of legal recognition of SSM does not succeed because the issue under scrutiny—the nature of marriage—is deeply embedded in, and in most cases integral to, many (if not most) citizens’ reasonable comprehensive doctrines. Thus, I argue that because of the effects and consequences of the legal recognition of SSM, it results (or will result) in a violation of JL against dissenting citizens. (shrink)

Alain Locke, an often neglected classical American Pragmatist, developed a pluralistic value theory as an antidote to the "value absolutism" he considered the root cause of social conflict. Values, for Locke, are not immutable features of a transcendent reality, but rather emerge from human functional attitudes, or what he calls "feeling-modes." However incommensurable the contextualized values of diverse cultures may appear, they can always be traced back to common modes of valuing. Recognizing the common character of our human faculty of (...) valuation allows us to see a basic functional equivalence among superficially conflicting values, thus undermining value absolutism. This paper suggests that one reason the debate over same-sex marriage in the United States has persisted is that the arguments have been advanced primarily in absolute value terms. Re-casting the debate in terms of a Lockean pluralistic value dialogue suggests a path out of the stalemate. (shrink)

What is truth? Michael Lynch defends a bold new answer to this question. Traditional theories hold that all truths are true in the same way. More recent theories claim that the concept of truth is of no real importance. Lynch argues against both these extremes: truth is a functional property whose function can be performed in more than one way.

Previous research indicates that Euro-American women are more upset by imagining their male partners committing homosexual infidelities than heterosexual ones. The present studies sought to replicate these findings and extend them to two non-Western cultures wherein masculine men frequently engage in sexual interactions with feminine third-gender males. Across six studies in three cultural locales, women were asked to rate their degree of upset when imagining that their partner committed infidelity that was heterosexual in nature, as well as infidelity that was (...) homosexual. In two Canadian undergraduate samples, women reported greater upset at imagining partner infidelity with a female, whereas a community sample of middle-aged women reported equal upset across infidelity types. Samoan women reported substantially less upset at the thought of partner infidelity with a third-gender male than with a female. Istmo Zapotec women reported equal upset toward infidelity with a female or a third-gender male, whereas a second Zapotec sample reported slightly greater upset at the thought of infidelity with a muxe. Results illustrate how cultural contexts moderate the degree to which same-sex infidelity scenarios are upsetting to women. (shrink)