G protein‐coupled receptors (GPCRs) are the largest family of transmembrane receptors and primarily signal through two main effector proteins: G proteins and β‐arrestins. Many agonists of GPCRs promote “biased” responses, in which different cellular signaling pathways are activated with varying efficacies. The mechanisms underlying biased signaling have not been fully elucidated, with many potential “hidden variables” that regulate this behavior. One contributor is “location bias,” which refers to the generation of unique signaling cascades from a given GPCR depending (...) upon the cellular location at which the receptor is signaling. Here, we review evidence that GPCRs are expressed at and traffic to various subcellular locations and discuss how location bias can impact the pharmacologic properties and characterization of GPCR agonists. We also evaluate how differences in subcellular environments can modulate GPCR signaling, highlight the physiological significance of subcellular GPCR signaling, and discuss the therapeutic potential of exploiting GPCR location bias. (shrink)

This dissertation is about prejudice. In particular, it examines the theoretical and ethical questions raised by research on implicit social biases. Social biases are termed "implicit" when they are not reported, though they lie just beneath the surface of consciousness. Such biases are easy to adopt but very difficult to introspect and control. Despite this difficulty, I argue that we are personally responsible for our biases and obligated to overcome them if they can bring harm to ourselves or to others. (...) My dissertation addresses the terms of their removal. It is grounded in a comprehensive examination of empirical research and, as such, is a contribution to social psychology. Although implicit social biases significantly influence our judgment and action, they are not reducible to beliefs or desires. Rather, they constitute a class of their own. Understanding their particular character is vital to determining how to replace them with more preferable habits of mind. I argue for a model of interpersonal fluency, a kind of ethical expertise that requires transforming our underlying dispositions of thought, feeling, and action. (shrink)

Our understanding of implicit bias and how to measure it has yet to be settled. Various debates between cognitive scientists are unresolved. Moreover, the public’s understanding of implicit bias tests continues to lag behind cognitive scientists’. These discrepancies pose potential problems. After all, a great deal of implicit bias research has been publicly funded. Further, implicit bias tests continue to feature in discourse about public- and private-sector policies surrounding discrimination, inequality, and even the purpose of science. (...) We aim to do our part by reconstructing some of the recent arguments in ordinary language and then revealing some of the operative norms or values that are often hidden beneath the surface of these arguments. This may help the public learn more about the science of implicit bias. It may also help both laypeople and scientists reflect on the values, interests, and stakeholders involved in establishing, justifying, and communicating scientific research. (shrink)

‘Unconscious bias happens by our brains making incredibly quick judgements and assessments without us realising. Biases are influenced by background, cultural environment and experiences and we may not be aware of these views and opinions, or of their full impact and implications. This article opposes this point of view by arguing that bias is not unconscious but is conscious and linked to Charles Mills’ ‘Racial Contract’ and its ‘epistemologies of ignorance’. These epistemologies emerge from what the Equality Challenge (...) Unit calls ‘our background, cultural environment and personal experience’. Asserting that racism stems from ‘unconscious bias’ diminishes white supremacy and maintains white innocence as a ‘will to forget’ institutional racism. In equality and diversity training ‘unconscious bias’ has become a performative act to move beyond racism through training to participate in a constructed ‘post-racial’ reality. The article argues that through decolonizing ‘unconscious bias’, ‘white fragility’ and ‘self-forgiveness’ we can begin to see hidden institutional whiteliness at the base of conscious bias. (shrink)

The scientist’s toolkit counts at least three practices: real, thought and numerical experiments. Although a deep investigation of the relationships between these types of experiments should shed light on the nature of scientific enquiry, I argue that it has been compromised by at least four factors: (i) a bias for the epistemological superiority of real experiments; (ii) an almost exclusive focus on the links between either thought or numerical experiments, and real experiments; (iii) a tendency to try and reduce (...) one kind to another; and (iv) an excessive attention to the outputs of these types of experiments, more than to their processes. In this paper I support an unbiased triangular comparative analysis that focuses on the processes involved in real, thought and numerical experiments, and claim that all three types of experimentation are fundamental to scientific research. I do so by clarifying different notions of experimental processes, and by introducing a distinction between two varieties of mental simulation that play a role in them (i.e., mental models and imaginings). I then compare real, thought and numerical experiments in light of this distinction, showing their similarities, but also fundamental differences, which suggest that none of them is dispensable. (shrink)

A self-fulfilling prophecy in neuroprognostication occurs when a patient in coma is predicted to have a poor outcome, and life-sustaining treatment is withdrawn on the basis of that prediction, thus directly bringing about a poor outcome for that patient. In contrast to the predominant emphasis in the bioethics literature, we look beyond the moral issues raised by the possibility that an erroneous prediction might lead to the death of a patient who otherwise would have lived. Instead, we focus on the (...) problematic epistemic consequences of neuroprognostic SFPs in settings where research and practice intersect. When this sort of SFP occurs, the problem is that physicians and researchers are never in a position to notice whether their original prognosis was correct or incorrect, since the patient dies anyway. Thus, SFPs keep us from discerning false positives from true positives, inhibiting proper assessment of novel prognostic tests. This epistemic problem of SFPs thus impedes learning, but ethical obligations of patient care make it difficult to avoid SFPs. We then show how the impediment to catching false positive indicators of poor outcome distorts research on novel techniques for neuroprognostication, allowing biases to persist in prognostic tests. We finally highlight a particular risk that a precautionary bias towards early withdrawal of life-sustaining treatment may be amplified. We conclude with guidelines about how researchers can mitigate the epistemic problems of SFPs, to achieve more responsible innovation of neuroprognostication for patients in coma. (shrink)

The author stands that thinking by analogy is a natural instrument human have because of the mirror neurons in our brain. However, is it that infallible to rely on? How can we be sure that our hidden biases will not harm our reflections? Implicit Association Bias (IAB), for instance, is a powerful intruder that affects our understanding, actions, and decisions on the unconscious level by cherishing the stereotypes based on specific characteristics such as ethnicity, sex, race, and so (...) on. To check if there is a correlation between the IAB effect and the people’s capacity to reason logically, the author had created an online-survey. The focus was on analogical reasoning and IAB tests concerning the question of gender equality in science and everyday life and age prejudices. (shrink)

Grounded in evidence-based cognitive behavioral therapy (CBT), The Blindspots Between Us reveals the most common "hidden" biases that blind us to the truth, and which lead to misunderstandings and damaged relationships. Using this guide, readers will learn to identify their own blindspots, and move beyond them for better relationships-and a better world.

In order to revise interpretive prejudgments, it is important to first recognize them for what they are. Problematically, the habitual overreliance on deficient prejudgments can make such recognition difficult. An impasse appears: How can one intervene on deficient interpretive resources if those very same resources conceal their deficiencies? I analyze James Joyce’s short story “The Dead,” in which the protagonist Gabriel is highly resistant to internalizing experiences that might otherwise prompt him to revise his interpretive projections. I argue that Gabriel (...) only becomes aware of his interpretive shortcomings after an experience of profound hesitation that allows him to affectively sense the limitations of his prejudice. Drawing from Hans-Georg Gadamer, Kristie Dotson, and Alia Al-Saji, I argue that Gabriel’s experience of hesitation temporarily denaturalizes his deeply entrenched sexism, circumventing the hermeneutical impasse described above. Read in this way, “The Dead” illustrates the power of affective experiences to unsettle highly resilient ways of seeing the world. (shrink)

How can self-deception avoid intention and conscious recognition? Nine processes of self-deception seem to involve biased links between plausible ideas. These processes allow self-deceivers to regard individual conclusions as fair and reasonable. Bias is only detected by comparing broad patterns, which individual self-deceivers will not do.

Material culture, strictly speaking, is substance culture. Nevertheless, studies on material culture are almost exclusively concerned with things. The specificities in the perception of substances and the related everyday practices are rarely taken into consideration. Although this can be explained by the history of anthropology, the bias towards associating material culture with “formed matter” is a foundational shortcoming. In consequence, particular perspectives on the material remain understudied, and the cultural relevance of substances as such is rarely taken into consideration. (...) Taking a perspective grounded in anthropology and phenomenology, this article intends to provide new approaches to substances that elucidate the particular modes of their perception, reveal their characteristics and reflect on particular notions implicit to substances. The final section of this contribution discusses two exemplary studies on substances and proposes transformation and incorporation as new fields of research that would contribute to a more explicit engagement with substances in material culture studies. (shrink)

Recent events around the world point to the dire need to counter harmful unconscious bias. Reams of evidence now exists that literal pre-judgement in regards to race, sex, ethnicity, age and religion among other categories strongly affects our behaviour in ways that when we consciously contemplate it, we would condemn. Using Community of Inquiry methods in developing critical reasoning and empathy offer some possible remedies but also hold pitfalls. The dilemma concerns the fact that if harmful unconscious connotative representations (...) are unconscious, then it’s terribly hard to spot and correct them. We need a better way of exploring our own poorly-arrived at beliefs: we need other people. Mikhail Bakhtin’s notion of dialogic understanding allows meaning to be created through the process of discussion. It gets particularly interesting when this idea combines with the notion of a “floating signifier.” This suggests that a discussion could then also alter the connotative value of words, signs and concepts through making what had been hidden overt. This paper explores the ways that the dilemma of damaging discourse could be altered and strategies for interrupting this, including the format of a Community of Inquiry. The promise offered by a Community of Inquiry is that connotative meanings can be made explicit. It also points to the challenge: unveiling hidden bias only becomes possible in a setting of great diversity. In the end, while a Community of Inquiry may not be able to solve the problem of unconscious bias, it may help combat the consequences. (shrink)

Recent events around the world point to the dire need to counter harmful unconscious bias. Reams of evidence now exists that literal pre-judgement in regards to race, sex, ethnicity, age and religion among other categories strongly affects our behaviour in ways that when we consciously contemplate it, we would condemn. Using Community of Inquiry methods in developing critical reasoning and empathy offer some possible remedies but also hold pitfalls. The dilemma concerns the fact that if harmful unconscious connotative representations (...) are unconscious, then it’s terribly hard to spot and correct them. We need a better way of exploring our own poorly-arrived at beliefs: we need other people. Mikhail Bakhtin’s notion of dialogic understanding allows meaning to be created through the process of discussion. It gets particularly interesting when this idea combines with the notion of a “floating signifier.” This suggests that a discussion could then also alter the connotative value of words, signs and concepts through making what had been hidden overt. This paper explores the ways that the dilemma of damaging discourse could be altered and strategies for interrupting this, including the format of a Community of Inquiry. The promise offered by a Community of Inquiry is that connotative meanings can be made explicit. It also points to the challenge: unveiling hidden bias only becomes possible in a setting of great diversity. In the end, while a Community of Inquiry may not be able to solve the problem of unconscious bias, it may help combat the consequences. (shrink)

For centuries, religion and philosophy have been the primary basis for efforts to guide humans to be more ethical. However, training in ethics and religion and imparting positive values and morality tests such as those emanating from the categorical imperative and the Golden Rule have not been enough to protect humankind from its bad behaviors. To improve ethics education educators must better understand aspects of human nature such as those that lead to “self-deception” and “personal bias.” Through rationalizations, faulty (...) reasoning and hidden bias, individuals trick themselves into believing there is little wrong with their own unethical behavior. The application of science to human nature offers the possibility of improving ethics education through better self-knowledge. The author recommends a new paradigm for ethics education in contemporary modern society. This includes the creation of a new field called “applied evolutionary neuro-ethics” which integrates science and social sciences to improve ethics education. The paradigm can merge traditional thinking about ethics from religious and philosophical perspectives with new ideas from applied evolutionary neuro-ethics. (shrink)

The rational status of the Bayesian calculus for revising likelihoods is compromised by the common but still unfamiliar phenomenon of information distortion. This bias is the distortion in the evaluation of a new datum toward favoring the currently preferred option in a decision or judgment. While the Bayesian calculus requires the independent combination of the prior probability and a new datum, information distortion invalidates such independence (because the prior influences the datum). Although widespread, information distortion has not generally been (...) recognized. First, individuals are not aware when they themselves commit this bias. In addition, it is often hidden in more obvious suboptimal phenomena. Finally, the Bayesian calculus is usually explained only with undistortable data like colored balls drawn randomly. Partly because information distortion is unrecognized by the individuals exhibiting it, no way has been devised for eliminating it. Partial reduction is possible in some situation such as presenting all data simultaneously rather than sequentially with revision after each datum. The potential dangers of information distortion are illustrated for three professional revision tasks: forecasting, predicting consumer choices from internet data, and statistical inference from experimental results. The optimality of the Bayesian calculus competes with people’s natural desire that their belief systems remain coherent in the face of new data. Information distortion provides this coherence by biasing those data toward greater agreement with the currently preferred position – but at the cost of Bayesian optimality. (shrink)

We propose that human reasoning relies on an inherence heuristic, an implicit cognitive process that leads people to explain observed patterns (e.g., girls wear pink) in terms of the inherent features of their constituents (e.g., pink is an inherently feminine color). We then demonstrate how this proposed heuristic can provide a unified account for a broad set of findings spanning areas of research that might at first appear unrelated (e.g., system justification, nominal realism, is–ought errors in moral reasoning). By revealing (...) the deep commonalities among the diverse phenomena that fall under its scope, our account is able to generate new insights into these phenomena, as well as new empirical predictions. A second main goal of this paper, aside from introducing the inherence heuristic, is to articulate the proposal that the heuristic serves as a foundation for the development of psychological essentialism. More specifically, we propose that essentialism—which is the common belief that natural and social categories are underlain by hidden, causally powerful “essences”—emerges over the first few years of life as an elaboration of the earlier, and more open-ended, intuitions supplied by the inherence heuristic. In the final part of the paper, we distinguish our proposal from competing accounts (e.g., Strevens' K-laws) and clarify the relationship between the inherence heuristic and related cognitive tendencies (e.g., the correspondence bias). In sum, this paper illuminates a basic cognitive process that emerges early in life and is likely to have profound effects on many aspects of human psychology. (shrink)

Participants maneuvered a rat image through a circular region on the computer screen to find a hidden target platform, blending aspects of two well-known spatial tasks. Like the Morris water maze task, participants first experienced a series of learning trials before having to navigate to the hidden target platform from different locations and orientations. Like the dot-location task, they determined the location of a position within a two-dimensional circular region. This procedure provided a way to examine how the (...) number of surrounding cues (1, 2, or 3) affects the memory for spatial location in navigation. Memory performance was better when there were more cues and when targets were close to cues, consistent with the idea that cues bolster fine-grain memory, especially in proximal regions. Early and late measures of bias in memory reflected biases in a direction toward the nearest cue, implicating a cue-based category structure of the navigational space. Collectively, results suggest cue-based spatial memory representations that have been inferred from the dot-location task generalize to a navigation task within a simple, computer-based environment, as demonstrated by the good fits of the spatial model developed for the dot-location task (Fitting, Wedell, & Allen, 2005, 2007). (shrink)

Open-mindedness appears as a potential intellectual virtue from the beginning of the rise of the literature on intellectual virtues. It often takes up a special role, sometimes thought of as a meta-virtue rather than a first-order virtue: as an ingredient that makes other virtues virtuous. Jason Baehr has attempted to give a unified account of open-mindedness as an intellectual virtue. He argues that the conceptual core of open-mindedness lies in the fact that a person departs, moves beyond, or transcends a (...) certain default cognitive standpoint. Two of his main aims are to show that (1) one does not need to assume a doxastic conflict or disagreement to be at the heart of open-mindedness—that is, there are also instances where the virtue of open-mindedness is needed when there is no opposing view to be considered—and (2) that not all forms of open-mindedness include rational assessment—that is, sometimes being open-minded is not about weighing evidence for and against a claim. So, his main aim is to show that there are various situations that afford open-mindedness, in each of which a slightly different kind of open-mindedness is called for. To unify all these different kinds of open-mindedness is then the goal of his work. He arrives at the following definition of open-mindedness (OM): an open-minded person is characteristically (a) willing and (within limits) able (b) to transcend a default cognitive standpoint (c) in order to take up or take seriously the merits of (d) a distinct cognitive standpoint. In this article, I take seriously Baehr’s suggestion of how to understand open-mindedness as an intellectual virtue and argue that the crux lies in formulating how we can be able to transcend a default cognitive standpoint. This is not as obvious as it has been taken to be in the literature on open-mindedness. Biases, overconfidence, and wishful thinking are difficult exactly because we don’t know that we are engaging in them. That is, they are systematically hidden from our consciousness, otherwise they would not be a bias, overconfidence, or wishful thinking. Hence, the crux of making open-mindedness open-minded is to see how it is possible to make something of one’s own mind visible that is systematically hidden from oneself. I argue that this problem can be solved by looking at research on attention. I base my considerations in this article on Sebastian Watzl’s account of attention, which essentially holds that paying attention is an activity of foregrounding and backgrounding mental contents. That is, attention is the activity of structuring mental contents into a priority structure of foreground and background. If I pay attention to the scene in front of me, I foreground the black letters on my screen, and I background the coffee cup next to them. In this way, I create a priority structure between the letters (as they appear to me) and the coffee cup (as it appears to me). I argue that what allows us to make something of our own mind visible that is systematically hidden from us is a special way of paying attention, hence a special way of foregrounding and backgrounding the involved mental contents. That is, the crux of what enables us to transcend a default cognitive standpoint, the conceptual core of open-mindedness, is a special kind of attention, which I will call ‘open-minded attention’ (OMA). The claim of this article is not that open-minded attention fully describes the virtue of open-mindedness (OMA is not sufficient for open-mindedness). Rather, what I try to show is that in all cases of open-mindedness it turns out that open-minded attention is the necessary component that ensures that we can indeed get rid of prior biases, that is, transcend also those implicit beliefs and expectations that are systematically hidden from us (OMA is necessary for open-mindedness). (shrink)

Slife and Reber accuse psychology of harboring a hidden, albeit unintentional, bias against theism in violation of the spirit of the American Psychological Association Council of Representatives resolution on religious prejudice. However, they are mistaken in categorizing a bias against theism in psychological research and theory as religious prejudice. Moreover, their discussion of religious prejudice morphs into promotion of Christian theology. 2012 APA, all rights reserved).

Patina is the word used for the green or brown film formed on the surface of old bronze, an excess of which can mask the true characteristics of the original masterpiece. Filippo Baldinucci used the word patina in a modern sense for first time in his book “Tuscan Vocabulary of the Art of Design”. Metaphors have been part of philosophical speech since the time of Plato. This figure of speech is used to attempt to provide a sensitive presence of an (...) idea to improve understanding and to make a more vivid perception of that concept. On analysing the creative process of contemporary re-search on health topics and its further dissemination, we defend the epistemological thesis that there is always some degree of patina on an original article and this may obscure the underlying scientific work. Conclusion: We consider that patina in scientific papers is very different from the concept of epidemiological bias. We think that any researcher who reads an original article acts as a restorer of knowledge. If a reader is aware of the existence of scientific patina, that reader will know how to look through it and see the masterpiece hidden underneath. (shrink)

When making decisions, humans can observe many kinds of information about others' activities, but their effects on performance are not well understood. We investigated social learning strategies using a simple problem-solving task in which participants search a complex space, and each can view and imitate others' solutions. Results showed that participants combined multiple sources of information to guide learning, including payoffs of peers' solutions, popularity of solution elements among peers, similarity of peers' solutions to their own, and relative payoffs from (...) individual exploration. Furthermore, performance was positively associated with imitation rates at both the individual and group levels. When peers' payoffs were hidden, popularity and similarity biases reversed, participants searched more broadly and randomly, and both quality and equity of exploration suffered. We conclude that when peers' solutions can be effectively compared, imitation does not simply permit scrounging, but it can also facilitate propagation of good solutions for further cumulative exploration. (shrink)

A journey into the hidden psychological influences that derail our decision-making. Why is it so difficult to end a doomed relationship? Why do we listen to advice just because it came from someone "important"? Why are we more likely to fall in love when there's danger involved? Here, organizational thinker Ori Brafman and his brother, psychologist Rom Brafman, answer these questions and more. Drawing on research from the fields of social psychology, behavioral economics, and organizational behavior, Sway reveals forces (...) that influence every aspect of our personal and business lives, including loss aversion, the diagnosis bias, and the "chameleon effect." The Brafmans not only uncover rational explanations for a wide variety of irrational behaviors, but also point readers toward ways to avoid succumbing to their pull.--From publisher description. (shrink)

The subject of this study is the problem of the failure of attempts by the scientific community to come to a common understanding of what exactly information can be as something encoded into material structures and moved along with them. At the same time, the following aspects of this problem are considered in detail: what is the immediate cause of the information problem; what are the objective and subjective prerequisites for its appearance; why the unresolved nature of this problem does (...) not interfere with the creation and development of communication systems, control and other "smart" devices; is there any general guideline for finding solutions to such problems, and what is it; what role did the philosophy of information play in turning the problem of information from a private scientific problem into a problem of the ideological level. The main results of the conducted research are as follows: the immediate cause of the information problem has been identified and a comprehensively substantiated solution to this problem has been given; it has been revealed that the incompleteness of the materialistic theory of cognition has become a fertile ground for the appearance of this problem; the circumstances that prevented its completion have been identified; the natural mechanism of control and cognition has been revealed, as a result of which the materialistic theory of cognition has been further developed the source of the ideal in the material world is revealed; it is shown that the mechanistic idea of information coding made the concept of information incompatible with the presence of any objective content; it is revealed what is actually hidden behind the words about information coding and its measurement; the nature of signals and signs is revealed; a kind of bias of the philosophy of information and a general error is revealed all known concepts of information. (shrink)

The purpose of cultural competence education for medical professionals is to ensure respectful care and reduce health disparities. Yet as Berger and Miller (2021) show, the cultural competence framework is dated, confused, and self-defeating. They argue that the framework ignores the primary driver of health disparities—systemic racism—and is apt to exacerbate rather than mitigate bias and ethnocentrism. They propose replacing cultural competence with a framework that attends to two social aspects of structural inequality: health and social policy, and institutional-system (...) activity; and two psychological aspects of structural inequality: the clinical encounter, and the epistemic. -/- We agree with the structural approach. To that end, we think it would be fruitful to include attention to physical contributors to structural inequality, namely the material artifacts used in medicine. Devices, tools, and technologies can materialize biases, perpetuate oppression, and contribute to health disparities. Granted, not everything that interests philosophers can be squeezed into medical education. Nevertheless, there are compelling reasons for including the study of material artifacts in education designed to reduce health disparities. First, devices and tools often carry forward biases from the past, and keep biases hidden from plain sight. Second, by studying these artifacts, future clinicians can begin to see themselves as part of a larger sociotechnical system. Finally, as medicine becomes increasingly tech-laden, it’s important for clinicians to see how material artifacts (including algorithms) connect individuals to structures. This will help to undermine oversimplified narratives according to which objective tools and technologies can correct for the bias and subjectivity of flawed human beings. (shrink)

There is a long history of women being underrepresented in biomedical and health research. Specific women’s health needs have been, and in some cases still are, comparatively neglected areas of study. Concerns about the health and social impacts of such bias and exclusion have resulted in inclusion policies from governments, research funders, and the scientific establishment since the 1990s. Contemporary understandings of foregrounding sex and gender issues within biomedical research range from women’s rights to inclusion, to links between human (...) rights, women’s health and sustainable development, and the increasing scientific and funding expectation for studies to consider the sex and gender implications of research design, results and impact. However, there are also exploitation issues to consider when foregrounding the inclusion of women as research participants, especially for research ethics committees and institutional review boards. A hidden risk is that exploitative research designs and practices may be missed, particularly by reviewers who may not have a nuanced understanding of gender-based harm. Utilizing contemporary case studies of ethics dumping, this paper highlights some of the concerns, and makes recommendations for IRBs/research ethics reviewers to help ensure that essential research is undertaken to the highest ethical standards. (shrink)

Freud and the Politics of Psychoanalysis is a sympathetic critique of Freud's work, tracing its political content and context from his early writings on hysteria to his late essays on civilization and religion. Brunner's central claim is that politics is a pervasive and essential component of all of Freud's discourse, since Freud viewed both the psyche and society primarily as constellations of power and domination. Brunner shows that when read politically, Freud's discourse can be seen to unite mechanics and meaning (...) into a plausible, fruitful and internally consistent theory of the mind, therapy, family and society. Part one deals with the medical and political background of Freud's work. It explains how Freud postulated mental principles that were the same for all races and nations. The second part is concerned with the logic and language of Freud's theory of the mind. Brunner also details how Freud introduced dynamics of dominance and subjugation into the very core of the psyche. Part three addresses dynamics of power in the clinical setting, which Freud forged out of a curious blend of authoritarian and liberal elements. Brunner focuses on how this setting creates an arena for verbal politics. He also examines various social factors that influenced the therapeutic practice of psychoanalysis, such as class, gender and education. Part four explores Freud's analysis of the family and large-scale social institutions. Though Brunner is critical of the authoritarian bias in Freud's social theory, he suggests that it provides a useful vocabulary to unmask hidden psychological aspects of domination and subjection. (shrink)

Research on moral disgust suffers from a methodological bias. The bulk of such investigation focuses almost exclusively on the operation of moral disgust within the psychology of a single individual, or as involving an interaction between two people. This leads to certain questions being salient, while other phenomena, which emerge only at the level of an entire community or society, are largely hidden from view. The present paper explains and defends a perspective that emphasizes the role of moral (...) disgust within a community. It also illustrates the usefulness of this perspective by applying it to three quite distinct accounts of moral disgust: Alexandra Plakias’s response model of moral disgust, David Pizarro’s idea that moral disgust is part of a behavioral immune system, and Jesse Prinz’s self‐consciously simple form of moral sentimentalism. (shrink)

Extreme Learning Machine is widely used in various fields because of its fast training and high accuracy. However, it does not primarily work well for Domain Adaptation in which there are many annotated data from auxiliary domain and few even no annotated data in target domain. In this paper, we propose a new variant of ELM called Discriminative Extreme Learning Machine with Cross-Domain Mean Approximation for unsupervised domain adaptation. It introduces Cross-Domain Mean Approximation into the hidden layer of ELM (...) to reduce distribution discrepancy between domains for domain bias elimination, which is conducive to train a high accuracy ELM on annotated data from auxiliary domains for target tasks. Linear Discriminative Analysis is also adopted to improve the discrimination of learned model and obtain higher accuracy. Moreover, we further provide a Discriminative Kernel Extreme Learning Machine with Cross-Domain Mean Approximation as the kernelization extension of DELM-CDMA. Some experiments are performed to investigate the proposed approach, and the result shows that DELM-CDMA and DKELM-CDMA could effectively extend ELM suitable for domain adaptation and outperform ELM and many other domain adaptation approaches. (shrink)

Objectives: To determine whether authors of scientific publications in molecular biology declare patents and other potential financial interests.Design: Survey of a 6-month sample of papers related to molecular biology in Nature.Methods: The esp@cenet worldwide patent search engine was used to search for patents applied for by the authors of scientific papers in Nature that were related to molecular biology and genetics, between January and June 2005.Results: Of the 79 papers considered, four had declared that certain authors had competing financial interests. (...) Seven papers in which no financial interests were declared had authors with patent applications that were based on the research in the paper or were closely related to it. Another paper had two authors with connections to biotechnology companies that were not disclosed.Conclusion: Two thirds of the papers in which authors had patent applications or company affiliations that might be considered to be competing financial interests did not disclose them. Failure to disclose such information may have negative implications on the perception of science in society and on its quality if the possible bias is hidden. Journals should make greater efforts to ensure full disclosure, and scientific institutions should consider failure to disclose financial interests as an example of scientific malpractice. Establishing a register of interests for scientists is one way to increase transparency and openness. (shrink)

There is much evidence, both in humans and rodents, that while navigating males tend to use geometric information whereas females rely more on landmarks. The present work attempts to alter the geometry bias in female rats. In Experiment 1 three groups of female rats were trained in a triangular-shaped pool to find a hidden platform, whose location was defined in terms of two sources of information, a landmark outside the pool and a particular corner of the pool. On (...) a subsequent test trial with the triangular pool and no landmark, females with prior experience with two other pool shapes–with a kite-shaped pool and with a rectangular-shaped pool, were significantly more accurate than control rats without such prior experience. Rats with a short previous experience–with the rectangular-shaped pool only did not differ from Group NPE. These results suggest that the previous experience with different shaped-pools could counteract the geometry bias in female rats. Then, Experiment 2A directly compared the performance of LPE males and females of Experiment 1, although conducting several test trials. The differences between males and females disappeared in the three tests. Moreover, in a final test trial both males and females could identify the correct corner in an incomplete pool by its local, instead of global, properties. Finally, Experiment 2B compared the performance of NPE rats, males and females, of Experiment 1. On the test trial with the triangular pool and no landmark, males were significantly more accurate than females. The results are explained in the framework of selective attention. (shrink)

Economics is often believed to be a `value-free' discipline, and even an `a-moral' one. My aim is to demonstrate that homo œconomicus can recover his ethical nature if the philosophical roots of contemporary economics are laid bare. This, however, requires us to look for an alternative foundation for the idea of `social order,' a foundation which economics is ill-equipped to provide because of its exclusive focus on calculative rationality. But a new ethical perspective on homo œconomicus and on the manner (...) in which he chooses his actions is possible. My aim here is to make this new perspective explicit.Two claims lie at the heart of this paper. The first claim is that economics as practised nowadays — that is, as a discipline concerned with the analysis of the interactions between individual decisions and the collective effects of these interactions — is a particular form of metaphysics, based on a particular articulation between self-centredness and other-centredness. The second claim is that, unbeknownst to the vast majority of economists, the basic principle of individual optimization contains the seed of a radical reformulation of what the emergence of `social order' is all about. More specifically, economics will be claimed to be a specific metaphysical discipline based on the monadological worldview inherited from Leibniz and re-arranged to fit the empiricist bias of 18th-century thinkers, and the principle of individual optimization will be claimed to be compatible with a very different metaphysical view of the human subject, a view which `turns subjectivity inside out', so to speak, and treats optimizing calculation as a response rather than as an initiative.The first claim is rather general, and not completely new — it has been hinted at, for example, by Jon Elster in an early book written in French, but it has received precious little attention among economists so far, with the result that economics has become increasingly blind to the philosophical roots of its most fundamental views on individual decision and on social order. The second claim applies to economics and homo œconomicus a general suggestion coming from Alain Renaut, that we ought to make good use of the accusations of incoherence voiced against the monadological scheme in order to re-think the way in which human subjectivity works. Renaut, however, remains at the level of the history of the philosophical concept of subjectivity. Although he does, in passing, make some mention of possible implications for the social sciences, he never goes into the full analysis of what the critique of monadological metaphysics implies for modern theories of society, and for economics in particular. One of my main goals here is to fill this gap.Let me now be more specific about the steps of my analysis. Defending my two claims will require, first of all, a rigorous understanding of the basic methodological stance adopted by economics, namely the idea that social order `emanates' from a bunch of self-centred subjectivities making separate optimizing decisions. Accordingly, in Section 2, I will trace out the analogy that exists between Leibnizian monadology and modern-day economics. The aim there will be to show that economics, unwittingly but for nevertheless deep ethical reasons, has remained `stuck' in a very specific metaphysical position which virtually no contemporary philosophy of subjectivity any longer acknowledges. Section 3, then, will show how the combination of monadology and empiricism which still prevails in contemporary economics can be overcome by entering an altogether distinct philosophical domain characterized by the primacy of Other over Self.While this alternative philosophical stance has experienced a surge of interest in recent decades, it has left the social sciences, and particularly economics, completely untouched. The reason is, I will claim, that this strand of philosophy adopts a form of methodological altruism which stands in contrast both to the methodological individualism of economics and to the methodological holism of various strands of post-Durkheimian sociology. In Section 4, then, I analyze some of the far-reaching consequences for economics which would flow from taking into account `non-I' motives which are not `We' motives, i.e., motives for action which are neither mere holist pastings onto individualism nor mere individualist mitigations of holism.The principle of choice of action through individual optimization will appear as the `hinge' between two worlds: although initially anchored within a worldview where social coexistence is a by-product of individual calculations, the idea of optimization will be seen to be compatible with a very different, and indeed almost reversed worldview, one where individual calculations emerge as by-products of social coexistence — the term `social' being itself radically re-thought in a non-holistic direction.The aim of my analysis, ultimately, is to formulate a challenge for contemporary economics and its implicit view of the interaction between individual and society: Can the combination of monadological and empiricist thinking so strongly ingrained in economics be overcome in the direction of a radically `other-oriented' view of the human subject? Many economists will doubtless believe it cannot; however, they will now, at least, have to explain why they hold to the older view and hence they will have to uncover their often hidden ethical and metaphysical presuppositions. I view this not as an undue disturbance or as mere conceptual hair-splitting, but as a timely opportunity to clarify some deep philosophical issues which haunt economics. (shrink)

The focus of this Perspective article is on the comparison of two of the most popular initial applicant screening methods: Resumes and application forms. The viewpoint offered is that application forms are superior to resumes during the initial applicant screening stage of selection. This viewpoint is supported in part based on criterion-related validity evidence that favors application forms over resumes. For example, the biographical data inventory, which can contain similar questions to those used in application forms, is one of the (...) most valid predictors of job performance, whereas job experience and years of education, which are often inferred from resumes and cover letters, are two of the least valid predictors of job performance. In addition to validity evidence, making decisions based on application forms as opposed to resumes is likely to help organizations defend against claims of discriminatory hiring while enhancing their ability to hire in a more diverse, equitable, and inclusive manner. For example, applicant names on resumes can lead to screening bias against members of identifiable subgroups, whereas an applicant’s name can be easily and automatically hidden from decision-makers when reviewing application forms. Despite these convincing arguments focused on applicant quality and diversity, a substantial research–practice gap regarding the use of resumes and cover letters remains. (shrink)

Although these authors sometimes resort to medical terminology, we strongly agree that addiction is not a disease and that the Brain Disease Model of Addiction captures only one part of the story and distorts the big picture. Yet Satel and Lilienfeld continue to conflate a neurobiological model with a disease model. They also complain that my modeling of addiction reveals a hidden “neurocentric” bias, despite my integration of multiple levels of analysis, exactly as they recommend.

Jeff Nisker describes his personal experience of a diagnosis of advanced prostate cancer and the kindnesses he received from friendly doctors. He claims that this narrative account supports the promotion of Prostate Specific Antigen screening for asymptomatic men and impugns statisticians, mistakenly thinking that their opposition to PSA screening derives from concerns about financial cost. The account inadvertently demonstrates the danger of over-reliance on a single ethical tool for critical analysis. In the first part of this response, we describe the (...) statistical evidence. The most reliable Cochrane meta-analyses have not shown that PSA screening saves lives overall. Moreover, the high false positive rate of PSA screening leads to overinvestigation which results in unnecessary anxiety and increased cases of unnecessary sepsis, urinary incontinence and sexual dysfunction. Then we describe how narrative ethics alone is an insufficient tool to make claims about policies, such as PSA screening, which have hidden harms. Although Nisker’s story-telling is compelling and evokes emotions, narrative ethics of this sort have an inherent bias against people who would be harmed by the counterfactual. Particular care must be taken to look for and consider those untellable stories. Ethicists who only consider narratives which are readily at hand risk harming those who are voiceless or protected by the status quo. PSA screening is the wrong tool to reduce prostate cancer deaths and narrative ethics is the wrong tool to appraise this policy. It is vital that the correct theoretical tools are applied to the medical and ethical questions under scrutiny. (shrink)

The Fast Casual Inference (FCI) algorithm searches for features common to observationally equivalent sets of causal directed acyclic graphs. It is correct in the large sample limit with probability one even if there is a possibility of hidden variables and selection bias. In the worst case, the number of conditional independence tests performed by the algorithm grows exponentially with the number of variables in the data set. This affects both the speed of the algorithm and the accuracy of (...) the algorithm on small samples, because tests of independence conditional on large numbers of variables have very low power. In this paper, I prove that the FCI algorithm can be interrupted at any stage and asked for output. The output from the interrupted algorithm is still correct with probability one in the large sample limit, although possibly less informative (in the sense that it answers “Can’t tell” for a larger number of questions) than if the FCI algorithm had been allowed to continue uninterrupted. (shrink)

This essay examines some of the arguments in David Deutsch's book The Fabric of Reality , chief among them its case for the so-called many-universe interpretation of quantum mechanics (QM), presented as the only physically and logically consistent solution to the QM paradoxes of wave/particle dualism, remote simultaneous interaction, the observer-induced 'collapse of the wave-packet', etc. The hypothesis assumes that all possible outcomes are realized in every such momentary 'collapse', since the observer splits off into so many parallel, coexisting, but (...) epistemically non-interaccessible 'worlds' whose subsequent branchings constitute the lifeline-or experiential world-series- for each of those proliferating centres of consciousness. Although Deutsch concedes that his 'multiverse' theory is counter-intuitive, he none the less takes it to be borne out beyond question by the sheer observational/predictive success of QM and the conceptual dilemmas that supposedly arise with alternative (single-universe) accounts. Moreover, he claims the theory resolves a range of longstanding philosophical problems, notably those of mind/body dualism, the various traditional paradoxes of time, and the freewill/determinism issue. The essay suggests on the contrary, that Deutsch unwittingly transposes into the framework of presentday quantum debate speculative themes from the history of rationalist metaphysics, often with bizarre or philosophically dubious results, and that he rules out at least one promising rival account, namely Bohm's 'hidden variables' theory. It goes on to consider reasons for resistance to that theory among proponents of the 'orthodox' (Copenhagen) doctrine, and for the strong anti-realist, at times even irrationalist bias that has characterized much of this discussion since Bohr's debates with Einstein about quantum non-locality, observer-intervention, and the limits of precise measurement. Finally, the contrast is pointed out between Deutsch's ontologically extravagant use of the many-worlds hypothesis (akin to certain ideas advanced by speculative metaphysicians from Leibniz down) and those realist modes of counterfactual reasoning- e.g. in Kripke and the early Putnam- which deploy similar arguments to very different causal-explanatory ends. (shrink)

This study firstly addresses three threads in Chris Marker’s work – theology, Marxism, and Surrealism – through a mapping of the work of both Giorgio Agamben and Jacques Derrida onto the varied production of his film and photographic work. Notably, it is late Agamben and late Derrida that is utilized, as both began to exit so-called post-structuralism proper with the theological turn in the late 1980s and early 1990s. It addresses these threads through the means to ends employed and as (...) ends proper (as production of semi-autonomous works that also, paradoxically, index a much larger field of inquiry and theoretical praxis). It is perhaps French “schizophrenia” regarding theological versus political agency that best accounts for the sardonic deployment of irony and humor in Marker’s work in the face of Big History. Such means to ends (plus a subtle anti-intellectualism vis-à-vis fashionable academic trends) tend to underscore the severity and ultimate sincerity of Marker’s overall cultural-political project. -/- Dossier Chris Marker is also a study of a late-modern chiasmus, impersonal-personal agency, as it comes to expression in the works of Marker, as the dynamic interplay of political and subjective agency. As chiasmus, the complementary halves of this often-apocalyptic dynamis (a semi-catastrophic, temporal or historical force-field) also – arguably – secretly agree to meet, through the work of art, in the futural (problematized in contemporary French post-phenomenological and post-post-structuralist theory as “the event).” Consistent with the classical figure of concordia discors, Marker resolves these irreducible warring aspects of life experience in an atemporal and ahistorical moment that inhabits the work of art from its inception. This redemptive aspect in art is also the ultimate gesture of the artwork as autonomous subject and “mask” (or “screen”) for forces that reside beyond the frame of the image or work, as its proverbial Other, or within the frame, as other to that Other. -/- Despite the complications of the as-yet unresolved post-modern condition (its nihilist-relativist bias), and its similar, mostly circular concerns with the image and/or media, Marker’s work is clearly not post-modern. In fact, when tested against immemorial cultural epiphenomena, that work withstands all attempts at categorization and/or art-historical analysis proper. It remains unassimilable to the post-modern cause ... What emerges, upon closer examination, and through rigorous re-contextualization, is the prescient force of Marker’s works toward that futural state buried in art that is also “theological,” versus atheological, and heedlessly anterior to cultural politics per se. -/- In the case of Marker, this age-old or immemorial “thing-in-itself” (the artwork as image of world-chiasmus) finds its foremost or penultimate formation in his very-still photography – the singular images that are also the building blocks for his renowned ciné-essays. Not without irony, this same austere, reductive force of the still image (as form of proscription) also inhabits the more complex, synthetic works (or montages) that he has formulated and presented “dramatically,” here and there, through the often-sketchy apparatuses of his new-media experiments, as of the late 1980s. Ultimately, this world-image as chiasmus was always present within his earliest literary projects, from the 1940s forward – most especially in books and essays, with or without actual images. -/- Marker’s “return” to photography (to exhibiting still photography in galleries), in the late 2000s, is in many ways a return to the singular object of the artist-critic’s desire; the image in/for itself, while that image – endlessly troubled or interrogated for decades – continues to speak “in tongues” anyway, often against, or oblivious to, the voice of the author/artist/narrator. -/- Marker is a High Romantic Christian Marxist. The “Christic” aspect is rightly well-hidden, but emerges when the eschatological versus historical center of his work is exposed (the existential-metaphysical fuse such as also inhabits the works of Caravaggio), and when his early years are examined in light of his later and/or final years. Marker’s semi-personal/semi-impersonal apocalyptic vision is writ large in diverse works that cross decades, figuring a redemptive, world-shattering formation of art as pleroma. (shrink)

Strict separation of church from a presumed ‘religion-blind’and strictly ‘neutral’state still is the preferred model in liberal, democratic, feminist, and socialist political theory. Focusing on the full, reciprocal relationships between society-culture-politics-nation-state and religions, this article makes a case in favor of ‘nonconstitutional pluralism’ in general, associative democracy in particular. Associative democracy recognizes religious diversity both individually and organizationally; it stimulates legitimate religious diversity; it prevents a hidden majority bias; and it provides a legitimate role for organized religions in (...) the provision of a wide range of services, including education, on one hand, and in the political process, on the other hand. That organized religions should be informed, heard, and consulted in contested issues should be a crucial component of democratic participation. This also might help prevent the development of religious fundamentalism. (shrink)

The importance of the hidden curriculum is recognised as a practical training ground for the absorption of medical ethics by healthcare professionals. Pakistan’s healthcare sector is hampered by the exclusion of ethics from medical and nursing education curricula and the absence of monitoring of ethical violations in the clinical setting. Nurses have significant knowledge of the hidden curriculum taught during clinical practice, due to long working hours in the clinic and front-line interaction with patients and other practitioners.