Large-scale sequencing tests, including whole-exome and whole-genome sequencing, are rapidly moving into clinical use. Sequencing is already being used clinically to identify therapeutic opportunities for cancer patients who have run out of conventional treatment options, to help diagnose children with puzzling neurodevelopmental conditions, and to clarify appropriate drug choices and dosing in individuals. To evaluate and support clinical applications of these technologies, the National Human Genome Research Institute and National Cancer Institute have funded studies on clinical and research sequencing under (...) the Clinical Sequencing Exploratory Research program as well as studies on return of results. Most of these studies use sequencing in real-world clinical settings and collect data on both the application of sequencing and the impact of receiving genomic findings on study participants. They are occurring in the context of controversy over how to obtain consent for exome and genome sequencing. (shrink)

William of Ockham (d. 1347) is well known for his commitment to parsimony and for his so-called ‘razor’ principle. But little is known about attempts among his own contemporaries to deflect his use of the razor. In this paper, I explore one such attempt. In particular, I consider a clever challenge that Ockham’s younger contemporary, Walter Chatton (d. 1343) deploys against the razor. The challenge involves a kind of dilemma for Ockham. Depending on how Ockham responds to this dilemma, his (...) razor will, Chatton argues, either prove unacceptably dull when it comes to determining ontological commitment or prove unacceptably sharp when it comes to determining commitments entailed by certain theological doctrines. While Chatton’s objection is subtle and interesting in its own right, the broader significance of the debate between these thinkers lies in the light it sheds on medieval approaches to issues surrounding metaphysical methodology. (shrink)

Given that one of the major goals of the practice of Philosophy for Children (P4C) is the development of critical thinking skills (Sharp 1987/2018, pp. 4 6), an urgent question that emerged for one of the authors, who is of Chinese Heritage and a novice practitioner at a P4C summer camp was whether this emphasis on critical thinking might make this practice incompatible with the fabric of Chinese culture. Filial piety (孝), which requires respect for one’s parents, elders, and ancestors (...) is considered an important virtue in Asian culture, as is the preservation of harmony. But if one of the goals of P4C is to teach youngsters to courageously pursue reasoned dialogue, does this not set-up young Asians for serious conflict when they come face-to-face with positions that are articulated by elders, but which are ones to which they are diametrically opposed; a racist grandmother, for instance, or an uncle who insists that those at the Tiananmen Square uprising were nothing but hooligan’s. It is this question that we will explore in this presentation. In the process, we will come to the conclusion that, when positions seem irreconcilable, rather than continuing to pursue rigorous critical interchange that may do little other than escalate insult, the facilitator, rather, ought to move toward creating a deeper understanding of each position juxtaposed against its opposing view (a process that we refer to as ‘collaborative caring’), so as to produce side-by-side understanding, knowing that communal bonds have been maintained and, hence, that the opportunity for genuine reasoned collaborative inquiry on other issues and at future times remains open. (shrink)

Richard Rorty’s neopragmatism is more similar to the self-described pragmatisms of his contemporaries Jürgen Habermas and Hilary Putnam than it is dissimilar from them. Indeed, the only significant difference between Rorty’s views and those of his interlocutors, and what forms the basis of their many public exchanges, is their respective stances toward the status of epistemic norms. Rorty’s arguments against Habermas’s endorsement of transcendental conditions that ground successful communication, and against Putnam’s contention that there exists a limit conception of truth (...) upon which the possibility for critique depends speak to the very heart of his philosophical differences from the Kantian pragmatisms of Habermas and Putnam. -/- This paper engages in a detailed exploration of the debates between Rorty and Habermas and between Rorty and Putnam over these matters. These debates provide us with a direct route to understanding Rorty’s own views on epistemic norms. That is, the comparison between his own position and those of his fellow neopragmatists throws into sharp relief Rorty’s belief in the radical contingency of epistemic norms. -/- This exploration profits from engaging a feminist lens because feminist critiques, specifically of Habermas’s work, draw attention to the inadequacies of his views that Rorty seeks to correct, inadequacies that can be easily translated to Putnam’s case as well. By approaching this issue from a feminist angle, the paper highlights the dissimilarities in the theoretical positions between Rorty and his contemporaries, and shows why this difference is more significant than it might seem at first blush. The paper concludes with the suggestion that Rorty’s emphasis on the radical contingency of epistemic norms can provide a basis for the kind of revolutionary social, political, and cultural change that is central to much recent feminist theory. (shrink)

Susan Stebbing’s paper “Logical Positivism and Analysis” (March 1933) was unusually critical of Wittgenstein. It put up a sharp opposition between Cambridge analytic philosophy of Moore and Russell and the positivist philosophy of the Vienna Circle to which she included Wittgenstein from 1929–32. Above all, positivists were interested in analyzing language, analytic philosophers in analyzing facts. Moreover, whereas analytic philosophers were engaged in directional analysis which seeks to illuminate the multiplicity of the analyzed facts, positivists aimed at final analysis (...) which “proves” that there are simples. Stebbing’s paper urged Wittgenstein to recast his philosophy and 1933 abandon those components of it that linked him to the Vienna Circle. (shrink)

Only human beings have a rich conceptual repertoire with concepts like tort, entropy, Abelian group, mannerism, icon and deconstruction. How have humans constructed these concepts? And once they have been constructed by adults, how do children acquire them? While primarily focusing on the second question, in The Origin of Concepts , Susan Carey shows that the answers to both overlap substantially. Carey begins by characterizing the innate starting point for conceptual development, namely systems of core cognition. Representations of core (...) cognition are the output of dedicated input analyzers, as with perceptual representations, but these core representations differ from perceptual representations in having more abstract contents and richer functional roles. Carey argues that the key to understanding cognitive development lies in recognizing conceptual discontinuities in which new representational systems emerge that have more expressive power than core cognition and are also incommensurate with core cognition and other earlier representational systems. Finally, Carey fleshes out Quinian bootstrapping, a learning mechanism that has been repeatedly sketched in the literature on the history and philosophy of science. She demonstrates that Quinian bootstrapping is a major mechanism in the construction of new representational resources over the course of childrens cognitive development. Carey shows how developmental cognitive science resolves aspects of long-standing philosophical debates about the existence, nature, content, and format of innate knowledge. She also shows that understanding the processes of conceptual development in children illuminates the historical process by which concepts are constructed, and transforms the way we think about philosophical problems about the nature of concepts and the relations between language and thought. (shrink)

Reconfiguring the human -- Lines, planes, and bodies: redefining human action -- Action as affect -- The transindividuality of affect -- The tongue -- Renaturalizing ideology: Spinoza's ecosystem of ideas -- The matrix -- Ideology critique today? -- The fly in the coach -- "I am in ideology," or the attribute of thought -- What is to be done? -- Man's utility to man: reason and its place in nature -- The politics of human nature -- Reason and the human (...) essence -- Man's utility to man -- Nonhuman utility -- Beyond the image of man -- Desire for recognition? Butler, Hegel, and Spinoza -- Spinoza in Hegel -- Desire in Hegel -- Conatus and cupiditas in Spinoza -- From interpersonal recognition to impersonal glory -- Judith Butler's post-Hegelian politics of recognition -- The impersonal is political: Spinoza and a feminist politics of imperceptibility -- The politics of recognition -- Elizabeth Grosz's critique of the politics of recognition -- Thinking beyond the (hu)man -- A politics of imperceptibility -- Nature, norms, and beasts -- The beast within -- Animal affects (and) the first man -- Ethics as ethology? (shrink)

After the success of the hardback, students and academics will welcome the publication of this book in paperback. The aim of the book is to explore the connection between two perspectives that have had a profound effect upon contemporary thought: post–modernism and feminism. Through bringing together and systematically analysing the relations between these, Hekman is able to make a major intervention into current debates in social theory and philosophy. The critique of Enlightenment knowledge, she argues, is at the core of (...) both post–modernism and feminism. Each also offers a basis for critical reflections about the other. In particular, post–modern philosophy provides a means of criticizing aspects of contemporary feminism and thus contributing to the development of a more sophisticated approach to current feminist issues. (shrink)

In this provocative book, Susan Bordo untangles the myths, ideologies, and pathologies of the modern female body. Bordo explores our tortured fascination with food, hunger, desire, and control, and its effects on women's lives.

This paper will suggest a mapping for human dynamics to see where emerging digital technology currently and could further affect the dynamics of the human, technological and natural, and the cultural forms that define them. Emerging technology will be seen to reveal and surpass the limitations of human measures built on human abilities and perception. and the social structures that are derived from them. The formation of this conceptual mapping is based on the premise that digital technology has the ability (...) to better relay and hence refine dynamics working at points where culture is created and necessitated in our perception of a shared reality. Technology thus alleviates the layering, representation, labelling, and reification notions of culture that are based in human perceptual limitations. Information as referential will be seen against the tendency of technology to offer succinct mediation and direct actions as a format for any change and application with refined cultural constructions. The mapping presents a notion of homeostasis or more bereft of balance at the point where the proximal dynamics of the unit, that is, the individual, is closely supported by the technology with a changing orientation to the dynamics of a natural environment. The notion of a person as an individual is also reconsidered in terms of technology and how this changing definition is part of how we conceptualize a balanced world. Nonlinear mapping rendered in a complex will be introduced to align these mixed dynamics. Complex is here defined as a concurrence of dynamics evident in shifts of change that act as a whole and where each action affects the whole. As measures are revealed so, too, will be the source of notions of linearity and nonlinearity; mapping; point of view as a basis of complexity; and evolutionary theory as a function of a labeling of cultural dynamics. (shrink)

Violence and the Remaking of a Self Susan J. Brison. Political activism (including lobbying for new legislation, speaking out, educating others, helping survivors) can also help to undo the double bind of self-blame versus helplessness.

Late Tokugawa society and the crisis of community -- Before the Kojikiden : the divine age narrative in Tokugawa Japan -- Motoori Norinaga : discovering Japan -- Ueda Akinari : history and community -- Fujitani Mitsue : the poetics off community -- Tachibana Moribe : cosmology and community -- National literature, intellectual history, and the new Kokugaku -- Conclusion : imagined Japan(s).

To explain the causal relation between institutional rules and people’s actions and expectations, Searle relies upon his concept of the Background, the thesis that intentional states function only given a background of capacities that do not themselves consist in intentional phenomena. Any sentence, for instance, only acquires truth conditions or other conditions of satisfaction against a background of capacities, dispositions, know-how, etc. that are not themselves part of the content of the sentence. The Background also structures expectations. La Rouchefoucauld said, (...) for instance, that few people would fall in love if they had never read about it. (shrink)

On July 4, 1990, while on a morning walk in southern France, Susan Brison was attacked from behind, severely beaten, sexually assaulted, strangled to unconsciousness, and left for dead. She survived, but her world was destroyed. Her training as a philosopher could not help her make sense of things, and many of her fundamental assumptions about the nature of the self and the world it inhabits were shattered.At once a personal narrative of recovery and a philosophical exploration of trauma, (...) this book examines the undoing and remaking of a self in the aftermath of violence. It explores, from an interdisciplinary perspective, memory and truth, identity and self, autonomy and community. It offers imaginative access to the experience of a rape survivor as well as a reflective critique of a society in which women routinely fear and suffer sexual violence.As Brison observes, trauma disrupts memory, severs past from present, and incapacitates the ability to envision a future. Yet the act of bearing witness, she argues, facilitates recovery by integrating the experience into the survivor's life's story. She also argues for the importance, as well as the hazards, of using first-person narratives in understanding not only trauma, but also larger philosophical questions about what we can know and how we should live.Bravely and beautifully written, Aftermath is that rare book that is an illustration of its own arguments. (shrink)

The Flight to Objectivity offers a new reading of Descartes' Meditations informed by cultural history, psychoanalytic and cognitive psychology, and feminist thought.

Susan Sherwin ist eine kanadische Philosophin und Wegbereiterin der feministischen Ethik. Bis zu ihrer Emeritierung war sie lange Zeit Professorin an der Dalhousie University in Halifax, Kanada. In ihrem Text „Foundations, Frameworks, Lenses: The Role of Theories in Bioethics“ von 1999 plädiert sie für eine kritische Reflexion gängiger Metaphern in der Bioethik.

The concept of "fitness" is a notion of central importance to evolutionary theory. Yet the interpretation of this concept and its role in explanations of evolutionary phenomena have remained obscure. We provide a propensity interpretation of fitness, which we argue captures the intended reference of this term as it is used by evolutionary theorists. Using the propensity interpretation of fitness, we provide a Hempelian reconstruction of explanations of evolutionary phenomena, and we show why charges of circularity which have been levelled (...) against explanations in evolutionary theory are mistaken. Finally, we provide a definition of natural selection which follows from the propensity interpretation of fitness, and which handles all the types of selection discussed by biologists, thus improving on extant definitions. (shrink)

If you're woke, you're left. If you're left, you're woke. We blur the terms, assuming that if you're one you must be the other. That, Susan Neiman argues, is a dangerous mistake. The intellectual roots and resources of wokeism conflict with ideas that have guided the left for more than 200 years: a commitment to universalism, a firm distinction between justice and power, and a belief in the possibility of progress. Without these ideas, Neiman argues, they will continue to (...) undermine their own goals and drift, inexorably and unintentionally, towards the right. In the long run, they risk becoming what they despise. One of the world's leading philosophical voices, Neiman makes this case by tracing the malign influence of two titans of twentieth-century thought, Michel Foucault and Carl Schmitt, whose work undermined ideas of justice and progress and portrayed social life as an eternal struggle of us against them. A generation schooled with these voices in their heads, raised in a broader culture shaped by the ruthless ideas of neoliberalism and evolutionary psychology, has set about changing the world. It's time they thought again. (shrink)

The United States Government does not mandate that US based firms follow US social and environmental law in foreign markets. However, because many developing countries do not have strong human rights, labor, and environmental laws, many multinationals have adopted voluntary corporate responsibility initiatives to self-regulate their overseas social and environmental practices. This article argues that voluntary actions, while important, are insufficient to address the magnitude of problems companies confront as they operate in developing countries where governance is often inadequate. The (...) United States can do more to ensure that its multinationals act responsibly everywhere they operate. First, policymakers should define the social and environmental responsibilities of global companies. They must consistently make their expectations for global business clear – and underscore that this objective can often be accomplished without mandates. Second, the US should closely examine the policies that undermine global Corporate Social Responsibility (CSR) and address the many conflicting signals sent by policymakers. Third, the President should make the US government a CSR model by examining how to use its purchasing power to promote human rights. Finally, the US government should require pension funds to report on the social and environmental consequences of their investments. In these ways, Americans can mind our business – and thus make sure that US based firms do not undermine social and environmental progress when they operate in the developing world. (shrink)

A defendant’s failure to show remorse is one of the most powerful factors in criminal sentencing, including capital sentencing. Yet there is currently no evidence that remorse can be accurately evaluated in a courtroom. Conversely there is evidence that race and other impermissible factors create hurdles to evaluating remorse. There is thus an urgent need for studies about whether and how remorse can be accurately evaluated. Moreover, there is little evidence that remorse is correlated with future law-abiding behavior or other (...) legitimate penal purposes, and, in fact, there is evidence that remorse is often conflated with shame, which is correlated with increased future criminality. More accurate information on the nature and evaluation of remorse can be used to reform the criminal justice system. (shrink)

If Savulescu and Kahane’s Principle of Procreative Beneficence were implemented regarding cognitive enhancement, the result would be highly impoverishing for future children. For, apart from being inadequate to rationality itself, advocates’ accounts of cognitive enhancement sever reason from the input to judgments and decision-making that other faculties provide. When handling desire, supporters of cognitive enhancement frame conflicts between reason and the nonrational in terms of self-governance or akratic failure, depending on which one triumphs. Further, so-called negative emotions are treated as (...) simply deleterious and hostile to the rational. Alliances of the nonrational with reason toward shared ends are hence unthinkable. Having critiqued advocates’ views directly, I amplify my assessment through engagement with Aristotle’s Nicomachean Ethics. Per Savulescu and Kahane, to know how to direct enhancement endeavors, “we need to form reasonable opinions on difficult questions about the nature of well-being and the good life.” Thus far, however, enhancement supporters have been largely silent on this crucial matter. Because the debate over enhancement is ultimately over what values our views of flourishing embody, it should be recast so that this crux is squarely at the fore. What is more, for our own and our children’s sakes, as we embark on this reframing, we would do well to bear in mind Aristotle’s insights about the nonrational in relation to reason and his unwavering focus on the human “that for the sake of which” (hou heneka) all that we do is, perforce, undertaken. (shrink)

Dehaene (this volume) articulates a naturalistic approach to the cognitive foundations of mathematics. Further, he argues that the ‘number line’ (analog magnitude) system of representation is the evolutionary and ontogenetic foundation of numerical concepts. Here I endorse Dehaene’s naturalistic stance and also his characterization of analog magnitude number representations. Although analog magnitude representations are part of the evolutionary foundations of numerical concepts, I argue that they are unlikely to be part of the ontogenetic foundations of the capacity to represent natural (...) number. Rather, the developmental source of explicit integer list representations of number are more likely to be systems such as the object–file representations that articulate mid–level object based attention, systems that build parallel representations of small sets of individuals. (shrink)

How we assess current calls for vigorous, or “radical”, enhancement through befitting procreative choices depends in part on the plausibility of supporters’ rejecting all substantive ties between their views and earlier eugenics. When denying such connections, today’s advocates of vigorous enhancement routinely emphasize that enhancement decisions would stem from individuals and families, not the state. In a multipronged critique, I show the untenability of transhumanists’ denials.

On ethics and gender -- Feminism as an ethics of gender -- Is ethics a man's subject? -- The matter of bodies -- The subject of language -- The power of agency -- Engendering ethics -- Conceiving of difference -- Subjected in hope -- For love of God.

As an intensive housing construction drive in the late 1950s began to provide separate apartments for millions of Soviet citizens, aesthetic experts envisioned the Soviet home as a potential site for the display of works of art and for amateur aesthetic production. In the context of de-Stalinization, reformist artists and aestheticians committed to the liberalization and modernization of Soviet artistic criteria, promoted the value of amateur art and even of home decorating in the formation of the new person who would (...) live under communism. They also pressed for affordable art and craft to be made available to ordinary people for their new homes. Thereby they would dwell in their new apartments surrounded by beauty in their everyday lives, and would thus, the experts argued, be brought closer to communist consciousness. Moreover sales of art to individual citizens would provide an alternative income stream to fund artists’ production. The possibility of private art consumption would therefore free artists to some extent from their reliance on state commissions and from the strict stylistic and thematic norms and hierarchies of Socialist Realism as established under Stalin. (shrink)

Jung: A Feminist Revision explores the relationship between feminist theory and Jungian studies. It combines an original student-friendly introduction to Jung, his life and work, his treatment of gender and the range of post-Jungian gender theory, with new research linking Jung to deconstruction, post-Freudian feminism, postmodernism, the sublime, and the postmodern body. Feminism has neglected Jung to its own detriment. While evaluating the reasons for this neglect, Jung: A Feminist Revision uses the diversity of feminist critical tools from historical analysis (...) to poststructuralism. In a fresh and illuminating study, this book provides both a critique of Jung and demonstrates his positive potential for future feminisms. New theories are explored which develop relationships between the work of Jung and Jacques Lacan, Luce Irigaray, Hélène Cixous, Julia Kristeva and Judith Butler. Particular attention is paid to the growth of post-Jungian studies of gender. This includes a cogent study of the tradition of Jungian feminism that looks to the feminine principle′ and narratives of goddesses. Jungian ′goddess′ feminism′s enduring appeal is re-examined in the context of postmodern re-thinking of subjectivity and gender. The book proposes a re-orientation of Jungian studies in its relationship to feminism. The result is an accessible text that introduces Jung and sets out his relevance to contemporary feminisms. This book will be essential reading for undergraduates and postgraduates studying feminist theory, psychoanalytical theory, literature and psychology. (shrink)

This study investigates the effectiveness of pedagogical practices used to teach business ethics. The business community has greatly increased its demands for better ethics education in business programs. Educators have generally agreed that the ethical principles of business people have declined. It is important, then, to examine how common methods of instruction used in business ethics could contribute to the development of higher levels of moral judgment competence for students. To determine the effectiveness of these methods, moral judgment competence levels (...) for undergraduate and graduate students from three institutions were measured and compared based upon the pedagogical method used in a business class. Significant differences were found for moral reasoning and moral competence scores depending on the method used for ethics instruction. Students in classes with more highly integrated ethics coverage scored higher in moral reasoning and moral competence. (shrink)