Interest is growing in the relocalization of staple crops, including wheat, in western Washington (WWA), a nontraditional wheat-growing area. Commercial bakers are potentially important food chain intermediaries in the case of relocalized wheat production. We conducted a mail survey of commercial bakers in WWA to assess their interest in sourcing wheat/flour from WWA, identify the characteristics of bakeries most likely to purchase wheat/flour from WWA, understand the factors important to bakers in purchasing regionally produced wheat/flour, and identify perceived barriers to (...) making such purchases. Sixty-one percent of survey respondents were interested in purchasing WWA wheat/flour. Bakers who used retail strategies to market their products were more likely to be interested in WWA wheat/flour compared to those not using retail methods. Bakers’ current purchases of Washington wheat/flour were not related to their interest in purchasing WWA flour. The most important factors bakers would consider in purchasing regionally produced wheat/flour were consistency of flour quality, quality of flour, and reliability of supply. Cost was the most frequently mentioned barrier to the purchase of regionally produced wheat/flour. Our results are relevant for other areas attempting to reconnect grain producers, commercial bakers, and consumers in mutually beneficial ways. (shrink)

Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

Durkheim's The Rules of Sociological Method has never enjoyed the same reputation as his major books, in part because the book is uncongenial to standard interpretations of Durkheim. In particular, its attacks on teleology do not fit his reputation as a functionalist The papers in this special issue address the work historically. Both Porter and Stedman Jones deal with aspects of the context in which Durkheim worked and transformed. Schmaus and Nemedi deal with problems of interpreting Durkheim's development, and (...) Platt discusses the reception of The Rules. The papers shed light on such important questions as the meaning of Durkheim's slogan “society is made of representations.” Durkheim, it appears, was not only what would now be called a constructionist, he went on to ask whether the fact that constructions are real in their consequences did not imply the reality causal reality of constructions and, therefore, a specific kind of “social realism.” The problem The Rules poses, of what is the fundamental stuff of society, is “classic” in significance, and Durkheim's answer is classically radical. (shrink)

The starting-point of this paper is one of the most disastrous pieces of advocacy in modern legal history. In October 1960, Penguin Books were prosecuted under Section 2 of the 1959 Obscene Publications Act for publishing an unexpurgated edition ofLady Chatterley's Lover.On the first day of the trial, Mr. Mervyn Griffith-Jones, Senior Treasury Counsel, did his best to wreck his case on the strength of one remark. He had previously tried to show that he was himself a man of (...) the world: ‘Let me emphasize this on behalf of the prosecution: do not approach this matter in any priggish, high-minded, super-correct, mid-Victorian manner’. He now proceeded to work this out in practice: ‘Would you approve of your young sons, young daughters—because girls can read as well as boys—reading this book? Is it a book that you would have lying around in your own house? Is it even a book that you would wish your wife or your servants to read?’. (shrink)

Jones's system of constraints promises interesting insights into the typology of kin term systems. Three problems arise: (1) the conflation of categories with algorithms that assign them threatens to weaken the typological predictions; (2) OT-type constraints have little psychological plausibility; (3) the conflation of kin-term systems and kinship systems may underplay the “utility function” character of real kinship in action.

If we think about comedy in terms of stock characters, Shakespeare provides some startling examples. Here, for instance, are two hypothetical casts: A jealous husband, a chaste wife, an irascible father, a clever malicious servant, a gullible friend, a bawdy witty maid; A pair of lovers, their irascible fathers, a bawdy serving woman, a witty friend, a malicious friend, a kindly foolish priest. Both of these groups represent recognizable comic configurations, though in fact they are also the casts of Othello (...) and Romeo and Juliet. Being able to see them in this light, I think, reveals something important about how both these tragedies work. Much of their dramatic force derives from the way they continually tempt us with comic possibilities. We are told in a prologue that Romeo and Juliet are star-crossed, but if inevitability is a requisite of tragedy, neither play will qualify for the genre: they are the most iffy dramas in the Shakespearean canon. At innumerable points in both plays, had anything happened differently, the tragic catastrophe would have been averted. Othello particularly teases the audience in this way—as the famous story about the man who leapt from his seat, furious at the impending murder of Desdemona, and shouted "You fool, can't you see she's innocent?" reveals. The story is no doubt apocryphal , but the point is that it is unique to this play: there are no similar tales of spectators leaping up to rescue Cordelia, to save Gloucester from blinding, to dash the asp from Cleopatra's hand. Stephen Orgel, professor of English at Johns Hopkins University, is the author of The Jonsonian Masque, The Illusion of Power, and the coauthor of Inigo Jones. The editor of Jonson's Complete Masques and of Jonson's Selected Masques , he is currently writing a book on the idea of theatrical genres in the Renaissance. (shrink)

Among the works of Aelius Aristides is preserved an address to an unnamed ‘king’. The prevailing view in this century has been that it is addressed to a third-century emperor, and was attributed to Aristides in error. In an article published in 1972, 134–52), I argued that the speech was genuine, and was delivered by Aristides in 144 before Antoninus Pius. In a recent article in this journal, 172–97), Stephen A. Stertz has undertaken to rebut this view, and advances (...) a novel one: the speech is a school exercise written in the third or perhaps the fourth century, and does not refer to any particular ‘king’, not even necessarily a Roman emperor. Rather than attempt to answer all of Stertz's arguments, I have selected as samples one each from several diverse fields. Manuscript tradition. In his first paragraph, Stertz suggests that the manuscript tradition of the Eis basilea itself impugns its authenticity. ‘The oration is entitled єς βασιλέα in three manuscripts and єς τόν ατοκρτορα in another. It has been pointed out that in the former group of manuscripts the title is not preceded by the words ριστεδου λόγος, thus casting doubt on Aristidean authorship'. The accompanying footnote refers to Keil's apparatus ad loc, and the reader might infer that this argument is borrowed from Aristides’ foremost editor. What Keil said was: ‘Titulus ες βασιλα STC : єς τòν ατοκρτορα U et in indice D m recentiss.’. (shrink)

Among the works of Aelius Aristides is preserved an address to an unnamed ‘king’. The prevailing view in this century has been that it is addressed to a third-century emperor, and was attributed to Aristides in error. In an article published in 1972 , 134–52), I argued that the speech was genuine, and was delivered by Aristides in 144 before Antoninus Pius. In a recent article in this journal , 172–97), Stephen A. Stertz has undertaken to rebut this view, (...) and advances a novel one: the speech is a school exercise written in the third or perhaps the fourth century, and does not refer to any particular ‘king’, not even necessarily a Roman emperor. Rather than attempt to answer all of Stertz's arguments, I have selected as samples one each from several diverse fields. Manuscript tradition. In his first paragraph, Stertz suggests that the manuscript tradition of the Eis basilea itself impugns its authenticity. ‘The oration is entitled єς βασιλέα in three manuscripts and єς τόν ατοκρτορα in another. It has been pointed out that in the former group of manuscripts the title is not preceded by the words ριστεδου λόγος, thus casting doubt on Aristidean authorship' . The accompanying footnote refers to Keil's apparatus ad loc, and the reader might infer that this argument is borrowed from Aristides’ foremost editor. What Keil said was: ‘Titulus ες βασιλα STC : єς τòν ατοκρτορα U et in indice D m recentiss.’. (shrink)

Winner of the Gustave O. Arlt Award in the HumanitiesThree understandings of the nature of religion--religion as experience, symbolic meaning, and power--have dominated scholarly discussions, in succession, for the past hundred years. Proponents of each of these three approaches have tended to downplay, ignore, or actively criticize the others. But why should the three approaches be at odds? Religion as it is practiced involves experiences, meanings, and power, so students of religion should attend to all three. Furthermore, theorists of religion (...) should have an account that carefully conceptualizes all three aspects, without regarding any of them as more basic than the others.Visions of Religion provides just such an account. Stephen S. Bush examines influential proponents of the three visions, arguing that each approach offers substantial and lasting contributions to the study of religion, although each requires revision.Bush rehabilitates the concepts of experience and meaning, two categories that are much maligned these days. In doing so, he shows the extent to which these categories are implicated in matters of social power. As for power, the book argues that the analysis of power requires attention to meaning and experience.Visions of Religion accomplishes all this by articulating a social practical theory of religion that can account for all three aspects, even as it incorporates them into a single theoretical framework. (shrink)

This is a biography of the works of Richard Price, 1723-1791, one of the leading radical intellectuals of the late-18th century. By profession a dissenting minister, he was also a mathematician, a political pamphleteer, particularly on the American and French Revolutions, and a moral philosopher.

Jecker, et al., argue against rejecting a location for an international bioethics conference based on a “litmus test” for several reasons, ranging from the practical to the theoretical. However, th...

As Nair-Collins and Joffe note, the concern that our tests for brain death do not successfully show that all brain functions have stopped is not new (Nair-Collins and Joffe 2023). As our abilities...

The internet is widely used for health information and support, often by vulnerable people. Internet-based research raises both familiar and new ethical problems for researchers and ethics committees. While guidelines for internet-based research are available, it is unclear to what extent ethics committees use these. Experience of gaining research ethics approval for a UK study (SharpTalk), involving internet-based discussion groups with young people who self-harm and health professionals is described. During ethical review, unsurprisingly, concerns were raised about the vulnerability of (...) potential participants. These were dominated by the issue of anonymity, which also affected participant safety and consent. These ethical problems are discussed, and our solutions, which included: participant usernames specific to the study, a closed website, private messaging facilities, a direct contact email to researchers, information about forum rules displayed on the website, a ‘report’ button for participants, links to online support, and a discussion room for forum moderators. This experience with SharpTalk suggests that an approach to ethics, which recognises the relational aspects of research with vulnerable people, is particularly useful for internet-based health research. The solutions presented here can act as guidance for researchers developing proposals and for ethics committees reviewing them. (shrink)

Autonomous vehicles have the potential to save tens of thousands of lives, but legal and social barriers may delay or even deter manufacturers from offering fully automated vehicles and thereby cost lives that otherwise could be saved. Moral philosophers use “thought experiments” to teach us about what ethics might say about the ethical behavior of AVs. If a manufacturer designing an AV decided to make what it believes is an ethical choice to save a large group of lives by steering (...) away from the large group towards a single individual, could the manufacturer be liable to that single individual? I believe the answer is yes. This article discusses famous “trolley problem” thought experiments in moral philosophy, which news articles have recently applied to AVs. After establishing a hypothetical case, applying product liability law to AV behavior may show a way, in some jurisdictions, that will permit a manufacturer to implement an ethical choice without triggering liability, but liability risk remains. I then turn to possible traditional defenses to see if they prevent liability for a manufacturer making what it believes is an ethical design choice—necessity, defense of self, and the sudden emergency doctrine. None of them provides an effective defense. Under current law, maximizing collision avoidance appears to minimize legal risk. I conclude that the only way to provide effective protection to a manufacturer seeking to implement ethical choices about AV behavior is through special legislation or regulation. (shrink)

Hintikka has criticized psychologists for "hasty epistemologizing," which he takes to be an unwarranted transfer of ideas from psychology (a discipline dealing with questions of fact) into epistemology (a discipline dealing with questions of method and theory). Hamlyn argues, following Hintikka, that Gibson's theory of perception is an example of such an inappropriate transfer, especially insofar as Hamlyn feels Gibson does not answer several important questions. However, Gibson's theory does answer the relevant questions, albeit in a new and radical way, (...) which suggests that the alleged distinction between psychology and epistemology is suspect. In fact, contrary to Hintikka and Hamlyn's claims, Gibson's theory of perception appears to be a valuable source of epistemological as well as psychological ideas. (shrink)

In this paper, I present and criticize two highly influential anti-skeptical proposals inspired by Wittgenstein’s (1969) remarks on ‘hinges’, namely Pritchard’s ‘hinge commitment strategy’ (2012, forthcoming a, forthcoming b) and Moyal-Sharrock ‘non epistemic strategy’ (2004,2005). I argue that both these proposals fail to represent a valid response to skeptical worries. Furthermore, I argue that following Wittgenstein’s analogy between ‘hinges’ and ‘rules of grammar’ we should be able to get rid of Cartesian skeptical scenarios as nonsensical, even if apparently intelligible, combination (...) of signs excluded from our epistemic practices. (shrink)

It is proposed that the Darwinian theoretical approach and account of living systems has not yet been clearly given. A first approximation to this is attempted, focussing on behavior in evolving environments. A theoretical terminology is defined emphasizing the mutuality of organism and environment and the existence of biologically theoretical entities.

William James argued for a philosophy of democracy and pluralism that advocates individual and collective responsibility for our social arrangements, our morality, and our religion. In James' view, democracy resides first and foremost not in governmental institutions or in procedures such as voting, but rather in the characteristics of individuals, and in qualities of mind and conduct. It is a philosophy for social change, counselling action and hope despite the manifold challenges facing democratic politics, and these issues still resonate strongly (...) today. In this book, Stephen Bush explores how these themes connect to James' philosophy of religion, his moral thought, his epistemology, his psychology, and his metaphysics. His fresh and original study highlights the relevance of James' thought to modern debates, and will appeal to scholars and students of moral and political philosophy. (shrink)

I agree fully that a “clearer picture of how vulnerability might manifest and how it can be accommodated, ideally without resorting to mere exclusion from research, is needed” (Friesen et al. 2023,...

William James is famous for his investigations of the “Varieties of Religious Experience” in which people encounter (what they take to be) the divine. But in his essay, “On a Certain Blindness in Human Beings,” his interest is in our experiences, not of anything purportedly supernatural, but of one another. He thinks we need to cultivate the capacity to apprehend the intrinsic value of others, even and especially of strangers. We do so in experiences of the wonder and beauty of (...) our fellow citizens, and of our harmony with them. Democratic societies require a sense of attraction to one another’s form of life if they are to inspire shared commitments to public goods. Whereas we shouldn’t reject the political significance of aversion, contestation, and dissonance, these negative attitudes do not suffice. Sustaining democratic engagement requires attractive attitudes, and among these are the wonder, beauty, and harmony that James promotes. (shrink)

Despite considerable interest in viral evolution, at least among virologists, viruses are rarely considered from the same evolutionary vantage point as other organisms. Early work of necessity emphasized phenotype and phenotypic variation (and therefore arguably was more oriented towards the broader biological and ecological perspectives). More recent work (essentially since the development of molecular evolution in the 1960's but beginning earlier) has concentrated on genotypic variation, with less clarity about the significance of such variations. Other aspects of evolutionary theory, especially (...) considerations of natural selection and of evolutionary constraints, have not widely been applied to viruses, and an evolutionary framework for virology has long been lacking. This becomes apparent in considering 'emerging' viruses, which have often been treated on an ad hoc basis. It was often felt that, because previously unrecognized viruses are involved, mechanisms of viral emergence must mirror the unpredictability of mutations in the viral genome. However, most examples of viral emergence are independent of mutation, at least initially, and are often pre-existing viruses in changed circumstances ('viral traffic'). This conclusion also readily follows from ordinary Darwinian premises, which would require that, like other living species, 'new' organisms are descended only from existing species. In this respect, from a Darwinian perspective, viruses would appear to resemble other organisms. (shrink)

An anxious resident paged ethics at 2:00 a.m. His patient, Mr. M, a twenty‐nine‐year‐old man with a history of multiple substance abuse, was in the hospital after cardiac arrest and lack of cerebral perfusion. Sadly, the young man probably met the criteria for brain death, but the final apnea test to confirm the diagnosis could not be done for another forty‐eight to seventy‐two hours because the Klonopin in his system might confound the results. The resident's concern, however, addressed a request (...) made by the patient's mother for a sperm harvest. The patient's mother maintained that her son had said he wanted to give her grandchildren. She wished to harvest sperm from him for a future use with an as‐yet‐to‐be‐determined surrogate mother. (shrink)

ABSTRACTTeam physicians have a complicated job that involves potentially conflicting obligations to multiple entities. Though responsible for the medical care of the athletes as individuals, they also have obligations to the team that employs them which can include returning athletes to play who are at heightened risk of re-injury. The fact that the athletes and owners have some overlapping interests only complicates this issue. Further, there are strong financial incentives to do what is necessary to obtain and keep a position (...) as a team physician. This article examines dual loyalty and conflict of interest in sports medicine, and argues that there is not now a widely accepted or adequate solution to either. Moving toward a solution will require fairly serious changes in the role of the team physician.Abbreviations: FIMS International Federation of Sports Medicine; NFL National Football League; MVP Most Valuable Player; RGIII Robert Griffin, III. (shrink)

Makins’s analysis of the philosophical justification of decision-making understates and so misinterprets the importance of patient values to ‘the deference principle.’ (Makins N,1, p1) He assesses autonomy and beneficence as two separate arguments in support of deferring to patient preferences, but they only work well considered together. Further, neither the constitutive nor the evidential view of beneficence fully recognises the importance of patient values to understanding the patient’s worldview, which in turn determines what risks and benefits matter most. Revising these (...) arguments enables a much fuller understanding of the importance of patient values to the practice of medicine, which will in turn improve the refinement of the deference principle. Autonomy requires beneficence, and vice versa, for either of them to be sufficient arguments for deferring to patient choices. Focusing on autonomy alone to justify deference overstates the value of choice in and of itself, as good medicine does not pursue just any choices. It seeks informed consent, which means that the choices we truly value are those made while understanding what is importantly relevant to the choice. A well-informed decision includes data about expected side effects and likelihood of beneficial effects; but it also includes knowing the patient’s values and goals. One must know what is actually valuable …. (shrink)

[Stephen Yablo] The usual charge against Carnap's internal/external distinction is one of 'guilt by association with analytic/synthetic'. But it can be freed of this association, to become the distinction between statements made within make-believe games and those made outside them-or, rather, a special case of it with some claim to be called the metaphorical/literal distinction. Not even Quine considers figurative speech committal, so this turns the tables somewhat. To determine our ontological commitments, we have to ferret out all traces (...) of nonliterality in our assertions; if there is no sensible project of doing that, there is no sensible project of Quinean ontology. /// [Andre Gallois] I discuss Steve Yablo's defence of Carnap's distinction between internal and external questions. In the first section I set out what I take that distinction, as Carnap draws it, to be, and spell out a central motivation Carnap has for invoking it. In the second section I endorse, and augment, Yablo's response to Quine's arguments against Carnap. In the third section I say why Carnap's application of the distinction between internal and external questions runs into trouble. In the fourth section I spell out what I take to be Yablo's version of Carnap. In the last I say why that version is especially vulnerable to the objection raised in the second. (shrink)

presents a puzzle as to whether Aristotle views morally virtuous activity as happiness, as book 1 seems to indicate, or philosophical contemplation as happiness, as book 10 seems to indicate. The most influential attempts to resolve this issue have been either monistic or inclusivist. According to the monists, happiness consists exclusively of contemplation. According to the inclusivists, contemplation is one constituent of happiness, but morally virtuous activity is another. In this essay I will examine influential defenses of monism. Finding these (...) accounts superior to inclusivism, but still deficient, I will present and defend a dualistic account of happiness in which two different types of happiness, one divine and one human, are present in Nicomachean Ethics. When Aristotle commends contemplation as a happiness that humans can attain, he is careful to specify that this activity corresponds to a capacity (nous) that is not, properly speaking, human, even though humans can exercise it. Contemplation, the divine good, is the highest good that humans can obtain, but it is not the characteristic human good. The characteristic human good corresponds to the specifically and merely human function, which is an activity of the compound of human reason and emotions. (shrink)