Targeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for (...) analyzing hypermutation and can predict the effects of the same parameters (survival probability, replication fidelity, mutation effect, and others) on the survival of cellular populations undergoing hypermutation as a result of severe stress. (shrink)

The purpose of this paper is twofold. First, it offers a critique of the normative foundations of the 2019 Quebec Act respecting the laicity of the State. This is primarily based on the theses we developed in La nation pluraliste. Repenser la diversité religieuse au Québec (Presses de l’Université de Montréal, 2018), and elaborates a suitable diversity management model for Quebec using the republican liberalism described in Rawls’ later work. This discussion draws attention to certain pitfalls in the concept of (...) secularism as defended by the Coalition Avenir Québec government. Second, we present a methodological discussion on how political philosophy can contribute to the formation of law, by examining how our criticism of Act respecting the laicity of the State corresponds to an exercise in implementing Rawls’ own method of thoughtful balance. (shrink)

A growing body of literature argues that achieving radical change in the agri-food system requires a radical renegotiation of our relationship with the environment alongside a change in our thinking and approach to transformational food politics. This paper argues that relational approaches such as a more-than-human ethic of care (MTH EoC) can offer a different and constructive perspective to analyse agri-food system transformation because it emphasises social structures and relationships as the basis of environmental change. A MTH EoC has not (...) yet been applied to regenerative agriculture, yet other literature on regenerative agriculture suggests that care may be present in these spaces and calls for the need for social science analysis of the regenerative movement. This paper uses a MTH EoC lens to reveal a diverse array of ways in which power is and can be deployed for change in the regenerative agriculture movement in Aotearoa, New Zealand. Globally, regenerative agriculture tends to be analysed through positivist, scientific approaches that focus on biophysical markers of ecological improvement. Yet, a relational approach reveals how engagement in regenerative agriculture is creating significant shifts in mindset towards more holistic and relational understandings of biological and social ecosystems. A regenerative mindset framework is suggested as a method of understanding the connection between a regenerative form of thinking, being and doing for farmers. Interviews suggested that this shift in farmers’ socio-ecological relations is crucial to the transformational potential of regenerative agriculture. This paper argues that relational analyses such as the MTH EoC approach used to analyse regenerative agriculture in this research, refresh the way we analyse agri-food system change. They also are critical to guiding and supporting on-the-ground socio-ecological shifts that are necessary to see agricultural transformation. (shrink)

Certain kinds of prediction, foreknowledge, and future‐oriented action appear to require settled future truths. But open futurists think that the future is metaphysically unsettled: if it is open whether p is true, then it cannot currently be settled that p is true. So, open futurists—and libertarians who adopt the position—face the objection that their view makes rational action and deliberation impossible. I defuse the epistemic concern: open futurism does not entail obviously counterintuitive epistemic consequences or prevent rational action.

I offer a new, limited solution to divine hiddenness based on a particular epistemic paradox: sometimes, knowing about a desired outcome or relevant features of that desired outcome would prevent the outcome in question from occurring. I call these cases epistemically self-defeating situations. This solution, in essence, says that divine hiddenness or silence is a necessary feature of at least some morally excellent or desirable states of affairs. Given the nature of the paradox, an omniscient being cannot completely eliminate hiddenness, (...) just as an omnipotent being cannot create a rock so heavy that they cannot lift it. Epistemically self-defeating situations provide an undercutting defeater for the assumption that any nonresistant nonbeliever could always, at any time, be in conscious relationship with a perfectly loving God. Thankfully, silence is a temporary feature of epistemically self-defeating situations: once the outcome is achieved, agents can know in full. (shrink)

Closely related to this is Mr. Bruner's "evolutionary instrumentalism," his conception of instruction as the means of transmitting the tools and skills of a ...

Though the publication of Kuhn's 'Structure of Scientific Revolutions' seemed to herald the advent of a unified study of the history and philosophy of science, it is a hard fact that history of science and philosophy of science have increasingly grown apart. Recently, however, there has been a series of workshops on both sides of the Atlantic (called '&HPS') to bring historians and philosophers of science together to discuss integrative approaches. This is therefore an especially appropriate time to explore the (...) problems with and prospects for integrating history and philosophy of science. The original essays in this volume, all from specialists in the history of science or philosophy of science, offer such an exploration from a wide variety of perspectives. The volume combines general reflections on the current state of history and philosophy of science with discussion of the relation between the two disciplines in specific historical and scientific cases"--Publisher's description, back cover. (shrink)

Ernst Cassirer: Scientific Knowledge and the Concept of Man by Seymour W. Itzkoff is currently one of the few books available in the English language that discusses the philosophy of twentieth-century German philosopher Ernst Cassirer. Itzkoff's study brings Cassirer's perspective directly into the contemporary debate over the evolution of human thought and its relationship to animal life. Further, Itzkoff places Cassirer directly in the context of recent philosophical thought, arguing for the importance of his Kantian perspective, a significance that (...) is amply vindicated by the current interest in Cassirer's ideas. For this second edition, Seymour has written a new introduction and has added a new retrospective essay. (shrink)

Eric Williams's Capitalism and Slavery is a classic in the sense that it irreversyibly altered our most basic way of looking at an historical event. Writing the book in 1944, Williams broke with the century of histories portraying the British abolition of slavery as a humanist event, a moral victory. His account of slavery in the British colonies was innovative in introducing the notion that economic, rather than moral, factors were decisive in the motivation and success of the abolitionists. The (...) two farthest-reaching claims of Capitalism and Slavery are that British colonial slave production and the slave trade enabled the industrial revolution to take place in Britain, and that the abolition movement resulted solely from changes in the British imperial economy. Though few historians since Williams have agreed with him on the centrality of industrialization in the slave colonies and abolition, his work has resulted in the inclusion of economic factors in all recent accounts of slavery and its abolition. By writing a simplistic history with a global context, Williams made it impossible for subsequent historians to write about abolition as an isolated moral act of the British Empire. (shrink)

Veganic agriculture, often described as farming that is free of synthetic and animal-based inputs, represents an alternative to chemical-based industrial agriculture and the prevailing alternative, organic agriculture, respectively. Despite the promise of veganic methods in diverse realms such as food safety, environmental sustainability, and animal liberation, it has a small literature base. This article draws primarily on interviews conducted in 2018 with 25 veganic farmers from 19 farms in the United States to establish some baseline empirical research on this farming (...) community. Its qualitative perspectives illuminate farmer perceptions of and experiences with veganic growing, including definitions, knowledge acquisition, values, and challenges. Results highlight a lack of agreement about the meaning of veganic agriculture in terms of allowable inputs and scope. Participants have drawn on a wide array of veganic and non-veganic resources to ascend their veganic production learning curves, also relying on experimentation and trial-and-error. Their farming is motivated by a diversity of real and perceived benefits, most notably consistency with veganism, food safety advantages, and plant and soil health benefits. Veganic product sourcing and the dearth of veganic agriculture-specific resources present considerable challenges to farmers. The article briefly discusses possibilities for developing veganic agriculture in the United States, such as through a US-based certification system and farmers’ associations, based on considerations of the trajectory of the US organic farming movement and veganic developments in Europe. Finally, the article suggests the importance of expanded research into soil health and fertility in plant-based systems to support practicing and potential veganic farmers. (shrink)

Michel Seymour | : Dans ce texte, j’examine sur un mode programmatique la relation qui existe entre les peuples et les territoires. Les frontières des peuples souverains sont-elles sacrées, naturelles et absolues, voire irréfragables ? Le territoire a-t-il une importance identitaire ? Si oui, cette relation identitaire repose-t-elle sur l’attachement sentimental des citoyens ou sur une préférence rationnelle ? Doit-on plutôt l’expliquer par un rapport historique ? Le territoire est-il un élément constitutif de l’identité d’un peuple ? Le principe (...) de l’intégrité du territoire a-t-il une priorité absolue sur le principe affirmant le droit à l’autodétermination des peuples ? Tel est l’éventail de questions qui peuvent être posées en ce qui concerne la relation entre les peuples et leurs territoires. Je veux présenter une perspective qui me semble être originale. Dans la perspective du libéralisme politique, je pars d’une conception institutionnelle du peuple. Je me propose d’indiquer ensuite comment cette approche permet d’envisager des réponses à ces questions. | : In this paper, I examine in a programmatic fashion the relationship between peoples and territories. Are the borders of sovereign peoples sacred, natural and absolute, or even irrebuttable ? Does territory plays an important role for identity ? If so, is this relationship based on the sentimental attachment of citizens or on a rational preference ? Should it be explained instead by a historical relationship ? Is territory even constitutive of the identity of a people ? Does the principle of territorial integrity have priority over the principle asserting the right to self-determination of peoples ? Such are the issues that can be raised concerning the relationship between peoples and their territories. I want to present an account that I take to be original. In accordance with political liberalism, I start from an institutional conception of peoples. I then indicate how this approach allows to consider answers to some of these questions. (shrink)

The key word in amy account of the different ways that visual details are presented by novels and films is "assert." I wish to communicate by that word the force it has in ordinary rhetoric: an "assertion" is a statement, usually an independent sentence or clause, that something is in fact the case, that it is a certain sort of thing, that it does in fact have certain properties or enter into certain relations, namely, those listed. Opposed to asserting there (...) is mere "naming." When I say, "The cart was tiny; it came onto the bridge," I am asserting that certain property of the cart of being small in size and that certain relation of arriving at the bridge. However, when I say "The green cart came onto the bridge," I am asserting nothing more than its arrival at the bridge; the greenness of the cart is not asserted but slipped in without syntactic fuss. It is only named. Textually, it emerges by the way. Now, most film narratives seem to be of the latter textual order: it requires special effort for films to assert a property or relation. The dominant mode is presentational, not assertive. A film doesn't say, "This is the state of affairs," it merely shows you that state of affairs. Of course, there could be a character or a voice-over commentator asserting a property or relation; but then the film would be using its sound track in much the same way as fiction uses assertive syntax. It is not cinematic description but merely description by literary assertion transferred to film. Filmmakers and critics traditionally show disdain for verbal commentary because it explicates what, they feel, should be implicated visually. So in its essential visual mode, film does not describe at all but merely presents; or better, it depicts, in the original etymological sense of that word: renders in pictorial form. I don't think that this is mere purism or a die-hard adherence to silent films. Film attracts that component of our perceptual apparatus which we tend to favor over the other senses. Seeing, after all, is believing. Seymour Chatman, professor in the department of rhetoric at the University of California, Berkeley, is the author of The Later Style of Henry James and Story and Discourse: Narrative Structure in Fiction and Film. His contribution to Critical Inquiry, "Reply to Barbara Herrnstein Smith" appeared in the Summer 1981 issue. (shrink)

Bailey (2021) offers a clever argument for the compatibility of determinism and moral responsibility based on the nature of intrinsic intentions. The argument is mistaken on two counts. First, it is invalid. Second, even setting that first point aside, the argument proves too much: we would be blameworthy in paradigm cases of non-blameworthiness. I conclude that we cannot reason from intentions to responsibility solely from the “inside out”—our possessing a blameworthy intention cannot tell us whether this intention is also blameworthy (...) in deterministic worlds. (shrink)

Bailey (2021) offers a clever argument for the compatibility of determinism and moral responsibility based on the nature of intrinsic intentions. The argument is mistaken on two counts. First, it is invalid. Second, even setting that first point aside, the argument proves too much: we would be blameworthy in paradigm cases of non-blameworthiness. I conclude that we cannot reason from intentions to responsibility solely from the “inside out”—our possessing a blameworthy intention cannot tell us whether this intention is also blameworthy (...) in deterministic worlds. (shrink)

Cet article vise à enrichir l’approche désagrégative proposée par Cécile Laborde dans Liberalism’s Religion [HUP, 2017] à l’aide de certaines intuitions rawlsiennes provenant de notre ouvrage La nation pluraliste [PUM, 2018]. En partant de la notion d’« accommodement raisonnable » telle que comprise dans le contexte légal du Québec et du Canada, nous parvenons à une interprétation des fondements normatifs de la distinction entre droits fondamentaux et accommodements qui repose sur la raison publique. La perspective que nous défendons permet ultimement (...) d’admettre des droits fondamentaux à la fois pour les personnes et pour les groupes. (shrink)

Some incompatibilists about free will or moral responsibility and determinism would abandon their incompatibilism were they to learn that determinism is true. But is it reasonable to flip-flop in this way? In this article, we contend that it is and show what follows. The result is both a defense of a particular incompatibilist strategy and a general framework for assessing other cases of flip-flopping.

In 100 essays, scholars from throughout the world introduce and analyze ancient, modern, and contemporary philosophers and philosophies. The first section explains 40 major western and non- western philosophies that underlie the major political theories. The second provides intellectual and biographical information on 26 philosophers and some of the schools surrounding them, such as Hobbesian and Machiavellian thought. The third explores philosophical ideas such as anarchy, women and democracy, and war and civil conflict. Each article provides a bibliography and identifies (...) related entries. c. Book News Inc. (shrink)