DNA methylation plays a key role in neural cell fate and provides a molecular link between early life stress and later-life behavioral phenotypes. Here, studies that combine neuroimaging methods and DNA methylation analysis in pediatric population with a history of adverse experiences were systematically reviewed focusing on: targeted genes and neural correlates; statistical models used to examine the link between DNA methylation and neuroimaging data also considering early life stress and behavioral outcomes. We identified 8 studies that report associations between (...) DNA methylation and brain structure/functions in infants, school age children and adolescents faced with early life stress condition. Results showed that several genes were investigated and different neuroimaging techniques were performed. Statistical model used ranged from correlational to more complex moderated mediation models. Most of the studies considered DNA methylation and neural correlates as mediators in the relationship between early life stress and behavioral phenotypes. Understanding what role DNA methylation and neural correlates play in interaction with early life stress and behavioral outcomes is crucial to promote theory-driven studies as the future direction of this research fields. (shrink)

This high-level study discusses Newtonian principles and 19th-century views on electrodynamics and the aether. Additional topics include Einstein's electrodynamics of moving bodies, Minkowski spacetime, gravitational geometry, time and causality, and other subjects. Highlights include a rich exposition of the elements of the special and general theories of relativity.

Recordando a Bachelard a medio siglo de su muerte (2011) -- Filosofia de la relatividad (2011) -- La proliferación de los conceptos de especie en la biología evolucionista (2010).

Eastern Market in Detroit is one of the oldest, continuously working public markets in the United States. Starting in 2006, the management changed and the market underwent a round of renovations. Since then, the Eastern Market Corporation has worked to increase the number of stands selling value-added food at the market. Following the EMC’s lead, the new vendors sell their fare in boutique style, putting specific care in the setup of the stands and in the visual and oral narratives they (...) use. Their presentation of food quality emphasizes craftsmanship and cultural values more than affordability or provenance. The interplay between these vendors and the EMC management point to two worlds identified by convention theory: domestic and market. The work of boutique food producers at Eastern Market manifests a composite arrangement between the domestic and market worlds where the authenticity of the products and regard for the customers are composite principles that solidify the compromise. (shrink)

Despite the ideal of dispossession, absolute poverty and the total absence of links with possession and human beings which shaped the myth of the monastic desert, the monastic economy and its management were very similar to the secular economic system, in that both were organised by networks based on families.This article tackles how and where material assets were produced and administered in Egyptian monasteries between the fourth and eighth centuries, and who was responsible for this function. The history of monasticism (...) is materially related to the institutionalisation of the society’s cultural and material systems of production. Consequently the economy was also transformed by monastic practices: history is linked to the definition and the successful affirmation of the figure of the oikonomos, the steward in charge of everyday life in monasteries. (shrink)

Volume 19, Issue 9, September 2019, Page 37-39.

A critical survey of the main philosophical theories about events and event talk, organized in three main sections: (i) Events and Other Categories (Events vs. Objects; Events vs. Facts; Events vs. Properties; Events vs. Times); (ii) Types of Events (Activities, Accomplishments, Achievements, and States; Static and Dynamic Events; Actions and Bodily Movements; Mental and Physical Events; Negative Events); (iii) Existence, Identity, and Indeterminacy.

This paper is concerned with certain ontological issues in the foundations of geographic representation. It sets out what these basic issues are, describes the tools needed to deal with them, and draws some implications for a general theory of spatial representation. Our approach has ramifications in the domains of mereology, topology, and the theory of location, and the question of the interaction of these three domains within a unified spatial representation theory is addressed. In the final part we also consider (...) the idea of non-standard geographies, which may be associated with geography under a classical conception in the same sense in which non-standard logics are associated with classical logic. (shrink)

Neste artigo, temos como objetivo perscrutar o funcionamento da verbo-visualidade de uma perspectiva dialógica do discurso, utilizando, como material de análise, uma videomontagem humorística acerca do ator político Dilma Rousseff, durante a campanha presidencial brasileira do ano de 2010. Primeiramente, procuramos refletir acerca de alguns pressupostos teórico-metodológicos de Bakhtin e de Brait, qual seja, o de verbo-visualidade, alicerçado na concepção bakhtiniana de linguagem. Em um segundo momento, detivemo-nos na análise do texto objeto do artigo, que se pautou na seguinte indagação: (...) como contribuem e funcionam os elementos verbais e visuais para produção e direcionamento de sentidos na videomontagem? Nossa hipótese é a de que os discursos carregados pela montagem criam uma trilha ideológica de sentido que leva os interlocutores a interpretar a então candidata como uma pessoa sem discurso, manipulável. Diante do exposto, tentaremos demonstrar a hipótese que sustentamos. (shrink)

In this paper, we extend the expressive power of the logics K3, LP and FDE with anormality operator, which is able to express whether a for-mula is assigned a classical truth value or not. We then establish classical recapture theorems for the resulting logics. Finally, we compare the approach via normality operator with the classical collapse approach devisedby Jc Beall.

Roberto Esposito is one of the most prolific and important exponents of contemporary Italian political theory.

This unique textbook states and proves all the major theorems of many-valued propositional logic and provides the reader with the most recent developments and trends, including applications to adaptive error-correcting binary search. The book is suitable for self-study, making the basic tools of many-valued logic accessible to students and scientists with a basic mathematical knowledge who are interested in the mathematical treatment of uncertain information. Stressing the interplay between algebra and logic, the book contains material never before published, such as (...) a simple proof of the completeness theorem and of the equivalence between Chang's MV algebras and Abelian lattice-ordered groups with unit - a necessary prerequisite for the incorporation of a genuine addition operation into fuzzy logic. Readers interested in fuzzy control are provided with a rich deductive system in which one can define fuzzy partitions, just as Boolean partitions can be defined and computed in classical logic. Detailed bibliographic remarks at the end of each chapter and an extensive bibliography lead the reader on to further specialised topics. (shrink)

Volume 1 of Politics, a work in constructive social theory. Newly available, the complete work of Politicsa program for a comprehensive progressive alternative to the dominant ideologies of social democracy and neo-liberalismfrom one of the worlds leading social and political thinkers. False necessity is the central theme in the three-volume series Politics. It presents both a way of explaining society and a program for changing it. The explanation develops a radical alternative to Marxism, showing how we can account for established (...) social arrangements without denying their contingency or our freedom. The program offers a progressive alternative to the now-dominant ideological conceptions of neoliberalism and social democracy: a set of institutional innovations that would democratize markets, deepen democracy and empower individuals. For this new edition, Unger has written a comprehensive introduction that explores the limits of our understanding of society and our practice of politics, and reconsiders proposals contained in the book as special cases of a larger family of untried political possibilities. (shrink)

The experience of “coming out” to parents is often a crucial event in the lives of lesbian and bisexual women, associated with lower internalized sexual stigma and higher positive LB identity. Few studies have compared the experiences of LB women in the CO process. Rather, most prior research has either: not addressed bisexuality or eliminated bisexual individuals from the analysis; combined bisexual women and bisexual men in the same sexual orientation group; or examined bisexual participants alongside lesbian women and gay (...) men, using a single monolithic measure. Thus, the present research aimed at investigating the role of ISS and positive LB identity in inhibiting or encouraging CO to parents in a sample of 241 lesbian women and 186 bisexual women, aged 18–40 years. Most participants reported that they had already revealed their sexual orientation to their mother and their father. More lesbian women had CO to both their mother and their father than had bisexual women. These lesbian women reported lower levels of ISS and higher levels of LB positive identity relative to bisexual women. On average, CO to mothers occurred at age 20, while CO to fathers occurred at age 22. LB women did not differ in the average age of CO to mothers or fathers, or in parental reactions to CO. Finally, ISS was found to affect the process of CO to both parents via positive identity, whereas sexual orientation was not found to moderate the path from ISS to CO to both parents. The present study contributes to our understanding of the differences between LB women when developing their sexual orientation, highlighting the relevance of a positive LB identity for CO to parents. Research and clinical implications and directions for future research are discussed. (shrink)

According to a leading view, emotions such as admiration, contempt, pride, and shame are important vehicles of agential development. Through admiration and contempt, we establish models and countermodels against which to shape our character; through pride and shame, we get a sense of how we measure up to them. Critics of this view object that these emotions always deliver uncompromising evaluations: admiration casts people in a completely positive light, while contempt casts aspersion on them. Therefore, insofar as they lack the (...) capacity for nuance, these emotions are systematically unfitting and misleading. This paper discusses this objection as originally formulated by John Doris as well as Macalester Bell’s response. Drawing from research on emotional intentionality, it will be argued that Doris’ and Bell’s accounts are respectively misguided criticisms and inadequate defences of these emotions. Their mistake lies in an invalid transition from the claim that these emotions are intentionally directed towards persons to the claim that they deliver global evaluations of those towards whom they are directed. By rejecting this inference, it will be shown that these emotions can deliver nuanced and fitting evaluations in a way Doris’ objection overlooks and Bell’s response precludes us from articulating. (shrink)

In this article Roberto Balzani, the mayor of Forlì, remembers Roberto Ruffilli, 25 years after his murder. The remembrance reconstructs the steps of his academic career and of his political commitment. Ruffilli graduated at the Catholic University of Milan; his researches in contemporary history placed him in an original position if compared with the Italian studies of the time. The constant attention towards the history of administration and the transformations of the state is the basis on which Ruffilli (...) built his proposals concerning the reform of the insitutional and political system. Balzani concludes the article by affirming that the problems of today aren't any different, that is why Ruffilli's proposals still demonstrate their modernity. (shrink)

This book by Roberto Esposito - a leading Italian political philosopher - is a highly original exploration of the relationship between human bodies and societies. The original function of law, even before it was codified, was to preserve peaceful cohabitation between people who were exposed to the risk of destructive conflict. Just as the human body's immune system protects the organism from deadly incursions by viruses and other threats, law also ensures the survival of the community in a life-threatening (...) situation. It protects and prolongs life. But the function of law as a form of immunization points to a more disturbing consideration. Like the individual body, the collective body can be immunized from the perceived danger only by allowing a little of what threatens it to enter its protective boundaries. This means that in order to escape the clutches of death, life is forced to incorporate within itself the lethal principle. Starting from this reflection on the nature of immunization, Esposito offers a wide-ranging analysis of contemporary biopolitics. Never more than at present has the demand for immunization come to characterize all aspects of our existence. The more we feel at risk of being infiltrated and infected by foreign elements, the more the life of the individual and society closes off within its protective boundaries, forcing us to choose between a self-destructive outcome and a more radical alternative based on a new conception of community. (shrink)

This paper discusses three relevant logics that obey Component Homogeneity - a principle that Goddard and Routley introduce in their project of a logic of significance. The paper establishes two main results. First, it establishes a general characterization result for two families of logic that obey Component Homogeneity - that is, we provide a set of necessary and sufficient conditions for their consequence relations. From this, we derive characterization results for S*fde, dS*fde, crossS*fde. Second, the paper establishes complete sequent calculi (...) for S*fde, dS*fde, crossS*fde. Among the other accomplishments of the paper, we generalize the semantics from Bochvar, Hallden, Deutsch and Daniels, we provide a general recipe to define containment logics, we explore the single-premise/single-conclusion fragment of S*fde, dS*fde, crossS*fdeand the connections between crossS*fde and the logic Eq of equality by Epstein. Also, we present S*fde as a relevant logic of meaninglessness that follows the main philosophical tenets of Goddard and Routley, and we briefly examine three further systems that are closely related to our main logics. Finally, we discuss Routley's criticism to containment logic in light of our results, and overview some open issues. (shrink)

As the worlds of economics, politics, culture, and communications face a growing wave of globalization that will likely continue, ethical challenges for journalists have also gone global. I propose a clear division between ethics codes for media owners, the public, and professional journalists and present a set of considerations and specific rules applicable only to the last group. In this article I advocate a universal code of journalistic ethics but point out problems and warn against dangers that have made the (...) application of such codes difficult in the past. A universal code should consider the voluntary nature of such an endeavor, the cultural and economic differences in various journalistic traditions, and the problem of producing solutions acceptable to all involved. (shrink)

A discussion with Roberto Andorno about global bioethics and biolaw, the Coronavirus pandemic, and its impact on human dignity and rights. Can we foresee the emerging new profile of global bioethics and biolaw in the post-Coronavirus era? How significant are they going to be in the future, after the enormous pressure that the Coronavirus pandemic has exercised on key political, legal, and ethical values? Must the voice of bioethicists -compared to the ‘hard’ scientific data- be louder in the future (...) concerning decisions about emergency social and medical measures? Is there a hope that public empowerment will support robust, global public engagement and meaningful deliberation? How much does Roberto Andorno’s view on human dignity reveal a supposed commitment to moral realism? The massive deaths of elderly people living in hospices of Sweden, Spain, and Italy, based on an implicit ‘fair innings’ view, has recently posed certain questions on the moral unacceptability of such practices. The same questions arise in the case of the legalization of euthanasia grounded on the implicit acceptance of the view that life is not worth living under certain circumstances. Is it possible that the human rights bodies worldwide will acquire executive power, and how could this become possible? How influential the ‘precautionary principle’ can become regarding clinical and research ethics in the future? How urgent is the importance of the introduction of bioethical education in the curricula of ‘hard’ empirical studies? Roberto Andorno discusses with us all these controversial and under heated public debate issues, giving sometimes provocative answers. (shrink)

A wide family of many-valued logics—for instance, those based on the weak Kleene algebra—includes a non-classical truth-value that is ‘contaminating’ in the sense that whenever the value is assigned to a formula φ⁠, any complex formula in which φ appears is assigned that value as well. In such systems, the contaminating value enjoys a wide range of interpretations, suggesting scenarios in which more than one of these interpretations are called for. This calls for an evaluation of systems with multiple contaminating (...) values. In this paper, we consider the countably infinite family of multiple-conclusion consequence relations in which classical logic is enriched with one or more contaminating values whose behavior is determined by a linear ordering between them. We consider some motivations and applications for such systems and provide general characterizations for all consequence relations in this family. Finally, we provide sequent calculi for a pair of four-valued logics including two linearly ordered contaminating values before defining two-sided sequent calculi corresponding to each of the infinite family of many-valued logics studied in this paper. (shrink)

This book describes the mathematical aspects of the semantics of programming languages. The main goals are to provide formal tools to assess the meaning of programming constructs in both a language-independent and a machine-independent way, and to prove properties about programs, such as whether they terminate, or whether their result is a solution of the problem they are supposed to solve. In order to achieve this the authors first present, in an elementary and unified way, the theory of certain topological (...) spaces that have proved of use in the modelling of various families of typed lambda calculi considered as core programming languages and as meta-languages for denotational semantics. This theory is now known as Domain Theory, and was founded as a subject by Scott and Plotkin. One of the main concerns is to establish links between mathematical structures and more syntactic approaches to semantics, often referred to as operational semantics, which is also described. This dual approach has the double advantage of motivating computer scientists to do some mathematics and of interesting mathematicians in unfamiliar application areas from computer science. (shrink)

ABSTRACT The philosophical tradition approaches to morals have their grounds predominantly on metaphysical and theological concepts and theories. Among the traditional ethics concepts, the most prominent is the Divine Command Theory (DCT). As per the DCT, God gives moral foundations to the humankind by its creation and through Revelation. Morality and Divinity are inseparable since the most remote civilization. These concepts submerge in a theological framework and are largely accepted by most followers of the three Abrahamic traditions: Judaism, Christianity, and (...) Islam: the greatest part of the human population. Holding faith and Revelation for its grounds, the Divine Command Theories are not strictly subject to the demonstration. The opponents to the Divine Command conception of morals, grounded in the impossibility of demonstration of its metaphysical and religious assumptions, have tried for many centuries (albeit unsuccessfully) to devalue its importance. They held the argument that it does not show material evidence and logical coherence and, for this reason, cannot be taken into account for scientific nor philosophical purposes. It is just a belief and, as so, should be understood. Besides these extreme oppositions, many other concepts contravene the Divine Command theories, in one or another way, in part or in full. Many philosophers and social scientists, from the classic Greek philosophy up to the present date, for instance, sustain that morality is only a construct, and thus culturally relative and culturally determined. However, this brings many other discussions and imposes the challenge to determine what is the meaning of culture, which elements of culture are morally determinant, and finally, what are the boundaries of such relativity. Moral determinists claim that everything related to human behavior, including morality, is determined, once free will does not exist. More recently, modern thinkers argued that there is a strict science of morality. However, the scientific method alone, despite explaining several facts and evidence, cannot enlighten the entire content and full meaning of ethics. Morals’ understanding requires a broader perception, and an agreement among philosophers, which they have never achieved. All of these questions have many different configurations depending on each philosophical strand, and start complex analysis and endless debates, as long as many of them are reciprocally conflictive. The universe and the atmosphere involving this thesis are the dominions of all these conceptual conflicts, observed from an objective and evolutionary standpoint. Irrespective of this circumstance and its intrinsic importance, however, these questions are far distant from the methodological approach of an analytical discussion on objective morals, what is, indeed, the aim and scope of this work. We should briefly revisit these prominent traditional theories because this thesis shelters a comparative study, and its assumptions at least differ profoundly from all traditional theories. Therefore, it becomes necessary offering direct and specific elements of comparison to the reader, for the right criticism, dispensing interruptive researches. However, even revisiting the traditional theories, for this comparative and critical exposure purpose, they will be kept by the side of our main concerns, as “aliena materia.” Irrespective of the validity of any or all of the elements of this discussion, and their meaning as the philosophical universe of this thesis, the purpose of this work is demonstrating and justifying the existence and meaning of prehistoric moral archetypes arisen directly from the very first social needs and efforts for survival. These archetypes are the definition of the essential foundation of ethics, its aggregation to the collective unconscious and corresponding logic organization and transmission to evolutionary stages of the human genome and different relations space-time, irrespective of any contemporary experience of the individuals. The system defined by these archetypes composes an evolutionary human social model. Is this a metaethical position? Yes, it is. Moreover, as in any metaethical reasoning, we should look carefully for the best and coherent routes, as the Analytical Philosophy offers them. Thus, this work should reasonably demonstrate that morals are not a cultural product of the civilized men or modern societies and that despite being subject to several cultural relative aggregations and subtractions, its essential foundations are archetypal and have never structurally changed. This reasoning induces that morality is an original attribute of the “homo sapiens”; it is not a property and nor an accident: it integrates the human essence and belongs to the realm of the ontological human identity. The human phenomena is a continuing process, playing its role between random determination and free will, and we need to question how morality began and how did it come to us in the present. (shrink)