Apoptosis is a physiological mechanism for the removal of unwanted or damaged cells. Apoptotic cells are rarely seen in living tissues, however, because of their rapid and efficient removal by phagocytosis. Phagocytotic cells such as macrophages or dendritic cells recognize apoptotic cells by specific changes of cell surface markers, which usually are not present on normal cells. One such event is the exposure of phosphatidylserine, which moves from the plasma membrane inner leaflet to the outer leaflet in preapoptotic cells. An (...) unresolved problem, however, was the nature of the phosphatidylserine receptor on the phagocytotic cells. In a recent issue of Nature, Fadok et al.(1) have reported the cloning of a phosphatidylserine receptor using an antibody raised against activated macrophages. Antibody treatment of these macrophages blocks this capacity to engulf. BioEssays 22:878–881, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

We examined social facilitation and emotional convergence in amusement, sadness, and fear in dynamic interactions. Dyads of friends or strangers jointly watched emotion-eliciting films while they either could or could not communicate nonverbally. We assessed three components of each emotion (expressions, appraisals, and feelings), as well as attention to and social motives toward the co-participant. In Study 1, participants interacted through a mute videoconference. In Study 2, they sat next to each other and either were or were not separated by (...) a partition. Results revealed that facilitation and convergence are not uniform across different emotions and emotion components. Particularly strong supporting patterns emerged for the facilitation of and convergence in smiling. When direct interaction was possible (Study 2), friends showed a general tendency for strong convergence, with the exception of fear-related appraisals. This suggests that underlying processes of emotional contagion and social appraisal are differentially relevant for different emotions. (shrink)

Emotional creativity (EC) is a pattern of cognitive abilities and personality traits related to originality and appropriateness in emotional experience. EC has been found to be related to various constructs across different fields of psychology during the past 30 years, but a comprehensive examination of previous research is still lacking. The goal of this review is to explore the reliability of use of the Emotional Creativity Inventory (ECI) across studies, to test gender differences and to compare levels of EC in (...) different countries. Thirty-five empirical studies focused on EC were retrieved and the coefficients required for the meta-analysis extracted. The meta-analysis revealed that women showed significantly higher EC than men (total N = 3,555). The same gender differences were also found when testing scores from three ECI subscales, i.e. emotional novelty, emotional preparedness and emotional effectiveness/authenticity. When comparing EC in 10 different countries (total N = 4,375), several cross-cultural differences were revealed. The Chinese sample showed a significantly lower average ECI total score than all the other countries. Based on the integration of results, the avenues for future research on EC and the breadth of influence of the concept of EC across different fields of psychology are discussed. Keywords: Emotional Creativity, Review, Meta-Analyses, Meta-Analysis, Definition, Emotional Creativity Inventory, ECI, Reliability, Gender Differences, Cross-cultural, Cross-culture, Personality Traits, NEO Personality Inventory, Big Five, Extraversion, Agreeableness, Openness to Experience, Introversion, Neuroticism, Emotions, Creativity, Cognition, Cognitive Abilities, Affect, Fantasy, Coping, Alexithymia, Anhedonia, Self-understanding, Motivation, Creativeness, Innovative Performance, Creative Ability, Artistic Creativity, Creative Thinking. MeSH Headings: Emotions, Creativity, Affect, Affective Symptoms, Gender, Sex, Gender Identity, Cross-Cultural Comparison, Transcultural Studies, Temperament, Extraversion, Neuroticism, Anhedonia, Creativeness, Cognition, Cognitive Function, Artistic Creativity, Creative Ability, Creative Thinking. (shrink)

The aim is to examine Alois Riehl’s contribution to the “culture war” (Kulturkampf) in the second half of the nineteenth century. We show that he used Kant’s autonomy principle to argue against the idea that religious dogmatism is a fundament of morality. We prove this thesis by focusing on the forgotten historical background, which is important for an understanding of Morals und Dogma. Originally this essay was an expert opinion for the court case of the socialist H. Tauschinski who was (...) accused of blasphemy. Tauschinski wrote an article in which he doubted the immortality of the soul and the existence of a personal God. These two dogmas of the Catholic Church were considered bу the Austrian authorities to be the foundations of public order. Riehl questioned not only the charge but also the validity of religious dogmas for morality. Based on Kant’s ethics, he argued for a moral indifferentism of religious dogmas. His career was significantly influenced by this essay, because of its anti-clerical content. During the culture war, Riehl repeatedly had problems with the authorities, especially in the Austro-Hungarian monarchy. The “Neurath-Haller Thesis” argues that in Austria the appointment of professorships was controlled and monitored by the state, with the goal of installing a philosophy which was beneficial to the interests of the state, and a strong anti-Kantianism in Austrian Philosophy as a consequence. We can agree with this thesis insofar as Riehl in the period of the “Catholic Renaissance” in Austria was not allowed to succeed Ernst Mach. The analysis of Riehl’s arguments allows us furthermore to understand Riehl as a neo-Kantian as early as 1871/1872, which has been questioned by many authors who think the early Riehl was no Kantian. (shrink)

Evidence for infants' sensitivity to behavior being goal oriented leaves it open as to whether they see such behavior as being designed to lead to an external goal or whether they see it, in addition, as being directed by an internal representation of the goal. We point out the difficulty of finding possible criteria for how infants or children view this matter.

The study investigates effects of the implementation of a law authorizing educational leave in Germany on individual participation in adult learning and education (ALE). In 2015, the federal state of Baden-Württemberg introduced the so-calledBildungszeitgesetz, legitimating an exemption for eligible employees of up to 5 days per year with continued payment of salary. Explaining participation in ALE is a central subject of educational research at national and international level. Current theoretical assumptions of rational choice and empirical findings of educational and socio-statistical (...) research suggest that within the general population, individuals’ availability of time affects the decision to participate and therefore lastly determines participation in ALE. However, current academia mainly discusses time as either a prerequisite for learning activities or as an observable outcome of participation and not as an explanatory factor. Furthermore, since recent studies remain on a descriptive level regarding influences of time on participation in ALE, no causal effects of the availability of time on participation are estimated. Hence, our study addresses this research gap by investigating effects of educational policy interventions such as theBildungszeitgesetzon participation in ALE. Policy interventions are ideally suited to examine the significance of time resources for participation, as the implementation of theBildungszeitgesetzprovides a specific timeframe for employees to participate in ALE outside of their working time. Drawing on data from the German National Educational Panel Study, we employ a difference-in-differences estimation strategy with propensity score matching and instrumental variable to identify the direct causal effect of the implementation of theBildungszeitgesetzon participation in ALE (N= 709). This combination toward causal inference controls for observed and unobserved baseline differences as well as heterogeneous treatment effects. The results reveal a non-significant but heterogeneous treatment effect of the implementation of theBildungszeitgesetzon individual participation in ALE. Contrary to our theoretical assumptions derived from rational choice approaches, we cannot confirm the hypothesis that the availability of time resources due to the implementation of theBildungszeitgesetzcauses a positive effect on participation in ALE. Furthermore, the results reveal that the implementation causes decreasing participation rates for younger adults, women and significantly for migrants. (shrink)

A common finding is that information order influences belief revision (e.g., Hogarth & Einhorn, 1992). We tested personal experience as a possible mitigator. In three experiments participants experienced the probabilistic relationship between pieces of information and object category through a series of trials where they assigned objects (planes) into one of two possible categories (hostile or commercial), given two sequentially presented pieces of probabilistic information (route and ID), and then they had to indicate their belief about the object category before (...) feedback. The results generally confirm the predictions from the Hogarth and Einhorn model. Participants showed a recency effect in their belief revision. Extending previous model evaluations the results indicate that the model predictions also hold for classification decisions, and for pieces of information that vary in their diagnostic values. Personal experience does not appear to prevent order effects in classification decisions based on sequentially presented pieces of information and in belief revision. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 40.2 (2002) 256-257 [Access article in PDF] Book Review Die Struktur des menschlichen Geistes nach Augustinus: Selbstreflexion und Erkenntnis Gottes in "De Trinitate" Johannes Brachtendorf. Die Struktur des menschlichen Geistes nach Augustinus: Selbstreflexion und Erkenntnis Gottes in "De Trinitate." Hamburg: Felix Meiner Verlag, 2000. Pp. viii + 335. Cloth, DM 128,00. "The Trinity" is arguably Augustine's (philosophically) most demanding work. Yet it is (...) precisely its philosophical quality that is nowadays sometimes called in question for its apparent lack of argumentative coherence. H. I. Marrou has even expressed the view that this may have been intended, as the text is designed as an exercitatioanimi, a spiritual-mental exercise; i.e., the argumentative gaps are deliberately left open to be filled in by whoever undergoes the exercise. This would mean that "The Trinity" lacks any philosophical or theological position or doctrine in particular, and that it must not be judged by the standards of philosophical discourse, even those of Augustine's own day and age. Brachtendorf sets out with a revision of that view. Augustine, he argues, does indeed formulate a particular position. The impression that there may be gaps in his arguments could well stem from a misunderstanding of some of them. Augustine, Brachtendorf reports in his first chapter (1), developed his teaching of the triune God in close contact with the philosophy of Plotinus. However, he distanced himself from Plotinus by analyzing the process of cognition not by taking as an example the divine nous, but the menshumana. Apart from that he developed an ontology of the Trinity (2) and only then analyzed the human mind in analogy to it (3-4). He also looked into the relationship of mind and language ("word") (5) and developed further some aspects of this relationship such as the trinitarian structure of the human mind (6), the relationship of knowledge and wisdom (7), the human mind as the image of God (8), the self-reflection of the human mind (9), language as an expression of that self-reflection in the image of God (10), and the concept of the "inner word" (11).Brachtendorf concludes with an appeal not to read into Augustine's link of notitia and amor that he was interested in the analysis of self-knowledge merely for ethical reasons. Amor, he argues, expressly includes operations of the intellect. Augustine's interest was therefore genuinely theoretical and intellectualist. Amor, for Augustine, was a force that creates knowledge as such, no matter what the content. Its impact is practical and theoretical. Referring to the works of Charles Taylor, Martin Heidegger, Max Scheler, Hans-Georg Gadamer, and Hannah Arendt, Brachtendorf demonstrates how influential Augustine was with this aspect of his thought in the development of "Subjekt"-centered philosophies in the twentieth century. Yet, as influential as this approach may have been in this particular field, arguing, as it did, for the ontological character of human subjectivity (i.e., that the human mind was naturally structured in a trinitarian way, but had to make its natural intelligence explicit in thought through the learning of language) it did not revolutionize [End Page 256] the understanding of language. In consequence it did not impress the philosophers of the linguistic turn, and that is probably why today the argument of "The Trinity" is so often found wanting.Pointing back to the source Brachtendorf's study is a welcome contribution to the subject and a useful guide for all who now--hopefully, and encouraged by this work--set out for themselves to have a (closer) look at the original. Josef Lössl Catholic University Leuven... (shrink)

Ever since ›Die Kunst der Entzweiung‹, one can detect a certain Lubitsch touch at work in Martin Seel’s books: subtlety, wit, finesse, elegance, nonchalance. In a general typology that tentatively orders philosophy in its relation to comedy, Seel accordingly belongs to the wellknown type of irony and humour. However, this type can only show its strength when it absorbs the unsettling intensity of experiences and the sting of indissoluble opposites, a synthesis for which Billy Wilder stands cinematically.

Alonso, Ángel Castigo y derecho sin libre albedrío ni responsabilidad Punishment and law without free will and no responsibility López Corredoira, Martín De los metarrelatos a la "muerte de los intelectuales". Una mirada al "Humanismo impenitente" desde la reconstrucción neonietzscheana postmoderna From meta - reports to the "demise of intellectuals". A view of "impenitent humanism" from post-modern neo-Nietzschean deconstruction Mora García, José Pascual Kant y el método de trascender en la filosofía de Karl Jaspers Kant and the transcendental method in (...) the Karl Jaspers philosophy Portuondo Pajón, Gladys L. La creatio ex Nihilo y sus implicaciones fenomenológicas en Levitas La creatio ex Nihilo and it's phenomenology implications in Levinas Ramírez, Gustavo ¿Qué significa meditar? What does it mean to meditate? Ramis Muscato, Pompeyo Sobre la violencia: Orígenes y antídoto Regarding violence: Origens and antidotes Vasquez, Eduardo Interdisciplinares Louis Kahn: Filosofía, arte y arquitectura Louis Kahn: Philosophy, arte and architecture Arellano Spinetti, Leonardo La oligarquía venezolana en el siglo XXI: Del estereotipo al anacronismo The Venezuelan oligarchy in the XXI century: From the stereotype to the anachronism Varela Manrique, Luz Coromoto Traducciones El arte de pensar Maurois, André Friedrich Nietzsche. 1844-1900. (shrink)

The variety of symptoms associated with schizophrenia are not easily unified under one coherent concept. Nevertheless, under the gaze of phenomenology, a disturbance of pre-reflexive experience has become increasingly apparent as the basis of the condition, which has so far been understood in two different ways: on the one hand, as a disturbance of basal self-experience, of my-ness or ipseity (Louis Sass, Josef Parnas, Dan Zahavi) and on the other hand, as a disturbance of the passive synthesis of inner (...) time consciousness (Aaron Mishara, Shaun Gallagher, Thomas Fuchs). The present work introduces a link between the two approaches by regarding the basal self-experience grounded in an inner time consciousness. Schizophrenia is thus described as a disturbance of the temporal constitution of self-experience, which on the one hand causes self-alienation and on the other impairs the pre-reflexive, embodied performance of thinking, perceiving and moving. These analyses are then applied to the social dimension of the disorder, which manifests itself, among other symptoms, in the loss of spontaneous attunement with others. (shrink)

Excerpt from Forschungen Uber die Lateinischen Aristoteles-Ubersetzungen des XIII Jahrhunderts Den XVIl. Band dieser, Beitrage kann ich nicht l1inausgehen lassen, ohne dem Verfasser der Abhandlung uber, Zeit und Ewigkeit nach Thomas von Aquino, welche den Band beginnt, meinem lieben Schuler Dr. Friedrich Josef Beemelmans, ein Wort des Gedenkens nachzurufen Zu Beginn des Weltkan1pfs voll Begeisterung mit dem Bayerischen InfanterieLeibregiment zur Verteidigung des Vaterlandes hinausgezogen, tapfer bewahrt im Kampf, an dem er, von einer Verwundung notdurftig geheilt, alsbald wieder teilnahn 1, (...) starb er am 29. September 1914 bei Flaucourt unweit Peronne den Hel(lentod fur das Vaterland. Viele Hoffnungen sanken Init ihm dahin: fur die Wissenschaft, in der es ihn aulzer zur Philosophie, die er am Institut catholique zu Paris und in Munchen gepflegt hatte, besonders Zur Mathen1atik l1inzog, welcher er als Geisteserbe seines verstorbenen Vaters der als Ministerialrat im Ministerium von ElsasLotliriiigeii insbesondere die technischen Angelegenheiten ver waltete eine besondere Vorliebe entgegenbrachte und die er in Verbindung mit der Philosophie zu seiner Lebens a11fgabe Inachen wollte, sowie fur seine tiefgepruftc, treu sorgende Mutter, eine Schwester des fruheren grolzbritannischen Botschafters in St. Petersburg, Sir Arthtir Nicolson, die an allen seinen Bestrebungen den tatigsten Anteil nahm und der er jederzeit der liebevollste Sohn war. Aber auch die "Beitrage" selbst haben in Inanclien Beziehungen die durch den Krieg geschaffenen Schwierigkeiten zu verspuren gehabt, wie man auch aus dem Vorwort Martin Grabn1anns zu seinen, Forschungen uber die lateinischen Aristoteles ubersetzungen des Xlll. Jahrhunderts" (Heft 5 - 6) ersehen kann. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.". (shrink)

Este artículo presenta primero las objeciones que John Crosby y Josef Seifert han opuesto a la noción boeciana de persona. Responde después a dichas objeciones mediante (a) una crítica a la metafísica que esas objeciones presuponen, (b) un mostrar cómo se puede atender a las principales preocupaciones de los fenomenólogos sin abandonar la noción boeciana, (c) un señalar algunos problemas teológicos que podría suscitar la metafísica fenomenológica y que, sin duda, esos dos autores desearían evitar.

Josef Pieper’s critique of Martin Heidegger’s Wahrheitsbegriff has been virtually ignored in both Pieper and Heidegger scholarship; however, Pieper’s critique of Heidegger is both lethal and affirmative. On the one hand, Pieper makes a strong case against Heidegger’s Wahrheitsbegriff in “Vom Wesen der Wahrheit” and yet on the other he affirms his thesis that “the essence of truth is freedom.” This paper attempts to mend this gap in the literature by first presenting Heidegger’s “Vom Wesen der Wahrheit,” the (...) essay in which Heidegger explicates his concept of truth. Second, I exegete the critique of Josef Pieper found in his “Heideggers Wahrheitsbegriff.” Third, I conclude the paper by contextualizing Pieper’s critique within Pieper’s Werke, and make a note of the philosophical insights derivative from Pieper’s less than simple relationship to Heidegger. (shrink)

Background In this study, we examined the ethical implications of Egypt’s new clinical trial law, employing the ethical framework proposed by Emanuel et al. and comparing it to various national and supranational laws. This analysis is crucial as Egypt, considered a high-growth pharmaceutical market, has become an attractive location for clinical trials, offering insights into the ethical implementation of bioethical regulations in a large population country with a robust healthcare infrastructure and predominantly treatment-naïve patients. Methods We conducted a comparative analysis (...) of Egyptian law with regulations from Sweden and France, including the EU Clinical Trials Regulation, considering ethical human subject research criteria, and used a directed approach to qualitative content analysis to examine the laws and regulations. This study involved extensive peer scrutiny, frequent debriefing sessions, and collaboration with legal experts with relevant international legal expertise to ensure rigorous analysis and interpretation of the laws. Results On the rating of the seven different principles (social and scientific values, scientific validity, fair selection of participants, risk-benefit ratio, independent review, informed consent and respect for participants) Egypt, France, and EU regulations had comparable scores. Specific principles (Social Value, Scientific Value, and Fair selection of participants) were challenging to directly identify due to certain regulations embodying 'implicit' principles more than explicitly stated ones. Conclusion The analysis underscores Egypt's alignment with internationally recognized ethical principles, as outlined by Emanuel et al., through its comparison with French, Swedish, and EU regulations, emphasizing the critical need for Egypt to continuously refine its ethical regulations to safeguard participant protection and research integrity. Key issues identified include the necessity to clarify and standardize the concept of social value in research, alongside concerns regarding the expertise and impartiality of ethical review boards, pointing towards a broader agenda for enhancing research ethics in Egypt and beyond. (shrink)

En el breve tratado _Del rimaritarsi_ (1542) el humanista italiano Sperone Speroni aborda un tema de interés en el Renacimiento, el de las viudas y las segundas nupcias. Se parte del análisis de este texto y se confronta con los de otros humanistas del mismo periodo, como Erasmo, Fusco, Valier, Trissino, Savonarola, Zarrabin, Cabei, Trotto, Dolce o Vives, para poder entender que la defensa del matrimonio también para la viuda es uno de los elementos clave del nuevo concepto de familia (...) en la sociedad moderna. (shrink)

There has been considerable progress in investigating collective actions in the last decades. However, the real progress is different from what many scholars take it to be. It lies in the fact that there is by now a wealth of different approaches from a variety of fields. Each approach has carved out fruitful mechanisms for explaining collective action, but is also faced with limitations. Given that situation, we submit that the next step in investigating collective action is to acknowledge the (...) plurality of approaches and bring them into dialogue. With this aim in mind, the present article discusses the strengths and weaknesses of some of the to our mind most relevant approaches to collective action in current debates. We begin with the collective intentionality framework, the team reasoning approach, and social identity theory. Then, we move to ecological social psychology, participatory sense-making, and, through the lenses of those frameworks, dynamical systems theory. Finally, we discuss practice theory. Against this background, we provide a proposal for a synthesis of the successful explanatory mechanisms as they have been carved out by the different research programs. The suggestion is, roughly, to understand collective action as dynamical interaction of a self-organizing system with its environment, shaped by a process of collective sense-making. (shrink)

The approach of structuralism came to philosophy from social science. It was also in social science where, in 1950–1970s, in the form of the French structuralism, the approach gained its widest recognition. Since then, however, the approach fell out of favour in social science. Recently, structuralism is gaining currency in the philosophy of mathematics. After ascertaining that the two structuralisms indeed share a common core, the question stands whether general structuralism could not find its way back into social science. The (...) nature of the major objections raised against French structuralism – concerning its alleged ahistoricism, methodological holism and universalism – are reconsidered. While admittedly grounded as far as French structuralism is concerned, these objections do not affect general structuralism as such. The fate of French structuralism thus does not seem to preclude the return of general structuralism into social science, rather, it provides some hints where the difficulties may lie. (shrink)

John Martin Fischer is one of the leading proponents of semi-compatibilism, one of the ideas proposed in the debates on free will and determinism. According to him, even if it is not possible to make a free choice once determinism is accepted, persons can be held morally responsible for their actions. Thus, the ability to choose one of several alternatives, i.e. to act otherwise, is not necessary for moral responsibility. In his translated article Responsibility and Inevitability, Fischer sketches an (...) outline of a theory of moral responsibility that explains how persons are responsible for their actions, for the actions they do not perform (omissions), and for the consequences of their actions or omissions. (shrink)

We argue for teleology as a description of the way in which we ordinarily understand others’ intentional actions. Teleology starts from the close resemblance between the reasoning involved in understanding others’ actions and one’s own practical reasoning involved in deciding what to do. We carve out teleology’s distinctive features more sharply by comparing it to its three main competitors: theory theory, simulation theory, and rationality theory. The plausibility of teleology as our way of understanding others is underlined by developmental data (...) in its favour. (shrink)

The question ‘What is death?’ is by no means exclusively or primarily a question of medical science. It is, in the last analysis, a philosophical question. The philosopher’s role in the discussion of death is twofold: On the one hand, he has to explore those highly intelligible and essentially necessary aspects of death which no other human science investigates. This task includes a phenomenology of life and death, an ontology and metaphysics, as well as a philosophical anthropology of death. It (...) likewise includes an analysis of the language of death and life and of the logical structure of the arguments used in the debates about life and death. On the other hand the philosopher has to warn representatives of other disciplines against concluding too much from the little they know and extending their methods to areas where they are not appropriate. Careful reflection on both philosophical knowledge and philosophical ignorance concerning death shows, I shall argue, that the definition of death in terms of ‘brain death’ ought to be rejected. (shrink)

Carl Menger's methodology describes reality as neatly organized, being constructed additively from strictly regular simple elements called pure types. Such a conception of the world's structure seems to invite mathematical treatment. Yet, his economics is not a mathematical one, and he even explicitly rejected mathematical approach to economics. This apparent puzzle is explained by Menger's failure to deliver in his methodological writings a realistic portrayal of what he was actually doing in his economics. His implicit ambition to retain the full (...) meaning of the natural language concepts while using them simultaneously as theoretical concepts makes his economics dependent on the general human knowledge. Because the latter is mostly non-mathematical, so has to remain the former. This makes his economics both richer as well as fuzzier as compared with mathematical economics. This seems to be the result of a deliberate decision to keep his economic theory more realistic. (shrink)