The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert Advisory Group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since (...) the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs Programme. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating and integrating evidence to identify causes of human cancer. The advancements adopted include strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. (shrink)

This paper aims to identify the constitutive rule of assertion, conceived by analogy with the rules of a game. That assertion has such rules is by no means obvious; perhaps it is more like a natural phenomenon than it seems. One way to find out is by supposing that it has such rules, in order to see where the hypothesis leads and what it explains. That will be done here. The hypothesis is not perfectly clear, of course, but we have (...) at least a crude conception of constitutive rules, which we may refine as we elaborate the hypothesis. Although no attempt will be made here to define ‘rule’, some remarks on constitutive rules will focus the discussion. (shrink)

On reading the last sentence, did you interpret me as saying falsely that everything — everything in the entire universe — was packed into my carry-on baggage? Probably not. In ordinary language, ‘everything’ and other quantifiers (‘something’, ‘nothing’, ‘every dog’, ...) often carry a tacit restriction to a domain of contextually relevant objects, such as the things that I need to take with me on my journey. Thus a sentence of the form ‘Everything Fs’ is true as uttered in a (...) context C if and only if everything that is relevant in C satisfies the predicate ‘F’; ‘everything’ ranges just over the contextually relevant things. Such generality is restricted in a context-relative way. (shrink)

§I schematises the evidence for an understanding of ‘know’ and other terms of epistemic appraisal that embodies contextualism or subject-sensitive invariantism, and distinguishes between those two approaches. §II argues that although the cases for contextualism and sensitive invariantism rely on a principle of charity in the interpretation of epistemic claims, neither approach satisfies charity fully, since both attribute metalinguistic errors to speakers. §III provides an equally charitable anti-sceptical insensitive invariantist explanation of much of the same evidence as the result of (...) psychological bias caused by salience effects. §IV suggests that the explanation appears to have implausible consequences about practical reasoning, but also that applications of contextualism or sensitive invariantism to the problem of scepticism have such consequences. §V argues that the inevitable difference between appropriateness and knowledge of appropriateness in practical reasoning, closely related to the difference between knowledge and knowledge of knowledge, explains the apparent implausibility. (shrink)

1. What are called ‘intuitions’ in philosophy are just applications of our ordinary capacities for judgement. We think of them as intuitions when a special kind of scepticism about those capacities is salient. 2. Like scepticism about perception, scepticism about judgement pressures us into conceiving our evidence as facts about our internal psychological states: here, facts about our conscious inclinations to make judgements about some topic rather than facts about the topic itself. But the pressure should be resisted, for it (...) rests on bad epistemology: specifically, on an impossible ideal of unproblematically identifiable evidence. 3. Our resistance to scepticism about judgement is not simply epistemic conservativism, for we resist it on behalf of others as well as ourselves. A reason is needed for thinking that beliefs tend to be true. 4. Evolutionary explanations of the tendency assume what they should explain. Explanations that appeal to constraints on the determination of reference are more promising. Davidson’s truth-maximizing principle of charity is examined but rejected. 5. An alternative principle is defended on which the nature of reference is to maximize knowledge rather than truth. It is related to an externalist conception of mind on which knowing is the central mental state. 6. The knowledge-maximizing principle of charity explains why scenarios for scepticism about judgement do not warrant such scepticism, although it does not explain how we know in any particular case. We should face the fact that evidence is always liable to be contested in philosophy, and stop using talk of intuition to disguise this unpleasant truth from ourselves. (shrink)

Can we turn the screw on counter-examples to the KK principle (that if one knows that P, one knows that one knows that P)? The idea is to construct cases in which one knows that P, but the epistemic status for one of the proposition that one knows that P is much worse than just one’s not knowing it. Of course, since knowledge is factive, there can’t be cases in which one knows that P and knows that one doesn’t know (...) that P (we can’t strengthen ¬KKp to K¬Kp)! If we can construct such cases, we may be able to use them to understand some puzzling epistemic phenomena. (shrink)

The paper criticizes epistemological conceptions of analytic or conceptual truth, on which assent to such truths is a necessary condition of understanding them. The critique involves no Quinean scepticism about meaning. Rather, even granted that a paradigmatic candidate for analyticity is synonymy with a logical truth, both the former and the latter can be intelligibly doubted by linguistically competent deviant logicians, who, although mistaken, still constitute counterexamples to the claim that assent is necessary for understanding. There are no analytic or (...) conceptual truths in the epistemological sense. The critique is extended to purportedly analytic inference rules. An alternative account is sketched on which understanding a word is a matter of participation in a linguistic practice, while synonymy and concept identity consist in sameness of truth-conditional semantic properties. Although there are philosophical questions about concepts, the idea that philosophical questions in general are conceptual questions generates only an illusion of insight into philosophical methodology. (shrink)

While there are several arguments on either side, it is far from clear as to whether or not countable additivity is an acceptable axiom of subjective probability. I focus here on de Finetti's central argument against countable additivity and provide a new Dutch book proof of the principle, To argue that if we accept the Dutch book foundations of subjective probability, countable additivity is an unavoidable constraint.

Discussions of higher-order vagueness rarely define what it is for a term to have nth-order vagueness for n>2. This paper provides a rigorous definition in a framework analogous to possible worlds semantics; it is neutral between epistemic and supervaluationist accounts of vagueness. The definition is shown to have various desirable properties. But under natural assumptions it is also shown that 2nd-order vagueness implies vagueness of all orders, and that a conjunction can have 2nd-order vagueness even if its conjuncts do not. (...) Relations between the definition and other proposals are explored; reasons are given for preferring the present proposal. (shrink)

It is argued that a subject's evidence consists of all and only the propositions that the subject knows.

Mechanistic philosophy of science views a large part of scientific activity as engaged in modelling mechanisms. While science textbooks tend to offer qualitative models of mechanisms, there is increasing demand for models from which one can draw quantitative predictions and explanations. Casini et al. (Theoria 26(1):5–33, 2011) put forward the Recursive Bayesian Networks (RBN) formalism as well suited to this end. The RBN formalism is an extension of the standard Bayesian net formalism, an extension that allows for modelling the hierarchical (...) nature of mechanisms. Like the standard Bayesian net formalism, it models causal relationships using directed acyclic graphs. Given this appeal to acyclicity, causal cycles pose a prima facie problem for the RBN approach. This paper argues that the problem is a significant one given the ubiquity of causal cycles in mechanisms, but that the problem can be solved by combining two sorts of solution strategy in a judicious way. (shrink)

The paper criticizes the truthmaker principle that every truth is made true by something. If we interpret ‘something’ as quantifying into sentence position, we can interpret the principle as a harmless logical truth, but that is not what advocates of the principle intend. They interpret ‘something’ as quantifying into name position, and the principle as requiring the existence of truthmaking individuals. The paper argues that we have no reason to believe the principle on this interpretation. Moreover, the converse Barcan formula (...) is inconsistent with the existence of truthmaking individuals for contingent truths. Considerations about our ability to count possible truthmaking individuals are used to argue that we should prefer the converse Barcan formula. (shrink)

Experiences of embodied remembering are familiar and diverse. We settle bodily into familiar chairs or find our way easily round familiar rooms. We inhabit our own kitchens or cars or workspaces effectively and comfortably, and feel disrupted when our habitual and accustomed objects or technologies change or break or are not available. Hearing a particular song can viscerally bring back either one conversation long ago, or just the urge to dance. Some people explicitly use their bodies to record, store, or (...) cue memories. Others can move skilfully, without stopping to think, in complex and changing environments thanks to the cumulative expertise accrued in their history of fighting fires, or dancing, or playing hockey. The forms of memory involved in these cases may be distinct, operating at different timescales and levels, and by way of different mechanisms and media, but they often cooperate in the many contexts of our practices of remembering. (shrink)

There is a constant temptation in philosophy to postulate a realm of phenomena in which nothing is hidden from us. Rene Descartes thought that one's own mind is such a realm. Ludwig Wittgenstein' enlarged the realm to everything that is of interest to philosophy. That they explained this special feature in very different ways hardly needs to be said; what is remarkable is their agreement on our possession of a cognitive home in which everything lies open to our view. Much (...) of our thinking – for example, in the physical sciences – must operate outside this home, in alien circumstances. The claim is that not all our thinking could be like that. (shrink)

§0. A familiar if obscure idea: an indicative conditional presents its consequent as holding in the actual world on the supposition that its antecedent so holds, whereas a subjunctive conditional merely presents its consequent as holding in a world, typically counterfactual, in which its antecedent holds. Consider this pair.

A theory of evidential probability is developed from two assumptions:(1) the evidential probability of a proposition is its probability conditional on the total evidence;(2) one's total evidence is one's total knowledge. Evidential probability is distinguished from both subjective and objective probability. Loss as well as gain of evidence is permitted. Evidential probability is embedded within epistemic logic by means of possible worlds semantics for modal logic; this allows a natural theory of higher-order probability to be developed. In particular, it is (...) emphasized that it is sometimes uncertain which propositions are part of one's total evidence; some surprising implications of this fact are drawn out. (shrink)

The paper responds to Neil Tennant's recent discussion of Fitch's so-called paradox of knowability in the context of intuitionistic logic. Tennant's criticisms of the author's earlier work on this topic are shown to rest on a principle about the assertability of disjunctions with the absurd consequence that everything we could make true already is true. Tennant restricts the anti-realist principle that truth implies knowability in order to escape Fitch's argument, but a more complex variant of the argument is shown to (...) elicit from his restricted principle exactly the consequences which it was intended to avoid. (shrink)

Being social creatures in a complex world, we do things together. We act jointly. While cooperation, in its broadest sense, can involve merely getting out of each other’s way, or refusing to deceive other people, it is also essential to human nature that it involves more active forms of collaboration and coordination (Tomasello 2009; Sterelny 2012). We collaborate with others in many ordinary activities which, though at times similar to those of other animals, take unique and diverse cultural and psychological (...) forms in human beings. But we also work closely and interactively with each other in more peculiar and flexible practices which are in distinctive ways both species-specific and culturally and historically contingent: from team sports to shared labour, from committee work to mass demonstrations, from dancing to reminiscing together about old times. (shrink)

Timothy Williamson; VII*—Equivocation and Existence, Proceedings of the Aristotelian Society, Volume 88, Issue 1, 1 June 1988, Pages 109–128, https://doi.org/10.

I put forward several desiderata that a philosophical theory of causality should satisfy: it should account for the objectivity of causality, it should underpin formalisms for causal reasoning, it should admit a viable epistemology, it should be able to cope with the great variety of causal claims that are made, and it should be ontologically parsimonious. I argue that Nancy Cartwright’s dispositional account of causality goes part way towards meeting these criteria but is lacking in important respects. I go on (...) to argue that my epistemic account, which ties causal relationships to an agent’s knowledge and ignorance, performs well in the light of the desiderata. Such an account, I claim, is all we require from a theory of causality. (shrink)

I. An argument is presented for the conclusion that the hypothesis that no one will ever decide a given proposition is intuitionistically inconsistent. II. A distinction between sentences and statements blocks a similar argument for the stronger conclusion that the hypothesis that I have not yet decided a given proposition is intuitionistically inconsistent, but does not block the original argument. III. A distinction between empirical and mathematical negation might block the original argument, and empirical negation might be modelled on Nelson''s (...) strong negation, but only on intuitionistically unacceptable assumptions. IV. Intuitionists may have to accept the original argument, and therefore be committed to a dubious view of time on which there cannot be merely inductive evidence for statements about the infinite future. (shrink)

According to this paper, respect for informed consent implies that subjects should often be told a good deal more than ethical guidelines explicitly or implicitly require. Unless subjects are informed of the researchers’ personal characteristics, views, and sponsors whenever they would be likely to consider them significant, their autonomy is being overridden. However, overriding subjects’ autonomy is sometimes required by the interests of researchers in not being discriminated against or suffering intrusions into their privacy. This paper resolves the conflict between (...) informed consent and the interests of researchers by recommending that (i) subjects generally should be told of the personal characteristics of researchers when relevant as part of the researchers’ job and (ii) that subjects should be told of researchers’ views when conceptually connected to the research and (iii) that subjects should almost always be told about sponsorship. While the paper explicitly limits the role of informed consent, these recommendations go significantly beyond most guidelines in their requirements about what information should be disclosed. (shrink)

The paper is a critique of Terry Horgan's transvaluationist theory of vagueness. It argues that Horgan's formulations equivocate between a semantic 'ought' and a semantic 'is'. On one reading, transvaluationism is trivially inconsistent. On another reading, it is consistent, but also consistent with an epistemic account of vagueness. In addition, the paper criticizes Horgan's attempt to recruit supervaluationism as a form of transvaluationism and his argument against vagueness in the world.

Background Machine learning (ML) is utilized increasingly in health care, and can pose harms to patients, clinicians, health systems, and the public. In response, regulators have proposed an approach that would shift more responsibility to ML developers for mitigating potential harms. To be effective, this approach requires ML developers to recognize, accept, and act on responsibility for mitigating harms. However, little is known regarding the perspectives of developers themselves regarding their obligations to mitigate harms.Methods We conducted 40 semi-structured interviews with (...) developers of ML predictive analytics applications for health care in the United States.Results Participants varied widely in their perspectives on personal responsibility and included examples of both moral engagement and disengagement, albeit in a variety of forms. While most (70%) of participants made a statement indicative of moral engagement, most of these statements reflected an awareness of moral issues, while only a subset of these included additional elements of engagement such as recognizing responsibility, alignment with personal values, addressing conflicts of interests, and opportunities for action. Further, we identified eight distinct categories of moral disengagement reflecting efforts to minimize potential harms or deflect personal responsibility for preventing or mitigating harms.Conclusions These findings suggest possible facilitators and barriers to the development of ethical ML that could act by encouraging moral engagement or discouraging moral disengagement. Regulatory approaches that depend on the ability of ML developers to recognize, accept, and act on responsibility for mitigating harms might have limited success without education and guidance for ML developers about the extent of their responsibilities and how to implement them. (shrink)

Timothy Williamson The Bulletin of Symbolic Logic, Volume 19, Issue 1, Page 123-126, March 2013.

Strategies to address misinformation and hesitancy about vaccines, including the fear of needles, and to overcome obstacles to access, such as the refrigeration that some vaccines demand, strongly suggest the need to develop new vaccine delivery technologies. But, given widespread distrust surrounding vaccination, these new technologies must be introduced to the public with the utmost transparency, care, and community involvement. Two emerging technologies, one a skin‐patch vaccine and the other a companion dye and detector, provide excellent examples of greatly improved (...) delivery technologies for which such a careful approach should be developed in order to increase vaccine uptake. Defusing fears and conspiracy mongering must be a key part of their rollout. (shrink)

I address Peter Mott's 'Margins for Error and the Sorites Paradox' , pp. 494–503). Mott criticizes my account of inexact knowledge, on which it satisfies margin for error principles of the form 'If one knows in a given case, one avoids false belief in sufficiently similar cases'. Mott's arguments are shown to be fallacious because they ignore the fact that our knowledge of inexact knowledge is itself inexact. In the examples discussed, the first-level inexact knowledge is perceptual. Since my defense (...) of an epistemicist theory of vagueness explains our ignorance of truth-values in borderline cases as the result of knowledge the inexactness of which has a conceptual source, the paper also contributes to the defense of epistemicism about vagueness. (shrink)

Several countries maintain universal health coverage, which implies responsibility to organize delivery formats of healthcare services and products for citizens. In Brazil, the health system has a principle of universal access for more than 30 years, but many deficiencies remain and the country observes a day practice for those seeking judicial decisions to determine provision of healthcare.

Recent Developments Content Type Journal Article DOI 10.1007/s11673-010-9235-5 Authors John Coggon, University of Manchester Centre for Social Ethics and Policy, Institute for Science, Ethics, and Innovation, School of Law Manchester UK Cameron Stewart, University of Sydney Centre for Health Governance, Law and Ethics, Sydney Law School Sydney NSW 2006 Australia Journal Journal of Bioethical Inquiry Online ISSN 1872-4353 Print ISSN 1176-7529 Journal Volume Volume 7 Journal Issue Volume 7, Number 2.