We have achieved a residue‐level resolution of genetic interaction mapping – a technique that measures how the function of one gene is affected by the alteration of a second gene – by analyzing point mutations. Here, we describe how to interpret point mutant genetic interactions, and outline key applications for the approach, including interrogation of protein interaction interfaces and active sites, and examination of post‐translational modifications. Genetic interaction analysis has proven effective for characterizing cellular processes; however, to date, systematic high‐throughput (...) genetic interaction screens have relied on gene deletions or knockdowns, which limits the resolution of gene function analysis and poses problems for multifunctional genes. Our point mutant approach addresses these issues, and further provides a tool for in vivo structure‐function analysis that complements traditional biophysical methods. We also discuss the potential for genetic interaction mapping of point mutations in human cells and its application to personalized medicine. (shrink)

Professional chaplains have the unique opportunity to provide spiritual care within institutional settings where other types of pastoral care may not exist. Serving within these institutions presents special challenges, including tension between multiple identities and responsibilities. This tension can create conflict within the Christian chaplain, and confusion as to whom they are ultimately beholden. The first section of the article discusses what I see as the five identity-related tensions a professional chaplain may experience serving in an institution. The second section (...) of the article outlines a Christian theology of calling built on the framework of Covenant Theology and God’s reconciling work of grace. This theology of calling orients the professional identity of the Christian chaplains, rooting them in a clear sense of their responsibilities within their institutional setting. Christian chaplains are beholden first to God and to the calling God places on their life. Proper orientation to that calling equips chaplains to reconcile any cognitive dissonance caused by identity-related tensions, thus opening up a richer spiritual dialogue with God as they live out their kingdom-advancing mission. (shrink)

As is well known, it was only in 1926 that a comprehensive mathematical theory of braids was published—that of Emil Artin. That said, braids had been researched mathematically before Artin’s treatment: Alexandre Theophile Vandermonde, Carl Friedrich Gauß and Peter Guthrie Tait had all attempted to introduce notations for braids. Nevertheless, it was only Artin’s approach that proved to be successful. Though the historical reasons for the success of Artin’s approach are known, a question arises as to whether other approaches (...) to deal with braids existed, approaches that were developed after Artin’s article and were essentially different from his approach. The answer, as will be shown, is positive: Modesto Dedò developed in 1950 another notation for braids, though one, which was afterward forgotten or ignored. This raises a more general question: what was the role of Artin’s notation, or, respectively, Dedò’s, that enabled either the acceptance or the neglect of their theories? More philosophically, can notation be an epistemic technique, prompting new discoveries, or rather, can it also operate an as obstacle? The paper will analyze the method introduced by Dedò to notate braids, and also its history and implications. It aims to show that Dedò, in contrast to Artin, focused on factorizations of braids and the algebraic relations between the operations done on these factorizations. Dedò’s research was done against the background of Oscar Chisini’s research of algebraic curves on the one hand and of Artin’s successful notation of braids on the other hand. Taking this into account, the paper will in addition look into the epistemic role of notation, comparing Dedò’s work with Artin’s, as both presented different notations of braids and their deformations. (shrink)

There is a problem about belief and knowledge in Plato's epistemology that has exercised serious students of Plato only to settle into a recent orthodoxy. Guthrie characterizes the problem and its current resolution this way: ‘In the Meno doxa appeared to be a dim apprehension of the same objects of which knowledge is a clear and complete understanding … in the Republic each is directed to different objects, knowledge to the Forms and doxa to the sensible world alone … (...) at least the opinion seems now to prevail that on the relationship between doxa and knowledge Meno and Republic are irreconcilable, and exhibit a complete change of mind on Plato's part.'. (shrink)

There is a problem about belief and knowledge in Plato's epistemology that has exercised serious students of Plato only to settle into a recent orthodoxy. Guthrie characterizes the problem and its current resolution this way: ‘In the Meno doxa appeared to be a dim apprehension of the same objects of which knowledge is a clear and complete understanding … in the Republic each is directed to different objects, knowledge to the Forms and doxa to the sensible world alone … (...) at least the opinion seems now to prevail that on the relationship between doxa and knowledge Meno and Republic are irreconcilable, and exhibit a complete change of mind on Plato's part.'. (shrink)

The belief that primitive men lived like beasts and that civilisation developed out of these brutal origins is found in numerous ancient authors, both Greek and Latin. It forms part of certain theories about the beginnings of culture current in late antiquity. These are notoriously difficult to trace to their sources, but they already existed in some form in the fifth century b.c. One idea common to these theories is that of progress, and for this reason a fragment of Xenophanes (...) is sometimes cited as their remote prototype: ‘The gods did not reveal all things to men from the beginning; instead, by seeking, men discover what is better in time’. Mainly on the strength of this fragment, Ludwig Edelstein devoted the first chapter of his bookThe Idea of Progress in Classical Antiquityto Xenophanes, and W. K. C. Guthrie has even declared that there is good reason to attribute to him a fuller account of progress, one that would include details found in later authors who speak of the early life of mankind. One of these details is the statement that the life of primitive men was ‘brutal’ or ‘beastlike’ (θηριώδης). In these authors the implication of that term varies from ‘unschooled in the basic crafts’ to ‘inhumanly violent and bloodthirsty’. In one sense or the other it is repeatedly encountered in ancient references to this subject. Accounts of primitive brutishness which make use of the wordθηριώδης(orθηριωδ⋯ςcan be found in theSuppliantsof Euripides, in the Hippocratic treatiseOn Ancient Medicine, in three passages of Diodorus, one of which is thought by some to contain Democritean doctrine, in four passages of Isocrates, in a fragment from a satyr-playSisyphuswhich the ancient sources attribute variously to Euripides and to Critias, in a fragment of Athenion, in a second-century inscription, in Plutarch, in Tatian, in Themistius, and in a scholion to Euripides. (shrink)

The belief that primitive men lived like beasts and that civilisation developed out of these brutal origins is found in numerous ancient authors, both Greek and Latin. It forms part of certain theories about the beginnings of culture current in late antiquity. These are notoriously difficult to trace to their sources, but they already existed in some form in the fifth century b.c. One idea common to these theories is that of progress, and for this reason a fragment of Xenophanes (...) is sometimes cited as their remote prototype: ‘The gods did not reveal all things to men from the beginning; instead, by seeking, men discover what is better in time’. Mainly on the strength of this fragment, Ludwig Edelstein devoted the first chapter of his book The Idea of Progress in Classical Antiquity to Xenophanes, and W. K. C. Guthrie has even declared that there is good reason to attribute to him a fuller account of progress, one that would include details found in later authors who speak of the early life of mankind. One of these details is the statement that the life of primitive men was ‘brutal’ or ‘beastlike’ . In these authors the implication of that term varies from ‘unschooled in the basic crafts’ to ‘inhumanly violent and bloodthirsty’. In one sense or the other it is repeatedly encountered in ancient references to this subject. Accounts of primitive brutishness which make use of the word θηριώδης (or θηριωδς can be found in the Suppliants of Euripides, in the Hippocratic treatise On Ancient Medicine, in three passages of Diodorus, one of which is thought by some to contain Democritean doctrine, in four passages of Isocrates, in a fragment from a satyr-play Sisyphus which the ancient sources attribute variously to Euripides and to Critias, in a fragment of Athenion, in a second-century inscription, in Plutarch, in Tatian, in Themistius, and in a scholion to Euripides. (shrink)

A medical student's ability to present a case history is a critical skill that is difficult to teach. Case histories presented without theatrical engagement may fail to catch the attention of their intended recipients. More engaging presentations incorporate ‘stage presence’, eye contact, vocal inflection, interesting detail and succinct, well organised performances. They convey stories effectively without wasting time. To address the didactic challenge for instructing future doctors in how to ‘act’, the Mayo Medical School and The Mayo Clinic Center for (...) Humanities in Medicine partnered with the Guthrie Theater to pilot the programme ‘Telling the Patient's Story’. Guthrie teaching artists taught storytelling skills to medical students through improvisation, writing, movement and acting exercises. Mayo Clinic doctors participated and provided students with feedback on presentations and stories from their own experiences in patient care. The course's primary objective was to build students' confidence and expertise in storytelling. These skills were then applied to presenting cases and communicating with patients in a fresher, more engaging way. This paper outlines the instructional activities as aligned with course objectives. Progress was tracked by comparing pre-course and post-course surveys from the seven participating students. All agreed that the theatrical techniques were effective teaching methods. Moreover, this project can serve as an innovative model for how arts and humanities professionals can be incorporated for teaching and professional development initiatives at all levels of medical education. (shrink)

According to the thesis of the guise of the normative, all desires are associated with normative appearances or judgments. But guise of the normative theories differ sharply over the content of the normative representation, with the two main versions being the guise of reasons and the guise of the good. Chapter 6 defends the comparative thesis that the guise of reasons thesis is more promising than the guise of the good. The central idea is that observations from the theory of (...) content determination can be used in order to constrain possible theories of the representational contents associated with desire. The authors argue that the initially most promising versions of the guise of the good fail to meet these constraints, and then explain the steep challenge confronting any who wish to craft a new guise of the good theory which meets the constraints while also preserving the initial motivations for adopting any guise of the normative theory at all. But a simple version of the guise of reasons not only avoids the troubles besetting the guise of the good but proceeds immediately from a deep diagnosis of the source of its difficulties. (shrink)

This handbook provides an overview of key ideas, questions, and puzzles in political epistemology. It is divided into seven sections: (1) Politics and Truth: Historical and Contemporary Perspectives; (2) Political Disagreement and Polarization; (3) Fake News, Propaganda, Misinformation; (4) Ignorance and Irrationality in Politics; (5) Epistemic Virtues and Vices in Politics; (6) Democracy and Epistemology; (7) Trust, Expertise, and Doubt.

Viral modernity is a concept based upon the nature of viruses, the ancient and critical role they play in evolution and culture, and the basic application to understanding the role of information and forms of bioinformation in the social world. The concept draws a close association between viral biology on the one hand, and information science on the other – it is an illustration and prime example of bioinformationalism that brings together two of the most powerful forces that now drive (...) cultural evolution. The concept of viral modernity applies to viral technologies, codes and ecosystems in information, publishing, education and emerging knowledge systems. This paper traces the relationship between epidemics, quarantine, and public health management and outlines elements of viral-digital philosophy based on the fusion of living and technological systems. We discuss Covid-19 as a ‘bioinformationalist’ response that represents historically unprecedented level of sharing information from the sequencing of the genome to testing for a vaccination. Finally, we look at the US response to Covid-19 through the lens of infodemics and post-truth. The paper is followed by three open reviews, which further refine its conclusions as they relate to philosophy and the notion of the virus as Pharmakon. (shrink)

In this paper I argue for the usefulness of the concept of ‘movement compression’ for understanding sport and games, and particularly the differences between traditional sport and eSport (as currently practised). I suggest that movement compression allows us to distinguish between different activities in terms of how movement quality (in the sense of the qualities the movement possesses, rather than that the movement is of ‘high quality’) affects outcome. While it applies widely, this concept can in particular help us to (...) understand the persistent idea that eSports are in some key way distinct from traditional sports. (shrink)

It is widely believed that open and public speech is at the heart of the democratic ideal. Public discourse is instrumentally epistemically valuable for identifying good policies, as well as necessary for resisting domination (e.g., by vocally challenging decision-makers, demanding public justifications, and using democratic speech to hold leaders accountable). But in our highly polarized and socially fragmented political environment, an increasingly pressing question is: do actual democratic societies live up to the ideal of inclusive public speech? In this essay, (...) I explore Maxime Lepoutre's defence of discursive democracy from the challenge of defective public discourse. I argue that political ignorance, dogmatism, and social fragmentation present more formidable challenges to discursive democracy than Lepoutre acknowledges. As a result, his account occasionally veers from warranted optimism to unwarranted idealism. (shrink)

From 1801–1807 Schelling continued to refine his early attempts at Naturphilosophie in the metaphysical framework of a transcendental Spinozism that he initially called Identity Philosophy. While mathematics and geometry provided the model for identity and its quantitative differentiation in early versions of identity theory, from 1804–1807, logic and theory of language offered a model of identity capable of unknotting persistent Spinozistic puzzles such as the connection between natura naturans and natura naturata—the absolute and its potencies—and the ontological status of the (...) individual. Schelling’s initial concepts of identity as “indifference” or “the identity of identity and difference,” themselves the offshoot of meditations on polarity and repeating structure in the philosophy of nature, make way for logical concepts such as “expression” or “affirmation” and the propositional operator “bond” or “Position” found in the copula. The new essays approach ultimate reality through Spinoza’s disjunction of God or nature, or productive and produced nature; so in addition to identity theory, a general metaphysics of nature prefaces treatments of specific natural phenomena. These dual metaphysics of God and nature inject a dynamic or expressive movement into identity that is not yet the unfolding of identity as grounding-and-division that Schelling will articulate in the 1809 Freedom Essay, but it carries a sense of motion and differentiation—or evolution and unfolding—not found in his earlier attempts. The entire identity philosophy period is best viewed as a step in Schelling’s lifelong project of reworking Spinoza by adding life and spirit to nature. (shrink)

The first edition of The Scientific Background to Modern Philosophy took the dialogue of science and philosophy from Aristotle through to Newton. This second edition adds eight chapters, taking the dialogue through the Enlightenment and up to Darwin. This anthology is an attempt to help bridge the gap between the history of science and the history of philosophy.

Als Plato de hedendaagse academie zou aanschouwen, zou hij niet alleen stomverbaasd zijn over de massificatie en de byzantijnse bureaucratie, maar gezien het ethische doel van de universiteit zou hij ook reden hebben om bezorgd te zijn.

Discussions of divine simplicity generally overlook the distinction between identity claims that are reductivist and identity claims that are eliminativist. If, for instance, the identity claim that 'the chair = a configuration of particles' is merely reductive, then there exist chairs and there exist configurations of particles and it turns out that they are identical. The identity in this case does not reduce the ontological complexity of the world. But if the identity claim is eliminativist, then it is true again (...) that chairs are configurations of particles, but chairs do not in fact exist. The illusory object that we call a chair turns out to be nothing over and above a configuration of physical particles. The chair reduces to the configuration of particles without remainder. The defense of divine simplicity in this paper argues that it is in this eliminativist sense that God's intrinsic properties are identical to God. (shrink)

Philosophers often claim that doing philosophy makes people better thinkers. But what evidence is there for this empirical claim? This paper reviews extant evidence and presents some novel findings. We discuss standardized testing scores, review research on Philosophy for Children and critical thinking skills among college students, and present new empirical findings. On average philosophers are better at logical reasoning, more reflective, and more open-minded than non-philosophers. However, there is an absence of evidence for the claim that studying philosophy led (...) to these differences. We present some preliminary and suggestive evidence that, although some of these differences may be attributable to philosophical training, others appear to be selection effects. The key takeaway is that more data are needed. We conclude by urging philosophers and interdisciplinary collaborators to gather more data to test the claim that studying philosophy makes people better thinkers. (shrink)

Recent experimental work on “natural” kind terms has shown evidence of both descriptive and nondescriptive reference determination. This has led some to propose ambiguity or hybrid theories, as opposed to traditional description and causal‐historical theories of reference. Many of those experiments tested theories against referential intuitions. We reject this method, urging that reference should be tested against usage, preferably by elicited production. Our tests of the usage of a biological kind term confirm that there are indeed both descriptive and causal‐historical (...) elements to the reference determination of some natural kind terms. We argue that to accommodate our results and earlier ones, we should abandon the common assumption that any one theory of reference fits all natural kind terms. Rather, it is likely that some terms are descriptive, some causal‐historical, some ambiguous, and some hybrid. This substantive conclusion is accompanied by a methodological one. Our experiments, like some earlier ones, found participants contradicting both each other and themselves. We argue that these contradictions indicate a lack of linguistic competence with the term. We conclude that these experiments have been faulty, because they test terms that are novel to participants and/or use fantastical vignettes. We provide some suggestions for future research. (shrink)

In de afgelopen tijd is compensatoir toetsen in het Nederlandse onderwijs een populaire toetsvorm geworden. Hierbij slaagt een student voor een reeks toetsen indien het gemiddelde op deze reeks voldoende is. In deze analyse betogen wij dat het compensatoire systeem echter zowel onverdedigbaar als moreel gezien onverantwoordelijk is. Het grote gevaar van compensatoire toetsregimes is namelijk dat het hiaten in kennis en vaardigheden tolereert, wat de validiteit van een diploma ondermijnt en bovendien medeburgers in gevaar brengt.

In this paper, I undertake a conceptual analysis of ordinary usages of the concepts of “litter” and “pollution.” If “litter” or “pollution” applies to space debris in its various contexts, then in dealing with space debris as an ethical concern, we may more neatly apply arguments for the wrongness of litter and pollution to these new contexts. After engaging in a conceptual analysis of “litter” and “pollution,” I consider whether these concepts apply to space debris, examining three contexts: (1) surface (...) debris on Moon and Mars, (2) intentionally crashing objects into gas giants, ice giants, and stars, and (3) the pressing issue of orbital space debris. I conclude by finding that neither “litter” nor “pollution” cleanly applies to any of these three contexts. (shrink)

Solidarity is a widespread but under-explored phenomenon. In this paper, I give a philosophical account of solidarity, answering three salient questions: What motivates acts of solidarity? What unifies different acts into tokens of a single type of act, one of solidarity? And what values do acts of solidarity exhibit? The answer to all three, I argue, involves a certain way of relating to others: identifying with them on the basis of shared features, and identifying with the larger group that one (...) and the others both belong to. (shrink)

Right after Philo’s about-face in Part 12 of the Dialogues, he gives an argument that the dispute between the theist and the atheist is merely verbal. Since everything is at least a little like everything else, the atheist must concede that the source of order is at least remotely like a human intellect, even if this source is something like a rotting turnip. This passage provides a major argument for dismissing Hume’s apparent avowals of theism in the Dialogues and elsewhere, (...) since Philo’s assertions are so loose as to let in a rotting turnip. The right reading of the passage is more interesting. The paragraph was written in 1776, right before Hume’s death. It’s thus one of the few philosophical texts written late enough to reflect his encounter with the French philosophes in the 1760s. We have good biographical evidence that Hume was criticized for being too much of a theist in France. The turnip is rotting not in order to make fun of the argument from design, but in order to make fun of d’Holbach's and Diderot's account of the origin of life, accounts that generalized dramatically from John Needham’s observations of nematodes in rotting wheat. In the rotting turnip paragraph, Hume is attempting to establish that the dispute between the theist and the atheist isn’t empirically tractable, that atheists will never outflank the apophatic theologian on the question of whether human minds are unlike God, and that if atheists are consistent with their analogical methods, they ought to be more open to the argument from design. (shrink)

Kant famously distinguishes between the methods of mathematics and of metaphysics, holding that metaphysicians err when they avail themselves of the mathematical method. Nonetheless, in the Metaphysical Foundations of Natural Science, he insists that mathematics and metaphysics must jointly ground ‘proper natural science’. This article examines the distinctive contributions and unity of mathematics and metaphysics to the foundations of the science of body. I argue that the two are distinct insofar as they involve distinctive sorts of grounding relations – mathematics (...) pertains to formal grounding, while metaphysics concerns material grounding – while they are unified insofar as they treat motion, the fundamental determination of the science of body. (shrink)

For Kant, philosophical investigations are inherently analytic. The proper method of philosophy is analysis, and the object of analysis are concepts. Hence, Kant’s short description of philosophy as “rational cognition […] from concepts” (KrV, A 837/B 865) can be substituted by “philosophy is conceptual analysis”. The article shows that Kant follows a representationalism about concepts and a combination of intensional and extensional feature semantics. Against the claim that Kant is a proponent of the concept-judgement-inversion, it is argued that concepts are (...) being articulated in form of singular terms, propositions, and sets of propositions alike. Kant interlinks different kinds of concepts with different kinds of definitions, as the reconstruction of his theory of definitions reveals. Philosophy foremost deals with what Kant calls “given” empirical and pure concepts. Such concepts are object of analysis, i.e., explication and exposition. The article ends with answers to five possible objections. Is philosophy all about analysis? (shrink)

In this essay, I examine Kant’s interpretation of Rousseau through the lens of Reflection 6593. This Reflection deserves scrutiny because it serves as a bridge between Kant’s well-known engagement with Rousseau in the mid-1760s and his later discussions of the vocation of the human being in the lectures on ethics and anthropology. Through a close reading of R 6593, I argue that the Reflection offers the earliest evidence of Kant’s philosophy of history and its integration into his treatment of the (...) human vocation. This change, I propose, is instigated by Rousseau’s “Abstract” of St. Pierre’s Perpetual Peace. I conclude that R 6593 is a crucial indicator of Kant’s evolving views on Rousseau and shows his enduring importance for understanding the formation of Kant’s mature political thought. (shrink)

The method of reflective equilibrium (MRE) is a method of justification popularized by John Rawls and further developed by Norman Daniels, Michael DePaul, Folke Tersman, and Catherine Z. Elgin, among others. The basic idea is that epistemic agents have justified beliefs if they have succeeded in forming their beliefs into a harmonious system of beliefs which they reflectively judge to be the most plausible. Despite the common reference to MRE as a method, its mechanisms or rules are typically expressed (...) in a metaphorical or simplified manner and are therefore criticized as too vague. Recent efforts to counter this criticism have been directed towards the attempt to provide formal explications of MRE. This paper aims to supplement these efforts by providing an informal working definition of MRE. This approach challenges the view that MRE can adequately be characterized only in the negative as a set of anti-essentialisms. I argue that epistemic agents follow MRE iff they follow four interconnected rules, which are concerned with a minimalistic form of foundationalism, a minimalistic form of fallibilism, a moderate form of holism, and a minimalistic form of rationality. In the critical spirit of MRE, the corresponding working definition is, of course, provisional and revisable. In general, the aim is to contribute to a reflective equilibrium (RE) concerning MRE. If it is successful, this working definition provides a better grasp of the most basic elements of the method and thereby enhances our understanding of it. (shrink)

The learning process of both students and teachers can be predicted based on the learning mode. Therefore, because of the COVID-19 pandemic, schools must start using online learning and abandon more traditional teaching techniques. Thus, this study investigates the relationship between self-efficacy and academic resilience among 150 senior high school students. Thus, the researchers employed General Self-Efficacy and Resilience Scale. Finally, the statistical analysis reveals that the r coefficient of 0.78 indicates a high positive correlation between the variables. The p-value (...) of 0.00, which is less than 0.05, leads to the decision to reject the null hypothesis. Hence, a significant relationship exists between self-efficacy and resilience among senior high school students. (shrink)

Climate change intersecting with complex socio-economic and political processes has produced distinctive patterns of crisis migration. However there exists a significant gap in understanding and theorizing these forms of migration creating significant policy challenges. Using a case study of an interstate migrant settlement in Bengaluru, India this article unpacks migration as an adaptation strategy through the lens of emotions. The article offers significant insights into how emotions affect the choice of migration as an adaptation strategy and shapes the differential experiences (...) of risks and vulnerability for different groups of people. Emphasizing such relational aspects of migration, the article calls for more research that develops a nuanced understanding of the emotional landscapes of migrants across migration pathways. (shrink)

Wolff's book defends the Kantian idea of a "general logic" whose principles underlie special systems of deductive logic. It thus undermines "logical pluralism," which tolerates the co-existence of divergent systems of modern logic without asking for consistent common principles. Part I of Wolff’s book identifies the formal language in which the most general principles of logic must be expressed. This language turns out to be a version of syllogistic language already used by Aristotle. The universal validity of logical principles, as (...) well as the translatability of other logical languages into this language, are shown to depend only on the meanings of its logical vocabulary. Part II of the book answers the metalogical question concerning the deductive relation between general logic and special logical systems, which also have their own (less general) principles. This part identifies the rules according to which logical rules can be derived from principles. The main result of the book is that the highest principles of logic and metalogics are provided by the syllogistic, when properly understood. (shrink)

Using Canada as a case study, this article argues that regulating biotechnology and nanotechnology is made unnecessarily complex and inherently unstable because of a failure to consult the public early and of-ten enough. Furthermore, it is argued that future regulators (and promoters) of nanotechnology may learn valuable lessons from the mistakes made in regulating biotechnology.

I offer new arguments for an unorthodox reading of J. L. Mackie’s Ethics: Inventing Right and Wrong, one on which Mackie does not think all substantive moral claims are false, but allows that a proper subset of them are true. Further, those that are true should be understood in terms of a “hybrid theory”. The proposed reading is one on which Mackie is a conceptual pruner, arguing that we should prune away error-ridden moral claims but hold onto those already free (...) of error. This reading is very different from the standard ones found in the literature. I build on recent work by Moberger and argue that this reading is better corroborated by close attention to the way in which Mackie argues at length that terms like “good” and “ought” are systematically context-sensitive, as well as by considerable additional textual evidence. This reading, however, faces an important challenge—to explain in what sense, if any, morality retains its “normativity” on the proposed reading. I argue that this challenge can be met, at least given some of Mackie’s further assumptions about the nature of rationality. (shrink)

Laboratory science is our only source of knowledge about the world as it is apart from our perceptions of the world. Empiricist philosophy, relying on evidence consisting in human perceptions, can only give us knowledge of phenomena making up the world-perceived, which recent neuroscience tells us is wholly and entirely constructed by our neuron-based human perceptual apparatus. In this light, empiricist philosophy should explicitly and fundamentally be reconceived as a method of thinking critically about phenomena, i.e. as a stripped down, (...) fallibilist, non-foundationalist version of “phenomenology”. I also describe implications of these proposals for thinking critically about and conceptualizing phenomena like the Cartesian “I”-that-thinks, consciousness, mind, personal identity, free will, and causal relationships between the brain and the conscious “I.”. (shrink)

Infantologies is a collective writing project designed to express and summarise important ideas, approaches and forms of advocacy in a short and condensed method, in order to present a network of d...

Social contract theory enjoys a long history in moral and political philosophy. Since the European Enlightenment, social contract theory has become one of the most important traditions in moral and political philosophy. This chapter provides a brief introduction to central concepts in social contract theory and their development over time. Most importantly, the chapter clarifies some of the distinct features of new approaches to social contract theory (or “new social contract theory” for short) that have evolved in the twenty-first century (...) and are most suitable for capturing the circumstances of contemporary societies, even if new social contract theory does not constitute a unified theoretical position but is best considered as a family of approaches, methods, and topics. The chapter also provides an overview of the contributions to this book and their connections both methodologically and thematically. (shrink)

First published in 1998. Routledge is an imprint of Taylor & Francis, an informa company.

What are the properties of composite objects, and how do the properties of composite objects and the properties of their proper parts relate to one another? The answers to these questions depend upon which view of composition one adopts. One view, which I call the orthodox view, is that composite objects are numerically distinct from their proper parts, individually and collectively. Another view, known as composition as identity, is that composite objects are numerically identical to their proper parts, taken together. (...) I argue that the orthodox view entails that the intuitive picture of composite objects and their properties that most accept is false. Not so for composition as identity. I also show that all of the available alternatives face serious difficulties. This puts composition as identity at an advantage over the orthodox view, at least when it comes to accounting for the properties of composite objects. (shrink)

It is an honor to be able to engage Ezequiel Di Paolo’s and David Sander’s reflections on relational conceptions of emotional development. In this reply, I elaborate on the role of emotion in the o...

In recent decades, perspectivism has developed into an epistemological research program claiming its independence. This autonomy stems from Perspectivism’s potential ability to resolve the contradictions between realist and constructivist programs. Perspectivism is based on the idea that the object depends on perspective, which constitutes any subjective attempt to cognize it. Perspectivists reconstruct and explain the factors involved in the formation of perspective, identifying the conditionality of epistemic acts, using concepts such as “position”, “point of view”, “view”, “angle”, “horizon”, “focus”, “picture”, (...) “context”, “aspect”, etc. Although these concepts are part of the perspectivist’s toolkit, their meanings and interrelation have so far been taken for granted and have not yet been critically and comprehensively analyzed. The purpose of this article is to take steps toward clarifying the conceptual basis for defending perspectivism as an epistemological program. Once consistently uncovered and correlated in a conceptual model, Perspectivist concepts can be used as a tool for a detailed analysis of theories, positions, and beliefs. The article begins with a preliminary description of the concept of perspectivism and its brief history as an epistemological program. In particular, the first modern attempts to outline perspectivist epistemology are described in the works of F. Kaulbach (1990), W. Stegmaier (2008), and M. Massimi (2017, 2020). The problem of identifying the special a priori status of perspectivist notions as a strategy for justifying the autonomy of Perspectivism is then posed. A method for demonstrating such a status, based on Kant’s transcendentalism and P. Strawson’s descriptive metaphysics, is then suggested. (shrink)

What is it about knowledge that makes us value it more highly than mere true belief? This question lies at the heart of epistemology and has challenged philosophers ever since it was first posed by Plato. Michael Welbourne's examination of the historical and contemporary answers to this question provides both an excellent introduction to the development of epistemology but also a new theory of the nature of knowledge. The early chapters introduce the main themes and questions that have provided (...) the context for modern discussions. The Platonic beginnings, Cartesian individualism and the tripartite analyses of knowledge are examined in turn. In the second half of this book, the focus shifts from conceptual analysis to an examination of the social practices surrounding knowledge, placing special emphasis on the notion of testimony. The author argues originally and persuasively that our idea of knowledge has its roots in communicative practices and that thinking about how testimony works as a source of beliefs actually gives us a handle on the very idea of knowledge itself. This book will be essential reading for anyone interested in epistemology, the philosophy of language, or the intersection between the two areas. (shrink)

Die philosophische Frage nach der Identität einer Person ist nicht wohlbestimmt. Es handelt sich keineswegs, wie der Gebrauch des Begriffes im Alltag oder auch in der Philosophie nahe legt, um ein einheitliches Phänomen. Vielmehr muss die Identität einer Person als Zusammenspiel von folgenden Fragen analysiert werden: Was macht die Ganzheit einer Person aus? Was muss der Fall sein, damit eine Person gestern mit der Person von heute "identisch" ist? Was verstehen wir unter Identität im Sinne von Selbstverstehen und Selbstbewusstsein? Es (...) wird gezeigt, wie sich die beiden "Identitäten" menschlicher Personen - Persistenz und Persönlichkeit -in unserem alltäglichen Verständnis miteinander verschränken. (shrink)

When P(E) > 0, conditional probabilities P(H|E)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$(H|E)$$\end{document} are given by the ratio formula. An agent engages in ratio conditionalization when she updates her credences using conditional probabilities dictated by the ratio formula. Ratio conditionalization cannot eradicate certainties, including certainties gained through prior exercises of ratio conditionalization. An agent who updates her credences only through ratio conditionalization risks permanent certainty in propositions against which she has overwhelming evidence. To avoid this undesirable consequence, (...) I argue that we should supplement ratio conditionalization with Kolmogorov conditionalization, a strategy for updating credences based on propositions E such that P(E) = 0. Kolmogorov conditionalization can eradicate certainties, including certainties gained through prior exercises of conditionalization. Adducing general theorems and detailed examples, I show that Kolmogorov conditionalization helps us model epistemic defeat across a wide range of circumstances. (shrink)