Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Certain puzzling cases have been discussed in the literature recently which appear to support the thought that knowledge can be obtained by way of deduction from a falsehood; moreover, these cases put pressure, prima facie, on the thesis of counter closure for knowledge. We argue that the cases do not involve knowledge from falsehood; despite appearances, the false beliefs in the cases in question are causally, and therefore epistemologically, incidental, and knowledge is achieved despite falsehood. We also show that the (...) principle of counter closure, and the concomitant denial of knowledge from falsehood, is well motivated by considerations in epistemological theory--in particular, by the view that knowledge is first in the epistemological order of things. (shrink)

Stewart Cohen’s New Evil Demon argument raises familiar and widely discussed concerns for reliabilist accounts of epistemic justification. A now standard response to this argument, initiated by Alvin Goldman and Ernest Sosa, involves distinguishing different notions of justification. Juan Comesaña has recently and prominently claimed that his Indexical Reliabilism (IR) offers a novel solution in this tradition. We argue, however, that Comesaña’s proposal suffers serious difficulties from the perspective of the philosophy of language. More specifically, we show that the two (...) readings of sentences involving the word ‘justified’ which are required for Comesaña’s solution to the problem are not recoverable within the two-dimensional framework of Robert Stalnaker to which he appeals. We then consider, and reject, an attempt to overcome this difficulty by appeal to a complication of the theory involving counterfactuals, and conclude the paper by sketching our own preferred solution to Cohen’s New Evil Demon. (shrink)

There is a growing movement advocating for using closed border policies as a tool for solving the climate crisis. On this view, which I call the green border argument, fighting climate change requires drastic reductions in the global population and/or per capita greenhouse gas (GHG) emissions. However, immigration into high-income countries—particularly from low-income countries—increases per capita emissions while leaving the population untouched. Therefore, the green border theorist argues, we should limit entry into high-income countries. I explain why this is a (...) mistake and why the political left should embrace a pro climate and pro migrant politic. -/- First, the argument significantly overstates the impact of immigration on global GHG emissions. Second, the progressive green border argument is normatively incoherent. It advocates for closing borders and eliminating poverty and other rights violations in sending countries. However, given the relationship between emissions and income, this argument would require rejecting all poverty reduction strategies—a conclusion the progressive theorist wants to avoid. Third, the argument is counterproductive. An open border politic better promotes climate justice. A key reason is that high-income countries perceive immigration to be one of the most serious short- and medium- term costs of climate change. Whereas closure allows them to avoid this “cost,” open borders would force them to eliminate push factors, incentivizing global adaptation and mitigation strategies. Moreover, a closed border politic creates divisions between those affected, undermining cross-border solidarity and contributing to the perception that environmentalism is a white, middle-class movement. (shrink)

Many supporters of open borders argue that restrictions on immigration are unjust in part because they undermine equal opportunity. Borders prevent the globally least-advantaged from pursuing desirable opportunities abroad, cementing arbitrary facts about birth and citizenship. In this paper I advance an argument from equal opportunity to global freedom of movement. In addition to preventing people from pursuing desirable opportunities, borders also create a prone, segregated population that can be dominated and exploited. Restrictions on mobility do not just trap people (...) in bad opportunity sets—they help create bad opportunities by isolating the negative externalities of production and foreign policy. Freedom of movement can play a vital role in spreading risks and burdens, incentivizing their mitigation. Using an analysis of feudalism, segregation, and the transnational economy, I illustrate the centrality of space and mobility, showing why freedom of movement is a necessary tool for preventing political and economic oppression. (shrink)

In this paper I present two reasons why generalized skill-selection--a policy whereby skill, education, and economic independence are indefinitely prioritized in immigration decisions--is pro tanto unjust. First, such policies feed into existing biases, exacerbating status harms for low-SES citizens. The claim that we prefer the skilled to the unskilled, the educated to the uneducated, and the financially secure to the insecure is also heard by citizens. And there is considerable overlap between this message and the stereotypes and biases that set (...) their social status. Skill-selection can reinforce these biases, offering state support for the claim that they are less desirable as members of the society. -/- Second, the need for skilled immigrants ordinarily depends upon and reinforces failures of fair equality of opportunity (FEO). According to the dependency thesis, the need for skilled migrants stems from a failure to ensure domestic FEO. Many low-SES residents would desire to work, for example, as doctors or nurses. However, unequal education, as well as poverty and debt, have made such opportunities largely inaccessible. According to the reinforcement thesis, skill-selection disincentivizes the pursuit of FEO. A state that can meet domestic labor needs through less costly immigration policies will be disinclined to pursue programs designed to equalize opportunities for low-SES residents. -/- Generalized skill-selection in high-income countries like the US is, therefore, pro tanto unjust. However, this is not an argument for excluding the skilled. Skilled immigrants can be admitted through other policies—open borders, family-reunification, or a lottery—without the state signaling that the skilled are more desirable or perpetuating failures of FEO. And states can, responding to local emergencies, temporarily select for particular professions without contributing to these injustices. These concerns only arise when skill is generally and indefinitely prioritized. (shrink)

Even after several decades of human drug development, there remains an absence of published, substantial, comprehensive data to validate the use of animals in preclinical drug testing, and to point to their pr...

Anuran amphibian metamorphosis is an immunologically interesting period. For the investigator, it provides an unusual opportunity for analyzing both humoral regulation of the immune response and the development and maintenance of self‐tolerance. Some of the questions one can ask are: Why don't immunocompetent larvae destroy antigenically disparate adult cells as they differentiate within them during metamorphosis? Do the dramatic hormonal changes occurring during this period regulate immunological function? How do animals in metamophorsis protect themselves from their immunologically hostile environment?

Often a division of concepts can help us better understand unknown or seldom charted philosophical terrain: historically, the distinctions and differences between idealism and materialism have proven helpful, but with Quentin Meillassoux‟s concept of correlationism, the divisions between realism and anti realismwhich once seemed clean-cut are now harder to understand. Graham Harman has gone a step further than Meillassoux‟s initial definition of correlationism, by which “we mean the idea according to which we only ever have access to the correlation between (...) thinking and being, and never to either term considered apart from the other,”2claiming in lectures that those who have pledged fidelity to the realism banner after Meillassoux aren‟t realist enough.Instead, says Harman, we should demand that any philosophy which claims to be realist must grant that no entity is more real than any other, whether they be atoms, quarks, institutions, regimes, human beings, bonobos, dreams or distant galaxies. A robust realism must maintain therefore that the universe is composed of objects of all shapes, sizes and types. It is here that I wish to stage something of an intervention; it seems to me that we could rather create a new division to help us understand the contemporary situation facing philosophy based on how various philosophies view objects. I propose that we contrast those philosophies which see objects only working through exterior means with those which grant some level of autonomy to objects; in other words, we should compare those philosophies which grant only an outer life to objects withthose which also grant them an inner life. A robust realism must not only count objects as means of our causal ends , or billiard balls in an extended chain of causation . Rather, a full-blown realism must look to the inner lives of objectsto understand the cosmos and not simply satisfy itself with studying their effects.By making this distinction, we can see more clearly the relevance of a number offigures who have yet to be regarded with any seriousness by the emerging speculative realism movement, creating another metaphysical option besidesweak and strong correlationism, eliminative materialism or idealism, speculative materialism and object-oriented philosophy, as well as better understand thefuture of speculative metaphysics. (shrink)

Most deontologists find bedrock in the Pauline doctrine that it is morally objectionable to do evil in order that good will come of it. Uncontroversially, this doctrine condemns the killing of an innocent person simply in order to maximize the sum total of happiness. It rules out the conscription of a worker to his or her certain death in order to repair a fault that is interfering with the live broadcast of a World Cup match that a billion spectators have (...) been enjoying. It rules out such sacrifice even if it would maximize the sum total of everyone's happiness. An act utilitarian, by contrast, would require the sacrifice of the one whenever this latter condition obtains, since such a utilitarian is committed to the view that one ought always to act so as to bring about the greatest sum total of happiness. An act utilitarian might, however, consistently hold that a large number of rather insignificant pleasures, such as that which a spectator derives from witnessing men in shorts running around and kicking a ball, is never sufficient to justify the infliction of a great harm on a single individual. 4 He might take such a position without abandoning utilitarianism by denying that the sum total of such minor pleasures could ever be sufficiently great to outweigh the harm of death to the one. Under the inspiration of John Stuart Mill, a utilitarian might draw a more general distinction between serious and trivial harms and pleasures and maintain that no amount of a trivial pleasure could ever amount to a sum of happiness that is greater than the disutility of a serious harm. (shrink)

Cumming (2008) argues that his Masked Ball problem undermines Millianism, and that we must instead treat names as variables. However, although the Masked Ball does pose a problem for the Millian given a standard view about the meaning of `believes', that view faces difficulties for independent reasons. I develop a novel ``neo Kaplanian'' attitude semantics to address this problem, and go on to show that with this alternative semantics in hand, the Millian is quite capable of accounting for the Masked (...) Ball. (shrink)

Much of children's early syntactic development can be seen as the acquisition of sentence-level constructions that correspond to relatively complex events and states of affairs. The current study was an attempt to determine the relative concreteness (verb-specificity) or abstractness (verb-generality) of such constructions for children just beginning to produce large numbers of multi-word utterances. Sixteen children at 2.0 years of age and sixteen children at 2,5 years of age participated (all English speaking). Each child was taught two novel verbs for (...) a highly transitive action: one in a transitive construction (Ernie is tamming the car) and one in an intransitive construction (with patient äs subject: The ball is meeking). They were then given opportunities to use their newly learned verbs, in many cases in discourse situations that encouraged use of the "opposite" construction (i.e., agent and patient-focused questions). Results showed that 2.0-year-old children almost never produced an utterance using a novel verb in anything other than the construction in which it had been modeled. Children at 2.5 years of age were somewhat more productive, but still the large majority of these children avoided using the experimental verbs in nonmodeled constructions. These results suggest that when English-speaking children produce simple transitive and intransitive utterances in their spontaneous speech, they are doing so on a verb-specific basis (verb Island constructions), schematizing more abstract constructions only later äs they discover patterns that apply across many such lexically specific constructions. (shrink)

The human visual system is amazing in its ability to guide us in a wide range of tasks - driving, reading, playing ball games, or reading music. Somehow our eyes just manage to find the information we need to perform such tasks. This book explores how our eyes process and communicate the data needed for us to negotiate the world around us.

In lieu of an abstract, here is a brief excerpt of the content:141 HUME AND CAUSAL INFERENCE Hume held that any time we reach by inference a belief about the existence or qualities of some object or event that we have not actually perceived, the inference is grounded in beliefs about causal relations holding between the object of belief and some other object or objects that have actually been experienced. I will examine here Hume's account of such causal inferences. There (...) are many places in the Treatise of Human Nature at which Hume seems to claim that causal inferences take place when and only when the percipient has had an extensive previous experience of objects of the respective types as regularly conjoined in relations of contiguity and temporal priority. It seems to me that reliance on these passages alone gives a distorted view of Hume's theory of causal inference. Contrary to appearances, Hume did not hold that extensive previous experiences of objects of the same types as properly conjoined is either necessary or sufficient for causal inference. Hume's view is more subtle and complicated, and there are important considerations of coherence and holism present in it. Getting Hume's view on this matter clear is important because it shows how he can escape some of the objections that have been laid against his theory, and it makes possible a reading of Hume as a causal realist. Hume's theory of inference provides the resources for drawing a distinction between accidental and genuine causal regularities and it is compatible with the view that causal relations (and not mere de facto regularities) hold among events in the world independently of their being perceived. The examination begins by looking at a different, but related, issue. Why does Hume think 142 that of the three types of association, only cause and effect association is capable of producing belief? Hume puts the question in the form of a possible objection to his account. For it may be said, that if all the parts of that hypothesis be true, viz. that these three species of relation are deriv'd from the same principles; that their effects in inforcing and inlivening our ideas are the same; and that belief is nothing but a more forcible and vivid conception of an idea; it shou'd follow, that that action of the mind may not only be deriv'd from the relation of cause and effect, but also from those of contiguity and resemblance. But as we find by experience, that belief arises only from causation, and that we can draw no inference from one object to another, except they be connected by this relation, we may conclude, that there is some error in that reasoning, which leads us into such difficulties. (T 107) It is important to note that Hume is talking here only about beliefs about the existence or situations of objects that have not been intuited or experienced. Beliefs about relations of ideas (e.g., that 2 + 2 = 4) are intuitions (or perhaps memories 2 of intuitions). Beliefs in the existence of things as experienced or in the previous existence of things as previously experienced automatically have the 3 vivacity of impressions or memory ideas. What Hume takes himself to need to explain is why cause and effect association allows for a transfer of this vivacity to an idea of an object or situation that has not itself been intuited or experienced and why 4 resemblance and contiguity association do not. If I see a green ball next to a red sweater, then I will normally subsequently believe that the green ball existed next to the red sweater at that time (at 143 least until my memories begin to lose vivacity). This is purely a matter of sense experience and memory. Now if I subsequently see a different red sweater (or the same sweater in a different location), I may be led to think of a green ball existing next to it purely through contiguity and resemblance association. But presumably I would not believe that a green ball existed next to the currently perceived red sweater unless I currently perceived a green ball or my belief was based on some 5 form of causal inference... (shrink)

Different doctors make different judgments about whether the same patient has breast cancer, tuberculosis, depression, and many other illnesses. Some case managers in child protective service agenc...

Different doctors make different judgments about whether the same patient has breast cancer, tuberculosis, depression, and many other illnesses. Some case managers in child protective service agenc...

Er was een niet te overbruggen kloof tussen de officiële barok-cultuur van het Habsburgse keizerrijk en het kritisch modernisme van de late negentiende eeuw. Herman Broch was een van de moderne schrijvers, die het meest afwijzend tegenover de officiële esthetische normen stond. Ook als politieke balling in de Verenigde Staten bleef hij een gelouterd verlichtingsidee aanhangen, dat hem met de na-oorlogse sociale filosoof Habermas verbindt.

We support Webb's insights into the potential benefits of using robotic modeling to better understand biological behavior. We defend the major points put forward by Webb by presenting a specific case study in which robotic modeling of mobile ball catching has helped refine and clarify aspects of our understanding of biological interceptive behavior.

We provide a cognitive analysis of how children represent belief using mental files. We explain why children who pass the false belief test are not aware of the intensionality of belief. Fifty-one 3½- to 7-year old children were familiarized with a dual object, e.g., a ball that rattles and is described as a rattle. They observed how a puppet agent witnessed the ball being put into box 1. In the agent’s absence the ball was taken from box 1, the child (...) was reminded of it being a rattle, and emphasising its being a rattle it was put back into box 1. Then the agent returned, the object was hidden in the experimenter’s hands and removed from box 1, described as a ‘‘rattle,” and transferred to box 2. Children who passed false belief had no problem saying where the puppet would look for the ball. However, in a different condition in which the agent was also shown that the ball was a rattle they erroneously said that the agent would look for the ball in box 1, ignoring the agent’s knowledge of the identity of rattle and ball. Their problems cease with their mastery of second-order beliefs. Problems also vanish when the ball is described not as a rattle but as a thing that rattles. We describe how our theory can account for these data as well as all other relevant data in the literature. (shrink)

As one looks into the crystal ball concerning the future of medicine, what might be seen? One vision is of genetic testing being carried out by medical technicians and then, as a result of this analysis, patients will be given a diagnosis of what is wrong with them. Next, they will be given a list of courses of action based on the tests. Once the list is presented to the patient, then she will choose her treatment. Then a clinician will (...) inoculate her or otherwise administer the genetic therapy. The entire process might go forward without the intervention of a physician! (shrink)

In this lively and entertaining book, Terence Ball maintains that 'classic' works in political theory continue to speak to us only if they are periodically re-read and reinterpreted from alternative perspectives. That, the author contends, is how these works became classics, and why they are regarded as such. Ball suggests a way of reading that is both 'pluralist' and 'problem-driven'--pluralist in that there is no one right way to read a text, and problem-driven in that the reinterpretation is motivated by (...) problems that emerge while reading these texts. In addition, the subsequent readings and interpretations become more and more suffused with the interpretations of others. This tour de force, always entertaining and eclectic, focuses on the core problems surrounding many of the major thinkers. Was Machiavelli really amoral? Why did language matter so much to Hobbes--and why should it matter to us? Are the roots of the totalitarian state to be found in Rousseau? Were the utilitarians sexist in their view of the franchise? The author's aim is to show how a pluralist and problem-centered approach can shed new light on old and recent works in political theory, and on the controversies that continue over their meaning and significance. Written in a lively and accessible style, the book will provoke debate among students and scholars alike. (shrink)

By creating certain marks on paper, or by making certain sounds-breathing past a moving tongue-or by articulation of hands and bodies, language users can give expression to their mental lives. With language we command, assert, query, emote, insult, and inspire. Language has meaning. This fact can be quite mystifying, yet a science of linguistic meaning-semantics-has emerged at the intersection of a variety of disciplines: philosophy, linguistics, computer science, and psychology. Semantics is the study of meaning. But what exactly is "meaning"? (...) What is the exact target of semantic theory? Much of the early work in natural language semantics was accompanied by extensive reflection on the aims of semantic theory, and the form a theory must take to meet those aims. But this meta-theoretical reflection has not kept pace with recent theoretical innovations. This volume re-addresses these questions concerning the foundations of natural language semantics in light of the current state-of-the-art in semantic theorising. (shrink)

Foucault, Power, and Education invites internationally renowned scholar Stephen J. Ball to reflect on the importance and influence of Foucault on his work in educational policy.

This chapter defends a view of semantics on which developing a semantic theory closely resembles developing a scale of measurement. The view helps explain how semantics has made so much progress despite deep disagreements about the target of semantic theorizing (e.g., between those who maintain that semantics is characterizing something psychological, and those who maintain that it is characterizing something social), how appeals to set-theoretic abstracta make sense despite Benacerraf-style worries and despite the fact that set-theoretic entities fit badly with (...) standard (e.g., causal) metasemantic views, and why the threat of radical context sensitivity does not undermine the semantic project. (shrink)

The Music Instinct Philip Ball provides the first comprehensive, accessible survey of what is known--and what is still unknown--about how music works its magic, and why, as much as eating and sleeping, it seems indispensable to humanity. --from publisher description.

_ Ideals and Ideologies: A Reader_, 9/e, is a comprehensive compilation of original readings representing all of the major 'isms'.It offers students a generous sampling of key thinkers in different ideological traditions and places them in their historical and political contexts. Used on its own or with _Political Ideologies and the Democratic Ideal_, the title accounts for the different ways people use ideology and conveys the ongoing importance of ideas in politics.

From the legendary inventor Daedalus to Goethe's tragic Faust, from the automata-making magicians of E.T.A Hoffmann to Mary Shelley's Victor Frankenstein – ...

1 Introducing Monsieur Foucault Stephen J. Ball Michel Foucault is an enigma, a massively influential intellectual who steadfastly refused to align himself ...

Morals from Motives develops a virtue ethics inspired more by Hume and Hutcheson's moral sentimentalism than by recently-influential Aristotelianism. It argues that a reconfigured and expanded "morality of caring" can offer a general account of right and wrong action as well as social justice. Expanding the frontiers of ethics, it goes on to show how a motive-based "pure" virtue theory can also help us to understand the nature of human well-being and practical reason.

This book fills a gap in studies of meaning by providing detailed case studies of attested corpus data on the meanings of words and phrases.

Catholic social teaching is the Church’s “best-kept secret,” as the saying goes, but is it becoming literally true? This paper tests the proposition that the US bishops are developing a pattern of obscuring or, in effect, hiding particular social teachings of the popes. The instances examined include the ideological error of single-issue advocacy; the meaning of the right to form labor unions; and the intrinsic value of nonhuman species and ecosystems. It would be true irony if the “best-kept secret” were (...) that the bishops were actually keeping a secret. The paper contends that this expression, now more than a metaphor, has acquired a double meaning to which one ought to attend, for papal social teaching should be openly embraced and handed on to the faithful. (shrink)