The exocyst is a conserved octameric complex that physically tethers a vesicle to the plasma membrane, prior to membrane fusion. It is important not only for secretion and membrane delivery but also, in mammalian cells, for cytokinesis, ciliogenesis, autophagy, tumorigenesis, and host defense. The combination of genome editing and advanced light microscopy of exocyst subunits in living cells has recently shown the complex to be much more dynamic than previously appreciated, and exposed how little we still know about its function (...) and regulation. (shrink)

The Millennium Development Goals were criticised for failing to address the issue of governance, and the associated notions of responsibility and accountability. The Sustainable Development Goals, we argue, need to recognise the structural constraints facing poor countries – the power imbalances in the global economic system that limit their ability to promote the prosperity and well-being of their people, as was clearly brought out by the Commission on Global Governance for Health, of which we were both members [Ottersen, O. P., (...) J. Dasgupta, C. Blouin, Paulo Buss, Virasakdi Chongsuvivatwong, Julio Frenk, Sakiko Fukuda-Parr, et al. 2014. “The Political Origins of Health Inequality: Prospects for Change.” Lancet 383: 630–667]. This article is divided into three parts. We begin by making the case for a global justice perspective which emphasises the responsibility – and hence also accountability – of international organisations and rule-making bodies. We next demonstrate the limitations of accountabi.. (shrink)

Children’s intentions should be respected. Parents are the key persons involved in decision-making related to their children. In Japan, the appropriate ages and standards for a child’s consent and assent, approval, and decision-making are not clearly defined, which makes the process of obtaining consent and assent for clinical research complex. The purpose of this paper is as follows: to understand the attitudes and motives of parents concerning children’s participation in medical research and the factors influencing their decision-making. We also sought (...) to clarify who has the right to be involved in decisions regarding children’s participation in research. A semi-structured Internet survey on parents’ opinions and attitudes and preferences concerning medical research involvement was conducted. Children were divided into three age groups (6–10-year-olds, 11–14-year-olds, and 15–18-year-olds), with three illness severity categories. Possible correlations between the number of children, children’s ages, parents’ educational levels, and parents’ attitudes were examined. Among the participants, 42.3% recognized the term “informed consent.” The proportion of participants who understood “informed consent” increased with educational level. Four out of five participants did not know, or had not heard of, the term “informed assent.” Furthermore, the percentage of those who understood the term “informed assent” increased with academic level. Participants generally believed in prioritizing parents’ opinions over children’s, and that parents and children would ideally reach a joint decision. Although many parents favored collaborative decision-making, they also wanted their own will reflected in the decision and felt they should receive important information before their children do. Decision-making was affected by the condition’s severity and prognosis. This indicates that most Japanese parents believe that their children have the right to know their disease name and treatment; nonetheless, they should be protected. Parents’ values and judgments regarding medical intervention involving their children varied. Children’s ability to consent to treatment and research believed to be in their best interests should be assessed appropriately. They should be permitted to provide consent or assent, and their views should be respected. Involving children in decision-making fosters more open communication and transparency between medical professionals, parents, and children. (shrink)

This volume concludes the two-volume sequel to Masao Abe's Zen and Western Thought. Like its companion, Buddhism and Interfaith Dialogue, this work contains many previously published essays and papers by Abe. Here he clarifies the true meaning of Buddhist emptiness in comparison with the Aristotelian notion of substance and the Whiteheadean notion of process.

Wenn auch das Postulat vollständiger Autarkie in der Gegenwart an Bedeutung verloren hat, so ist doch die Forderung nach einer begrenzten Autarkie der Staaten wenigstens in bestimmten Wirtschaftsbereichen grundsätzlich unentbehrlich für ihr friedliches Nebeneinanderbestehen. Das damit angesprochene Problem läßt sich am negativ zu bewertenden Beispiel Japans sehr deutlich aufzeigen, einem Land, das einerseits seinen ungewöhnlichen Reichtum der Ausbeutung anderer nicht industrieller Staaten verdankt, das andererseits jedoch im Bereich der Agrarwirtschaft vom Ausland abhängig ist. In einer solchen unbalancierten wechselseitigen Abhängigkeit liegen (...) prinzipielle Gefahren für eine friedliche Koexistenz. (shrink)

1 Buddhist-Christian Dialogue: Its Significance and Future Task1 The contemporary world is rapidly shrinking due to the remarkable advancement of science ...

We clarify the significance of quasiprobability in quantum mechanics that is relevant in describing physical quantities associated with a transition process. Our basic quantity is Aharonov’s weak value, from which the QP can be defined up to a certain ambiguity parameterized by a complex number. Unlike the conventional probability, the QP allows us to treat two noncommuting observables consistently, and this is utilized to embed the QP in Bohmian mechanics such that its equivalence to quantum mechanics becomes more transparent. We (...) also show that, with the help of the QP, Bohmian mechanics can be recognized as an ontological model with a certain type of contextuality. (shrink)

Written by one of Japan's foremost contemporary thinkers and scholars, Zen and Modern Society is the third in a series of essay collections on Zen Buddhism as seen in the context of Western thought. Throughout his career, Masao Abe has articulated the meaning of Zen thought in a uniquely compelling way - at once, true to the original tradition and appropriately relevant to a variety of comparative standpoints, ranging from Biblical Judeo-Christianity to modern existentialism, phenomenology, and postmodernism. As a (...) leading representative of the Kyoto School, which has sought a critical, comparative linking of Eastern and Western thought, Abe has based his approach on constructive, mutually respectful yet critical intellectual interaction and dialogue with some of the leading figures in the West (including Paul Tillich, Hans Kung, and Eugene Borowitz) as well as dozens of colleagues, students, and disciples. Together with the previous volumes, this work examines and exemplifies some key features of Kyoto School thought. While the essays presented here should be read in light of the socio-political criticism that has since been lodged against the Kyoto School and, more particularly, i. (shrink)

サンデルや現代コミュニタリアンは、なぜ今、古代からの西洋政治思想「共通善」を改めて説くのか。新たな実践哲学が、ここから始まる。.