C/D box snoRNAs (SNORDs) are an abundantly expressed class of short, non‐coding RNAs that have been long known to perform 2′‐O‐methylation of rRNAs. However, approximately half of human SNORDs have no predictable rRNA targets, and numerous SNORDs have been associated with diseases that show no defects in rRNAs, among them Prader‐Willi syndrome, Duplication 15q syndrome and cancer. This apparent discrepancy has been addressed by recent studies showing that SNORDs can act to regulate pre‐mRNA alternative splicing, mRNA abundance, activate enzymes, and (...) be processed into shorter ncRNAs resembling miRNAs and piRNAs. Furthermore, recent biochemical studies have shown that a given SNORD can form both methylating and non‐methylating ribonucleoprotein complexes, providing an indication of the likely physical basis for such diverse new functions. Thus, SNORDs are more structurally and functionally diverse than previously thought, and their role in gene expression is under‐appreciated. The action of SNORDs in non‐methylating complexes can be substituted with oligonucleotides, allowing devising therapies for diseases like Prader‐Willi syndrome. (shrink)

For more than a century, law schools have trained students to 'think like a lawyer'. In these times of legal crisis, both in legal education and in global society, what does that mean for the rest of us? In this book, thirty leading international scholars - including Louis Assier-Andrieu, Marianne Constable, Yves Dezalay, Denise Ferreira da Silva, Bryant G. Garth, Peter Goodrich, Duncan Kennedy, Martti Koskenniemi, Shaun McVeigh, Samuel Moyn, Annelise Riles, Charles F. Sabel and William H. Simon - (...) examine what is distinctive about legal thought. They probe the relation between law and time, law and culture, and legal thought and legal action; the nature of current legal thought; the geography of legal thought; and the conditions for recognition of a new 'contemporary' style of law. This work will help theorists, social scientists, historians and students understand the intellectual context of legal problems, legal doctrine, and jurisprudential trends in the current conjuncture. (shrink)

I articulate the challenge disagreement poses for epistemic contextualism, and then discuss several possible replies on behalf of the contextualist.

This paper surveys attempts in the recent literature to offer a modal condition on knowledge as a way of resolving the problem of scepticism. In particular, safety-based and sensitivity-based theories of knowledge are considered in detail, along with the anti-sceptical prospects of an explicitly anti-luck epistemology.

Epistemicists claim that vague predicates have precise but unknow- able cutoffs. I argue against against the standard, Williamsonian, answer, that appeals to metalinguistic safety: we can know that p even if our true belief that p is metalinguistically lucky. I then propose that epistemicists should be diagonalized epistemicists and show how this alternative formulation of the view avoids the chal- lenge. However, in an M. Night Shyamalan-style twist, I then argue we should not be diagonalized epistemicists either.

This paper explores the prospects for safety-based theories of knowledge in the light of some recent objections.

Much of the recent debate regarding scepticism has focussed on a certain template sceptical argument and a rather restricted set of proposals concerning how one might deal with that argument. Throughout this debate the ‘Moorean’ response to scepticism is often cited as a paradigm example of how one should not respond to the sceptical argument, so conceived. As I argue in this paper, however, there are ways of resurrecting the Moorean response to the sceptic. In particular, I consider the prospects (...) for three such proposals in this regard: a classical epistemic internalist neo-Mooreanism, a classical epistemic externalist neo-Mooreanism, and a non-classical McDowellian epistemic internalist neo-Mooreanism, and maintain that the last two of these proposals (both of which make appeal to a disjunctivist account of perception, broadly conceived) merit further exploration. Indeed, I claim that a suitably qualified version of neo-Mooreanism would actually sit quite well with the general philosophical motivations behind other key anti-sceptical views and I argue that given this fact neo-Mooreanism is actually at a dialectical advantage relative to other views when it comes to dealing with the sceptical problem as it is typically conceived. (shrink)

Grey zone attacks tend to paralyze response for two reasons. First, they present us with choice scenarios of inherently dilemmatic structure, e.g., Prisoners’ Dilemmas and games of chicken, complicated by difficult conditions of choice, such as choice under risk or amid vagueness. Second, they exploit our uncertainty about how much we do or should care about the things under attack¬—each attack is small in effect, but their effects accumulate: how should we decide whether to treat a given attack as something (...) meriting a serious response rather than a mere irritation to be ignored? This chapter brings standard decision theoretic tools to bear on the issues, tools such as the maximization of expected utility principle, and the precautionary principle. But it also develops three innovations. It shows that seeing it as possible to make choices not just of actions given our values, but also choices of values themselves, can extricate us from certain kinds of decision paralysis. It shows how we can rationally regard ourselves as having bright decision lines even when nothing in the circumstance of choice has these lines in its structure. And it shows how certain conflict escalation risks from the former two strategies can be managed by both parties seeing that cooperation can yield a sharable surplus of goods, and that cooperation can be rational upon a rationally defensible change in their values so that each comes to derive utility from the success of both parties. This yields cooperative solutions to what amount to Prisoners’ Dilemmas. The Cold War was prosecuted on the logic of strategic rationality and that part of game theory that is deterrence theory. We need a new logic from decision theorists for the games that constitute grey zone conflict. (shrink)

It is claimed that McDowell’s treatment of scepticism offers a potential way of resurrecting the much derided ‘Moorean’ response to scepticism in a fashion that avoids the problems facing classical internalist and externalist construals of neo-Mooreanism. I here evaluate the prospects for a McDowellian neo-Mooreanism and, in doing so, offer further support for the view.

The status of boundaries and borders, questions of global poverty and inequality, criteria for the legitimate uses of force, the value of international law, human rights, nationality, sovereignty, migration, territory, and citizenship: debates over these critical issues are central to contemporary understandings of world politics. Bringing together an interdisciplinary range of contributors, including historians, political theorists, lawyers, and international relations scholars, this is the first volume of its kind to explore the racial and imperial dimensions of normative debates over global (...) justice. (shrink)

A common criticism of the use of algorithms in criminal justice is that algorithms and their determinations are in some sense ‘opaque’—that is, difficult or impossible to understand, whether because of their complexity or because of intellectual property protections. Scholars have noted some key problems with opacity, including that opacity can mask unfair treatment and threaten public accountability. In this paper, we explore a different but related concern with algorithmic opacity, which centers on the role of public trust in grounding (...) the legitimacy of criminal justice institutions. We argue that algorithmic opacity threatens the trustworthiness of criminal justice institutions, which in turn threatens their legitimacy. We first offer an account of institutional trustworthiness before showing how opacity threatens to undermine an institution’s trustworthiness. We then explore how threats to trustworthiness affect institutional legitimacy. Finally, we offer some policy recommendations to mitigate the threat to trustworthiness posed by the opacity problem. (shrink)

Recent work in cognitive science of religion (CSR) is beginning to converge on a very interesting thesis—that, given the ordinary features of human minds operating in typical human environments, we are naturally disposed to believe in the existence of gods, among other religious ideas (e.g., seeAtran [2002], Barrett [2004; 2012], Bering [2011], Boyer [2001], Guthrie [1993], McCauley [2011], Pyysiäinen [2004; 2009]). In this paper, we explore whether such a discovery ultimately helps or hurts the atheist position—whether, for example, it lends (...) credence to atheism by explaining away religious belief or whether it actually strengthens some already powerful arguments against atheism in the relevant philosophical literature.We argue that the recent discoveries of CSR hurt, not help, the atheist position—that CSR, if anything, should not give atheists epistemic assurance. (shrink)

Criticism plays an essential role in the growth of scientific knowledge. In some cases, however, criticism can have detrimental effects; for example, it can be used to ‘manufacture doubt’ for the purpose of impeding public policy making on issues such as tobacco consumption and greenhouse gas emissions (e.g., Oreskes & Conway 2010). In this paper, we build on previous work by Biddle and Leuschner (2015) who argue that criticism that meets certain conditions can be epistemically detrimental. We extend and refine (...) their account by arguing that such criticism can be epistemically corrupting—it can create social conditions that are conducive to the development of epistemic vice by agents operating within them. (shrink)

The chapter begins by exploring a philosophical case study of the use of intuitions — viz., the debate regarding the problem of radical scepticism, paying particular attention to key figures within this debate such as Barry Stroud, John Austin, and Ludwig Wittgenstein. It contends that this debate demonstrates something interesting about the nature of intuitions and the role that they can play in philosophical inquiry. In particular, the chapter argues that we need to think of the philosophical use of intuitions (...) as at least sometimes involving a significant level of expertise. The chapter closes by considering the relevance of this point about philosophical intuitions to the negative programme in experimental philosophy. (shrink)

Reformed epistemology and cognitive science have remarkably converged on belief in God. Reformed epistemology holds that belief in God is basic—that is, belief in God is a natural, non-inferential belief that is immediately produced by a cognitive faculty. Cognitive science of religion also holds that belief in gods is (often) non-reflectively and instinctively produced—that is, non-inferentially and automatically produced by a cognitive faculty or system. But there are differences. In this paper, we will show some remarkable points of convergence, and (...) a few points of divergence, between Reformed epistemology and the cognitive science of religion. (shrink)

In this paper, I do three things. First, I offer an overview of an anti- luck epistemology, as set out in my book, Epistemic Luck. Second, I attempt to meet some of the main criticisms that one might level against the key theses that I propose in this work. And finally, third, I sketch some of the ways in which the strategy of anti- luck epistemology can be developed in new directions.

Experimental philosophy (or “x-phi”) is a way of doing philosophy. It is “traditional” philosophy, but with a little something extra: In addition to the expected philosophical arguments and engagement, x-phi involves the use of empirical methods to test the empirical claims that arise. This extra bit strikes some as a new, perhaps radical, addition to philosophical practice. We don’t think so. As this chapter will show, empirical claims have been common across the history of Western philosophy, as have appeals to (...) empirical observation in attempting to support or subvert these claims. While conceptions of philosophy have changed over time, across these changes we find philosophers employing empirical methods in pursuing their philosophical questions. Our primary aim in this chapter is to illustrate this fact. We begin by discussing the relevance of history to experimental philosophy (Section 2), then offer a necessarily condensed and highly selective history of empirical work in Western philosophy, ranging from the ancients (Section 3), to the early moderns (Section 4), to the late moderns (Section 5), and on to the present (Section 6). (shrink)

Leading researchers in the philosophy of mind present and explore cutting edge research in the exciting new field of experimental philosophy.

Liberalism is a term employed in a dizzying variety of ways in political thought and social science. This essay challenges how the liberal tradition is typically understood. I start by delineating different types of response—prescriptive, comprehensive, explanatory—that are frequently conflated in answering the question “what is liberalism?” I then discuss assorted methodological strategies employed in the existing literature: after rejecting “stipulative” and “canonical” approaches, I outline a contextualist alternative. Liberalism, on this account, is best characterised as the sum of the (...) arguments that have been classified as liberal, and recognised as such by other self-proclaimed liberals, over time and space. In the remainder of the article, I present an historical analysis of shifts in the meaning of liberalism in Anglo-American political thought between 1850 and 1950, focusing in particular on how Locke came to be characterised as a liberal. I argue that the scope of the liberal traditionexpanded during the middle decades of the twentieth century, such that it came to be seen by many as the constitutive ideology of the West. This capacious understanding of liberalism was a product of the ideological wars fought against “totalitarianism” and assorted developments in the social sciences. Today we both inherit and inhabit it. (shrink)

Both advocates and critics of experimental philosophy often describe it in narrow terms as being the empirical study of people’s intuitions about philosophical cases. This conception corresponds with a narrow origin story for the field—it grew out of a dissatisfaction with the uncritical use of philosophers’ own intuitions as evidence for philosophical claims. In contrast, a growing number of experimental philosophers have explicitly embraced a broad conception of the sub-discipline, which treats it as simply the use of empirical methods to (...) inform philosophical problems. And this conception has a corresponding broad origin story—the field grew out of a recognition that philosophers often make empirical claims and that empirical claims call for empirical support. In this paper, I argue that the broad conception should be accepted, offering support for the broad origin story. (shrink)

Recent scholarship in philosophy of science and technology has shown that scientific and technological decision making are laden with values, including values of a social, political, and/or ethical character. This paper examines the role of value judgments in the design of machine-learning systems generally and in recidivism-prediction algorithms specifically. Drawing on work on inductive and epistemic risk, the paper argues that ML systems are value laden in ways similar to human decision making, because the development and design of ML systems (...) requires human decisions that involve tradeoffs that reflect values. In many cases, these decisions have significant—and, in some cases, disparate—downstream impacts on human lives. After examining an influential court decision regarding the use of proprietary recidivism-prediction algorithms in criminal sentencing, Wisconsin v. Loomis, the paper provides three recommendations for the use of ML in penal systems. (shrink)

I develop a reduction of grounding to essence. My approach is to think about the relation between grounding and essence on the model of a certain conceptof existential dependence. I extend this concept of existential dependence in a coupleof ways and argue that these extensions provide a reduction of grounding to essenceif we use sorted variables that range over facts and take it that for a fact to obtain is forit to exist. I then use the account to resolve various (...) issues surrounding the concept of grounding and its connection with essence; apply the account to paradigm cases andto the impure logic of grounding; and respond to objections. (shrink)

In this article, I explore recent work on realist political theory and international politics. I discuss how scholarship on the topic emanates from two different fields—International Relations and political philosophy—and argue that there is a good case for greater engagement between them. I open by delineating various kinds of realism, showing that the term covers a wide variety of methodological and political approaches. In particular, I suggest, it is important to recognize the difference between liberal and radical approaches. The remainder (...) of the essay examines assorted examples of realist international political theorizing, work that ranges from attempts to rewrite the canon of 20th century political thought to contributions to the vibrant global justice debates. (shrink)

This paper focuses on the concept of collective essence: that some truths are essential to many items taken together. For example, that it is essential to conjunction and negation that they are truth-functionally complete. The concept of collective essence is one of the main innovations of recent work on the theory of essence. In a sense, this innovation is natural, since we make all sorts of plural predications. It stands to reason that there should be a distinction between essential and (...) accidental plural predications if there is a distinction among singular predications. In this paper I defend the view that the concept of collective essence is governed by the principle of Monotonicity: that something is essential to some items only if it is essential to any items to which they belong. (shrink)

A certain construal of the Gettier problem is offered, according to which this problem concerns the task of identifying the anti-luck condition on knowledge. A methodology for approaching this construal of the Gettier problem—anti-luck epistemology—is set out, and the utility of such a methodology is demonstrated. It is argued that a range of superficially distinct cases which are meant to pose problems for anti-luck epistemology are in fact related in significant ways. It is claimed that with these cases properly understood, (...) anti-luck epistemology is able to offer a suitable diagnosis of them which doesn’t threaten the necessity of the anti-luck condition for knowledge. (shrink)

When this work was first published in 1960, it immediately filled a void in Kantian scholarship. It was the first study entirely devoted to Kant's _Critique of Practical Reason_ and by far the most substantial commentary on it ever written. This landmark in Western philosophical literature remains an indispensable aid to a complete understanding of Kant's philosophy for students and scholars alike. This _Critique_ is the only writing in which Kant weaves his thoughts on practical reason into a unified argument. (...) Lewis White Beck offers a classic examination of this argument and expertly places it in the context of Kant's philosophy and of the moral philosophy of the eighteenth century. (shrink)

This work draws an analogical defence of strong emotionism—the metaethical claim that moral properties and concepts consist in the propensity of actions to elicit emotional responses from divergent emotional perspectives. I offer a theory that is in line with that of Prinz. I build an analogy between moral properties and what I call emotion-dispositional properties. These properties are picked out by predicates such as ‘annoying’, ‘frightening’ or ‘deplorable’ and appear to be uncontroversial and frequent cases of attribution error—the attributing of (...) subjective emotional states as mind-independent properties. I present a linguistic analysis supporting the claim that moral properties and their related concepts are reducible to a subset of emotion-dispositional properties and concepts. This is grounded in the observation that utterances featuring moral predicates function linguistically and conceptually in analogous ways to emotion-dispositional predicates. It follows from this view that asserted moral utterances are truth-apt relative to ethical communities, but that speakers misconceive the extensions of predicates. I show how the framework of Cognitive Linguistics allows us to explain this error. Further analysis of moral and non-moral utterances exposes the deeper conceptual schemas structuring language through cognitive construal processes. An understanding of these processes, coupled with an emotionist elucidation of moral properties and concepts, makes the attribution error an expected upshot of the emotionist thesis, rather than an uncomfortable consequence. (shrink)

The aim of this paper is to address the neglected but important problem of differentiating between epistemically beneficial and epistemically detrimental dissent. By “dissent,” we refer to the act of objecting to a particular conclusion, especially one that is widely held. While dissent in science can clearly be beneficial, there might be some instances of dissent that not only fail to contribute to scientific progress, but actually impede it. Potential examples of this include the tobacco industry’s funding of studies that (...) questioned the link between smoking and lung cancer, and the attempt by the petroleum industry and other groups to cast doubt upon the conclusion that human consumption of fossil fuels contributes to global climate change. The problem of distinguishing between good and bad dissent is important because of the growing tendency of some stakeholders to attempt to delay political action by ’manufacturing doubt’. Our discussion in this paper focuses on climate science. This field, in our view, is rife with instances of bad dissent. On the basis of our discussion of climate science, we articulate a set of sufficient conditions for epistemically problematic dissent in general, which we call “the inductive risk account of epistemically detrimental dissent.”. (shrink)

The idea of a returning golden age is widely understood and commonly presented both as a staple of Augustan propaganda and as a pervasive aspiration of Augustan society. TheCarmen Saeculare—an official commission for a public festival—is presented as a means by which the regime proclaimed to an enthusiastic populace the imminent renascence of the golden race. The aim of this article is to draw attention both to thefailureof theCarmen Saeculareexplicitly to proclaim the renascence of the race, and to the critique (...) implicit in the poem of the very idea of a renascence. The golden race, according to this reading, might be undesirable on account of its very goldenness. The golden race was the subject of a complex myth at the centre of a complex discourse: neither the ‘official’ nor the popular response to the idea of its return can have been as simple as they are frequently portrayed. (shrink)

This paper examines the state of the field of “science and values”—particularly regarding the implications of the thesis of transient underdetermination for the ideal of value-free science, or what I call the “ideal of epistemic purity.” I do this by discussing some of the main arguments in the literature, both for and against the ideal. I examine a preliminary argument from transient underdetermination against the ideal of epistemic purity, and I discuss two different formulations of an objection to this argument—an (...) objection that requires the strict separation of the epistemic from the practical. A secondary aim of the paper is to suggest some future directions for the field, one of which is to replace the vocabulary of values that is often employed in the literature with a more precise one. (shrink)

This essay* takes two notions of autonomy and two notions of explanation and argues that colours occur in explanations that fall under all of them. The claim that colours can be used to explain anything at all may seem to some people an outrage. But their pessimism is unjustified and the orthodox dispositional view which may seem to support it, I shall argue, itself has difficulties. In broad terms, Section 2 shows that there exist good straight scientific laws of colour, (...) constituting what one might call a phenomenal science. Section 3 offers a larger view of what we are doing when we attribute colours to things, a view which makes it a case of holistic explanation, similar in many ways to psychological explanation. Section 2 emphasizes the model of scientific explanation, and Section 3 the holistic model found in rational explanation; but it will emerge that colour explanation in different ways fits both models, as it also does the two principal notions of autonomy that the first section identifies. (shrink)

Through the lenses of cognitive science of religion, successful god concepts must possess a number of features. God concepts must be counterintuitive, an intentional agent, possessing strategic information, able to act in the human world in detectable ways and capable of motivating behaviors that reinforce belief. That Santa Claus appears to be only inconsistently represented as having all five requisite features Santa has failed to develop a community of true believers and cult. Nevertheless, Santa concepts approximate a successful god concept (...) more closely than other widespread cultural characters such as Mickey Mouse and the Tooth Fairy, in part explaining Santa's relative cultural prominence. (shrink)

In this article I pursue two main lines of argument. First, I seek to delineate two distinctive modes of justifying imperialism found in nineteenth-century political thought (and beyond). The 'liberal civilizational'li model, articulated most prominently by John Stuart Mill, justified empire primarily in terms of the benefits that it brought to subject populations. Its proponents sought to 'civilize'lthe 'barbarian'. An alternative `republican' model focused instead on the benefits - glory, honour and power above all - that accrued to the imperial (...) state. Less concerned with spreading civilization, its proponents concentrated on fortifying the imperial polity. Second, I offer a 'republican' interpretation of the writings of the historian and public moralist J.A. Froude (1818-94), arguing that he both diagnosed the problems of modern Britain and prescribed imperial solutions to those problems, based on his reading of the fate of the Roman republic. (shrink)

(No abstract is available for this citation).

Does Augustine put his finger on time? -- Time for history -- Determination -- Self-determination -- Time, knowledge and truth.

What is it for something to be essential to an item? For some time, it was standard to think that the concept of necessity alone can provide an answer: for something to be essential to an item is for it to be strictly implied by the existence of that item. We now tend to think that this view fails because its analysans is insufficient for its analysandum. In response, some argue that we can supplement the analysis in terms of necessity (...) with a further condition. In this paper I argue that this view is untenable in its current form. I then provide a glimmer of hope to those who think that essence is at least partially analyzable in terms of necessity. (shrink)

In this chapter, I explicate several general views and arguments that bear on the notion and contemporary theories of human welfare, as found in two foundational Daoist texts, the Daodejing and the Zhuangzi. Ideas drawn from the Daodejing include its objections to desire theories of human welfare and its distinction between natural and acquired desires. Insights drawn from the Zhuangzi include its arguments against the view that death is bad for the dead, its attempt to develop a workable theory of (...) well-being for those who are skeptical about such theories, and the prudential benefits of what I call "philosophical double-vision.". (shrink)

An overview of the import of disjunctivism to the problem of radical scepticism is offered. In particular, the disjunctivist account of perceptual experience is set out, along with the manner in which it intersects with related positions such as naïve realism and intentionalism, and it is shown how this account can be used to a motivate an anti-sceptical proposal. In addition, a variety of disjunctivism known as epistemological disjunctivism is described, and it is explained how this proposal offers a further (...) way of responding to radical scepticism. (shrink)

ABSTRACTIn this paper, I develop a truthmaker semantics for essence and use the semantics to investigate the explanatory role of essence.