Methods and equations for analysing the kinetics of enzyme-catalysed reactions were developed at the beginning of the 20th century in two centres in particular; in Paris, by Victor Henri, and, in Berlin, by Leonor Michaelis and Maud Menten. Henri made a detailed analysis of the work in this area that had preceded him, and arrived at a correct equation for the initial rate of reaction. However, his approach was open to the important objection that he took no account of (...) the hydrogen-ion concentration (a subject largely undeveloped in his time). In addition, although he wrote down an expression for the initial rate of reaction and described the hyperbolic form of its dependence on the substrate concentration, he did not appreciate the great advantages that would come from analysis in terms of initial rates rather than time courses. Michaelis and Menten not only placed Henri's analysis on a firm experimental foundation, but also defined the experimental protocol that remains standard today. Here, we review this development, and discuss other scientific contributions of these individuals. The three parts have different authors, as indicated, and do not necessarily agree on all details, in particular about the relative importance of the contributions of Michaelis and Menten on the one hand and of Henri on the other. Rather than force the review into an unrealistic consensus, we consider it appropriate to leave the disagreements visible. (shrink)

In this paper I discuss some thoughts Judith Butler presents regarding corporeal vulnerability. This might help to elucidate the problem of whether critical education is still possible today. I first explain why precisely the possibility of critique within education is a problem for us today. This is because the traditional means of enhancing a critical attitude in pupils, stimulating their self-reflective capacities, contributes to the continued existence and strengthening of the current societal and political regime. A way out of this (...) deadlock is offered from within a Foucauldian perspective. Criticality here refers to an experience of exposure and expropriation of the self. This kind of limit-experience is also of a central importance in the most recent work of Judith Butler. She links this experience to the corporeal condition of susceptibility. Our bodies have a public dimension as we are inescapably exposed to one another. The main argument of my paper has to do with whether this appeal to corporeal vulnerability might offer a new way of thinking about the public realm and about the possibility of critique, especially within the field of education. I conclude the paper by showing the originality of Butler's thought in this respect and the possibilities it opens for thinking in a radically new way about critical pedagogy. (shrink)

In late nineteenth- and early twentieth-century Germany, the integration of product-evaluating certificates and reports into advertisements triggered repeated condemnations of “advertisement- Gutachten”, and scientists and science administrators introduced various restrictions to prevent the appearance of such documents. At the same time, the provision of Gutachten to private individuals and firms seemed crucial to the success of many private and public laboratories. Some chemical and other professionals, moreover, argued that the authoring and use of Reklamegutachten could represent a “scientific” and, therefore, (...) ethical practice. By examining the contested history of the advertisement- Gutachten, this article reveals how a previously tolerated knowledge service lost its legitimacy in a particular place and period of time, and highlights the challenges of eliminating this practice or restoring its legitimacy afterward. The article also explores how professional scientists’ approaches to maintaining a reputation for integrity in the face of commercial and competitive pressures related to the better-known efforts of professionals in other fields, particularly the medical. I emphasize that, in determining whether a Gutachten qualified as scientific, the nature and transparency of the underlying research process was only one of the criteria that were considered, and often not the most significant yardstick. At the same time, however, ideas about the personal and professional/institutional integrity of providers of Gutachten were inextricably connected with assessments of the honesty and objectivity of their research. (shrink)

This volume explores the relevance of decline within the republican tradition. The essays in this volume focus on the Dutch Republic during the revolutionary era, as well as early modern Spain and Venice, the German Enlightenment, and the Weimar Republic.

People narrating the experience of dysregulated anger after a brain injury call upon metaphor in patterned ways to help them make sense of their situation. Here, I analyze the use of the metaphor of the doubled self in a personal narrative of brain injury, and I situate this metaphor in its cultural history by analyzing Dr Jekyll and Mr Hyde and The Incredible Hulk as landmark moments in its development. A pattern of thought reflecting Seneca’s philosophy on the incompatibility of (...) anger with rational selfhood emerges. I discuss implications for the way we care for people struggling with post-brain-injury anger. (shrink)

Volume 19, Issue 5, May 2019, Page W1-W2.

Negotiation and deliberation are two context types or genres of discourse widely studied in the argumentation literature. Within the pragma-dialectical framework, they have been characterised in terms of the conventions constraining the use of argumentative discourse in each of them. Thanks to these descriptions, it has become possible to analyse the arguers’ strategic manoeuvres and carry out more systematic, context-sensitive evaluations of argumentative discussions. However, one issue that still must be addressed in the pragma-dialectical theory—and other contextual approaches to argumentation—is (...) how to distinguish negotiation and deliberation in practice. In this paper, I seek to develop criteria that can help the analyst identify them in discourse. To this end, I characterise the felicity conditions of the superordinate speech acts defining and structuring deliberation and negotiation encounters. (shrink)

In this review of empirical studies we aimed to assess the influence of religion and world view on nurses' attitudes towards euthanasia and physician assisted suicide. We searched PubMed for articles published before August 2008 using combinations of search terms. Most identified studies showed a clear relationship between religion or world view and nurses' attitudes towards euthanasia or physician assisted suicide. Differences in attitude were found to be influenced by religious or ideological affiliation, observance of religious practices, religious doctrines, and (...) personal importance attributed to religion or world view. Nevertheless, a coherent comparative interpretation of the results of the identified studies was difficult. We concluded that no study has so far exhaustively investigated the relationship between religion or world view and nurses' attitudes towards euthanasia or physician assisted suicide and that further research is required. (shrink)

In this paper we explore a new way to deal with social inequality and injustice in an educational way. We do so by offering a particular reading of a scene taken from Minnelli's film The Band Wagon which is often regarded as overly western-centred and racist. We argue, however, that the way in which words and movements in this scene function are expressive of an event that can be read as a new beginning and that it is for this reason (...) in and of itself educational. By drawing on Agamben's and Cavell's insights on childhood and what it means to acquire a language, we argue that in this scene a form of childhood is displayed which denotes a general condition for education to take place in children and grown-ups alike. Hence, education can be understood as a interruption of existing power structures and as a transformation of one's existence. (shrink)

In this article Joris Vlieghe defends the view that technologies of reading and writing are more than merely instruments that support education, arguing that these technologies themselves decide what education is all about and that they form subjectivity in substantial ways. Expanding on insights taken from media theory, Vlieghe uses the work of Bernard Stiegler in order to develop a “technosomatic” account of literacy initiation, that is, a perspective that zooms in on the physical dimensions of how to operate (...) writing and reading technologies. He argues that that the bodily gestures and disciplines that constitute literacy give rise to a particular space of experience, which comes down to a heavily embodied, first-hand sense of what it means to be able to produce script. Vlieghe contends that the advent of digital writing and reading technologies implies a fundamental shift in this sense of ability, and that in order to understand digital literacy we need to take into account the technosomatic aspects of learning to read and write with digital media. (shrink)

As artificial intelligence (AI) deployment is growing exponentially, questions have been raised whether the developed AI ethics discourse is apt to address the currently pressing questions in the field. Building on critical theory, this article aims to expand the scope of AI ethics by arguing that in addition to ethical principles and design, the organizational dimension (i.e. the background assumptions and values influencing design processes) plays a pivotal role in the operationalization of ethics in AI development and deployment contexts. Through (...) the prism of critical theory, and the notions of underdetermination and technical code as developed by Feenberg in particular, the organizational dimension is related to two general challenges in operationalizing ethical principles in AI: (a) the challenge of ethical principles placing conflicting demands on an AI design that cannot be satisfied simultaneously, for which the term ‘inter-principle tension’ is coined, and (b) the challenge of translating an ethical principle to a technological form, constraint or demand, for which the term ‘intra-principle tension’ is coined. Rather than discussing principles, methods or metrics, the notion of technical code precipitates a discussion on the subsequent questions of value decisions, governance and procedural checks and balances. It is held that including and interrogating the organizational context in AI ethics approaches allows for a more in depth understanding of the current challenges concerning the formalization and implementation of ethical principles as well as of the ways in which these challenges could be met. (shrink)

Communities, scientists, policy-makers and industries are requiring farmers to address environmental and wellbeing challenges in their on-farm management, transitioning away from a productivity dominated focus towards a multi-faceted system focus that includes environmental and social values. This paper analyses how Miraka Ltd., an Aotearoa-New Zealand indigenous owned and operated milk company, has taken on the role of institutional entrepreneur to enable and support change towards a multi-faceted system amongst its supply farmers. Observations and interviews were carried out to: identify farmers’ (...) changes in practices, beliefs and values over the last ten years; and identify how Miraka functions as an indigenous entrepreneur in the agricultural sector. Findings show that interviewees were initially guided by business and family-oriented values, beliefs and practices, but in response to the institutional entrepreneurship by Miraka, approximately half of the interviewees changed these values, beliefs and practices, by internalising people and environmental values. The main strategies employed by Miraka were mobilisation of material resources such as incentives and awards, creation of a rationale addressing environmental and social concerns in the dairy sector, and proactive connection with new actors. The research shows an indigenous owned small-medium enterprise can make changes in values, beliefs and practices amongst its supply farmers, but requires a stronger shared base of values to contribute to a wider economic change. The discussion connects these findings to wider literature on diverse economies and indigenous entrepreneurship to identify to what extent an indigenous small-medium enterprise can contribute to a system change. (shrink)

The essays in this collection explore our reliance on experts within a historical context and across a wide range of fields, including agriculture, engineering, health sciences and labour management. Contributors argue that experts were highly aware of their audiences and used performance to gain both scientific and popular support.

Introduction: Decisions to withdraw or withhold curative or life-sustaining treatment can have a huge impact on the symptoms which the palliative-care team has to control. Palliative-care patients and their relatives may also turn to palliative-care physicians and nurses for advice regarding these treatments. We wanted to assess Indian palliative-care nurses and physicians’ attitudes towards withholding and withdrawal of curative or life-sustaining treatment. Method: From May to September 2008, we interviewed 14 physicians and 13 nurses working in different palliative-care programmes in (...) New Delhi, using a semi-structured questionnaire. For the interviews and analysis of the data we followed Grounded-Theory methodology. Results: Withholding a curative or life-sustaining treatment which may prolong a terminal cancer patient’s life with a few weeks but also has severe side-effects was generally considered acceptable by the interviewees. The majority of the interviewees agreed that life-sustaining treatments can be withdrawn in a patient who is in an irreversible coma. The palliative-care physicians and nurses were of the opinion that a patient has the right to refuse life-saving curative treatment. While reflecting upon the ethical acceptability of withholding or withdrawal of curative or life-sustaining treatment, the physicians and nurses were concerned about the whole patient and other people who may be affected by the decision. They were convinced they can play an important advisory role in the decision-making process. Conclusion: While deciding about the ethical issues, the physicians and nurses do not restrict their considerations to the physical aspects of the disease, but also reflect upon the complex wider consequences of the treatment decisions. (shrink)

In this article I defend the thesis of a strong similarity between the modern critique of Christian revelation and the main arguments of contemporary pluralist theologians. As a relevant spokesperson of modern thought I take Karl Jaspers. After having presented his most important writings on religion and belief, I discuss three general features of modern thought, namely, subjectivism, ethical humanism and universalism. I argue that these characteristics not only figure in Jaspers’ critique of Christianity, but that they are also fundamental (...) to the pluralist theology of religions. Then I focus on characteristics of modern thought regarding religion in particular. First I analyse the specific kind of ‘natural theology’ in Jaspers’ philosophy and in pluralism, and I continue with the question of christology. In both cases I discern a parallel intuition. With a view to Jaspers’ most crucial objection to the Christian revelation, I maintain that he ultimately rejects both the reality and the possibility of God revealing Godself in the history of humankind. And I immediately ask whether the philosophical presuppositions of pluralism do not tend towards the same radical rejection. In my conclusion, I raise questions about the approach represented by Jaspers and so-called pluralist theologians. In addition to being irreducibly ambiguous, it does not seem to constitute the guarantee of tolerance that both Jaspers and pluralists declare it to be. (shrink)

The goal of this paper is to describe the link between financial performance and the level of sustainability. In a novel approach, the paper classifies firms based on past financial success to address a potentially reciprocal relationship. For the groups of better and worse performing firms and for the entire sample, the above link is then tested, also accounting for non-linearity in the relationship. We show that environmental management system (EMS) implementation as a proxy for a firm's sustainability level is (...) only positively associated with the financial performance of financially well-performing firms. Conversely, it has a negative association with the performance of less good firms. We show that this implies that firms cannot change from good to bad performance, and vice versa, solely through the implementation of an EMS, and also that the result remains when introducing non-linearity in the link. Based on this result, we discuss implications for the direction of causality. (shrink)

On the basis of a close reading of three authors , I try to elucidate what the growing presence of digital technologies in our lives implies for the sphere of schooling and education. Developing a technocentric perspective, I discuss whether what is happening today concerns just the newest form of humankind's fundamental dependency on a technological milieu or that it concerns a fundamental shift. From Flusser, I take the idea that the practice of writing shapes human subjectivity, as well as (...) our very sense of history and progress, and that with the advent of digital technologies the possibility of a posthistorical era is granted. I confront this idea with Stiegler's analysis of technological tools and practices as strongly materialized memories, which amounts to a plea for securing the link with the particular history behind the technologies we use. Here, education should play a conservative role and take responsibility for using technologies in a correct way. I argue that Stiegler is not wholly consistent on this point and, moreover, that his view precludes the possibility to rethink the very meaning of education under present conditions. This possibility is opened if we turn to a philosopher which is ruthlessly criticized by Stiegler for being a technophobe: Agamben. I argue, however, that a more detailed reading of Agamben—n combination with Flusser—might show a completely different and far more positive appreciation for digital technology and that this view offers an opening for rethinking what education is all about. (shrink)

In an attempt to reject Cartesian Dualism, some philosophers and scientists of the late twentieth century proposed a return to the ancient position that Descartes had opposed, i.e., Aristotle’s psychological hylomorphism, which applied to living beings the ontological thesis, according to which every substance is a compound of matter (hyle) and form (morphe). In this perspective, the soul is actual possession of the body’s capacity to perform a series of life functions. Therefore, according to Aristotle, soul and body are reciprocally (...) interdependent aspects of the living being, so that we must consider the former as an enmattered form, and the latter as an enformed or ensouled matter. This means that, for Aristotle, all the functions of the soul, even the highest ones like thought, are essentially connected with the body, since they ultimately require sensations. This paper illustrates and supports this doctrine in detail, especially in relation to the cognitive processes of the human mind. (shrink)