Abstractp53 has a determinant role in cancer prevention and is among the most studied proteins in the world. The majority of studies devoted to this protein are carried out in cell lines because they are easy to use and have naturally emerged as the main research tool in laboratories. However, the p53 pathway is commonly deregulated in cancer cells, from which the experimental cell lines are generally derived. The fact that the pathway is deregulated challenges the relevance of using cancer‐derived (...) cell lines to study wild‐type p53 activities, or, in a broader sense, to study any normal cellular process. In the present article, we identify and discuss a number of limitations of cell lines using examples related to p53. Finally, we point out the general limitations of cell lines and propose solutions as alternatives to these cells. (shrink)

In this article, we present a modal logic that extends the basic modal logic with two dynamic operators: copy ( ), which replicates the current model, labelling each copy with a different propositional symbol and respecting accessibility relations even between distinct copies; and remove ( ), which deletes paths in the model that satisfy certain intermediate conditions. We call the resulting logic. We study its computational complexity, and its relative expressivity with respect to (static) modal logics and, and the dynamic (...) epistemic Action Model Logic,. (shrink)

In this article, we present a modal logic that extends the basic modal logic ML with two dynamic operators: copy, which replicates the current model, labelling each copy with a different prop...

Physicien de formation, Francois Bastien a enseigne dans de nombreux domaines: mathematiques, electricite, optique, thermodynamique, physique des vibrations, physique des capteurs, acoustique des solides, informatique, electronique numerique et electrotechnique. Il a tenu un blog ou se sont regroupees certaines interrogations sur les sciences exactes. Son livre presente donc des reflexions sur la recherche scientifique. Un changement d'echelle de la communaute scientifique entraine necessairement un bouleversement. L'auteur tend a sortir de la doctrine hors de l'ecole point de salut qui freine (...) la promotion sociale, en proposant par exemple un Musee de la Science inconnue. Il invite egalement a lutter contre les effets de la multiplication des publications scientifiques, en faisant naitre des journaux de critiques scientifiques comme il en existe pour la litterature. Par ailleurs, la prise en compte des limites de la science, d'un point de vue philosophique et pratique, est discutee. (shrink)

In this paper I argue against a widely accepted model of utterance interpretation, namely the LS model, according to which the literal interpretation of an utterance (the proposition literally expressed by that utterance) must be computed before non-literal interpretations can be entertained. Alleged arguments in favor of this model are shown to be fallacious, counterexamples are provided, and alternative models are sketched.

Kunc, Francois When I told another lawyer that I was coming here tonight he sent me an email commiserating that 'the art of after dinner speaking is doubly difficult for judges who are expected to be witty and entertaining, but not say anything controversial-or maybe nothing at all'. I also had the pleasure of spending some time recently with your Bishop Peter, who admonished me to 'keep it light'.

In this survey paper, I start from two classical theses of speech act theory: that speech act content is uniformly propositional and that sentence mood encodes illocutionary force. These theses have been questioned in recent work, both in philosophy and linguistics. The force/content distinction itself – a cornerstone of 20‐century philosophy of language – has come to be rejected by some theorists, unmoved by the famous ‘Frege–Geach’ argument. The paper reviews some of these debates.

In a series of papers, Sperber provides the following analysis of the phenomenon of ill-understood belief (or 'quasi-belief', as I call it): (i) the quasi-believer has a validating meta-belief, to the effect that a certain representation is true; yet (ii) that representation does not give rise to a plain belief, because it is 'semi-propositional'. In this paper I discuss several aspects of this treatment. In particular, I deny that the representation accepted by the quasi-believer is semantically indeterminate, and I reject (...) Sperber's claim that quasi-belief is a credal attitude distinct from plain belief. (shrink)

Diversity of evidence is widely claimed to be crucial for evidence amalgamation to have distinctive epistemic merits. Bayesian epistemologists capture this idea in the variety-of-evidence thesis: ceteris paribus, the strength of confirmation of a hypothesis by an evidential set increases with the diversity of the evidential elements in that set. Yet, formal exploration of this thesis has shown that it fails to be generally true. This article demonstrates that the thesis fails in even more circumstances than recent results would lead (...) us to expect. Most importantly, it can fail whatever the chance that the evidential sources are unreliable. Our results hold for two types of degrees of variety: reliability independence and testable aspect independence. We conclude that the variety-of-evidence thesis can, at best, be interpreted as an exception-prone rule of thumb. (shrink)

Diversity of evidence is widely claimed to be crucial for evidence amalgamation to have distinctive epistemic merits. Bayesian epistemologists capture this idea in the variety-of-evidence thesis: ceteris paribus, the strength of confirmation of a hypothesis by an evidential set increases with the diversity of the evidential elements in that set. Yet, formal exploration of this thesis has shown that it fails to be generally true. This article demonstrates that the thesis fails in even more circumstances than recent results would lead (...) us to expect. Most importantly, it can fail whatever the chance that the evidential sources are unreliable. Our results hold for two types of degrees of variety: reliability independence and testable aspect independence. We conclude that the variety-of-evidence thesis can, at best, be interpreted as an exception-prone rule of thumb. (shrink)

It has often been observed that the meaning of a word may be affected by the other words which occur in the same sentence. How are we to account for this phenomenon of 'semantic flexibility'? It is argued that semantic flexibility reduces to context-sensitivity and does not raise unsurmountable problems for standard compositional accounts. On the other hand, it would be a mistake to assume too simple a view of context-sensitivity. Two basic forms of context-sensitivity are distinguished in the paper. (...) The second form — sense modulation — shows that, in a sense, there is more in the meaning of the whole than can be derived from the meanings of the parts. (shrink)

In modal logic, propositions are evaluated relative to possible worlds. A proposition may be true relative to a world w, and false relative to another world w'. Relativism is the view that the relativization idea extends beyond possible worlds and modalities. Thus, in tense logic, propositions are evaluated relative to times. A proposition (e.g. the proposition that Socrates is sitting) may be true relative to a time t, and false relative to another time t'. In this paper I discuss, and (...) attempt to rebut, two classical objections to Relativism. The first objection, due to Frege, is the objection from incompleteness. I distinguish two possible relativist responses to that objection, one of which corresponds to the view I actually defend : Moderate Relativism. The second objection is due to Mark Richard, who argued that the objects of belief cannot be relativistic. I show that that objection can be met within the Moderate Relativist framework. In the last section, I deal with special forms of disagreement that have loomed large in recent discussions of Relativism. (shrink)

The variety-of-evidence thesis has been criticized by Bovens and Hartmann. This article points to two limitations of their Bayesian model: the conceptualization of unreliable evidential sources as randomizing and the restriction to comparing full independence to full dependence. It is shown that the variety-of-evidence thesis is rehabilitated when unreliable sources are reconceptualized as systematically biased. However, it turns out that allowing for degrees of independence leads to a qualification of the variety-of-evidence thesis: as Bovens and Hartmann claimed, more independence does (...) not always imply stronger confirmation. (shrink)

Review of Insensitive Semantics, by H. Cappelen and E. Lepore.

This article maintains that an important class of scientific generalizations should be reinterpreted: they have typically been understood as ceteris paribus laws, but are, in fact, generics. Four arguments are presented to support this thesis. One argument is that the interpretation in terms of ceteris paribus laws is a historical accident. The other three arguments draw on similarities between these generalizations and archetypal generics: they come with similar inferential commitments, they share a syntactic form, and the existing theories to make (...) sense of them are alike. Once these generalizations are properly understood as generics, the recent cognitive approach to generics can be extended to the study of the relevant sciences. The last section indicates ways in which this extension is fruitful for the two strands of research that we combine: the philosophy of science literature on generalizations and the semantics literature on generics. (shrink)

This article examines two theses formulated by Russo and Williamson in their study of causal inference in the health sciences. The two theses are assessed against evidence from a specific case in the social sciences, i.e., research on the institutional determinants of the aggregate unemployment rate. The first Russo–Williamson Thesis is that a causal claim can only be established when it is jointly supported by difference-making and mechanistic evidence. This thesis is shown not to hold. While researchers in my case (...) study draw extensively on both types of evidence, one causal claim out of the three analyzed is established even though it is exclusively supported by mechanistic evidence. The second Russo–Williamson Thesis is that standard accounts of causality fail to handle the dualist epistemology highlighted in the first Thesis. I argue that a counterfactual-manipulationist account of causality—which is endorsed by many philosophers as well as many social scientists—can perfectly make sense of the typical strategy in my case study to draw on both difference-making and mechanistic evidence; it is just an instance of the common strategy of increasing evidential variety. (shrink)

I argue that immunity to error through misidentification primarily characterizes thoughts that are 'implicitly' de se, as opposed to thoughts that involve an explicit self-identification. Thoughts that are implicitly de se involve no reference to the self at the level of content: what makes them de se is simply the fact that the content of the thought is evaluated with respect to the thinking subject. Or, to put it in familiar terms : the content of the thought is a property (...) which the thinking subject self-ascribes (as in the Loar/Lewis/Chisholm analysis). After answering an objection (to the effect that immunity can affect explicit de se thoughts), I extend the analysis to demonstrative thoughts, which also exhibit the property of immunity to error through misidentification. (shrink)

In the first part of this paper I sketch a theory of indexical concepts within a broadly epistemic framework. In the second part I discuss and dismiss an argument due to Jerry Fodor, to the effect that any epistemic approach to concept individuation (including the theory of indexical concepts I will sketch) is doomed to failure.

Aristotle’s philosophical insights into ethics, wisdom and practice have drawn the attention of scholars. In the current professional context where ethics are often compromised, this debate assumes a necessary urgency. This subject is highly relevant to business schools, given the general neglect of this quality in executive management development. Our research involved an analysis of contemporary literature on phronesis in the management scholarship, practice and teaching domains. Our definition of phronesis identifies themes and paradoxes distilled from this literature. Stories are (...) by nature multi-layered and paradoxical, embracing ambiguity and contradiction, so we incorporate narrative as essential to our enquiry. While it appears to be easily grasped, phronesis is complex, nuanced and paradoxical, seen as an unorganised set of characteristics in the management scholarship domain. We argue that the neglect of phronesis in modernity flows from the challenging nature of developing it, itself the consequence of its indistinctness. It calls for Einstein’s words “I would give my life for the simplicity on the other side of complexity”. This article argues that developing this virtue as a form of practical wisdom, should be an integral part of executive management development if we are to cultivate morally responsible leadership. A typology of managerial phronesis will encourage contextually appropriate leadership excellence based on the virtue-attributes of managers-as-scholars. The typology we propose is based on a Grounded Theory synthesis of relevant literature. We adopt a phenomenological stance. Through incorporating Grounded Theory second order themes, we offer a grainier understanding of the qualities of managerial phronesis. (shrink)

Contribution au numéro spécial de la Revue Internationale de Philosophie sur John Searle.

. This article analyzes the epistemic contributions of models by distinguishing three roles that they might play: an evidential role, a revealing role and a stimulating role. By using an account of learning based on the philosophical understanding of propositional knowledge as true justified belief, the paper provides the conditions to be fulfilled by a model in order to play a determined role. A case study of an economic model of the labor market—the DMP model—illustrates the usefulness of these conditions (...) in articulating debates over the epistemic contributions of a given model. (shrink)

A number of distinct (though related) issues are raised in the debate over Contextualism in the philosophy of language. My aim in this chapter for the Cambridge Handbook of Pragmatics is to disentangle them, so as to get a clearer view of the positions available (where a 'position' consists of a particular take on each of the relevant issues simultaneously).

In this article, I argue against a widely accepted model of utterance interpretation, namely the LS model (literality‐based serial model), according to which the literal interpretation of an utterance (the proposition literally expressed by that utterance) must be computed before nonliteral interpretations can be entertained. Alleged arguments in favor of this model are shown to be fallacious, counter‐examples are provided, and alternative models are sketched.

In the present study, we examined how the religiousness of European Muslim immigrants is related to multiple collective identities , attachment to one or both cultures, and acculturation as a process realized through a variety of domains in personal and social life. Two groups were included: young Muslims born of immigration from Muslim countries and, for comparison, young non-Muslims born of immigration from other countries. In both groups, high religiousness predicted attachment to origin identity and culture; low religiousness and religious (...) doubting predicted identification with the host country and acculturation. Interestingly, the religiousness of Muslim immigrants also predicted high identification as citizen of the world, whereas the religiousness of the other immigrants was related to low European identity. Finally, some discrepancy between claiming new identities and effectively experiencing acculturation was found. Interpretations are provided on both a general level and a contextual level. (shrink)

The article introduces a special issue on “Rethinking Liberal Multiculturalism: Foundations, Practices and Methodologies.” The contributions presented in this special issue were discussed during the conference « Multicultural Citizenship 25 Years Later », held in Paris in November 2021. Their aim is to take stock of the legacy of Kymlicka’s contribution and to highlight new developments in theories of liberal multiculturalism and minority rights. The contributions do not purport to challenge the legitimacy of theories of multiculturalism and minority rights, they (...) rather aim at deepening our understanding of the foundations of liberal multiculturalism and of its practical implementation, sensitive to social scientific dynamics of diverse societies. Without abandoning the general idea that cultural minorities should be granted special minority rights, the essays presented raise new questions about three dimensions central to liberal multiculturalism: its normative foundations, its practical categories of minorities or groups, and its fact-sensitive methodology. Taken together they shed light on the renewed variety of theories of liberal multiculturalism highlighting their complexity and internal disagreements. To introduce these articles, the article first draws a brief historical overview of the debates on multiculturalism since the 1990s (section 1). It then highlights the distinctive aspects of Kymlicka’s contribution (section 2) and identifies recent research trends (section 3). Doing so, it explains how the articles gathered here both expand on those distinctive aspects and explore those new research avenues. The section 4 summarizes the contributions. (shrink)

La notion de passage n’a pas été conceptualisée en linguistique ; cependant, elle se révèle utile dans des domaines d’application aussi divers que la thématique, la recherche d’information ou la représentation des connaissances.En s’appuyant sur l’expérience de la sémantique de corpus, cette étude précise la notion de passage par l’examen des rapports de sémiosis entre contenu et expression du passage, comme par l’étude des rapports contextuels au sein du passage et entre passages. Tenant compte des rapports entre fonds et formes (...) sémantiques, puis des transformations entre passages, l’investigation conduit à préciser des phénomènes qui intéressent tant la textualité que l’intertextualité, de la citation à la traduction. (shrink)

In this article, we compare Ricard Zappata-Barrero’s interculturalism with Tariq Modood’s multiculturalism. We will discuss the relation between distinct elements that compose both positions. We examine how recent discussions on interculturalism have the potential to contribute to theories of multiculturalism without undermining their core principles. Our position is close to that of Modood’s as he has already carefully tried to incorporate interculturalist insights into his own multiculturalism. Yet we provide a raise a few questions regarding Modood’s treatment of the relation (...) between multiculturalism and interculturalism. After summarizing each author’s potion (I), we will comment on the following set of relations between their basic elements: (II) The relation between intercultural contact and intercultural dialogue; (III) The relation between contact at the local level and the societal/state level; (IV) The relation between group-specific measures, intercultural contact and mainstreaming. (shrink)

In Why Tolerate Religion?, Brian Leiter argues against the special legal status of religion, claiming that religion should not be the only ground for exemptions to the law and that this form of protection should be, in principle, available for the claims of secular conscience as well. However, in the last chapter of his book, he objects to a universal regime of exemptions for both religious and secular claims of conscience, highlighting the practical and moral flaws associated with it. We (...) believe that Leiter identifies a genuine and important contemporary legal and philosophical problem. We find much to admire in his reasoning. However, we raise questions about two claims that are crucial for his argument. The first claim is that it is not religion as such, but conscience that deserves toleration and respect. The second claim is that respect for religion and conscience demands ‘principled toleration’ but does not entail stronger policies of legal exemptions. Against the first claim, we argue that Leiter does not successfully distinguish religious belief from secular conscience and morality; and he does not explain why secular conscience deserves respect. Against the second claim, we argue that the most promising theories of legal exemptions are not classical theories of liberal toleration. (shrink)

In this paper I argue that the self-referential component which Searle rightly detects in the truth-conditions of perceptual judgments comes from the perceptual ‘mode' and is not an aspect of the ‘content' of the judgment, contrary to Searle's claim.

Current philosophical accounts of causation suggest that the same causal assertion can have different meanings. Yet, in actual social-scientific practice, the possible meanings of some causal generalisations intended to support policy prescriptions are not always spelled out. In line with a standard referentialist approach to semantics, we propose and elaborate on four questions to systematically elucidate the meaning of causal generalisations. The analysis can be useful to a host of agents, including social scientists, policy-makers, and philosophers aiming at being socially (...) relevant. To illustrate our proposal, we analyse the complexities related to the meaning of causal generalisations in the context of a concrete case of economic research which is explicitly intended to guide public policy, namely, the OECD research on the causes of unemployment. (shrink)

Le sujet qui perçoit, ressent, se remémore, ou imagine a conscience de son activité mentale, et notamment du mode — perceptif, mnésique ou autre — de ses états. Le mode des états expérientiels va de pair avec une relation spécifique (variable selon le mode) du sujet à ce que l'état représente. Par exemple, le sujet qui se remémore se trouve (normalement) dans une certaine relation à la scène remémorée : il a perçu celle-ci dans le passé. La thèse principale de (...) l'article est que le sujet conscient d'être dans un état donné s'auto-attribue implicitement cette relation avec ce que l'état représente. Cette auto-attribution implicite (immunisée aux erreurs d'identification) constitue la présence du sujet «comme sujet » dans le contenu de ses expériences, distincte de sa présence « comme objet » lorsqu'il fait lui-même partie de la scène représentée. [English abstract] The subject who perceives, feels, remembers or imagines is conscious of his or her experiential states and, in particular, of their ‘mode'. The mode is what enables us to classify experiential states into types such as perceptions, memories, etc., quite independent of the content of the state (what is perceived, remembered, etc.). It is argued that the mode M of an experience determines that (if all goes well) a certain relation RM holds between the subject of the experience and what the experience represents. For example, the subject who remembers a scene normally stands in a certain relation to the scene in question, that of having perceived it in the past. The article's main thesis is that the subject of an experiential state implicitly self-ascribes the relevant relation to what the state represents. This implicit self-ascription (which is immune to error through misidentification) corresponds to the presence of the subject « as subject » in the content of his or her experience. (shrink)

In this chapter, we discuss social network analysis as a method for the history of economics. We argue that social network analysis is not primarily a method of data representation but foremost a method of discovery and confirmation. It is as such a promising method that should be added to the toolbox of the historian of economics. We furthermore argue that, to be meaningfully applied in history, social network analysis must be complemented with historical knowledge gained by other means and (...) often by more traditional, mostly qualitative, methods. It should therefore be viewed as a method that complements rather than replaces more established approaches in the history of economics. (shrink)

Many liberals and secularists believe that religious schooling should not be publicly funded or that it should simply be banned. Challenging those views, I claim that although liberal states may refuse to fund and may even ban certain illiberal separate religious schools, it is impermissible, for distinctively liberal reasons, to completely ban publicly funded religious schooling. I will however argue that providing religious instruction within common public schools is more desirable than having separate religious schools. I argue that providing religious (...) instruction within common public schools is a better way to balance the educational interests of parents, children and society than banning religious schooling altogether; authorizing it but refusing to fund it; or having publicly funded separate religious schools. (shrink)

In developmental lexical–gustatory synesthesia, specific words can trigger taste perceptions and these synesthetic associations are generally stable. We describe a case of multilingual lexical–gustatory synesthesia for whom some synesthesias were bidirectional as some tastes also triggered auditory word associations. Evoked concurrents could be gustatory but also tactile sensations. In addition to words and pseudowords, many voices were effective inducers, suggesting increased connections between cortical taste areas and both voice-selective and language-selective areas. Lasting changes in some evoked tastes occurred during childhood (...) suggesting that some plasticity can be present after the initial learning of associations. Inducers were often linked to taste concurrents phonologically or semantically, but also through identifiable childhood episodes . Several inducers were phonologically linked to episodic inducers suggesting a process of secondary acquisition for many inducers. Implications of these observations are discussed. (shrink)

The most common way of analysing the meaning of causal generalisations relies on referentialist semantics. In this article, we instead develop an analysis based on inferentialist semantics. According to this approach, the meaning of a causal generalisation is constituted by the web of inferential connections in which the generalisation participates. We distinguish and discuss five classes of inferential connections that constitute the meaning of causal generalisations produced in policy-oriented economic research. The usefulness of our account is illustrated with the analysis (...) of generalisations about unemployment put forward by the Organisation for Economic Co-operation and Development in its highly influential 1994 OECD Jobs Study. The article ends with a discussion of some crucial philosophical questions about the use of inferentialism in the analysis of causal generalisations. (shrink)