In 1798 Dr Edward Jenner published his famous account of “vaccination”. Some claim that a Research Ethics Committee, had it existed in the 1790s, might have rejected his work. I provide the historical context of his work and argue that it addressed a major risk to the health of the community, and, given the devastating nature of smallpox and the significant risk of variolation, the only alternative preventative measure, Jenner’s study had purpose, justification and a base in (...) the practice of the day. (shrink)

The massive expansion of information from the seventeenth century placed considerable demands on mental capacity, and individual scholars responded with strategies of memory training and note?taking that prompted, relieved or replaced memory. It has been acknowledged how cowpox inoculation (vaccination) and smallpox inoculation (variolation) stimulated new forms of record keeping and the standardization and tabulation of medical data for scientific analysis and to inform public policy. Yet the key figure in these developments, Edward Jenner, while a careful observer (...) who thought hard about the patterns he discerned, did not take good notes either from his reading or of his observations. He depended a great deal on his memory, especially a remarkable visual memory, consolidating his recollections and refining his thinking more through conversation and familiar letters than careful note?taking and writing. It was rather in the work of the practitioners who took up Jenners? writings, including some laymen and women, that we find the keeping of records of their vaccinations, in order to provide patient records and to report the results to friends, colleagues and a wider public. (shrink)

Martin Sand and Luca Chiapperino find in the concept of serendipity a versatile umbrella term to reassess their previous work on moral luckLuck (also, Epistemic Luck, Moral Luck) and collectiveCollectiveresponsibilityResponsibility. Moral luck supposedly occurs when someone receives praise or blame for things beyond control. Given the ubiquity of luckLuck (also, Epistemic Luck, Moral Luck), this seems to be a seriously disquieting aspect of ordinary morality. The rewards and recognition for serendipitous discoveries fall into exactly this category. That is: more than (...) the intentions, actions, and characters of scientists matters for discoveries to obtain, just as in cases of moral luckLuck (also, Epistemic Luck, Moral Luck) something beyond morality affectsAffect our moral judgments. Even if a theoretical way of resolving the conceptual ambiguities that underlie this debate were found, there remain practical questions of how to perform stratification in science and innovationInnovation in ways that both hinge on, and yet refrain from, considerations of desert and achievement. With the example of Edward Jenner’sJenner, EdwardluckLuck (also, Epistemic Luck, Moral Luck)- and serendipity-infused discoveryDiscovery (also, Scientific Discovery) of vaccination, the authors attempt to better understand the intricate valueValue trade-offs that underlie stratification policies in science, which have to be constantly re-negotiated to maintain their legitimacy. Thereby, Sand and Ciapperino aim to take a bold step towards understanding the ethicsEthics of serendipity. (shrink)

During a smallpox epidemic in April 1721, Lady Mary Wortley Montagu asked Dr. Charles Maitland to "engraft" her daughter, thus instigating the first documented inoculation for smallpox (_Variola_ virus) in England. Engrafting, or variolation, was a means of conferring immunity to smallpox by placing pus taken from a smallpox pustule under the skin of an uninfected person to create a local infection. The introduction of infectious viral matter, however, could trigger fullblown smallpox, and the practice was controversial for both this (...) reason and the pervasive conviction that it was immoral to intentionally infect a human body. Eventually, engrafting was phased out altogether in favor of vaccination, a much safer procedure established by Edward Jenner in the late eighteenth century. Montagu's decision was influenced by her experiences in Constantinople, where she had spent a year, and where engrafting was commonplace. As a smallpox survivor herself, Montagu had taken an interest in Turkish inoculation practices, and had had her son Edward engrafted while in Turkey. She was not the first person to import the idea of smallpox inoculation to England, nor the first English person to have their child inoculated (other English children had been inoculated while visiting Turkey), yet she quickly became known for importing and popularizing smallpox inoculation. At the request of her acquaintances, she took her inoculated daughter with her on a round of visits into elite households to demonstrate the safety of the procedure. The reputation she gained was both positive and negative: monuments were erected in her honor, encomiastic poems were published, and Voltaire declared her "a woman of as fine a genius, and endued with as great a strength of mind as any of her sex in the British Kingdoms"; however, anti-inoculationists ridiculed her, some society figures regarded her warily, and Alexander Pope satirized her in his poetry.

Montagu’s pioneering role in the smallpox debate is undoubtedly significant: she instigated the first smallpox inoculation on English soil, and she was largely responsible for making the practice acceptable in elite circles. My interest in this essay is in the nature and significance of Montagu’s reputation as an inoculation pioneer. I will argue that her reputation was based on the particular combination of her social position as a Whig and an aristocratic woman; her interest in progressive and enlightened forms of social, political, and scientific thought; her standing in influential literary circles; and, not least, the force of her own personality. In broad terms, I offer Montagu’s involvement in the smallpox debate as a case study in a new kind of public role becoming available to elite women in the early eighteenth century — a role that caused considerable discomfort among her peers and in the medical community, and one that stimulated a widespread controversy in print publications of the day. (shrink)

The ability to effectively prevent smallpox was the greatest medical accomplishment of the first half of the 19th century. From 1838 to 1840, half a century after vaccination was introduced but before it became mandatory in England, data about the general population of England and Wales recorded 70 deaths per million from smallpox; only 180, 900 vaccinations were recorded. In London alone from 1848 to 1852, there were 4, 858 youthful deaths from smallpox, 67% of which occurred during the first (...) five years of life (Simon 1857).In a report to the House of Commons in 1802, Edward Jenner (1749-1823) stated that person-to-person vaccination was a basic principle of his procedure. He gained confidence in it from the case .. (shrink)

A seminal 1921 work by the linguist Edward Sapir, outlining his influential ideas and hypotheses on language and its speakers.

Discusses Indian Buddhist philosophy in three phases of its development.

What is the connection between philosophy as studied in universities and those general views of man and reality which are commonly considered "philosophy"? Through his attempt to rediscover this connection, Craig offers a view of philosophy and its history since the early 17th century. Craig discusses the two contrary visions of man's essential nature that dominated this period--one portraying man as made in the image of God and required to resemble him as closely as possible, the other depicting man as (...) the autonomous creator of his own environment and values--and uses this context to clarify previously opaque textual detail. Illustrating how general concepts embodied by philosophical thought can be embodied in other media--especially literary--the author brings together disparate disciplines; he also reveals striking similarities between Anglo-American and certain 20th-century continental European lines of thought. (shrink)

Mind and Body in Early China critiques Orientalist accounts of early China as a radical "holistic" other, which saw no qualitative difference between mind and body. Drawing on knowledge and techniques from the sciences and digital humanities, Edward Slingerland demonstrates that seeing a difference between mind and body is a psychological universal, and that human sociality would be fundamentally impossible without it. This book has implications for anyone interested in comparative religion, early China, cultural studies, digital humanities, or science-humanities (...) integration. (shrink)

Explores the metaphysical, epistemological, and hermeneutical theories of Schelling’s final system concerning the nature and meaning of religious mythology.

We agree with Heyes that an explanation of human uniqueness must appeal to cultural evolution, and not just genes. Her account, though, focuses narrowly on internal cognitive mechanisms. This causes her to mischaracterize human behavior and to overlook the role of material culture. A more powerful account would view cognitive gadgets as spanning organisms and their (shared) environments.

(2013). Sickle Cell Disease and the “Difficult Patient” Conundrum. The American Journal of Bioethics: Vol. 13, No. 4, pp. 3-10. doi: 10.1080/15265161.2013.767954.

In the debate about the nature and identity of possible worlds, philosophers have neglected the parallel questions about the nature and identity of moments of time. These are not questions about the structure of time in general, but rather about the internal structure of each individual time. Times and worlds share the following structural similarities: both are maximal with respect to propositions (at every world and time, either p or p is true, for every p); both are consistent; both are (...) closed (every modal consequence of a proposition true at a world is also true at that world, and every tense-theoretic consequence of a proposition true at a time is also true at that time); just as there is a unique actual world, there is a unique present moment; and just as a proposition is necessarily true iff true at all worlds, a proposition is eternally true iff true at all times. In this paper, I show that a simple extension of my theory of worlds yields a theory of times in which the above structural similarities between the two are consequences. (shrink)

It is proposed that the Darwinian theoretical approach and account of living systems has not yet been clearly given. A first approximation to this is attempted, focussing on behavior in evolving environments. A theoretical terminology is defined emphasizing the mutuality of organism and environment and the existence of biologically theoretical entities.

In this paper, we describe "metaphysical reductions", in which the well-defined terms and predicates of arbitrary mathematical theories are uniquely interpreted within an axiomatic, metaphysical theory of abstract objects. Once certain (constitutive) facts about a mathematical theory T have been added to the metaphysical theory of objects, theorems of the metaphysical theory yield both an analysis of the reference of the terms and predicates of T and an analysis of the truth of the sentences of T. The well-defined terms and (...) predicates of T are analyzed as denoting abstract objects and abstract relations, respectively, in the background metaphysics, and the sentences of T have a reading on which they are true. After the technical details are sketched, the paper concludes with some observations about the approach. One important observation concerns the fact that the proper axioms of the background theory abstract objects can be reformulated in a way that makes them sound more like logical axioms. Some philosophers have argued that we should accept (something like) them as being logical. (shrink)

This article offers suggestions for categorizing combat-related moral injuries, highlights possible causes of these injuries in veterans, and touches upon broadly-conceived measures to prevent and repair them. The first part identifies three prevailing definitions – lost trust, guilt, and harm to one’s capacity for right action and moral virtue – and argues for an emphasis on the latter. In service of highlighting areas for future empirical research and clinical awareness, the second part outlines possible veteran-related causes associated with these three (...) definitions, including unwarranted distrust of authorities, misapplying the theodicy problem to human acts, undue survivor’s guilt, wars that fail to meet ad bellum criteria, causing permissible collateral damage, and killing combatants without regret and for pleasure. The third part mentions strategies for preventing character harm, and then discusses the cognitive, rehabituative, and psychological aspects of moral repair. (shrink)

This is a book grounded in the real ethical challenges of modern business practice, with a world-religious perspective so necessary in an era of globalization.

The object of this book is to explain the Critical Philosophy in its relation to the general development of Philosophy, and especially to the stages of that development which immediately preceded it… From the Preface.

In this unique study of the process of filmmaking, director Edward Dmytryk blends abstract film theory and the practical realities of feature film production to provide an artful and elegant analysis of the conceptual foundations of filmmaking and film studies. Dmytryk explores the technical principles underlying the craft of filmmaking and how their use is effective in developing the viewer's involvement in the cinematic narrative. Originally published in 1988, this reissue of Dmytryk's classic book includes a new critical introduction (...) by Joe McElhaney. (shrink)

This book provides the first comprehensive introduction to Simone de Beauvoir's philosophical thought. Beauvoir has long been recognized as the twentieth century's leading feminist writer, but the full extent of her significance as a philosopher is just coming into focus. This study examines the history of Beauvoir's development into one of the most original and influential thinkers of her era. The Fullbrooks begin with an account of Beauvoir's formation as a philosopher. They then explore her early writing on philosophical method (...) and the ways this shaped her fiction. The book traces the development of Beauvoir's central theories of embodied consciousness and intersubjectivity, and examines her concepts of the "individual" and the "social other". An analysis of Beauvoir's ethics of liberation leads to philosophical readings of her great works of applied ethics, The Second Sex and Old Age. Finally, Beauvoir's contribution to continuing debates about consciousness, the body, the self and the other is reassessed. The publication of this introduction to Beauvoir's philosophy is an important contribution to the current renaissance of Beauvoir studies. Clear, accessible and lively, this book is essential reading not only for students of Beauvoir but for anyone interested in the submerged record of women's impact on philosophy. (shrink)

I attempt to solve a problematic feature of Scheler's intentional feeling. Spiritual feelings are disembodied and elements of William James's pragmatism offer a way to make elements of Scheler's phenomenology more concrete than Scheler's phenomenology allows. I then further develop this insight since contact between both Scheler and James opens up possible trajectories and affinities that, in the end, reveal both thinkers share an affective underpinning to their respective metaphysics. In both thinkers, reality is given as felt. As such, this (...) underpinning becomes a basis for interpreting Scheler's later metaphysics through Jamesian pragmatism. (shrink)

The so-called ergodic hierarchy (EH) is a central part of ergodic theory. It is a hierarchy of properties that dynamical systems can possess. Its five levels are egrodicity, weak mixing, strong mixing, Kolomogorov, and Bernoulli. Although EH is a mathematical theory, its concepts have been widely used in the foundations of statistical physics, accounts of randomness, and discussions about the nature of chaos. We introduce EH and discuss its applications in these fields.

In this paper, the author replies to a question raised about theories of nonexistent objects. The question concerns the way names of fictional characters, when analyzed as names which denote nonexistent objects, acquire their denotations. Since nonexistent objects cannot causally interact with existent objects, it is thought that we cannot appeal to a‘dubbing’or a‘baptism’. The question is, therefore, what is the starting point of the chain? The answer is that storytellings are to be thought of as extended baptisms, and the (...) details of this response receive attention in the paper. Once the storytelling is complete, and the characters have been baptized, a priori metaphysical principles linking the storytelling with the realm of nonexistent objects provide the referential, non‐causal connection between the names used in the storytelling and the objects denoted by such names. (shrink)

Decision-theoretic representation theorems have been developed and appealed to in the service of two important philosophical projects: in attempts to characterise credences in terms of preferences, and in arguments for probabilism. Theorems developed within the formal framework that Savage developed have played an especially prominent role here. I argue that the use of these ‘Savagean’ theorems create significant difficulties for both projects, but particularly the latter. The origin of the problem directly relates to the question of whether we can have (...) credences regarding acts currently under consideration and the consequences which depend on those acts; I argue that such credences are possible. Furthermore, I argue that attempts to use Jeffrey’s non-Savagean theorem in the service of these two projects may not fare much better. (shrink)

In this paper, I respond to D. Jacquette's paper, "Mally's Heresy and the Logic of Meinong's Object Theory" (History and Philosophy of Logic, 10 (1989): 1-14), in which it is claimed that Ernst Mally's distinction between two modes of predication, as it is employed in the theory of abstract objects, is reducible to, and analyzable in terms of, a single mode of predication plus the distinction between nuclear and extranuclear properties. The argument against Jacquette's claims consists of counterexamples to his (...) reductions and analyses. Reasons are offered for thinking that no such reduction/analysis of the kind Jacquette proposes could be successful. (shrink)

Philosophers and logicians talk of arguments for conclusions. In a recent paper, Jeffrey Goodman identifies a common way of thinking about what an argument is. I propose a definition that is quite different to this common way. I also make two objections to Goodman’s proposed definition.

Biobanks hold out the prospect of significant public and private benefit, as genetic information contained in tissue samples is mined for information. However, the storing of human tissue samples and genetic information for research and/or therapeutic purposes raises a number of serious privacy and autonomy concerns. These concerns are compounded when one considers the possibility that a biobank or its owner might go bankrupt. Insolvency impairs the ability of enforcement regimes, and liability-based regimes in particular, to enforce legal norms. The (...) goal of this essay is to develop guideposts for thinking about private and public enforcement of privacy imposed by donors on tissue samples and/or genetic information when a biobank becomes insolvent. (shrink)

After two generations of emphasis on governmental inefficiency and the need for deregulation, we now see growing interest in the possibility of constructive governance, alongside public calls for new, smarter regulation. Yet there is a real danger that regulatory reforms will be rooted in outdated ideas. As the financial crisis has shown, neither traditional market failure models nor public choice theory, by themselves, sufficiently inform or explain our current regulatory challenges. Regulatory studies, long neglected in an atmosphere focused on deregulatory (...) work, is in critical need of new models and theories that can guide effective policy-making. This interdisciplinary volume points the way toward the modernization of regulatory theory. Its essays by leading scholars move past predominant approaches, integrating the latest research about the interplay between human behavior, societal needs and regulatory institutions. The book concludes by setting out a potential research agenda for the social sciences. (shrink)