This comprehensive Gandhi reader provides an essential new reference for scholars and students of his life and thought. It is the only text available that presents Gandhi's own writings, including excerpts from three of his books—An Autobiography: The Story of My Experiments with Truth, Satyagraha in South Africa, Hind Swaraj —a major pamphlet, Constructive Programme: Its Meaning and Place, and many journal articles and letters, along with a biographical sketch of his life in historical context and recent essays by highly (...) regarded scholars. (shrink)

The history of human subjects research and controversial procedures in relation to it has helped form the field of bioethics. Ethically questionable elements may be identified during research design, research implementation, management at the study site, or actions by a study’s investigator or other staff. Post-approval monitoring (PAM) may prevent violations from occurring or enable their identification at an early stage. In U.S.-initiated human subjects research taking place in resource-constrained countries with limited development of research regulatory structures, arranging a site (...) visit from a U.S. research ethics committee (REC) becomes difficult, thus creating a potential barrier to regulatory oversight by the parent REC. However, this barrier may be overcome through the use of digital technologies, since much of the world has at least remote access to the Internet. Empirical research is needed to pilot test the use of these technologies for research oversight to ensure the protection of human subjects taking part in research worldwide. (shrink)

A hallmark of positive‐sense RNA viruses is the formation of membranous shelters for safe replication in the cytoplasm. Once considered invisible to the immune system, these viral shelters are now found to be antagonized through the cooperation of autophagy proteins and anti‐microbial GTPases. This coordinated effort of autophagy proteins guiding GTPases functions against not only the shelters of viruses but also cytoplasmic vacuoles containing bacteria or protozoa, suggesting a broad immune‐defense mechanism against disparate vacuolar pathogens. Fundamental questions regarding this process (...) remain: how the host recognizes these membranous structures as a target, how the autophagy proteins bring the GTPases to the shelters, and how the recruited GTPases disrupt these shelters. In this review, these questions are discussed, the answers to which will significantly advance our understanding of the response to vacuole‐like structures of pathogens, thereby paving the way for the development of broadly effective anti‐microbial strategies for public health. (shrink)

A collection of essays introducing and assessing the work of political theorist Wendy Brown. Includes an original essay by Brown and a reply to her critics.

Principled discussions of civil rights became inherently less likely as a direct result of the observation by Earl Warren, in Brown v. Board of Education, that, respecting freedmen, “Education of Negroes was almost non-existent, and practically all of the race were illiterate,” and in proportion as that observation increasingly became the foundation of common opinion on the subject. Warren's observation was not true in any meaningful or non-trivial sense. Nevertheless, it served to perpetuate the myth of a backward people needing (...) help to catch up instead of the truth of a people being held back. That is the perspective – the disadvantaged group perspective – that ultimately infected all discussion of civil rights, even after the designation of so-called “disadvantaged groups” had been extended beyond American blacks. To define civil rights, we may well begin with what all mankind would likely recognize. Thus the dictionary definition of “civil rights” stands: “the rights that belong to all individuals in a nation or community touching property, marriage, and the like.” In that definition the term “rights” may be further expanded to mean “legitimate claims,” following the definition of right as law – as “a claim or title or interest in anything whatever that is enforceable by law.” This definition applies with minimal distinction of regimes intruding and, therefore, without the host of recent complications in the United States that create the impression that civil rights have something to do with pluralism. Previously, the generic definition was thought to exhaust the meaning of the term in the United States. (shrink)

Mr. Agar has collected his adversaria on the Odyssey which have been enjoying cold storage these many years in the blue depths of the Journal of Philology, and increased them by about three-quarters. He has produced a very interesting and valuable book, the most important contribution to the linguistic history of the Homeric text that has been made for a long time. Mr. Agar holds that the language of Homer represents the original ‘Achaean’ speech, and that its abnormalities in vocabulary, (...) word-formation and metre are the result of natural unforced processes of transmission. This position, held by so well equipped and so trenchant an investigator as Mr. Agar, is reassuring. It does not involve any of the mythological factors of the Higher or the Lower Criticism still recommended among us by Mr. Leaf, Father Browne and Mr. Verrall–Pisistratus, Onomacritus, the Ionian conquest of Smyrna, the Thessalian Iliad, the original Achilleis,–and disagrees with Professor Murray's sinister diagnosis clear away the Attic surface and there rises beneath another surface with another set of corruptions, where Ionic rhapsodes have introduced just the same elements of confusion into an Aeolic or at least a pre-Ionic language. The confusion of tongues is deep down in the heart of the Homeric, dialect, and no surgery in the world can cut beneath it’ . The last ten years’ work in Comparative Philology has made it clearer and clearer that the rule-of-thumb for distinguishing the historical non-Dorian dialects does not apply to the heroic and post-heroic age, and that the terms ‘Aeolic’ and ‘Ionic’ in their usual sense should disappear from the history of Homer. The Homeric tongue derives directly from the pre-colonial language of Greece wherein two elements are discernible, the original Ionian and the Achaean or North-Greek which overlaid it. (shrink)

Mr. Agar has collected his adversaria on the Odyssey which have been enjoying cold storage these many years in the blue depths of the Journal of Philology, and increased them by about three-quarters. He has produced a very interesting and valuable book, the most important contribution to the linguistic history of the Homeric text that has been made for a long time. Mr. Agar holds that the language of Homer represents the original ‘Achaean’ speech, and that its abnormalities in vocabulary, (...) word-formation and metre are the result of natural unforced processes of transmission. This position, held by so well equipped and so trenchant an investigator as Mr. Agar, is reassuring. It does not involve any of the mythological factors of the Higher or the Lower Criticism still recommended among us by Mr. Leaf, Father Browne and Mr. Verrall–Pisistratus, Onomacritus, the Ionian conquest of Smyrna, the Thessalian Iliad, the original Achilleis,–and disagrees with Professor Murray's sinister diagnosis clear away the Attic surface and there rises beneath another surface with another set of corruptions, where Ionic rhapsodes have introduced just the same elements of confusion into an Aeolic or at least a pre-Ionic language. The confusion of tongues is deep down in the heart of the Homeric, dialect, and no surgery in the world can cut beneath it’. The last ten years’ work in Comparative Philology has made it clearer and clearer that the rule-of-thumb for distinguishing the historical non-Dorian dialects does not apply to the heroic and post-heroic age, and that the terms ‘Aeolic’ and ‘Ionic’ in their usual sense should disappear from the history of Homer. The Homeric tongue derives directly from the pre-colonial language of Greece wherein two elements are discernible, the original Ionian and the Achaean or North-Greek which overlaid it. (shrink)

The article responds to an overlooked objection put by Allen Buchanan to John Rawls’s theory of justice: that implementing the Difference Principle over time may require gross and frequent disruptions of people’s framing and execution of long-term plans. Having strengthened Buchanan’s objection to resolve significant weaknesses in his main counterexample, I argue that the best response to this objection draws on the concept of the rule of law, specifically, the legal doctrine of legitimate expectations, which can be found in (...) English, French, and European Union administrative law. I also explore the suitability of incorporating this doctrine into Justice as Fairness given its absence in United States constitutional and administrative law. Finally, I turn to consider the question of what the government owes to agents in whom legitimate expectations are induced and then frustrated. Here I introduce the Precept of Administrative Liability. (shrink)

Allen Thompson's review of the ClimateEthics article entitled “ A Comprehensive Ethical Analysis of the Copenhagen Accord. ”1 is a welcome response to the objective of ClimteEthics, namely to provo...

Allen Thompson's review of the ClimateEthics article entitled “ A Comprehensive Ethical Analysis of the Copenhagen Accord. ”1 is a welcome response to the objective of ClimteEthics, namely to provo...

This volume brings together a collection of new essays by leading scholars on the subject of causation in the early modern period, from Descartes to Lady Mary Shepherd. Aimed at researchers, graduate students and advanced undergraduates, the volume advances the understanding of early modern discussions of causation, and situates these discussions in the wider context of early modern philosophy and science. Specifically, the volume contains essays on key early modern thinkers, such as Descartes, Hobbes, Spinoza, Leibniz, Hume, Kant. It also (...) contains essays that examine the important contributions to the causation debate of less widely discussed figures, including Louis la Forge, Thomas Brown and Lady Mary Shepherd. (shrink)

This volume is as substantial in content as it is in heft. The sequel to the author’s The Concept of Woman: The Aristotelian Revolution, 750 BC – 1250 AD, the present book continues the ambitious project of analyzing texts that treat the concept of woman using philosophical reasoning or sense-evidence to defend an argument. Ultimately, the goal is to bring the analysis through 2000 A.D. The use of many texts and genres across several centuries to recover information about women also (...) informs Women and Spiritual Equality in Christian Tradition by Patricia Ranft, a work with similar conclusions. A constant theme through both volumes of The Concept of Woman is the complementarity of the sexes: “explanations of the respective identities of woman and of man are both needed to explain the identity of the human being”. “A deep impulse in Christianity towards integral gender complementarity reappears at different moments in history,” Allen asserts, finding St. Augustine the first to advance complementarity. She argues that the concepts of woman and of man become more complex with the Renaissance’s “discovery of the interiority of the human being”. In the fifteenth century such complementarity was renewed by Christine de Pizan, Leonardo Bruni, and Laura Cereta, yet full articulation remained centuries away. (shrink)

La pensée d’Anne Fausto-Sterling, biologiste reconnue dans l’espace anglophone, historienne des sciences et professeure à l’université de Brown (Rhode Island), est enfin accessible au lectorat français. La traduction de Sexing the Body, publié en 2000 aux États-Unis a été initiée par l’Institut Émilie du Châtelet pour le développement et la diffusion des études sur les femmes, le sexe et le genre et financée par la Région Ile-de-France. Dans sa préface américaine, l’auteure rappelle combien d...

In this book, Newell makes the case for unified theories by setting forth a candidate.

Obtaining informed consent from patients prior to a medical or surgical procedure is a fundamental part of safe and ethical clinical practice. Currently, it is routine for a significant part of the consent process to be delegated to members of the clinical team not performing the procedure (eg, junior doctors). However, it is common for consent-taking delegates to lack sufficient time and clinical knowledge to adequately promote patient autonomy and informed decision-making. Such problems might be addressed in a number of (...) ways. One possible solution to this clinical dilemma is through the use of conversational artificial intelligence using large language models (LLMs). There is considerable interest in the potential benefits of such models in medicine. For delegated procedural consent, LLM could improve patients’ access to the relevant procedural information and therefore enhance informed decision-making.In this paper, we first outline a hypothetical example of delegation of consent to LLMs prior to surgery. We then discuss existing clinical guidelines for consent delegation and some of the ways in which current practice may fail to meet the ethical purposes of informed consent. We outline and discuss the ethical implications of delegating consent to LLMs in medicine concluding that at least in certain clinical situations, the benefits of LLMs potentially far outweigh those of current practices. (shrink)

This masterful work on Kant's Religion within the Boundaries of Mere Reason explores Kant's treatment of the Idea of God, his views concerning evil, and the moral grounds for faith in God. Kant and Religion works to deepen our understanding of religion's place and meaning within the history of human culture, touching on Kant's philosophical stance regarding theoretical, moral, political, and religious matters. Wood's breadth of knowledge of Kant's corpus, philosophical sharpness, and depth of reflection sheds light not only on (...) Kant, but also on the fate of religion and its relation to philosophy in the modern world. (shrink)