The involvement of developing countries in international clinical trials is necessary for the development of appropriate medicines for local populations. However, the absence of appropriate structures for ethical review represents a barrier for certain countries. Currently there is very little information available on existing structures dedicated to ethics in western and central Africa. This article briefly describes historical milestones in the development of networks dedicated to capacity building in ethical review in these regions and outlines the major conclusions of two (...) workshops on this issue, which were held in September and October 2002 in Libreville, Gabon, and Paris, France. The workshops were the culmination of collaboration between the African Malaria Network Trust (AMANET) and the Pan African Bioethics Initiative (PABIN). They produced an update on ethics organizations with regard to mission, function, activities, members, and contact people, in eight countries within the regions discussed. As a result of the commitment of mandated delegates, a further prominent outcome followed these workshops: the creation of national structures, where none existed before, dedicated to the ethical review of clinical trials. (shrink)

The involvement of developing countries in international clinical trials is necessary for the development of appropriate medicines fo.

The contents and structure of semantic memory have been the focus of much recent research, with major advances in the development of distributional models, which use word co‐occurrence information as a window into the semantics of language. In parallel, connectionist modeling has extended our knowledge of the processes engaged in semantic activation. However, these two lines of investigation have rarely been brought together. Here, we describe a processing model based on distributional semantics in which activation spreads throughout a semantic network, (...) as dictated by the patterns of semantic similarity between words. We show that the activation profile of the network, measured at various time points, can successfully account for response times in lexical and semantic decision tasks, as well as for subjective concreteness and imageability ratings. We also show that the dynamics of the network is predictive of performance in relational semantic tasks, such as similarity/relatedness rating. Our results indicate that bringing together distributional semantic networks and spreading of activation provides a good fit to both automatic lexical processing (as indexed by lexical and semantic decisions) as well as more deliberate processing (as indexed by ratings), above and beyond what has been reported for previous models that take into account only similarity resulting from network structure. (shrink)

Corporate governance guidelines are a mechanism that a firm can enact which should reduce agency costs and better align the interests of boards and the suppliers of capital. This study examines stock price reactions primarily attributable to institutional investors occurring when corporations announce the enactment of corporate governance guidelines. A final sample of 77 firms was derived from the first announcement of corporate governance guidelines exclusive to the SEC-EDGAR database. The results indicate that good governance does matter. Firms that announced (...) the enactment of corporate governance guidelines experienced increased stock prices following the announcements. There was an immediate (days 1–4) reaction for firms that provided all or part of the guidelines’ substance; a delayed (days 8–10) reaction occurred for those firms that only referenced the guidelines’ enactment. Additionally, firms with either a potentially greater following or that had a previous history of acrimonious relations with stakeholders were rewarded by the announcement of the enactment of guidelines. (shrink)

A number of recent models of semantics combine linguistic information, derived from text corpora, and visual information, derived from image collections, demonstrating that the resulting multimodal models are better than either of their unimodal counterparts, in accounting for behavioral data. Empirical work on semantic processing has shown that emotion also plays an important role especially in abstract concepts; however, models integrating emotion along with linguistic and visual information are lacking. Here, we first improve on visual and affective representations, derived from (...) state‐of‐the‐art existing models, by choosing models that best fit available human semantic data and extending the number of concepts they cover. Crucially then, we assess whether adding affective representations (obtained from a neural network model designed to predict emojis from co‐occurring text) improves the model's ability to fit semantic similarity/relatedness judgments from a purely linguistic and linguistic–visual model. We find that, given specific weights assigned to the models, adding both visual and affective representations improves performance, with visual representations providing an improvement especially for more concrete words, and affective representations improving especially the fit for more abstract words. (shrink)

A set of images can be considered as meaningfully different for an observer if they can be distinguished phenomenally from one another. Each phenomenal difference must be supported by some neurophysiological differences. Differentiation analysis aims to quantify neurophysiological differentiation evoked by a given set of stimuli to assess its meaningfulness to the individual observer. As a proof of concept using high-density EEG, we show increased neurophysiological differentiation for a set of natural, meaningfully different images in contrast to another set of (...) artificially generated, meaninglessly different images in nine participants. Stimulus-evoked neurophysiological differentiation (over 257 channels, 800 ms) was systematically greater for meaningful vs. meaningless stimulus categories both at the group level and for individual subjects. Spatial breakdown showed a central-posterior peak of differentiation, consistent with the visual nature of the stimulus sets. Temporal breakdown revealed an early peak of differentiation around 110 ms, prominent in the central-posterior region; and a later, longer-lasting peak at 300–500 ms that was spatially more distributed. The early peak of differentiation was not accompanied by changes in mean ERP amplitude, whereas the later peak was associated with a higher amplitude ERP for meaningful images. An ERP component similar to visual-awareness-negativity occurred during the nadir of differentiation across all image types. Control stimulus sets and further analysis indicate that changes in neurophysiological differentiation between meaningful and meaningless stimulus sets could not be accounted for by spatial properties of the stimuli or by stimulus novelty and predictability. (shrink)

Chapter LEARNING BY UNDERSTANDING ANALOGIES Russell Greiner1 ABSTRACT2 This article describes a method for learning by analogy — ie, for proposing new ...

Prayer and the temple were two of the most prominent themes in the Third Gospel and they have garnered scholarly interest. However, the discussion about prayer vis-à-vis the temple in Luke’s special source (L) has gone unnoticed. Using source criticism and narrative criticism, the research shows a connection between prayer and the temple in L. The relationship between the two reflects the development from a belief in the temple as a place for praying and receiving an answer, to Jesus who (...) intercedes for the people. This article argues that the prayer in Luke’s special source revealed Jesus as the new, personified temple through whom the L communities prayed and received answers to their prayers. Based on this finding, this article then shows the possible reconstruction of the separation between Judaism and Christianity from the perspective of L communities. Contribution: This article contributes to the discussion on Lukan Christology by proposing that Jesus is the new personified temple as understood by the L communities. Such a depiction lends new support to Dunn’s reconstruction of the parting of the ways between Jews and Christians. (shrink)

Malgré les déclarations d'intention et les efforts des écologistes, la planète est en danger. Ses ennemis cherchent un profit immédiat à empoisonner l'air, les sols et l'eau, à abattre les arbres et les animaux. Ils trouvent un intérêt à détruire la réalité pour lui substituer un monde virtuel contrôlable. Cet essai invite à établir de nouvelles relations entre la planète et les hommes.

El artículo analiza la función de la teología cristiana en la sociedad actual. A tal fin, el autor comienza por sintetizar los elementos más característicos de la sociedad que se está gestando. En segundo lugar, propone la necesidad de una mediación cultural para la comunicación del evangelio. Seguidamente, el autor reclama el necesario diálogo de la teología con la cultura y la universidad. Y el estudio termina por presentar sintéticamente el papel de los centros superiores de enseñanza de la teología, (...) según las recomendaciones de la Veritatis Gaudium del papa Francisco. (shrink)

Dans cet ouvrage, Herbert Spencer propose une exploration approfondie de la psychologie, explorant les principes fondamentaux qui sous-tendent notre perception et notre compréhension du monde qui nous entoure. Ce livre est un classique de la psychologie moderne et une lecture indispensable pour les étudiants et les professionnels. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United (...) States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Prayer, the central spirituality in the theological and ethical life of Christ’s disciples, has not yet received significant attention from Johannine scholars. Although some scholars emphasised and discussed prayer in the New Testament, Johannine scholars have failed to recognise the significance of prayer in the Fourth Gospel. Using narrative criticism the article aims to uncover the relationship between prayer and koinonia in the Fourth Gospel. The research on the theme of prayer and koinonia conducted in the Fourth Gospel has yielded (...) the finding that prayer was a manifestation of abiding in Jesus. Koinonia was a form of prayer. Contribution: The article fills the lacuna in Johannine studies, more specifically, in the field of prayer and koinonia. The article, which is in line with the scope of HTS Theological Studies, and offers a new interpretation of prayer and koinonia in the Fourth Gospel. (shrink)

Jeremy Bentham entend rompre avec les théories du contrat social et proposer une justification utilitariste de la démocratie. Or, aucune théorie de la démocratie ne peut se dispenser d’une théorie du « demos ». L’utilitarisme benthamien comporte ainsi un renouvellement de la question du peuple dans chacun de ses aspects, ontologique, politique et moral. Bentham développe une véritable théorie du peuple qui, bien que méconnue, constitue un tournant dans l’histoire de la philosophie politique.

Critical reflection on clinical ethics consultation is essential to the field. Johnson and colleagues (2015) have helpfully summarized the consultation experience of a children's specialty hospital...

La crise de 2008 est une crise de gouvernance des entreprises, notamment des banques, qui, pour faire des profits élevés, sont allées jusqu’à compromettre leur existence. Comment faire en sorte que l’entreprise ne soit pas seulement préoccupée de maximiser le cours de l’action, alors que jusque dans les sciences sociales, elle est réduite à cela? L’entreprise est apparue à la fin du XIX e siècle pour révolutionner la vie quotidienne grâce aux découvertes scientifiques. L’entreprise est une association de partenaires dans (...) une création collective de modes de vie, dont les partenaires financiers, mais aussi les ingénieurs, les consommateurs, le personnel. Il faut refonder l’entreprise et qu’elle se donne une mission qui exprime son projet à long terme et à laquelle souscrivent les actionnaires. (shrink)

The quantum formalism ofdistinguishable, yetequivalent particles (with symmetric or antisymmetric wave functions) is here worked out. The result is an entirely explicit formulation of the way in which classical mechanics emerges from quantum mechanics for such particles. Distinguishability is achieved at the cost of dynamical precision; the two are, in fact, complementary.

It is shown here that the microcanonical ensemble for a system of noninteracting bosons and fermions contains a subensemble of state vectors for which all particles of the system are distinguishable. This “IQC” (inner quantum-classical) subensemble is therefore fully classical, except for a rather extreme quantization of particle momentum and position, which appears as the natural price that must be paid for distinguishability. The contribution of the IQC subensemble to the entropy is readily calculated, and the criterion for this to (...) be a good approximation to the exact entropy is a logarithmically strengthened form of the usual criterion for the validity of classical statistics in terms of the thermal de Broglie wavelength and the average volume per particle. Thus, it becomes possible to derive the Maxwell-Boltzmann distribution directly from the ensemble in the classical limit, using fully classical reasoning about the distinguishability of particles. The entropy is additive—theN! factor of the Boltzmann count cancels out in the course of the calculation, and the “N! paradox” is thereby resolved. The method of “correct Boltzmann counting” and the lowest term of the Wigner-Kirkwood series for the partition function are seen to be partly based on the IQC subensemble, and their partly nonclassical nature is clarified. The clear separation in the full ensemble of classical and nonclassical components makes it possible to derive the classical statistics of indistinguishable particles from their quantum statistics in a controlled, explicit way. This is particularly important for nonequilibrium theory. The treatment of molecular collisions along too-literally classical lines turns out to require exorbitantly high temperatures, although there are suggestions of indirect ways in which classical nonequilibrium theory might be justified at ordinary temperatures. The applicability of exact classical ergodic and mixing theory to systems at ordinary temperatures is called into question, although the general idea of coarse-graining is confirmed. The concepts on which the IQC idea is based are shown to give rise to a series development of thermostatistical quantities, starting with the distinguishable-particle approximation. (shrink)