Entre 1805 et 1819, Maine de Biran et Ampere echangerent une correspondance si abondante, si riche, si coherente, qu'il a paru souhaitable de consacrer un volume autonome a ces documents, pour une large part restes inedits. Pour Maine de Biran, Ampere est un interlocuteur consistant, qui permet de mettre a l'epreuve les principes philosophiques elabores dans les grands textes de la maturite; il est de plus le grand artisan de la conversion a l'ontologie, operee par le philosophe autour de 1813: (...) c'est dans ces lettres que la question du noumene est posee et discutee longuement. En Maine de Biran, Ampere dispose d'un partenaire de choix, qui lui offre l'occasion de tester les diverses classifications des operations psychiques auxquelles il attache une si grande importance. (shrink)

Absorbing biography of the creative and destructive scientific genius and tragic life of Andr?-Marie Amp're.

This article explores André-Marie Ampère's autobiography in order to analyse the dynamics of science in early 19th century French institutions. According to recent works that have emphasised the value of biographies in the history of science, this study examines Ampère's public self-representation to show the cultural transformations of a life dedicated to science in post-revolutionary French society. With this aim, I have interpreted this manuscript as an outstanding example of the scientific rhetoric flourishing in early 19th (...) century French Romanticism, which celebrated the life and works of men of science by means of biographies. Following this approach, Ampère's account has been analysed in relation to certain commonplaces shared with other autobiographies of that time, such as his traumatic experience linked to the French Revolution. Finally, this article discusses Ampère's autobiography as revealing an emerging model of scientific personae, i.e. a new collective way of thinking, feeling and perceiving, which announced the category of the modern scientist. (shrink)

En 1814, Ampère publie une théorie de la combinaison chimique des corps qu'il fonde sur la science des cristaux de Hauy, sur « les résultats de belles expériences » de Gay-Lussac et sur une hypothèse « sur la proportionnalité entre les volumes des gaz et leur nombre de particules ». A la même époque, il met en évidence, en philosophie, les rôles de l'abstraction et des « rapports » dans les connaissances humaines ; ces concepts éclairent la mathématisation mise (...) en œuvre dans cette théorie chimique. Bien que conçue tardivement, la classification des sciences d'Ampère nous aide à situer, rétrospectivement, la théorie des combinaisons chimiques dans les sciences mathématiques et physiques. (shrink)

Não sei por qual fatalidade sucede que as coisas das quais mais falamos entre os homens são, ordinariamente, aquelas que menos conhecemos. Tal é, entre mil outras, a matéria que pretendo tratar: o Belo. Todo mundo fala sobre isso, todo mundo raciocina sobre isso. Não há círculos no pátio, sociedades nas cidades, ecos nos campos, abóbodas nos templos, que não ressoem o Belo. Queremos o belo em toda parte: belo nas obras da natureza, belo nas produções da arte, belo nas (...) obras do espírito, belo nos costumes; e, se o encontramos em alguma parte, é pouco dizer que por ele somos tocados; somos atingidos, tomados, encantados. Mas pelo que o somos? (shrink)

Le parcours que je me propose de faire par la pensée cartésienne passe par les moments suivants : d’abord, on essaie de découvrir dans la pensée médiévale tardive, en prenant comme référence non pas seulement Nicolas de Cues, mais aussi quelques aspects du nominalisme, l’émergence d’une métaphysique du pouvoir qui a, elle aussi, comme point de départ, le concept d’infini ; deuxièmement, on essaie de démontrer comment cette métaphysique du pouvoir passe, en Descartes, par sa théorie de la création des (...) vérités éternelles, par les noms qu’il va privilégier pour parler de Dieu et par le concept de causa sui ; troisièmement, on voit comment cette métaphysique du pouvoir se réfléchit dans une anthropologie de la volonté qui réinterprète, d’une façon tout à fait particulière, le motif médiéval de l’homme en tant que « imago Dei » ; finalement, on voit comment l’essence de la pensée « sub specie machinae » peut être vue, en même temps, comme une affirmation du pouvoir de l’homme dans une anticipation du « verum ipsum factum » de Vico, déjà anticipé aussi dans la pensée cusaine et dans sa conception créatrice de la connaissance humaine. (shrink)

This timely Research Handbook offers significant insights into an understudied subject, bringing together a broad range of socio-legal studies of medicine to help answer complex and interdisciplinary questions about global health - a major challenge of our time. Interdisciplinary chapters explore both how the terrain of medicine can generate new questions about law, regulation and the state, and how the law intersects with health and medicine at every level. Bringing together leading international scholars, the Research Handbook assembles concrete case studies (...) to suggest avenues for further research on socio-legal inquiries, such as the construction of disorders by law, the reparation of injuries, and how race and gender impact justice. The Research Handbook for Socio-Legal Studies of Medicine and Health will be an inspiring read for researchers, academics and graduate students in the fields of health law, socio-legal studies, and gender and sexuality. (shrink)

Central sensitization refers to the increased responsiveness of nociceptive neurons in the central nervous system after repeated or sustained peripheral nociceptor activation. It is hypothesized to play a key role in the development of chronic pain. A hallmark of central sensitization is an increased sensitivity to noxious mechanical stimuli extending beyond the injured location, known as secondary hyperalgesia. For its ability to modulate the transmission and the processing of nociceptive inputs, attention could constitute a promising target to prevent central sensitization (...) and the development of chronic pain. It was recently shown that the experimental induction of central sensitization at both forearms of healthy volunteers using bilateral high-frequency electrocutaneous stimulation (HFS), can be modulated by encouraging participants to selectively focus their attention to one arm, to the detriment of the other arm, resulting in a greater secondary hyperalgesia on the attended arm as compared to the unattended one. Given the potential value of the question being addressed, we conducted a preregistered replication study in a well-powered independent sample to assess the robustness of the effect, i.e., the modulatory role of spatial attention on the induction of central sensitization. This hypothesis was tested using a double-blind, within-subject design. Sixty-seven healthy volunteers performed a task that required focusing attention toward one forearm to discriminate innocuous vibrotactile stimuli while HFS was applied on both forearms simultaneously. Our results showed a significant increase in mechanical sensitivity directly and 20 min after HFS. However, in contrast to the previous study, we did not find a significant difference in the development of secondary hyperalgesia between the attended vs. unattended arms. Our results question whether spatial selective attention affects the development of secondary hyperalgesia. Alternatively, the non-replication could be because the bottom-up capture of attention caused by the HFS-mediated sensation was too strong in comparison to the top-down modulation exerted by the attentional task. In other words, the task was not engaging enough and the HFS pulses, including those on the unattended arm, were too salient to allow a selective focus on one arm and modulate nociceptive processing. (shrink)

El interés de la presente compilación es el de recoger algunas de las principales reflexiones del pensamiento político contemporáneo. Se propone como tarea central el examen y la problematización de algunos presupuestos extendidos en la tradición de la filosofía occidental. Por medio de este cuestionamiento, se busca desestabilizar asunciones que atraviesan nuestros modos habituales de concebir el sujeto, la acción y el espacio políticos, y de comprender la manera como estos son configurados por el lenguaje. Es así como una amplia (...) gama de autores encuentra un espacio común de discusión: la urgencia de plantear alternativas tanto crítica como de compresión de lo político, que permitan movilizar nuevas maneras de concebir la acción y la configuración de nuestros modos de ser en común; alternativas que incluso pueden encontrarse ya allí, a la sombra de lo político, en sus recodos escondidos, silenciados; en lugares o motivos que tal vez han pasado desapercibidos por no hacer parte de un discurso e interpretación dominantes. En particular, interesa aquí rescatar aquellas reflexiones que abordan esta tarea desde tres ejes temáticos concretos: la pregunta por la relación entre ley y violencia, la necesidad de repensar el ser en común, y, por último, el problema de cómo concebir los pasajes y discontinuidades entre la singularidad de la contingencia histórica, cultural, lingüística, y la posibilidad o promesa de lo universal. (shrink)

In spite op compulsory voting, the number of non-voters increased at the last general elections in Belgium to 7.3 per cent. This evolution can largely be explained by demographic factors. The number of blank or invalid voters reaches nearly the same level. Concerning this form of political non-participation, we noticed considerable differences occur between the types of elections due to factors such as the importance and the proximity of the proper institution, the social distance between candidate and citizen and the (...) main issue of the elections.The analysis of both phenomena over time at the level of the individual voters based on surveys shows that electoral absenteeism is rather accidental, white blanc and invalid voting is more permanent. From the analysis of absenteeism and blanc and invalid voting emerge on the one hand socio-economic factors which jeopardize electoral participation in a direct or indirect way, and on the other hand, attitudes and behaviour reflecting political indifference, alienation and hostility. (shrink)

André-Marie Ampère fut un savant et un penseur éclectique. Sa pratique scientifique et sa réflexion philosophique n’ont cessé d’être hantées par le problème de la portée ontologique de nos connaissances. Ce problème émerge chez Ampère dans un cadre conceptuel kantien qui insiste sur la part de subjectivité déterminant nos représentations. La pensée d’Ampère va alors impliquer une véritable controverse intériorisée avec le fantôme de Kant. Tout en insistant sur l’origine subjective de nos idées, Ampère (...) a cherché à contredire l’idéalisme qu’il associait irrémédiablement au kantisme. Pour soutenir un réalisme structural, il interprète alors la notion de « forme » à travers un filtre physiologique lui permettant d’affirmer la probabilité d’une analogie entre les noumènes et les phénomènes. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)