Friends of Wright-entitlement cannot appeal to direct epistemic consequentialism (believe or accept what maximizes expected epistemic value) in order to account for the epistemic rationality of accepting Wright-entitled propositions. The tenability of direct consequentialism is undermined by the “Truth Fairy”: a powerful being who offers you great epistemic reward (in terms of true beliefs) if you accept a proposition p for which you have evidence neither for nor against. However, this chapter argues that a form of indirect epistemic consequentialism seems (...) promising as a way to deal with the Truth Fairy problem. The relevant form of indirect consequentialism accommodates evidentialism but allows for exceptions in the case of anti-sceptical hypotheses. Since these are the kind of propositions to which Wright-entitlement is supposed to apply—i.e. cornerstone propositions—indirect consequentialism is entitlement-friendly. (shrink)

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

Nietzsche values intellectual honesty, but is dubious about what he calls the will to truth. This is puzzling since intellectual honesty is a component of the will to truth. In this paper, I show that this puzzle tells us something important about how Nietzsche conceives of our pursuit of truth. For Nietzsche, those who pursue truth occupy unstable ground, since being honest about the ultimate reasons for that pursuit would mean that truth could no longer satisfy the important human needs (...) it satisfies at present. We can pursue truth, or be honest about what in us is served by such a pursuit, but not both. Nietzsche aims to show that understanding and owning up to this instability is the sort of affirmation of human life to which we ought to aspire, and is the price we pay for being free from otherworldly morality. (shrink)

The concept of 'levels of organization' has come under fire recently as being useless for scientific and philosophical purposes. In this paper, we show that 'levels' is actually a remarkably resilient and constructive conceptual tool that can be, and in fact is, used for a variety of purposes. To this effect, we articulate an account of the importance of the levels concept seen in light of its status as a major organizing concept of biology. We argue that the usefulness of (...) ‘levels’ is best seen in the heuristic contributions the concept makes to treating and structuring scientific problems. We illustrate this with two examples from biological research. (shrink)

Nietzsche is famously a critic of Mitleid, compassion or pity. He claims that because it must condemn all suffering, a morality of compassion is unable to recognize the ennobling aspects of suffering, and so is unable to recognize what is good and noble about those aspects of the human condition susceptible to suffering. Compassion thus robs our finitude of significance. Alongside his criticisms of compassion, however, at numerous places we see Nietzsche distinguishing between conceptions of compassion made different by the (...) different forms of life in which they are implicated. “Compassion,” for Nietzsche, is too broad a term, capturing a range of moral phenomena and their attendant eliciting conditions, deep... (shrink)

Abstract.There is ample evidence that humans (and other primates) possess a knowledge instinct—a biologically driven impulse to make coherent sense of the world at the highest level possible. Yet behavioral decision‐making data suggest a contrary biological drive to minimize cognitive effort by solving problems using simplifying heuristics. Individuals differ, and the same person varies over time, in the strength of the knowledge instinct. Neuroimaging studies suggest which brain regions might mediate the balance between knowledge expansion and heuristic simplification. One region (...) implicated in primary emotional experience is more activated in individuals who use primitive heuristics, whereas two areas of the cortex are more activated in individuals with a strong knowledge drive: one region implicated in detecting risk or conflict and another implicated in generating creative ideas. Knowledge maximization and effort minimization are both evolutionary adaptations, and both are valuable in different contexts. Effort minimization helps us make minor and routine decisions efficiently, whereas knowledge maximization connects us to the beautiful, to the sublime, and to our highest aspirations. We relate the opposition between the knowledge instinct and heuristics to the biblical story of the fall, and argue that the causal scientific worldview is mathematically equivalent to teleological arguments from final causes. Elements of a scientific program are formulated to address unresolved issues. (shrink)

Nietzsche criticizes the shared suffering of compassion as a basis for ethics, yet his challenge to overcome compassion seeks not to extinguish all fellow feeling but instead urges us to transform the way we relate to others, to learn to share not suffering but joy. For Schopenhauer, we act morally when we respond to another’s suffering, while we are mistrustful of the joys of others. Nietzsche turns to the type of relationality exempli!ied by friendship, understood as shared joy, in order (...) to help him to articulate his ethical ideal for human beings. (shrink)

We hypothesize that aspects of animal multicellularity originated before the divergence of metazoans from fungi and social amoebae. Polarized epithelial tissues are a defining feature of metazoans and contribute to the diversity of animal body plans. The recent finding of a polarized epithelium in the non‐metazoan social amoeba Dictyostelium discoideum demonstrates that epithelial tissue is not a unique feature of metazoans, and challenges the traditional paradigm that multicellularity evolved independently in social amoebae and metazoans. An alternative view, presented here, is (...) that the common ancestor of social amoebae, fungi, and animals spent a portion of its life cycle in a multicellular state and possessed molecular machinery necessary for forming an epithelial tissue. Some descendants of this ancestor retained multicellularity, while others reverted to unicellularity. This hypothesis makes testable predictions regarding tissue organization in close relatives of metazoans and provides a novel conceptual framework for studies of early animal evolution.Editor's suggested further reading in BioEssays Searching for Eve: Basal metazoans and the evolution of multicellular complexity Abstract. (shrink)

There is ample evidence that humans (and other primates) possess a knowledge instinct—a biologically driven impulse to make coherent sense of the world at the highest level possible. Yet behavioral decision-making data suggest a contrary biological drive to minimize cognitive effort by solving problems using simplifying heuristics. Individuals differ, and the same person varies over time, in the strength of the knowledge instinct. Neuroimaging studies suggest which brain regions might mediate the balance between knowledge expansion and heuristic simplification. One region (...) implicated in primary emotional experience is more activated in individuals who use primitive heuristics, whereas two areas of the cortex are more activated in individuals with a strong knowledge drive: one region implicated in detecting risk or conflict and another implicated in generating creative ideas. Knowledge maximization and effort minimization are both evolutionary adaptations, and both are valuable in different contexts. Effort minimization helps us make minor and routine decisions efficiently, whereas knowledge maximization connects us to the beautiful, to the sublime, and to our highest aspirations. We relate the opposition between the knowledge instinct and heuristics to the biblical story of the fall, and argue that the causal scientific worldview is mathematically equivalent to teleological arguments from final causes. Elements of a scientific program are formulated to address unresolved issues. (shrink)

The slogans of social movements are often put forward as simple truths, so that advocacy has consisted in changing social conditions such that these new truth claims are accepted as true: that women’s rights are human rights, that Black lives matter. Social movements critical of the political ascendance of Donald Trump, however, have been concerned not merely with this or that truth claim, but with the status—epistemological, social, and political—of truth itself. Those examining this post-truth moment have often turned to (...) Friedrich Nietzsche, who for many is synonymous with the kind of postmodern conception of truth at the center of post-truth politics. However, while it is true that Nietzsche offers valuable... (shrink)

A critic of metaphysically robust accounts of the human self, Nietzsche means not to do away with the self entirely, but to reimagine it. He pursues an account according to which the unity of the self is born out of a coherent organization of drives and yet is not something other than that organization. Readers of Nietzsche have pointed to a so-called “lack of fit” between this theoretical account of the self, according to which the self is nothing apart from (...) the organization of drives, and Nietzsche’s practical account of human agency, which often seems to require that the self be something more than mere drives. I suggest Nietzsche’s interest in Greek agonistic norms of contest sheds light on this apparent incongruity. Agonistic relationships, insofar as they cultivate contest among diverse forces, are for Nietzsche one appropriate model for the subjectivity of beings whose psychology is similarly characterized by contest among diverse forces—that is, beings like us. (shrink)

Representing a variety of interpretive strategies, and looking closely at a wide range of Nietzsche’s works, the papers in this issue are nevertheless united by a common concern to make clear whether and how our understanding of Nietzsche is improved by paying closer attention to his treatment of virtue. For Nietzsche’s overlapping projects of interrogating inherited values and of envisioning forms of human life outside of the present moral economy of guilt and retribution both grow out of concerns central to (...) virtue ethics. That is, Nietzsche is asking whether morality in its present state is good for human beings, where what counts as good has to do with the kind of creatures we are, and so what it takes for us to flourish. (shrink)

Conventional quantum mechanics with a complex Hilbert space and the Born Rule is derived from five axioms describing experimentally observable properties of probability distributions for the outcome of measurements. Axioms I, II, III are common to quantum mechanics and hidden variable theories. Axiom IV recognizes a phenomenon, first noted by von Neumann (in Mathematical Foundations of Quantum Mechanics, Princeton University Press, Princeton, 1955) and independently by Turing (Teuscher and Hofstadter, Alan Turing: Life and Legacy of a Great Thinker, Springer, Berlin, (...) 2004), in which the increase in entropy resulting from a measurement is reduced by a suitable intermediate measurement. This is shown to be impossible for local hidden variable theories. Axiom IV, together with the first three, almost suffice to deduce the conventional rules but allow some exotic, alternatives such as real or quaternionic quantum mechanics. Axiom V recognizes a property of the distribution of outcomes of random measurements on qubits which holds only in the complex Hilbert space model. It is then shown that the five axioms also imply the conventional rules for any finite dimension. (shrink)

It is shown that completely entangled two-particle quantum states are simultaneous eigenstates of a large set of commuting, nonlocal observables, a characterization that generalizes to multiparticle systems. This leads to a nonstatistical proof of the Bell-EPR no-hidden-variable theorem for two-particle systems and to a family of multiparticle generalizations of the three-particle system of Greenberger, Horne, and Zeilinger.

We propose the SIMS model can be strengthened by detailing the dynamic interaction between sensorimotor activation and contextual conceptual information. Rapidly activated evaluations and contextual knowledge can guide and constrain embodied simulations. In addition, we stress the potential importance of extending the SIMS model to dynamic social interactions that go beyond the passive observer.

Nietzsche, Foucault, and Rorty are each ethical thinkers in that widest sense that concerns questions of who we ought to be, and each seeks to answer those questions through accounts of self-creation that are distinguished by the style and scope of embeddedness in some community they rely on. Nietzsche’s is a middle-ground position between Rorty and Foucault since he offers an affirmation of community, on grounds that Rorty might accept, without acquiescence to the status quo, a concern for Foucault. Nietzsche (...) aims to place himself in a community, but one in part defined by its vigilance in identifying its blind spots, in knowing that it does not always know itself. In particular, I would like to say that Rorty misses the force of Nietzsche’s views on self-creation and the affirmation of community because Rorty mischaracterizes Nietzsche’s perspectivism by construing it along narrative rather than affective or physiological lines. (shrink)

If we think of political progress as indexed to some permanent standard, and then agree that it is Nietzsche who dispels the authority of any such standard, then we may perhaps conclude that after Nietzsche, progress is ruled out. I want to show, however, that we find in Nietzsche comfort for a continued vision of human progress through engaged political action. I suggest that we look to Derrida and Rorty as offering a view of a post-Nietzschean democracy the engine of (...) which is an account of ameliorative progress that is at home in the Enlightenment tradition while avoiding its universalist pretensions. (shrink)

Throughout his writings, Nietzsche problematizes self-knowledge, trying to displace rather than satisfy our drive for it. Describing self-knowledge as an ideal only for a certain kind of human being, he writes that it is the community that says, “‘you shall be knowable, express your inner nature by clear and constant signs—otherwise you are dangerous [...]. We despise the secret and unrecognizable.—Consequently, you must consider yourself knowable, you may not be concealed from yourself, you may not believe that you change’”.1 And (...) he argues that what we call self-knowledge develops in the first instance not in order that we might know ourselves, but only in response to our need to... (shrink)

The Western evangelical church has lost both the passion for and the art of reading Scripture orally in worship. This exploration of the biblical roots of reading Scripture orally examines both the Old and the New Testament evidence, noting particularly the paradigm established by Moses in Deuteronomy 31:9-13 and modeled by Ezra in Nehemiah 8 that reflects the formative reading of Scripture. Since literacy was limited and few had access to written copies of the Scriptures in ancient Israel and in (...) the early church, public hearing of the Word of God provided the primary means of inspiration and spiritual formation. The essay concludes with a discussion of the implications of the biblical evidence for evangelicals today, including specific guidelines for developing the art of reading the Scriptures in corporate worship. (shrink)

Current medical and legal literature generally favors a definition of death based on total cessation of brain functioning. It does not, however, supply the reasoning for this recommendation. None of the arguments for whole-brain death is convincing; there exists, however, a satisfactory rationale for identifying death with cortical death. Policymakers should refrain from endorsing any of these arguments, focussing instead on the pragmatic tasks involved in guiding medical care at the end of life.

Edmund Burke, long considered modern conservatism's founding father, is also widely believed to be an opponent of empire. However, Daniel O'Neill turns that latter belief on its head. This fresh and innovative book shows that Burke was a passionate supporter and staunch defender of the British Empire in the eighteenth century, whether in the New World, India, or Ireland. Moreover--and against a growing body of contemporary scholarship that rejects the very notion that Burke was an exemplar of conservatism--O'Neill demonstrates (...) that Burke's defense of empire was in fact ideologically consistent with his conservative opposition to the French Revolution. Burke's logic of empire relied on two opposing but complementary theoretical strategies: Ornamentalism, which stressed cultural similarities between "civilized" societies, as he understood them, and Orientalism, which stressed the putative cultural differences distinguishing "savage" societies from their "civilized" counterparts. This incisive book also shows that Burke's argument had lasting implications, as his development of these two justifications for empire prefigured later intellectual defenses of British imperialism"--Provided by publisher. (shrink)

In this paper I will present a puzzle about epistemic akrasia, and I will use that puzzle to motivate accepting some non-standard views about the nature of epistemological judgment. The puzzle is that while it seems obvious that epistemic akrasia must be irrational, the claim that epistemic akrasia is always irrational amounts to the claim that a certain sort of justified false belief—a justified false belief about what one ought to believe—is impossible. But justified false beliefs seem to be possible (...) in any domain, and it’s hard to see why beliefs about what one ought to believe should be an exception. I will argue that when we get clearer about what sort of psychological state epistemic akrasia is, we can resolve the puzzle in favor of the intuitive view that epistemic akrasia is always irrational. (shrink)

Biology and history are often viewed as closely related disciplines, with biology informed by history, especially in its task of charting our evolutionary past. Maximizing the opportunities for cross-fertilization in these two fields requires an accurate reckoning of their commonalities and differences-precisely what this volume sets out to achieve. Specially commissioned essays by a team of recognized international researchers cover the full panoply of topics in these fields and include notable contributions on the correlativity of evolutionary and historical explanations, applying (...) to history the latest causal-mechanical approach in the philosophy of biology, and the question of generalized laws that might pertain across the two subjects. The collection opens with a vital interrogation of general issues on explanation that apart from potentially fruitful areas of interaction (could the etiology of the causal-mechanical perspective in biology account for the historical trajectory of the Roman Empire?) this volume also seeks to chart relative certainties distinguishing explanations in biology and history. It also assesses techniques such as the use of probabilities in biological reconstruction, deployed to overcome the inevitable gaps in physical evidence on early evolution. Methodologies such as causal graphs and semantic explanation receive in-depth analysis. Contributions from a host of prominent and widely read philosophers ensure that this new volume has the stature of a major addition to the literature. (shrink)

Many modern conservatives and feminists trace the roots of their ideologies, respectively, to Edmund Burke and Mary Wollstonecraft, and a proper understanding of these two thinkers is therefore important as a framework for political debates today. According to Daniel O’Neill, Burke is misconstrued if viewed as mainly providing a warning about the dangers of attempting to turn utopian visions into political reality, while Wollstonecraft is far more than just a proponent of extending the public sphere rights of man to (...) include women. Rather, at the heart of their differences lies a dispute over democracy as a force tending toward savagery or toward civilization. Their debate over the meaning of the French Revolution is the place where these differences are elucidated, but the real key to understanding what this debate is about is its relation to the intellectual tradition of the Scottish Enlightenment, whose language of politics provided the discursive framework within and against which Burke and Wollstonecraft developed their own unique ideas about what was involved in the civilizing process. (shrink)

I defend the cosmopolitan instrumentalist theory of secession, according to which a group has a right to secede only if this would promote cosmopolitan justice. I argue that the theory is preferable to other theories of secession because it is an entailment of cosmopolitanism, which is independently attractive, and because, unlike other theories of secession, it allows us to give the answers we want to give in cases like secession of the rich or secession that would make things worse for (...) minorities. I defend the view against the objections that it allows for colonialism and annexation, that it is not a distinct theory, and that it is impractical. (shrink)

Supporters of open borders sometimes argue that the state has no pro tanto right to restrict immigration, because such a right would also entail a right to exclude existing citizens for whatever reasons justify excluding immigrants. These arguments can be defeated by suggesting that people have a right to stay put. I present a new form of the exclusion argument against closed borders which escapes this “right to stay put” reply. I do this by describing a kind of exclusion that (...) has not been discussed in depth, which I call “territorial exclusion.” Territorial exclusion is the process according to which the group that wishes to exclude current citizens secedes from the territory in which those citizens reside. I argue that the wrongness of territorial exclusion explains why there is no pro tanto right for a state to exclude immigrants, because otherwise there would be a pro tanto right for the state to kick people out by seceding from the territory they inhabit. Because kicking people out like this is typically wrong, borders cannot be closed. (shrink)