Is it OK to lie to Siri? Is it bad to mistreat a robot for our own pleasure? Under what condition should we grant a moral status to an artificial intelligence (AI) system? This paper looks at different arguments for granting moral status to an AI system: the idea of indirect duties, the relational argument, the argument from intelligence, the arguments from life and information, and the argument from sentience. In each but the last case, we find unresolved issues (...) with the particular argument, which leads us to move to a different one. We leave the idea of indirect duties aside since these duties do not imply considering an AI system for its own sake. The paper rejects the relational argument and the argument from intelligence. The argument from life may lead us to grant a moral status to an AI system, but only in a weak sense. Sentience, by contrast, is a strong argument for the moral status of an AI system—based, among other things, on the Aristotelian principle of equality: that same cases should be treated in the same way. The paper points out, however, that no AI system is sentient given the current level of technological development. (shrink)

Is it OK to lie to Siri? Is it bad to mistreat a robot for our own pleasure? Under what condition should we grant a moral status to an artificial intelligence system? This paper looks at different arguments for granting moral status to an AI system: the idea of indirect duties, the relational argument, the argument from intelligence, the arguments from life and information, and the argument from sentience. In each but the last case, we find unresolved issues with (...) the particular argument, which leads us to move to a different one. We leave the idea of indirect duties aside since these duties do not imply considering an AI system for its own sake. The paper rejects the relational argument and the argument from intelligence. The argument from life may lead us to grant a moral status to an AI system, but only in a weak sense. Sentience, by contrast, is a strong argument for the moral status of an AI system—based, among other things, on the Aristotelian principle of equality: that same cases should be treated in the same way. The paper points out, however, that no AI system is sentient given the current level of technological development. (shrink)

Many think that a specific aspect of phenomenal consciousness – valenced or affective experience – is essential to consciousness’s moral significance (valence sentientism). They hold that valenced experience is necessary for well-being, or moral status, or psychological intrinsic value (or all three). Some think that phenomenal consciousness generally is necessary for non-derivative moral significance (broad sentientism). Few think that consciousness is unnecessary for moral significance (non-necessitarianism). In this paper I consider the prospects for these views. I first consider the prospects (...) for valence sentientism in light of Vulcans, beings who are conscious but without affect or valence of any sort. I think Vulcans pressure us to accept broad sentientism. But I argue that a consideration of explanations for broad sentientism opens up possible explanations for non-necessitarianism about the moral significance of consciousness. That is, once one leans away from valence sentientism because of Vulcans, one should feel pressure to accept a view on which consciousness is not necessary for well-being, moral status, or psychological intrinsic value. (shrink)

According to a common view, sentience is necessary and sufficient for moral status. In other words, whether a being has intrinsic moral relevance is determined by its capacity for conscious experience. The _epistemic objection_ derives from our profound uncertainty about sentience. According to this objection, we cannot use sentience as a _criterion_ to ascribe moral status in practice because we won’t know in the foreseeable future which animals and AI systems are sentient while ethical questions regarding the (...) possession of moral status are urgent. Therefore, we need to formulate an alternative criterion. I argue that the epistemic objection is dissolved once one clearly distinguishes between the question what determines moral status and what criterion should be employed in practice to ascribe moral status. Epistemic concerns are irrelevant to the former question and—I will argue—criteria of moral status have inescapably to be based on sentience, if one concedes that sentience determines moral status. It follows that doubts about our epistemic access to sentience cannot be used to motivate an alternative criterion of moral status. If sentience turns out to be unknowable, then moral status is unknowable. However, I briefly advocate against such strong pessimism. (shrink)

According to an orthodox view, the capacity for conscious experience (sentience) is relevant to the distribution of moral status and value. However, physicalism about consciousness might threaten the normative relevance of sentience. According to the indeterminacy argument, sentience is metaphysically indeterminate while indeterminacy of sentience is incompatible with its normative relevance. According to the introspective argument (by François Kammerer), the unreliability of our conscious introspection undercuts the justification for belief in the normative relevance of consciousness. I (...) defend the normative relevance of sentience against these objections. First, I demonstrate that physicalists only have to concede a limited amount of indeterminacy of sentience. This moderate indeterminacy is in harmony with the role of sentience in determining moral status. Second, I argue that physicalism gives us no reason to expect that introspection is unreliable with respect to the normative relevance of consciousness. (shrink)

1. 1.1. Suffering is bad. This is why, ceteris paribus, there are strong moral reasons to prevent suffering. Moreover, typically, those moral reasons are stronger when the amount of suffering at st...

The AI world was rocked with controversy when Blake Lemoine, an AI researcher at Google claimed that their new LaMDA model was sentient. This Curmudgeon’s Corner article explores his claims critically by contrasting them to the original LaMDA paper released by the team of researchers at Google. The piece explores the human tendency for anthropomorphization via historical chatbots such as Eliza and potential reasons why we developed this propensity. It addresses the potential causes for the model’s choice of words. Subsequently, (...) using the scoring criteria of the language model, I provide an explanation for the model’s behavior in the conversation with Lemoine. Finally, I explore some of Lemoine’s assertions and break down the logical gaps they hold. I conclude on a potential reorientation of the debate in view of our unfortunate tendency. (shrink)

A discussion concerning whether to conceive Artificial Intelligence systems as responsible moral entities, also known as “artificial moral agents”, has been going on for some time. In this regard, we argue that the notion of “moral agency” is to be attributed only to humans based on their autonomy and sentience, which AI systems lack. We analyze human responsibility in the presence of AI systems in terms of meaningful control and due diligence and argue against fully automated systems in medicine. (...) With this perspective in mind, we focus on the use of AI-based diagnostic systems and shed light on the complex networks of persons, organizations and artifacts that come to be when AI systems are designed, developed, and used in medicine. We then discuss relational criteria of judgment in support of the attribution of responsibility to humans when adverse events are caused or induced by errors in AI systems. (shrink)

To assess the intelligence of machines, Alan Turing proposed a test of imitation known as the imitation game, famously known as the Turing test. To assess whether artificial intelligent (AI) systems could be moral or not, Colin Allen et al. developed a test of imitation in the context of morality, a test known as the Moral Turing Test (MTT), which I will, in this paper, call the moral imitation game. There are arguments against developing any type of MTT or moral (...) imitation game. Rather than developing a moral imitation game, this paper proposes a criterion of imitation for AI systems in the moral scenario. To develop a criterion of imitation, I explore the notion of moral attribution in detail. Within the case of moral attribution, I introduce the subject‐ascriber distinction. The notion of moral attribution and the subject‐ascriber distinction is employed to address the following questions: (a) how is the assessment in MTT arranged?, (b) what is the role of the interrogator in the MTT?, and (c) what information is to be concealed from the interrogator? The first question deals with the aspect of assessment, the second question deals with the reordering of the role of the interrogator and the third one deals with the concealment aspect of the imitation game. After that, a criterion of imitation for AI systems is put forward. Using the subject‐ascriber distinction in moral attribution and David Lewis' Mad Pain and Martian Pain cases, it is argued that the notion of sentience is insignificant for the ascriber for moral attributions. (shrink)

Conscious sentient AI seems to be all but a certainty in our future, whether in fifty years’ time or only five years. When that time comes, we will be faced with entities with the potential to experience more pain and suffering than any other living entity on Earth. In this paper, we look at this potential for suffering and the reasons why we would need to create a framework for protecting artificial entities. We look to current animal welfare laws and (...) regulations to investigate why certain animals are given legal protections, and how this can be applied to AI. We use a meta-theory of consciousness to determine what developments in AI technology are needed to bring AI to the level of animal sentience where legal arguments for their protection can be made. We finally speculate on what a future conscious AI could look like based on current technology. (shrink)

The transformers that drive chatbots and other AI systems constitute large language models (LLMs). These are currently the focus of a lively discussion in both the scientific literature and the popular media. This discussion ranges from hyperbolic claims that attribute general intelligence and sentience to LLMs, to the skeptical view that these devices are no more than “stochastic parrots”. I present an overview of some of the weak arguments that have been presented against LLMs, and I consider several of (...) the more compelling criticisms of these devices. The former significantly underestimate the capacity of transformers to achieve subtle inductive inferences required for high levels of performance on complex, cognitively significant tasks. In some instances, these arguments misconstrue the nature of deep learning. The latter criticisms identify significant limitations in the way in which transformers learn and represent patterns in data. They also point out important differences between the procedures through which deep neural networks and humans acquire knowledge of natural language. It is necessary to look carefully at both sets of arguments in order to achieve a balanced assessment of the potential and the limitations of LLMs. (shrink)

We are sometimes unsure of the moral status of our relationships with other entities. Recent case studies in this uncertainty include our relationships with artificial agents (robots, assistant AI, etc.), animals, and patients with “locked-in” syndrome. Do these entities have basic moral standing? Could they count as true friends or lovers? What should we do when we do not know the answer to these questions? An influential line of reasoning suggests that, in such cases of moral uncertainty, we need meta-moral (...) decision rules that allow us to either minimize the risks of moral wrongdoing or improve the choice-worthiness of our actions. One particular argument adopted in this literature is the “risk asymmetry argument,” which claims that the risks associated with accepting or rejecting some moral facts may be sufficiently asymmetrical as to warrant favoring a particular practical resolution of this uncertainty. Focusing on the case study of artificial beings, this article argues that this is best understood as an ethical-epistemic challenge. The article argues that taking potential risk asymmetries seriously can help resolve disputes about the status of human–AI relationships, at least in practical terms (philosophical debates will, no doubt, continue); however, the resolution depends on a proper, empirically grounded assessment of the risks involved. Being skeptical about basic moral status, but more open to the possibility of meaningful relationships with such entities, may be the most sensible approach to take. (shrink)

While philosophers have been debating for decades on whether different entities—including severely disabled human beings, embryos, animals, objects of nature, and even works of art—can legitimately be considered as having moral status, this question has gained a new dimension in the wake of artificial intelligence (AI). One of the more imminent concerns in the context of AI is that of the moral rights and status of social robots, such as robotic caregivers and artificial companions, that are built to interact with (...) human beings. In recent years, some approaches to moral consideration have been proposed that would include social robots as proper objects of moral concern, even though it seems unlikely that these machines are conscious beings. In the present paper, I argue against these approaches by advocating the “consciousness criterion,” which proposes phenomenal consciousness as a necessary condition for accrediting moral status. First, I explain why it is generally supposed that consciousness underlies the morally relevant properties (such as sentience) and then, I respond to some of the common objections against this view. Then, I examine three inclusive alternative approaches to moral consideration that could accommodate social robots and point out why they are ultimately implausible. Finally, I conclude that social robots should not be regarded as proper objects of moral concern unless and until they become capable of having conscious experience. While that does not entail that they should be excluded from our moral reasoning and decision-making altogether, it does suggest that humans do not owe direct moral duties to them. (shrink)

This paper reflects on the problem of endowing Artificial Intelligence with legal subjectivity, especially with regard to civil law. It is necessary to reject the myth that the criteria of legal subjectivity are sentience and reason. Arguing that AI may have potential legal subjectivity based on an analogy to animals or juristic persons suggests the existence of a single hierarchy or sequence of entities, organized according to their degree of similarity to human beings; also, that the place of an (...) entity in this hierarchy determines the scope of subjectivity attributed to it. Rather, it is participation or presence in social life, whatever the role, that is the true criterion of subjectivity. In addition, it is clear that even if AI is not currently a significant participant in social life, it will be in the nearest future. Despite the potential dangers associated with endowing AI with some kind of subjectivity, such a course is inescapable, and should be considered sooner rather than later. (shrink)

The aim of this thesis is to advance a philosophically justifiable account of Artificial Moral Agency (AMA). Concerns about the moral status of Artificial Intelligence (AI) traditionally turn on questions of whether these systems are deserving of moral concern (i.e. if they are moral patients) or whether they can be sources of moral action (i.e. if they are moral agents). On the Organic View of Ethical Status, being a moral patient is a necessary condition for an entity to qualify as (...) a moral agent. This view claims that because artificial agents (AAs) lack sentience, they cannot be proper subjects of moral concern and hence cannot be considered to be moral agents. I raise conceptual and epistemic issues with regards to the sense of sentience employed on this view, and I argue that the Organic View does not succeed in showing that machines cannot be moral patients. Nevertheless, irrespective of this failure, I also argue that the entire project is misdirected in that moral patiency need not be a necessary condition for moral agency. Moreover, I claim that whereas machines may conceivably be moral patients in the future, there is a strong case to be made that they are (or will very soon be) moral agents. Whereas it is often argued that machines cannot be agents simpliciter, let alone moral agents, I claim that this argument is predicated on a conception of agency that makes unwarranted metaphysical assumptions even in the case of human agents. Once I have established the shortcomings of this “standard account”, I move to elaborate on other, more plausible, conceptions of agency, on which some machines clearly qualify as agents. Nevertheless, the argument is still often made that while some machines may be agents, they cannot be moral agents, given their ostensible lack of the requisite phenomenal states. Against this thesis, I argue that the requirement of internal states for moral agency is philosophically unsound, as it runs up against the problem of other minds. In place of such intentional accounts of moral agency, I provide a functionalist alternative, which makes conceptual room for the existence of AMAs. The implications of this thesis are that at some point in the future we may be faced with situations for which no human being is morally responsible, but a machine may be. Moreover, this responsibility holds, I claim, independently of whether the agent in question is “punishable” or not. (shrink)

Smart city discourses often invoke the Panopticon, a disciplinary architecture designed by Jeremy Bentham and popularly theorized by Michel Foucault, as a model for understanding the social impact of AI technologies. This framing focuses attention almost exclusively on the negative ramifications of Urban AI, correlating ubiquitous surveillance, centralization, and data consolidation with AI development, and positioning technologies themselves as the driving factor shaping privacy, sociality, equity, access, and autonomy in the city. This paper describes an alternative diagram for Urban AI—the (...) Polyopticon: a distributed, polyvalent, multi-modal network of synthetic intelligences. It posits that fourth industrial revolution technologies change the political, social, and psychodynamic relationships of sentience and witness in the city, shifting the effects of watching and watched beyond the exclusive domain of top-down surveillance and discipline. The Polyopticon poses a more expansive and ambivalent spectrum of possibilities for Urban AI scenarios, one that undermines the totalizing, singular, and cerebral notion of intelligence that so often characterizes Urban AI and smart city critiques. (shrink)

The marker approach is taken as best practice for answering the distribution question: Which animals are conscious? However, the methodology can be used to increase confidence in animals many presume to be unconscious, including C. elegans, leading to a trilemma: accept the worms as conscious; reject the specific markers; or reject the marker methodology for answering the distribution question. I defend the third option and argue that answering the distribution question requires a secure theory of consciousness. Accepting the hypothesis all (...) animals are conscious will promote research leading to secure theory, which is needed to create reliable consciousness tests for animals and AIs. Rather than asking the distribution question, we should shift to the dimensions question: How are animals conscious? (shrink)

Should artificial intelligences ever be included as co-authors of democratic decisions? According to the conventional view in democratic theory, the answer depends on the relationship between the political unit and the entity that is either affected or subjected to its decisions. The relational conditions for inclusion as stipulated by the all-affected and all-subjected principles determine the spatial extension of democratic inclusion. Thus, AI qualifies for democratic inclusion if and only if AI is either affected or subjected to decisions by the (...) political unit in relevant ways. This paper argues that the conventional view is too simple; that it neglects democratic reasons to recognize only agents and/or moral patients as participants in decision-making. The claim defended is that AAP and ASP implicitly affirm requirements for agency and patiency. In ASP, the entity included must be an agent understood either in terms of legal status, capacity to comply with the law or ability to recognize legitimate authority. In AAP, the entity included must be a patient, understood either in terms of capacity for sentience or consciousness. Thus, the idea here is to explore the potential democratic inclusion of artificial intelligences by an updated account of the relevant conditions of agency and patiency that are implicit in democratic theory. Although conceivable that AI is or will be either affected or subjected in relevant ways to decisions made by political units, it is far less clear that AI will ever be agents or patients in the sense required for democratic inclusion. (shrink)

From the initial analysis of John Morris in 1976 about if computers can lie, I have presented my own treatment of the problem using what can be called a computational lying procedure. One that uses two Turing Machines. From there, I have argued that such a procedure cannot be implemented in a Turing Machine alone. A fundamental difficulty arises, concerning the computational representation of the self-knowledge a machine should have about the fact that it is lying. Contrary to Morris’ claim, (...) I have thus suggested that computers – as far as they are Turing Machines – cannot lie. Consequently, I have claimed that moral agency attribution to a robot or any other automated AI system, cannot be made, strictly grounded on imitating behaviors. Self-awareness as an ontological grounding for moral attribution must be evoked. This can pose a recognition problem from our part, should the sentient system be the only agent capable of acknowledging its own sentience. (shrink)

Recent debates about the biological and evolutionary conditions for sentience have generated a renewed interest in fine-grained functionalism. According to one such account advanced by Peter Godfrey-Smith, sentience depends on the fine-grained activities characteristic of living organisms. Specifically, the scale, context and stochasticity of these fine-grained activities. One implication of this view is that contemporary artificial intelligence is a poor candidate for sentience. Insofar as current AI lacks the ability to engage in such living activities it will (...) lack sentience, no matter what its coarse-grained functions. In this paper, we review the case for fine-grained functionalism and show that there are contemporary machines that fulfil the fine-grained functional criteria identified by Godfrey-Smith, and thus are candidates for sentience. Molecular machines such as Brownian computers are analogous to metabolic activity in their scale, context and stochasticity, and can serve as the basis of AI. Molecular computation is a promising candidate for artificial sentience according to contemporary philosophical accounts of sentience. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:On the Conceivability of Artificially Created EnlightenmentPaul Andrew PowellPointsman can only possess the zero and the one. He cannot, like [Roger] Mexico, survive anyplace in between.... [H]e imagines the cortex of the brain as a mosaic of tiny on/off elements.... [E]ach point is allowed only the two states:... [o]ne or zero.... [B]rain mechanics assumes the presence of these bi-stable points....If ever the Anti-pointsman existed, Roger Mexico is the man.... (...) How can Mexico play, so at his ease, with these symbols of randomness and fright? Innocent as a child, perhaps unaware—perhaps—that in his play he wrecks the elegant rooms of history.—Thomas Pynchon, Gravity's RainbowWhen I first read about the Dalai Lama's remark that "if all the external conditions and the karmic action were there, a stream of consciousness might actually enter into a computer,"1 I couldn't help but wonder if a computer could then attain enlightenment. The answer, at first, seemed simple and obvious (though perhaps distasteful for some): if the machine was self-aware, sentient, and conscious, then it would be only reasonable to assume that it could also attain enlightenment. Yes, simple and obvious, of course, but this takes for granted some very large and complex issues. After all, what makes for self-awareness, sentience, and consciousness to begin with, and how would we manufacture them in a machine?If we take a moment to think about the creation of artificial enlightenment the paradox becomes clear. In order to manufacture enlightenment, we must first manufacture samsara, because for a Buddhist, enlightenment is the "event" of deconstructing the problematic natures of "self," sentience (suchness), and consciousness, all of which are samsaric illusions. "Self," sentience, and consciousness represent the prerequisites of samsara/Nirvana, realized or unrealized, artificial or organic. They represent the prerequisites of desire. They represent the prerequisites for the illusion of death and birth. And thus they represent the truly salient issues that must be addressed before we can assemble our complicated hard (and soft) ware. Interestingly, because computational information consists of a conceptualized, dualistic [End Page 123] binary system of ones and zeroes, and because the nature of Nirvana/samsara also consists of a conceptualized, dualistic system of "self"/"other," technology, in theory anyway, may probably be capable of manufacturing a facsimile of samsara, if only because computational information is, by its very nature, samsaric to begin with. Of course, all this demands that consciousness, self-awareness, and sentience be a function of information processing. Personally, I believe they are, and that, in fact, the words information and samsara are synonymous with one another. Thus it follows that information technology will most certainly be capable of manufacturing the prerequisites, at least, of enlightenment. If that blunt statement strikes you as utterly preposterous, technically impossible, or even offensive, you might want to first read any number of excellent texts describing the future of artificial intelligence (AI). Two of the best popular books on the subject are Robot by Hans Moravec and The Age of Spiritual Machines by Ray Kurzweil. These will assuage your doubts concerning the soft problem, or, as it is sometimes called, the nuts-and-bolts problem.With these considerations in mind, let's see what we can come up with.In order to arrive at what you are not You must go through the way in which you are not.—T.S. Eliot, "East Coker" (The Four Quartets)For most Buddhists, enlightenment can be defined as seeing through the illusion of the self and experiencing unadulterated suchness. In the words of Master Wolfgang Kopp, "The seer, the seen, and the process of seeing are one. The thinker, the thought, and the process of thinking fall together into one and multiplicity melts away. There is neither inside, nor outside in this state. There is only 'suchness,' tathata."2 So, enlightenment is suchness, or, things as they are, revealed as all that there is. As engineers of enlightenment, it would appear then that are at least two components we need to build into our machine: an illusionary "self" and suchness, or things as they are. As we shall see, the... (shrink)

In the future, when we compare the welfare of a being of one substrate (say, a human) with the welfare of another (say, an artificial intelligence system), we will be making an intersubstrate welfare comparison. In this paper, we argue that intersubstrate welfare comparisons are important, difficult, and potentially tractable. The world might soon contain a vast number of sentient or otherwise significant beings of different substrates, and moral agents will need to be able to compare their welfare levels. However, (...) this work will be difficult, because we lack the same kinds of commonalities across substrates that we have within them. Fortunately, we might be able to make at least some intersubstrate welfare comparisons responsibly in spite of these issues. We make the case for cautious optimism and call for more research. (shrink)

In philosophy of mind, zombies are imaginary creatures that are exact physical duplicates of conscious subjects but for whom there is no first-personal experience. Zombies are meant to show that physicalism—the theory that the universe is made up entirely out of physical components—is false. In this paper, I apply the zombie thought experiment to the realm of morality to assess whether moral agency is something independent from sentience. Algorithms, I argue, are a kind of functional moral zombie, such that (...) thinking about the latter can help us better understand and regulate the former. I contend that the main reason why algorithms can be neither autonomous nor accountable is that they lack sentience. Moral zombies and algorithms are incoherent as moral agents because they lack the necessary moral understanding to be morally responsible. To understand what it means to inflict pain on someone, it is necessary to have experiential knowledge of pain. At most, for an algorithm that feels nothing, ‘values’ will be items on a list, possibly prioritised in a certain way according to a number that represents weightiness. But entities that do not feel cannot value, and beings that do not value cannot act for moral reasons. (shrink)

In what ways should we include future humanoid robots, and other kinds of artificial agents, in our moral universe? We consider the Organic view, which maintains that artificial humanoid agents, based on current computational technologies, could not count as full-blooded moral agents, nor as appropriate targets of intrinsic moral concern. On this view, artificial humanoids lack certain key properties of biological organisms, which preclude them from having full moral status. Computationally controlled systems, however advanced in their cognitive or informational capacities, (...) are, it is proposed, unlikely to possess sentience and hence will fail to be able to exercise the kind of empathic rationality that is a prerequisite for being a moral agent. The organic view also argues that sentience and teleology require biologically based forms of self-organization and autonomous self-maintenance. The organic view may not be correct, but at least it needs to be taken seriously in the future development of the field of Machine Ethics. (shrink)

In some languages every statement must contain a specification of the type of evidence on which it is based: for example, whether the speaker saw it, or heard it, or inferred it from indirect evidence, or learnt it from someone else. This grammatical reference to information source is called 'evidentiality', and is one of the least described grammatical categories. Evidentiality systems differ in how complex they are: some distinguish just two terms (eyewitness and noneyewitness, or reported and everything else), while (...) others have six or even more terms. Evidentiality is a category in its own right, and not a subcategory of epistemic or some other modality, nor of tense-aspect. Every language has some way of referring to the source of information, but not every language has grammatical evidentiality. In English expressions such as I guess, they say, I hear that, the alleged are not obligatory and do not constitute a grammatical system. Similar expressions in other languages may provide historical sources for evidentials. True evidentials, by contrast, form a grammatical system. In the North Arawak language Tariana an expression such as "the dog bit the man" must be augmented by a grammatical suffix indicating whether the event was seen, or heard, or assumed, or reported. This book provides the first exhaustive cross-linguistic typological study of how languages deal with the marking of information source. Examples are drawn from over 500 languages from all over the world, several of them based on the author's original fieldwork. Professor Aikhenvald also considers the role evidentiality plays in human cognition, and the ways in which evidentiality influences human perception of the world.. This is an important book on an intriguing subject. It will interest anthropologists, cognitive psychologists and philosophers, as well as linguists. (shrink)

The Salivaomics Knowledge Base (SKB) is designed to serve as a computational infrastructure that can permit global exploration and utilization of data and information relevant to salivaomics. SKB is created by aligning (1) the saliva biomarker discovery and validation resources at UCLA with (2) the ontology resources developed by the OBO (Open Biomedical Ontologies) Foundry, including a new Saliva Ontology (SALO). We define the Saliva Ontology (SALO; http://www.skb.ucla.edu/SALO/) as a consensus-based controlled vocabulary of terms and relations dedicated to the salivaomics (...) domain and to saliva-related diagnostics following the principles of the OBO (Open Biomedical Ontologies) Foundry. The Saliva Ontology is an ongoing exploratory initiative. The ontology will be used to facilitate salivaomics data retrieval and integration across multiple fields of research together with data analysis and data mining. The ontology will be tested through its ability to serve the annotation ('tagging') of a representative corpus of salivaomics research literature that is to be incorporated into the SKB. Background Saliva (oral fluid) is an emerging biofluid for non-invasive diagnostics used in the detection of human diseases. The need to advance saliva research is strongly emphasized by the National Institute of Dental and Craniofacial Research (NIDCR), and is included in the NIDCR's 2004- 2009 expert panel long-term research agenda [1]. The ability to monitor health status, disease onset, progression, recurrence and treatment outcome through noninvasive means is highly important to advancing health care management. Saliva is a perfect medium to be explored for personalized individual medicine including diagnostics, offering a non-invasive, easy to obtain means for detecting and monitoring diseases. Saliva testing potentially allows the patient to collect their own saliva samples at home, yielding convenience for the patient and savings in health costs, and facilitating multiple sampling. Specimen collection is less objectionable to patients and easier in children and elderly individuals. Due to these advantages. (shrink)

We suggest that as people move to construe robots as social agents, interact with them, and treat them as capable of social ties, they might develop (close) relationships with them. We then ask what kind of relationships can people form with bots, what functions can bots fulfill, and what are the societal and moral implications of such relationships.

There is a need recognized by the National Institute of Dental & Craniofacial Research and the National Cancer Institute to advance basic, translational and clinical saliva research. The goal of the Salivaomics Knowledge Base (SKB) is to create a data management system and web resource constructed to support human salivaomics research. To maximize the utility of the SKB for retrieval, integration and analysis of data, we have developed the Saliva Ontology and SDxMart. This article reviews the informatics advances in saliva (...) diagnostics made possible by the Saliva Ontology and SDxMart. (shrink)

It is demonstrated on the basis of the Dirac equation that quarks cannot be confined by a vector gluon potential of the form(r/r 0)a or[ln(r/r 0]a, a>0, if the quark-gluon interaction conserves parity. In order to confine quarks with the parity-conserving interaction, the effective gluon potential must be a pseudovector or a scalar. These are shown in a simple Yang-Mills field with theSU(2) group.

本书包括:最早的军事智慧之光及其衰落—中国古代近代军事思想;他山之玉和真理源头—外国军事思想;人类最伟大的军事战略—毛泽东军事思想;现代化、正规化革命军队的利器—邓小平新时期军队建设思想;新世纪富国强 兵的行动指南—江泽民国防和军队建设思想五章内容。.

本书从回忆母亲中医治病开始,一路写来,有中医的神奇、有中医的道理、有中医与西医的区别、有人生的智慧、有豁达的胸襟、有现代人常常忽略的东西、有不少值得深思的问题.

本书简要介绍了从明中叶至辛亥革命这一历史时期中国文化史上的主流思潮。全书按历史顺序分别评介了晚明人文主义思潮、明清之际启蒙主义思潮、嘉道之际实学思潮和19世纪末—20世纪初的新民思潮。.

In lieu of an abstract, here is a brief excerpt of the content:Toleration and Justice in the Laozi:Engaging with Tao Jiang's Origins of Moral-Political Philosophy in Early ChinaAi Yuan (bio)IntroductionThis review article engages with Tao Jiang's ground-breaking monograph on the Origins of Moral-Political Philosophy in Early China with particular focus on the articulation of toleration and justice in the Laozi (otherwise called the Daodejing).1 Jiang discusses a naturalistic turn and the re-alignment of values in the Laozi, resulting in a naturalization (...) of justice (impartiality) by rejecting artificial humaneness and rigid hierarchical moral-political structures. In this Laozian just world, there is no room for human intervention and rigid top-down enforcement of values, thus leaving justice to naturalized Heaven or Dao as the ultimate source of the cosmos.Based on Jiang's interpretative context, I show that there is a twofold justification for the "paradoxical" and "elusive"2 value of political toleration.3 A negative expression of toleration focuses on non-interference with choices, and non-enforcement of values toward those whom one reasonably disagrees with and regards as morally wrong. Such an attitude of toleration results in practical advantages such as avoiding entrenchment in bloodshed, abandonment, and deprivation.A positive expression of toleration operating in the Laozian ideal world requires equal protection of people as capable knowers, including those to whom we object. Such protection includes their ways of expression and an unbiased recognition of them as equally capable knowers so that they are heard without bias and prejudice. Such a kind of toleration is revealed as a constituent component of justice since it enables equal contribution toward the shaping of society without discrimination. In other words, toleration is seen as naturalized justice in a Laozian world within which no one is "being wronged with the capacity as a knower"—a kind of epistemic justice articulated by Miranda Fricker (Fricker 2007).4 [End Page 466]This article discusses how Jiang's political reconstruction of Laozian philosophy contains the seeds for a discussion of toleration, a value associated with distributive justice and against epistemic injustice. First, it introduces Jiang's arguments on a naturalization of justice and impartiality as Heavenly attributes in the Laozi. Second, it articulates the value of tolerance in the Laozi. Finally, I compare Laozian toleration with Confucian toleration using youwei- wuwei metaethical criticism.Moral-Political Philosophy in the LaoziJiang's interpretative framework about the origins of distributive justice in the Laozi starts with a discussion of the cosmogonic-mystical worldviews that signal "a new understanding of the nature of the cosmos, as well as a broad reorientation in the Heaven-human relationship in the mid-Warring States period" (p. 192). Differing from the interests in the origins of human culture or civilization in the Ru and Mo traditions, Jiang agrees with Franklin Perkins and identifies a "cosmogonic turn" in the late fourth century b.c. that reveals a demotion of anthropomorphic Heaven. By paring Heaven with earth and accordingly decentering human beings in the intellectual discourse, the Laozi directs equal values to the ten thousand things, with humans as just one among them (Perkins 2016, quoted in Jiang 2021, p. 196).5 Laozi's philosophy thus stands out by rejecting Heaven as caring for human affairs while taking Dao as the ultimate origin of the cosmos, as claimed in chapter 5 of the received text: "Heaven and earth are not humane; they treat ten-thousand things in the world as straw dogs; the sage is not humane; he treats people as straw dogs" (p. 199).With Jiang's reading of a naturalistic heaven, we see a re-alignment between cosmos and the human since sage-rulers follow the Heaven-Dao. The Laozian Dao is "self-so-ing" (ziran 自然), "accommodating" (rong 容), and "impartial" (gong 公), and thus marks a sharp contrast to Confucian familial bias resulting in "actively intervening in human affairs on behalf of the (certain) humans by appointing them to carry out its mission" (p. 200). With the sage emulating the ultimate Dao, the Laozi replaces the Confucian anthropocentric Heaven, which focuses on partiality (qin 親) and humaneness (ren 仁).This Laozian understanding of the cosmos also grounds its philosophical departure from Mohism despite both having a political... (shrink)

Why do people comply with coronavirus disease 2019 public health guidance? This study considers cultural-psychological foundations of variation in beliefs about motivations for such compliance. Specifically, we focused on beliefs about two sources of prosocial motivation: desire to protect others and obligation to society. Across two studies, we observed that the relative emphasis on the desire to protect others as an explanation for compliance was greater in the United States settings associated with cultural ecologies of abstracted independence than in Chinese (...) settings associated with cultural ecologies of embedded interdependence. We observed these patterns for explanations of psychological experience of both others and self, and for compliance with mandates for both social distancing and face masks. Discussion of results considers both practical implications for motivating compliance with public health guidance and theoretical implications for denaturalizing prevailing accounts of prosocial motivation. (shrink)

Civics and Moral Educationwas implemented as a new moral education programme in Singapore schools in 1992. This paper argues that the underlying theme is that of citizenship training and that new measures are under way to strengthen the capacity of the school system to transmit national values for economic and political socialisation. The motives and motivation for retaining a formal moral education programme have remained strong. A discussion of the structure and content of key modules in Civics and Moral Education (...) shows how curriculum writers have attempted to integrate separate strands of civics and moral education from earlier programmes and present them in a less divisive manner. The paper also assesses the impact of the written civics and moral education programme on teachers and pupils, and the way in which strategies have been used by curriculum agencies to overcome possible obstacles at the curriculum implementation phase. (shrink)