How does microbiota research impact our understanding of biological individuality? We summarize the interdisciplinary summer school on "Microbiota, Symbiosis and Individuality: Conceptual and Philosophical Issues" (July 2019), which was supported by a European Research Council starting grant project "Immunity, DEvelopment, and the Microbiota" (IDEM). The summer school centered around interdisciplinary group work on four facets of microbiota research: holobionts, individuality, causation, and human health. The conceptual discussion of cutting-edge empirical research provided new insights into microbiota and highlights the value of (...) incorporating into meetings experts from other disciplines, such as philosophy and history of science. (shrink)

In this paper we address the issue of how to think about immunity. Many immunological writings suggest a straightforward option: the view that the immune system is primarily a system of defense, which naturally invites the talk of strong immunity and strong immune response. Despite their undisputable positive role in immunology, such metaphors can also pose a risk of establishing a narrow perspective, omitting from consideration phenomena that do not neatly fit those powerful metaphors. Building on this analysis, we argue (...) two things. First, we argue that the immune system is involved not only in defense. Second, by disentangling various possible meanings of ‘strength’ and ‘weakness’ in immunology, we also argue that such a construal of immunity generally contributes to the distortion of the overall picture of what the immune system is, what it does, and why it sometimes fails. Instead, we propose to understand the nature of the immune system in terms of contextuality, regulation, and trade-offs. We suggest that our approach provides lessons for a general understanding of the organizing principles of the immune system in health and disease. For all this to work, we discuss a wide range of immunological phenomena. (shrink)

A distinction between different notions of “structure” and “function” is suggested for interpreting the overwhelming amount of data on microbiome structure and function. Sequence data, biochemical agents, interaction networks, taxonomic communities, and their dynamics can be linked to potential or actual biochemical activities, causal roles, and selected effects, respectively. This conceptual clarification has important methodological consequences for how to interpret existing data and approach open questions in contemporary microbiome research practice. In particular, the field will have to start thinking about (...) notions of function more directly. Also see the video abstract here https://youtu.be/j5pq5uGld1k. (shrink)

In our commentary on Lynch et al.’s target paper, we focus on decomposition as a research strategy. We argue that not only the presumptive microbial causes but also their supposed phenotypic effects need to be decomposed relative to each other. Such a dual decomposition strategy ought to improve the way in which causal claims in microbiome research can be made and understood.

In our commentary on Lynch et al.’s target paper, we focus on decomposition as a research strategy. We argue that not only the presumptive microbial causes but also their supposed phenotypic effects need to be decomposed relative to each other. Such a dual decomposition strategy ought to improve the way in which causal claims in microbiome research can be made and understood.

In our commentary on Lynch et al.’s target paper, we focus on decomposition as a research strategy. We argue that not only the presumptive microbial causes but also their supposed phenotypic effects need to be decomposed relative to each other. Such a dual decomposition strategy ought to improve the way in which causal claims in microbiome research can be made and understood.

I will offer a conceptual analysis of different notions of structure and function of viral immunogens and of different structure-function relationships. My focus will then be on the mechanisms by which the desired immune response is induced and why strategies based on three-dimensional molecular antigen structures and their rational design are limited in their ability to induce the desired immunogenicity. I will look at the mechanisms of action of adjuvants (thus the wordplay with Janeway's "immunologist's dirty little secret"). Strategies involving (...) adjuvants and other (more successful) vaccination strategies rely on taking into account activities and functions ("what is going on"), and not just the structures involved ("who is there"), in binding in a "lock and key" fashion. Functional patterns as well as other organizational and temporal patterns, I will argue, are crucial for inducing the desired immune response and immunogenicity. The 3D structural approach by itself has its benefitsand its limits, which I want to highlight by this philosophical analysis, pointing out the importance of structure-function relationships. Different functional aspects such as antigenicity, immunogenicity, and immunity need to be kept separate and cannot be reduced to three-dimensional structures of vaccines. Taking into account different notions of structure and function and their relationships might thus advance our understanding of the immune system and rational HIV vaccine design, to which end philosophy can provide useful tools. (shrink)

'Structure' and 'function' are both ambiguous terms. Discriminating different meanings of these terms sheds light on research and explanatory practice in molecular biology, as well as clarifying central theoretical concepts in the life sciences like the sequence-structure-function relationship and its corresponding scientific "dogmas". The overall project is to answer three questions, primarily with respect to proteins: What is structure? What is function? What is the relation between structure and function? The results of addressing these questions lead to an answer to (...) the title question, what the statement 'structure determines function' means. (shrink)

The increased incidence of morbidity and mortality due to Clostridium difficile infection, had led to the emergence of fecal microbial transplantation (FMT) as a highly successful treatment. From this, a 32 strain stool substitute has been derived, and successfully tested in a pilot human study. These approaches could revolutionize not only medical care of infectious diseases, but potentially many other conditions linked to the human microbiome. But a second revolution may be needed in order for regulatory agencies, society and medical (...) practitioners to accept and utilize these interventions, monitor their long term effects, have a degree of control over their use, or at a minimum provide guidelines for donors and recipients. (shrink)

The paper deals with the question of the structure of knowledge and the precise relationship between propositional "knowledge that" and dispositional "knowledge how." In the first part of my essay, I provide an analysis of the term 'knowing how' and argue that the usual alternatives in the recent epistemological debate – knowing how is either a form of propositional or dispositional knowledge – are misleading. In fact it depends on the semantic and pragmatic context of the usage of this term (...) whether 'knowing how' refers to a type of dispositional knowledge, to propositional knowledge, or to a hybrid form of both. Only in the first case, can one say that dispositional know how cannot be reduced to any form of propositional knowledge. Yet, this case is the most interesting one to consider in the investigation of the nature of knowledge, if one assumes that knowing that p presupposes "having found out that p." Having found something out, however, presupposes certain acts of epistemic inquiry and corresponding epistemic abilities. Examined more carefully, it is shown that the dispositional knowledge-how is a necessary condition for propositional knowledge-that, hence propositional knowledge-that is a species of the dispositional knowledge-how. Accordingly, dispositional knowledge has to be understood as being at the very core of our notion of knowledge, including propositional knowledge. (shrink)

In his "Ontological proof", Kurt Gödel introduces the notion of a second-order value property, the positive property P. The second axiom of the proof states that for any property φ: If φ is positive, its negation is not positive, and vice versa. I put forward that this concept of positiveness leads into a paradox when we apply it to the following self-reflexive sentences: (A) The truth value of A is not positive; (B) The truth value of B is positive. Given (...) axiom 2, sentences A and B paradoxically cannot be both true or both false, and it is also impossible that one of the sentences is true whereas the other is false. (shrink)

When in doubt, for the embryo. New arguments on the moral status of human embryos. - In the first part of our essay we distinguish the philosophical from the legal and political level of the embryo debate and describe our indirect justification strategy. It consists in renouncing a determination of the dignity-giving φ-properties and instead starting from premises that are undoubted by all discussion partners. In the second part we reconstruct and criticize the species, continuum, identity and potentiality arguments. The (...) species argument only has a certain plausibility, if at all, as a critical argument. From the continuum argument and identity argument we take over the idea of numerical identity (NI) and link it with the core idea of the potentiality argument (P). So we come to the NIP argument: -/- (NIP) -/- (1) Every living human body that is the bearer of (or has) potential φ-properties has dignity. (2) Every viable human embryo is a living human body that is the bearer of (or has) potential φ properties. Therefore, (3) Every viable human embryo has dignity. -/- Reversibly comatose people and newborns are protected because they have the potential to have actual personal characteristics in the future; our thesis is that embryos that are capable of development also have the same potential in moral terms. The basic idea of numerical identity, with which we support the second premise, is that every human being, from embryonic existence to adulthood, forms a physical unity. In a detailed part, we deal with the crown princess, gametes, parthenogenesis, somatic cell, pronuclear stage, biological heteronome early embryo, multiple, fusion, Siamese twin, hydatidiform mole and finally trophoblast problems. In a third part, the indirect argument is supplemented by a metatheoretical cautionary argument. It states that in situations where there is doubt as to whether a being falls within the scope of a moral norm, but there are sufficiently strong reasons for this subsumption, it must be assumed that this is the case if the contrary assumption and the positive effects it may have are in no acceptable proportion to the moral harm that would result if that subsumption were not made. The main result of our considerations is therefore: When in doubt, for the embryo. (shrink)

ObjectiveTo determine to what extent physical fitness indicators and/or moderate to vigorous physical activity may account for final mathematics academic performance awarded at the end of primary school.MethodsSchool-aged youth were sampled in a repeated-measures, longitudinal design in Grade 6, and again in Grade 9. The youth completed a fitness test battery consisting of: flamingo balance test, standing long jump, backward obstacle course, plate tapping, sit ups, sit and reach, handgrip, and 20-m shuttle run. APmath scores were obtained for all children (...) at the end of Grade 5, end of Grade 8, and end of Grade 9. In a sub-sample of Grade 6 youth, MVPA was measured objectively via SenseWear Pro Armbands for seven consecutive days, with measurements repeated in Grade 9.ResultsMath scores decreased from Grade 6 to 9 for both boys and girls. MVPAOB was reduced by ∼45.7 min from Grade 6 to 9. Significant main and interaction effects are noted for each fitness indicator. A backward stepwise multiple regression analysis determined significant shared variance in final APmath grade to the change scores from Grade 6 to Grade 9 in: ΔAPmath, Δbackward obstacle course, Δsit and reach, and Δsit-ups [R2 = 0.494, F = 43.67, p < 0.0001]. A second regression was performed only for the youth who completed MVPAOB measurements. In this sub-sample, MVPAOB did not significantly contribute to the model.ConclusionLongitudinal changes in youth fitness and their delta change in APmath score accounted for 49.4% of the variance in the final math grade awarded at the end of Grade 9. Aerobic power, upper body strength, and muscular endurance share more common variance to final math grade in boys, whereas whole-body coordination was the more relevant index in girls; this finding suggests that future research exploring the relationship of AP and PF should not be limited to cardiorespiratory fitness, instead encompassing muscular and neuro-muscular components of PF. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:82 HISTORY OF PHILOSOPHY phy) than the aspects considered in the earlier chapters. The attempts of these men to formulate theories of the cosmos and of natural phenomena, to take the place of Aristotle's natural philosophy, are described as honest and original speculative endeavors, with a few features which can be construed as anticipations of seventeenth-century scientific philosophy, but basically lacking the soundness of method and evidence that could (...) make them adequate substitutes for the Aristotelian system. "The Aristotelian tradition of natural philosophy," as Kristeller states, "was not overthrown by the outside attacks of the humanists or Platonists, nor by the suggestive theories of the natural philosophers. It yielded only in and after the seven~ teenth century, when the new science of Galileo and his successors was able to deal with its subject matter on the basis of a firmly established and superior method" (p. 96). All of the essays in this book are distinguished by their concern for historical truth and objectivity, by their attempt to present the thought of the eight authors in the context of the times and in terms of the interests and purposes of the writers themselves, and by the rich and enlightened perspectives of historical understanding brought to bear on the subjects discussed. But what is most attractive, and indeed striking, in this work of Kristeller, as in the other books and essays he has written on Renaissance thought, is his own conviction that the cultural and philosophical ideals which characterized the Italian Renaissance are of intrinsic and enduring value in their own right.Unlike many other expositers and partisans of Renaissance thought, who extol it because it anticipated modem science, or because it was secularist,or anti-scholastic, or "this-worldly"rather than "other-worldly", Kristeller admires it for just what it was. And to those who define philosophy as logical analysis, or as existentialism,or as pragmatism or neo=seholasticism, and on that basis claim that the Italian Renaissance made no contribution to philosophy, Kristeliermakes no apologies. There is no necessary repugnance between scholarship and philosophy, or between original thought and an understanding and appreciation of the classics,nor is cultural barbarism a necessary prerequisite of the pursuit of truth. The values which Kristellerdefends in our time are very much those which Erasmus defended in the sixteenth century. "There is such a thing as the autonomy of culture," Kristeller remarks (p. 94), "and it has always been the task and duty of scholars to defend this territory against the deeper inroads of religious and politicalinfluences." The inroads in our time have been made by differentfanaticisms than those of the sixteenth century, but the defense of the integrity of scholarship and of liberal culture has been a task and duty to which Paul Kristeller has been faithful throughout his long and fruitfulcareer. ER~S~ A. MooDY University of California, Los Angeles Ren$ Descartes: Regulae ad direct~onem ingenii. Texte critique ~tabli par Giovanni Crapulli, avec la version hollandaise du XVH ~m~ si~ele. (La Haye: Martinus Nijhoff, 1966. -" Archives Intemationales d'histeire des iddes, t. 12. Pp. xxxiii + 80 + 80* + 40. Guilders 38.75.) This edition of the Regulae is important because for the first time since the great AdamTannery edition of 1896--1913 a major work of Descartes has been independently re-edited from the sources according to the most advanced editorial principles. The historian of philosophy -the user--will ask four questions: (1) Why a new edition? (2) What does it offer? (3) How does it affect the AT text? (4) What edition should be used and cited? Here briefly, are the answers as one user sees them. 1. The Regulae were posthumously published in 1701. Besides this edito princeps (A) there exists the so-called Hanover manuscript (H) with emendations by Leibniz (L). These were kdam's sources. But the Regulae became known first through the Dutch translation of Glazemaker, published in 1684 (N) which Adam knew but did not use. This led Dr. Crapulli to a review of the whole editorial problem. He concluded that A, H and N were prepared from BOOK REVIEWS 83 three different manuscripts, none of them Descartes's original (which is lost... (shrink)

Infinite time register machines (ITRMs) are register machines which act on natural numbers and which are allowed to run for arbitrarily many ordinal steps. Successor steps are determined by standard register machine commands. At limit times register contents are defined by appropriate limit operations. In this paper, we examine the ITRMs introduced by the third and fourth author (Koepke and Miller in Logic and Theory of Algorithms LNCS, pp. 306–315, 2008), where a register content at a limit time is set (...) to the lim inf of previous register contents if that limit is finite; otherwise the register is reset to 0. The theory of these machines has several similarities to the infinite time Turing machines (ITTMs) of Hamkins and Lewis. The machines can decide all ${\Pi^1_1}$ sets, yet are strictly weaker than ITTMs. As in the ITTM situation, we introduce a notion of ITRM-clockable ordinals corresponding to the running times of computations. These form a transitive initial segment of the ordinals. Furthermore we prove a Lost Melody theorem: there is a real r such that there is a program P that halts on the empty input for all oracle contents and outputs 1 iff the oracle number is r, but no program can decide for every natural number n whether or not ${n \in r}$ with the empty oracle. In an earlier paper, the third author considered another type of machines where registers were not reset at infinite lim inf’s and he called them infinite time register machines. Because the resetting machines correspond much better to ITTMs we hold that in future the resetting register machines should be called ITRMs. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:260 HISTORY OF PHILOSOPHY Christian business" is not knowledge but experience. He founds religious certainty on individual inspiration and emphasizes charity against external written law. A man inspired by God becomes autonomous and acquires a mind of his own--independent of external authorities. This valuable study (pp. 5-109) is followed by an extensive bibliography (pp. 113--209) in which it could be added that Vald~s' Al[abeto Cristiano was reprinted in 1948 (...) by the Editorial "La Aurora" of Buenos Aires. In 1946 this publisher considered (in the Preface to his reprint of Vald~s' Dicilogo de Doctrina Cristiana, p. 12) republishing also Vald6s' Ciento y diez consideraciones divinas. PAUL T. FUrIRMAN~ Columbia Theological Seminary Descartes. Oeuvres philosophiques. Tome I (1618-1637.) Textes 6tablis, pr6sent6s et annot6s par Ferdinand Alqui6. l~dition illustr6e. (Paris: Garnier Fr6res, 1965. [Glassiques Garnier.] Pp. 829 + 12 plates.) The publication of this massive paperbound volume is an event in Descartes studies. It is the first in a three-volume edition of Descartes' complete philosophical works in French, an edition which is original in its plan, up-to-date in scholarship, worked from the sources, and superbly annotated, the only truly new edition since Charles Adam completed the great AT in 1913. Professor Alqui6 defines the word "philosophical" almost as broadly as Descartes did. To the specifically philosophical texts he adds generous portions of the non-mathematical scientific works. All Latin texts are given in French translation (the Meditations are to appear bilingually.) The spelling is modern. The AT pagination appears in the margin, but the volume number should be given there too. Scholars working with AT and AM (Adam-Milhaud's Correspondance de D.) should take note of the textual corrections and emendations in this Edition dlquid. In the battle of Descartes interpretation Professor Alqui6 takes the chronological stand. Where Martial Gueroult sees a marvellously wrought monolithic system, there Alqui6 sees development and growth: to understand Descartes one must follow his "itin6raire philosophique" step by step. In his new role as editor he practices what he preached. This is the first edition to take us in unbroken, rigorously chronological sequence from the first extant writing through the year of the Discours de la mdthode. Even the correspondence is broken up and inserted between the writings in its chronological place. (Just about half of Descartes' letters of this period--none written to him--are given:.58 as against 27 in the Pl6i'ade edition.) The volume opens with a few (too few) paragraphs from the Compendium Musicae of 1618 and sections from the Cogitationes privatae, including the complete text of Baillet's account of the Dream of Descartes. The Regulae appear in a new, annotated translation by Jacques Brunschvicg. Le Monde et le Traitd de l'Homme, treated as one manuscript, is here, all but complete. After the Discours de la mdthode we get the first six chapters of the Dioptrique and four of the ten chapters of Mdtdores. All omitted chapters are summarized. The little Traitd de la m~canique brings up the rear. The missing Gdom(trie is to appear in a companion volume of collected mathematical writings, promised for some later date. The reader who never read all of Descartes' writings between 1618 and 1637 in fl~eir chronological order will find a new vista opening up. This is particularly true of the sixty-odd pages of earliest writings. But here the editor's principle of excluding "mathematical " texts works against his clear intention of keeping interpretation out: "Une ~dition BOOK REVIEWS 261 de Descartes," he writes, "n'est pas une th~se sur la philosophie de Descartes." Alqui6 here (and only here) excludes not only all purely mathematical texts but also those on mechanics, optics, acoustics, hydraulics, automata, etc., and even epistemologically significant items like "hi omni questione debet dari aliquod medium," "Si funis," and the full text of the ars memoriae passage. The only exception is Descartes' answer to Beeckman's problem regarding free fall, truncated at the point where Descartes with the characteristic dlan of these years continues: "Ut autem hujus scientiae fundamenta jaciam...". AlquiCs general justification for the exclusion of "mathematics" rests upon the evidence that Descartes himself... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:82 HISTORY OF PHILOSOPHY phy) than the aspects considered in the earlier chapters. The attempts of these men to formulate theories of the cosmos and of natural phenomena, to take the place of Aristotle's natural philosophy, are described as honest and original speculative endeavors, with a few features which can be construed as anticipations of seventeenth-century scientific philosophy, but basically lacking the soundness of method and evidence that could (...) make them adequate substitutes for the Aristotelian system. "The Aristotelian tradition of natural philosophy," as Kristeller states, "was not overthrown by the outside attacks of the humanists or Platonists, nor by the suggestive theories of the natural philosophers. It yielded only in and after the seven~ teenth century, when the new science of Galileo and his successors was able to deal with its subject matter on the basis of a firmly established and superior method" (p. 96). All of the essays in this book are distinguished by their concern for historical truth and objectivity, by their attempt to present the thought of the eight authors in the context of the times and in terms of the interests and purposes of the writers themselves, and by the rich and enlightened perspectives of historical understanding brought to bear on the subjects discussed. But what is most attractive, and indeed striking, in this work of Kristeller, as in the other books and essays he has written on Renaissance thought, is his own conviction that the cultural and philosophical ideals which characterized the Italian Renaissance are of intrinsic and enduring value in their own right.Unlike many other expositers and partisans of Renaissance thought, who extol it because it anticipated modem science, or because it was secularist,or anti-scholastic, or "this-worldly"rather than "other-worldly", Kristeller admires it for just what it was. And to those who define philosophy as logical analysis, or as existentialism,or as pragmatism or neo=seholasticism, and on that basis claim that the Italian Renaissance made no contribution to philosophy, Kristeliermakes no apologies. There is no necessary repugnance between scholarship and philosophy, or between original thought and an understanding and appreciation of the classics,nor is cultural barbarism a necessary prerequisite of the pursuit of truth. The values which Kristellerdefends in our time are very much those which Erasmus defended in the sixteenth century. "There is such a thing as the autonomy of culture," Kristeller remarks (p. 94), "and it has always been the task and duty of scholars to defend this territory against the deeper inroads of religious and politicalinfluences." The inroads in our time have been made by differentfanaticisms than those of the sixteenth century, but the defense of the integrity of scholarship and of liberal culture has been a task and duty to which Paul Kristeller has been faithful throughout his long and fruitfulcareer. ER~S~ A. MooDY University of California, Los Angeles Ren$ Descartes: Regulae ad direct~onem ingenii. Texte critique ~tabli par Giovanni Crapulli, avec la version hollandaise du XVH ~m~ si~ele. (La Haye: Martinus Nijhoff, 1966. -" Archives Intemationales d'histeire des iddes, t. 12. Pp. xxxiii + 80 + 80* + 40. Guilders 38.75.) This edition of the Regulae is important because for the first time since the great AdamTannery edition of 1896--1913 a major work of Descartes has been independently re-edited from the sources according to the most advanced editorial principles. The historian of philosophy -the user--will ask four questions: (1) Why a new edition? (2) What does it offer? (3) How does it affect the AT text? (4) What edition should be used and cited? Here briefly, are the answers as one user sees them. 1. The Regulae were posthumously published in 1701. Besides this edito princeps (A) there exists the so-called Hanover manuscript (H) with emendations by Leibniz (L). These were kdam's sources. But the Regulae became known first through the Dutch translation of Glazemaker, published in 1684 (N) which Adam knew but did not use. This led Dr. Crapulli to a review of the whole editorial problem. He concluded that A, H and N were prepared from BOOK REVIEWS 83 three different manuscripts, none of them Descartes's original (which is lost... (shrink)

Book review on Pavel Gregorić – George Karamanolis (vyd.) Pseudo-Aristotle: De Mundo (On The Cosmos). A Commentary. Cambridge (Cambridge University Press) 2021, 245 str.

Este libro, resultado de un esfuerzo compartido por diversas instituciones, investigadores y editores, encabezados por el Grupo de Investigación E Pluribus Unum? Ethnic Identities in Transnational Integration Processes in the Americas de la Universidad de Bielefeld, trata un tema central para el futuro de nuestras mestizas sociedades latinoamericanas: la necesaria construcción -en el presente que vivimos- de la interculturalidad en nuestra América Latina. Esto en el nuevo contexto donde los ..

The ideal of value free science states that the justification of scientific findings should not be based on non-epistemic (e.g. moral or political) values. It has been criticized on the grounds that scientists have to employ moral judgements in managing inductive risks. The paper seeks to defuse this methodological critique. Allegedly value-laden decisions can be systematically avoided, it argues, by making uncertainties explicit and articulating findings carefully. Such careful uncertainty articulation, understood as a methodological strategy, is exemplified by the current (...) practice of the Intergovernmental Panel on Climate Change (IPCC). (shrink)

I. The framework. 1, Aristotle's project and methods. 2, The perceptual capacity of the soul. 3, The sensory apparatus. 4, The common sense and the related capacities -- II. The terminology. 1, Overlooked occurrences of the phrase 'common sense'. 2, De anima III.1 425a27. 3, De partibus animalium IV.10 686a31. 4, De memoria et reminiscentia 1 450a10. 5, De anima III.7 431b5. 6, Conclusions on the terminology -- III. Functions of the common sense. 1, Simultaneous perception and cross-modal binding. 2, (...) Perceptual discrimination. 3, Waking, sleep, and control of the senses. 4, Perceiving that what we see and hear, and monitoring of the senses. 5, Other roles of the common sense -- Conclusion. (shrink)

In 1936 R.A.Fisher asked the pointed question, "Has Mendel's Work Been Rediscovered?" The query was intended to open for discussion whether someone altered the data in Gregor Mendel's classic 1866 research report on the garden pea, "Experiments in Plant-Hybridization." Fisher concluded, reluctantly, that the statistical counts in Mendel's paper were doctored in order to create a better intuitive fit between Mendelian expected values and observed frequencies. That verdict remains the received view among statisticians, so I believe. Fisher's analysis is a (...) tour de force of so-called "Goodness of Fit" statistical tests using c2 to calculate significance levels, i.e., P-values. In this presentation I attempt a defense of Mendel's report, based on several themes. (1) Mendel's experiments include some important sequential design features that Fisher ignores. (2) Fisher uses particular statistical techniques of Meta-analysis for pooling outcomes from different experiments. These methods are subject to critical debate. and (3) I speculate on a small modification to Mendelian theory that offers some relief from Fisher's harsh conclusion that Mendel's data are too good to be true. (shrink)

When does a human being begin to exist? Barry Smith and Berit Brogaard have argued that it is possible, through a combination of biological fact and philosophical analysis, to provide a definitive answer to this question. In their view, a human individual begins to exist at gastrulation, i. e. at about sixteen days after fertilization. In this paper we argue that even granting Smith and Brogaard's ontological commitments and biological assumptions, the existence of a human being can be shown to (...) begin much earlier, viz., with fertilization. Their interpretative claim that a zygote divides immediately into two substances and therefore ceases to exist is highly implausible by their own standards, and their factual claim that there is no communication between the blastomeres has to be abandoned in light of recent embryological research. (shrink)

In the debate about the moral status of human embryos, it is not always clear which arguments are actually disputed. This book offers students and researchers, but also laypersons interested in the current debate, the opportunity to inform themselves about the current state of discussion and to learn about the most important arguments in a clear and concise form. These arguments are as follows: Since embryos as members of the species homo sapiens sapiens are human beings, they possess dignity (species (...) argument); embryos develop continuously, i.e. without morally relevant incisions, into adult human beings possessing dignity (continuum argument); embryos are identical with adult human beings possessing dignity (identity argument); embryos have the potential to become human beings, and this potential is without restriction worth protecting (potentiality argument). These arguments are each represented by a pro position and a contra position and defended or criticized. In an accompanying contribution by the editors, the four arguments in context are reconstructed, evaluated, and supported by new arguments. (shrink)

By means of multi-agent simulations, it investigates the truth and consensus-conduciveness of controversial debates. The book brings together research in formal epistemology and argumentation theory.

As climate policy decisions are decisions under uncertainty, being based on a range of future climate change scenarios, it becomes a crucial question how to set up this scenario range. Failing to comply with the precautionary principle, the scenario methodology widely used in the Third Assessment Report of the International Panel on Climate Change (IPCC) seems to violate international environmental law, in particular a provision of the United Nations Framework Convention on Climate Change. To place climate policy advice on a (...) sound methodological basis would imply that climate simulations which are based on complex climate models had, in stark contrast to their current hegemony, hardly an epistemic role to play in climate scenario analysis at all. Their main function might actually consist in ‘foreseeing future ozone-holes’. In order to argue for these theses, I explain first of all the plurality of climate models used in climate science by the failure to avoid the problem of underdetermination. As a consequence, climate simulation results have to be interpreted as modal sentences, stating what is possibly true of our climate system. This indicates that climate policy decisions are decisions under uncertainty. Two general methodological principles which may guide the construction of the scenario range are formulated and contrasted with each other: modal inductivism and modal falsificationism. I argue that modal inductivism, being the methodology implicitly underlying the third IPCC report, is severely flawed. Modal falsificationism, representing the sound alternative, would in turn require an overhaul of the IPCC practice. (shrink)

This article discusses how inference to the best explanation can be justified as a practical meta - argument. It is, firstly, justified as a practical argument insofar as accepting the best explanation as true can be shown to further a specific aim. And because this aim is a discursive one which proponents can rationally pursue in — and relative to — a complex controversy, namely maximising the robustness of one’s position, IBE can be conceived, secondly, as a meta - argument. (...) My analysis thus bears a certain analogy to Sellars ’ well - known justification of inductive reasoning ; it is based on recently developed theories of complex argumentation. (shrink)

This chapter goes into crucial questions related to the impact of technology on our privacy, our personal identity and our social relationships. While technology often seems extremely convenient in helping us remember things and share our experiences with others, this episode shows that it can have highly undesirable side‐effects as well. Technologies like the grain put inevitable pressures not only on privacy and trust but also on our ability to create and tell our life stories. In this chapter, we show (...) how getting to know each other's entire history and achieving full transparency about ourselves and others will likely destroy crucial and valuable aspects of our social lives. (shrink)

Suppose a fire broke out in a fertility clinic. One had time to save either a young girl, or a tray of ten human embryos. Would it be wrong to save the girl? According to Michael Sandel, the moral intuition is to save the girl; what is more, one ought to do so, and this demonstrates that human embryos do not possess full personhood, and hence deserve only limited respect and may be killed for medical research. We will argue, however, (...) that no relevant ethical implications can be drawn from the thought experiment. It demonstrates neither that one always ought to let the embryos die, nor does it allow for any general conclusion concerning the moral status of human embryos. (shrink)

Zusammenfassung Fußballfans bilden eine eigene Subkultur, die sich selbst noch einmal im Fußballstadion von den anderen Zuschauern als soziale Gruppierung unterscheidet. Ausgehend von Schütz’s Lebensweltbegriff wird die Fankultur als ein geschlossenes Sinngebiet mit einem eigenen Realitätsakzent sowie einem besonderen Erkenntnis- und Erlebnisstil aufgefasst. Der vorliegende Beitrag analysiert die konstitutiven Elemente dieser fanspezifischen Lebenswelt am Beispiel der Fangemeinschaft des FC Energie Cottbus. Die dort beobachteten Rituale, symbolischen Darstellungsmittel, Selbstinszenierungen und Kollektivausdrücke stellen die Konstitutionsbedingungen für einen gemeinsamen Wirklichkeitsentwurf dar. Es wird gezeigt, (...) dass es der Fankultur, trotz der ständigen Spielerwechsel und fortschreitenden Ökonomisierung im Fußball, keineswegs an Vielfalt und identitätsstiftenden Orientierungen fehlt. (shrink)

In der Reihe werden herausragende monographische Untersuchungen und Sammelbände zu allen Aspekten der Philosophie Kants veröffentlicht, ebenso zum systematischen Verhältnis seiner Philosophie zu anderen philosophischen Ansätzen in Geschichte und Gegenwart. Veröffentlicht werden Studien, die einen innovativen Charakter haben und ausdrückliche Desiderate der Forschung erfüllen. Die Publikationen repräsentieren den aktuellsten Stand der Forschung.

Die dritte, vollständig überarbeitete Auflage des bewährten Studienbuches wurde um elf Einträge erweitert: Abduktion (Schluss auf die beste Erklärung), Clusterdefinition, Experimentelle Philosophie, Explikation, Kontextdefinition, Kriterien, Methode, Naturalistischer Fehlschluss, Neologismus, notwendig und hinreichend – mengentheoretisch und Stipulative Definition. Zudem enthält der Band einen wertvollen Anhang mit einem philosophischen Kanon, den wichtigsten logischen Regeln und einem umfangreichen Register, das neben den deutschen auch alle wichtigen englischen Fachbegriffe umfasst. Wer philosophieren will, muss, methodisch betrachtet, vor allem drei Dinge tun: analysieren, argumentieren und interpretieren. (...) Jede Person – ob Anfänger/in, Schüler/in, Student/in oder fortgeschrittene/r Wissenschaftler/in – kann mit diesem Buch lernen, Begriffe zu analysieren, Argumente zu verstehen, zu bewerten und zu entwickeln. Im Unterschied zu anderen Einführungsbüchern kommt auch die Interpretation zu ihrem vollen Recht. Mit diesem Buch können die Methoden der Philosophie praxisnah gelernt und geübt werden. Es präsentiert deshalb so etwas wie einen methodischen Werkzeugkasten, der sich ausgezeichnet für die Schule, die Universität und auch das Selbststudium eignet. (shrink)