We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

A classic exposition of Kant's ethical thought.

The present volume contains the lectures and papers given at the 1994 international conference on hermeneutics in Halle (Germany). The conference aimed at a state of the art in the light of recent developments in science and humanities. The place in which the conference was held is renowned for its centuries-old tradition in hermeneutics and among the lectures there are indeed some devoted to this history. For the most part, however, the papers concentrate on present-day problems in fields as different (...) as comparative literature, religious studies, bible exegesis, esthetics, social sciences, intercultural dialogue. The theme of the conference, "strangeness and familiarity", reflects the tension in which any interpretation process is situated and that any theory of interpretation has to account for. The contributions to the volume are in German and French. (shrink)

M. Tulli Ciceronis libri qui ad rem publicam et ad philosophiam spectant; vol. ix. Cato Maior de Senectute, Laelius de Amicitia; 50 Pf. vol. x. De Officiis; 80 Pf. ed. Th. Schiche, Leipzig, Freytag.M. Tulli Ciceronis Orationes Selectae; vol. i. Oratio pro Sex. Roscio Arnerino; 30 Pf. vol. ii. In Q. Caecilium Diuinatio, in C. Verrem Accusationis, Lib. iv. v.; ed. H. Nohl; 80 Pf. Leipzig, Freytag.M. Tulli Ciceronis Scripta quae remanserunt omnia. Recognovit C. F. W. Mueller. Partis ii. vol. (...) iii. Leipzig, Teubner, 1886. 2 Mk. 10. (shrink)

CHAPTER INTRODUCTION At first sight Plotinus' philosophy is full of contradictions. The same entity will appear with different characteristics in different ...

Originally published: London: Allen & Unwin, 1936.

This old difficulty has recently received a new explanation from the pen of Dr. E. G. Hardy . Dr. Hardy believes—and his view has met with some acceptance—that the disability, under which these Gallic candidates for admission to the Senate laboured, was the want of a municipalis origo. Up to this time, he contends, only Romans who were members of a town of Roman or Latin rights were eligible for admission to the Senate. Now in the Tres Galliae there were (...) practically no such towns: these Gallic chiefs possessed the ciuitas individually by special grant and not as members of any municipality. Hence the door of the curia was closed to them while it was open to Romans from Lugdunum or Vienna. (shrink)

In the Classical Quarterly of April, 1914, I ventured to call in question the explanation of this well-known difficulty put forward by Dr. E G. Hardy in his Roman Laws and Charters. Dr. Hardy has done me the honour of replying to my article in the October Quarterly, but his lengthy argument entirely fails to convince me.

This old difficulty has recently received a new explanation from the pen of Dr. E. G. Hardy. Dr. Hardy believes—and his view has met with some acceptance—that the disability, under which these Gallic candidates for admission to the Senate laboured, was the want of a municipalis origo. Up to this time, he contends, only Romans who were members of a town of Roman or Latin rights were eligible for admission to the Senate. Now in the Tres Galliae there were practically (...) no such towns: these Gallic chiefs possessed the ciuitas individually by special grant and not as members of any municipality. Hence the door of the curia was closed to them while it was open to Romans from Lugdunum or Vienna. (shrink)

This scarce antiquarian book is a facsimile reprint of the original. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment for protecting, preserving, and promoting the world's literature in affordable, high quality, modern editions that are true to the original work.

Introduction: why the De anima commentaries? This book will concentrate on interpretations of the De anima in late antiquity, and what we can learn from ...

The long-term persistence of neurotic symptoms, such as anxiety, poses difficult problems for any psychological theory. An attempt is made to revive the Watson-Mowrer conditioning theory and to avoid the many criticisms directed against it in the past. It is suggested that recent research has produced changes in learning theory that can be used to render this possible. In the first place, the doctrine of equipotentiality has been shown to be wrong, and some such concept as Seligman's “preparedness” is required, (...) that is the notion that certain CS are biologically prepared to be more readily connected with anxiety responses than others. In the second place, the law of extinction has to be amended, and the law of incubation or enhancement added, according to which the exposure of the CS-only may, under certain specified conditions, have the effect of increasing the strength of the CR, rather than reducing it. The major conditions favouring incubation are Pavlovian B conditioning, that is a type of conditioning in which the CR is a drive; a strong UCS, and short exposure of the CS-only. (shrink)

The relative neglect of Greek commentary by modern Aristotelian scholarship could be justified, if only the neglectors had sufficient knowledge of the material they disdain. The curt dismissal of ancient views on the active intellect by W. D. Ross is perhaps a paradigm case of misplaced condemnation, for he evidently failed to take account of what their authors were about. It would be open to those who wish to discount these commentators to argue that they were, to a greater or (...) lesser extent, influenced by their Neoplatonism, and that this impairs their judgment on Aristotelian problems. But that would not be sufficient ground for total neglect: it merely indicates the need for careful utilization. One might go so far as to ask whether it is not perfectly possible for a commentator who happened to be a Neoplatonist to offer straightforward and reasonably unbiased commentary on Aristotle. Even if the answer to that question were negative, is it not likely that such Neoplatonic views as he read into Aristotle would at least be slanted towards Aristotelianism? (shrink)