In this open peer commentary, we categorize the possible “neuroscience in national security” definitions of misuse of science and identify which, if any, are uniquely presented by advances in neuroscience. To define misuse, we first define what we would consider appropriate use: the application of reasonably safe and effective technology, based on valid and reliable scientific research, to serve a legitimate end. This definition presents distinct opportunities for assessing misuse: misuse is the application of invalid or unreliable science, or is (...) the use of reliable scientific methods to serve illegitimate ends. Ultimately, we conclude that while national security is often a politicized issue, assessing the state of scientific progress should not be. (shrink)

The current informal practice of pharmacometrics as a combination art and science makes it hard to appreciate the role that informatics can and should play in the future of the discipline and to comprehend the gaps that exist because of its absence. The development of pharmacometric informatics has important implications for expediting decision making and for improving the reliability of decisions made in model-based development. We argue that well-defined informatics for pharmacometrics can lead to much needed improvements in the efficiency, (...) effectiveness, and reliability of the pharmacometrics process. The purpose of this paper is to provide a description of the pervasive yet often poorly appreciated role of informatics in improving the process of data assembly, a critical task in the delivery of pharmacometric analysis results. First, we provide a brief description of the pharmacometric analysis process. Second, we describe the business processes required to create analysis-ready data sets for the pharmacometrician. Third, we describe selected informatic elements required to support the pharmacometrics and data assembly processes. Finally, we offer specific suggestions for performing a systematic analysis of existing challenges as an approach to defi ning the next generation of pharmacometric informatics. (shrink)

This book is devoted to a different proposal--that the logical structure of the scientist's method should guarantee eventual arrival at the truth given the scientist's background assumptions.

To achieve impact, academics need to create personal impact development plans, focused on what and on whom to have an impact and the necessary competencies to do so. Profession and university leaders play a critical role in the successful implementation of such plans.

In this paper, I explore the question of whether the expected consequences of holding a belief can affect the rationality of doing so. Special attention is given to various ways in which one might attempt to exert some measure of control over what one believes and the normative status of the beliefs that result from the successful execution of such projects. I argue that the lessons which emerge from thinking about the case ofbelief have important implications for the way we (...) should think about the rationality of a number of other propositional attitudes,such as regret, desire, and fear. Finally,I suggest that a lack of clarity with respect to the relevant issues has given rise to a number of rather serious philosophical mistakes. (shrink)

The passage above comes from the opening pages of Merleau-Ponty’s essay on Edmund Husserl. It proposes a risky interpretive principle. The main feature of this principle is that the seminal aspects of a thinker’s work are so close to him that he is incapable of articulating them himself. Nevertheless, these aspects pervade the work, give it its style, its sense and its direction, and therefore belong to it essentially. As Martin Heidegger writes, in a passage quoted by Merleau-Ponty: " The (...) greater the work of a thinker – which in no way coincides with the breadth and number of writings – the richer is what is un-thought in this work, which means, that which emerges in and through this work as having not yet been thought. 2 " The goal of Merleau-Ponty’s essay, he says, is “to evoke this un-thought-of element in Husserl’s thought”. 3. (shrink)

I begin by examining a recent debate between John McDowell and Christopher Peacocke over whether the content of perceptual experience is non-conceptual. Although I am sympathetic to Peacocke’s claim that perceptual content is non-conceptual, I suggest a number of ways in which his arguments fail to make that case. This failure stems from an over-emphasis on the "fine-grainedness" of perceptual content - a feature that is relatively unimportant to its non-conceptual structure. I go on to describe two other features of (...) perceptual experience that are more likely to be relevant to the claim that perceptual content is non-conceptual. These features are 1) the dependence of a perceived object on the perceptual context in which it is perceived and 2) the dependence of a perceived property on the object it is perceived to be a property of. (shrink)

A number of authors have argued recently that the content of perceptual experience can, and even must, be characterized in conceptual terms. Their claim, more precisely, is that every perceptual experience is such that, of necessity, its content is constituted entirely by concepts possessed by the subject having the experience. This is a surprising result. For it seems reasonable to think that a subject’s experiences could be richer and more fine-grained than his conceptual repertoire; that a subject might be able, (...) for example, to discriminate in experience more shades of colors than he has color concepts. The key move in their argument, therefore, is to articulate the conceptual content of experience using demonstrative, instead of general, concepts. For instance, these authors argue that the content of my perceptual experience of a particular shade of green is properly characterized in terms of the concept expressed by the linguistic utterance “that shade”. Even if I don’t possess a general concept for the shade I’m seeing—a concept of the kind typically expressed using color names like ‘chartreuse’ or ‘lime’—nevertheless, these authors argue, the content of the experience can still be characterized conceptually using a demonstrative concept that I do possess. (shrink)

The scientific, personal, and social implications of this revolutionary work are staggering. MARGINS OF REALITY is nothing less than a fundamental reevaluation of how the world really works.

There you are at the opera house. The soprano has just hit her high note – a glassshattering high C that fills the hall – and she holds it. She holds it. She holds it. She holds it. She holds it. She holds the note for such a long time that after a while a funny thing happens: you no longer seem only to hear it, the note as it is currently sounding, that glass-shattering high C that is loud and (...) high and pure. In addition, you also seem to hear something more. It is difficult to express precisely what this extra feature is. One is tempted to say, however, that the note now sounds like it has been going on for a very long time. Perhaps it even sounds like a note that has been going on for too long. In any event, what you hear no longer seems to be limited to the pitch, timbre, loudness, and other strictly audible qualities of the note. You seem in addition to experience, even to hear, something about its temporal extent. (shrink)

Challenging the undesirability of disability is a shared responsibility that requires us to imagine disability differently. In order to imagine disability differently, we need to understand how the neoliberal hegemonic social imagination—key to processes that create good disabled and able-bodied neoliberal subjects—works to curtail who is perceived to have a desirable body. In order to desire disability differently, we must begin with marginal, heterotopic imaginations whereby disability is not something to overcome, but rather is part of a life worth living. (...) In this article, I build on Foucault’s concepts of heterotopia, milieu, and the government of things, and Karen Barad’s agential realism, as well as draw on the work of Mel Chen and Rod Michalko in order to argue that the heterotopic imagination reconfigures how we consider disability to emerge, with whom, and where. By mobilising the heterotopic imagination, we can come to recognise that disability does not emerge as an individualised human body, but rather is an intracorporeal, non-anthropocentric multiplicity. To desire disability differently through the heterotopic imagination is not simply to allow the current formulation of disability to become desirable, but rather to radically alter how we desire disability, in addition to altering what disability is, how it is practised, and what it can be. (shrink)

Theoretical explication of a growing body of empirical data on consciousness-related anomalous phenomena is unlikely to be achieved in terms of known physical processes. Rather, it will first be necessary to formulate the basic role of consciousness in the definition of reality before such anomalous experience can adequately be represented. This paper takes the position that reality is constituted only in the interaction of consciousness with its environment, and therefore that any scheme of conceptual organization developed to represent that reality (...) must reflect the processes of consciousness as well as those of its environment. In this spirit, the concepts and formalisms of elementary quantum mechanics, as originally proposed to explain anomalous atomic-scale physical phenomena, are appropriated via metaphor to represent the general characteristics of consciousness interacting with any environment. More specifically, if consciousness is represented by a quantum mechanical wave function, and its environment by an appropriate potential profile, Schrödinger wave mechanics defines eigenfunctions and eigenvalues that can be associated with the cognitive and emotional experiences of that consciousness in that environment. To articulate this metaphor it is necessary to associate certain aspects of the formalism, such as the coordinate system, the quantum numbers, and even the metric itself, with various impressionistic descriptors of consciousness, such as its intensity, perspective, approach/avoidance attitude, balance between cognitive and emotional activity, and receptive/assertive disposition. With these established, a number of the generic features of quantum mechanics, such as the wave/particle duality, and the uncertainty, indistinguishability, and exclusion principles, display metaphoric relevance to familiar individual and collective experiences. Similarly, such traditional quantum theoretic exercises as the central force field and atomic structure, covalent molecular bonds, barrier penetration, and quantum statistical collective behavior become useful analogies for representation of a variety of consciousness experiences, both normal and anomalous, and for the design of experiments to study these systematically. (shrink)

Epistemic luck has been the focus of much discussion recently. Perhaps the most general knowledge-precluding type is veritic luck, where a belief is true but might easily have been false. Veritic luck has two sources, and so eliminating it requires two distinct conditions for a theory of knowledge. I argue that, when one sets out those conditions properly, a solution to the generality problem for reliabilism emerges.

ABSTRACT This essay thinks through the relationship between dystopia and utopia, in particular, how the constellation of past and present in radical demands amid state and economic violence is that which creates “crisis”—an estrangement from the present, a reclaiming of past insurgency, and the possibilities for other worlds.

Postural instability in Parkinson’s disease (PD) is characterized by impaired postural responses to transient perturbations, increased postural sway in stance and difficulty transitioning between tasks. In addition, some studies suggest that loss of dopamine in the basal ganglia due to PD results in difficulty using proprioceptive information for motor control. Here, we quantify the ability of subjects with PD and age-matched control subjects to use and re-weight sensory information for postural control during steady-state conditions of continuous rotations of the stance (...) surface or visual surround. We measure the postural sway of subjects in response to a pseudorandom, surface-tilt stimulus with eyes closed, and in response to a pseudorandom, visual-tilt stimulus. We use a feedback control model of the postural control system to interpret our results, focusing on sensory weighting as a function of stimulus amplitude. We find that subjects with PD can re-weight their dependence upon sensory information in response to changes in surface- or visual-stimulus amplitude. Specifically, subjects with PD behaved like age-matched control subjects by decreasing proprioceptive contribution to stance control with increasing surface-tilt amplitude, and decreasing visual contribution with increasing visual-tilt amplitude. However, subjects with PD do not decrease their reliance on proprioception as much as age-matched controls for small increases in surface-stimulus amplitudes. Levodopa medication did not affect sensory re-weighting behaviors for postural control. The impairment in PD subject’s ability to respond differently to small changes in surface rotation amplitudes is consistent with an increased threshold for perceiving proprioceptive signals, which may result from decreased signal-to-noise in the dopaminergic pathways associated with sensory processing and/or sensory integration. (shrink)

In the dissertation I explore three central issues in Plotinus' philosophical psychology: The fall of the soul, the relationships of soul and body, and the concept of the ego. ;Chapter 1 introduces the issues. Chapter 2 argues for a dual-aspect theory about the soul's fall. Chapter 3 characterizes the relationships between soul and body. Much of the chapter is devoted to distancing Plotinus' dualism from Cartesian dualism. The chapter ends with a discussion of Plotinus on perception. Chapter 4 investigates the (...) concept of the ego, the function of the ego in union with the One, and the relationship between the ego and the other powers of the soul. (shrink)

Background As our society is ageing, nursing homes are finding it increasingly difficult to deal with an expanding population of patients with dementia and a decreasing workforce. A potential answer to this problem might lie in the use of technology. However, the use and application of surveillance technology in dementia care has led to considerable ethical debate among healthcare professionals and ethicists, with no clear consensus to date. Aim To explore how surveillance technology is viewed by care professionals and ethicists (...) working in the field, by investigating the ideal application of surveillance technology in the residential care of people with dementia. Methods Use was made of the concept mapping method, a computer-assisted procedure consisting of five steps: brainstorming, prioritising, clustering, processing by the computer and analysis. Various participants (ranging from ethicists to physicians and nurses) were invited on the basis of their professional background. Results The views generated are grouped into six categories ranging from the need for a right balance between freedom and security, to be beneficial and tailored to the resident, and clearly defined procedures to competent and caring personnel, active monitoring and clear normative guidance. The results are presented in the form of a graphic chart. Conclusions There appears to be an inherent duality in the views on using surveillance technology which is rooted in the moral conflict between safety and freedom. Elaboration of this ethical issue has proved to be very difficult. (shrink)

One construal of convergent realism is that for each clear question, scientific inquiry eventually answers it. In this paper we adapt the techniques of formal learning theory to determine in a precise manner the circumstances under which this ideal is achievable. In particular, we define two criteria of convergence to the truth on the basis of evidence. The first, which we call EA convergence, demands that the theorist converge to the complete truth "all at once". The second, which we call (...) AE convergence, demands only that for every sentence in the theorist's language, there is a time at which the theorist settles the status of the sentence. The relative difficulties of these criteria are compared for effective and ineffective agents. We then examine in detail how the enrichment of an agent's hypothesis language makes the task of converging to the truth more difficult. In particular, we parametrize first-order languages by predicate and function symbol arity, presence or absence of identity, and quantifier prefix complexity. For nearly each choice of values of these parameters, we determine the senses in which effective and ineffective agents can converge to the complete truth on an arbitrary structure for the language. Finally, we sketch directions in which our learning theoretic setting can be generalized or made more realistic. (shrink)

This article claims that Asha Bhandary’s theory of justice in Freedom to Care: Liberalism, Dependency Care, and Culture is right to stress the interdependency of justice and care in addressing structural oppressions, but wrong in upholding liberalism’s capacity for doing so. Against her procedural mechanism of education for caregiving skills in particular, I point to the critical and generative methods of social reproduction feminism and Transformative Justice as models of radical praxis in the collective work of politically centering and radically (...) transforming cultures of care. (shrink)

In the academic world, a researcher's number of publications can carry huge professional and financial rewards. This truth has led to many unethical authorship assignments throughout the world of publishing, including within faculty-student collaborations. Although the American Psychological Association passed a revised code of ethics in 1992 with special rules pertaining to such collaborative efforts, it is widely acknowledged that unethical assignments of authorship credit continue to occur regularly. This study found that of the 604 APA-member respondents, 165 felt they (...) had been involved in an unethical or unfair authorship assignment. Furthermore, nontenured faculty members and women were statistically more likely to be involved in an unethical or unfair assignment of authorship credit than tenured faculty members or men. (shrink)

The French medical context is characterized by institutionalization of the ethical reflection in health care facilities and an important disparity between spaces of ethical reflection. In theory, the healthcare professional may mobilise an arsenal of resources to help him in his ethical reflection. But what happens in practice? We conducted semi-structured interviews with 22 health-care professionals who did and did not have recourse to clinical ethical committees. We also implemented two focus groups with 18 professionals involved in various spaces of (...) ethical reflection in order to let them debate about a better way to organize ethical reflection in their institutional contexts. The qualitative analysis allows to us to underline the coexistence of different conceptions of ethics among health care professionals. We also observed that the participants in our study shared the experience of ethically problematic situations as roadblocks in the process of communication and decision-making. We therefore report the factors which favour or inhibit the ethical course leading to the resolution or at the very least soothing of the situation at hand. Finally, we discuss methodological issues and underline the fact that while the patient is at the heart of the professional’s ethical preoccupations, this does not imply that they are actors in decisions that concern them. (shrink)

Arthur C. Danto is unique among philosophers for the breadth of his philosophical mind, his eloquent writing style, and the generous spirit embodied in all his work. Any collection of essays on his philosophy has to engage him on all these levels, because this is how he has always engaged the world, as a philosopher and person. In this volume, renowned philosophers and art historians revisit Danto's theories of art, action, and history, and the depth of his innovation as a (...) philosopher of culture. Essays explore the importance of Danto's philosophy and criticism for the contemporary art world, along with his theories of perception, action, historical knowledge, and, most importantly for Danto himself, the conceptual connections among these topics. Danto himself continues the conversation by adding his own commentary to each essay, extending the debate with characteristic insight, graciousness, and wit. Contributors include Frank Ankersmit, Hans Belting, Stanley Cavell, Donald Davidson, Lydia Goehr, Gregg Horowitz, Philip Kitcher, Daniel Immerwahr, Daniel Herwitz, and Michael Kelly, testifying to the far-reaching effects of Danto's thought. Danto brought to philosophy the artist's unfettered imagination, and his ideas about postmodern culture are virtual road maps of the present art world. This volume pays tribute to both Danto's brilliant capacity to move between philosophy and contemporary culture and his pathbreaking achievements in philosophy, art history, and art criticism. (shrink)

Understanding how a nurse acts in a particular situation reveals how nurses enact their ethics in day-to-day nursing. Our ethical frameworks assist us when we experience serious ethical dilemmas. Yet how a nurse responds in situations of daily practice is contingent upon all the presenting cues that build the current moment. In this article, we look at how a home care nurse responds to the ethical opening that arises when the nurse enters a person’s home. We discuss how the home (...) presents the nurse with knowledge that informs the provision of ethical nursing care. The analysis is based on findings from an interpretive research study in palliative home care in Canada. Through interpretive analysis of a nursing situation we delineate how the nurse engages with the whole and acts inside the moment. The analysis shows how home care nurses are ethically determined to engage with whatever is going on in a patient’s home. (shrink)

Working against both Hegelian recognition and ethics based on vulnerability, I argue for response ethics or an ethics of ambivalence. While the ideal of mutual recognition is admirable, in practice, recognition is experienced as conferred by the very groups and institutions responsible for withholding it in the first place. In other words, recognition is distributed according to an axis of power that is part and parcel of systems of dominance and oppression. I both challenge the concept of vulnerability as exclusive (...) to, or constitutive of, humanity, on the one hand, and criticize the concept for leveling differences in levels of vulnerability, on the other. (shrink)

The development of the emerging science of ecology influenced the later work of both Heidegger and Merleau-Ponty. Both use zoology, biology, and ecology intheir attempts to navigate between mechanism and vitalism, but their interpretations and use of the life sciences take them on divergent paths and lead them to radically different conclusions regarding the relationship between man and animal. This essay takes up the problematic of kinship with animals in Heidegger and Merleau-Ponty. Beyond the texts of these two thinkers are (...) the more general stakes of the relationships between humans and animals and the question of whether or not animals can be our kin. (shrink)