The commentator’s motivation for accompanying Varela in a foray into immunology lay in the clear-cut, value-laden contrast between traditional immunology and the new organism-centred view pioneered by Vaz and Coutinho. In the twenty years that have elapsed, models have become increasingly complicated so that this clear-cut contrast has been obscured. In immunology as in cognitive science, the radicality of Varela’s views is disturbing for the mainstream community.

Originating in the work of Ernst Haeckel and Wilhelm Preyer, and advanced by a Prussian embryologist, Wilhelm Roux, the idea of struggle for existence between body parts helped to establish a framework, in which population cell dynamics rather than a predefined harmony guides adaptive changes in an organism. Intended to provide a causal-mechanical view of functional adjustments in body parts, this framework was also embraced later by early pioneers of immunology to address the question of vaccine effectiveness and pathogen (...) resistance. As an extension of these early efforts, Elie Metchnikoff established an evolutionary vision of immunity, development, pathology, and senescence, in which phagocyte-driven selection and struggle promote adaptive changes in an organism. Despite its promising start, the idea of somatic evolution lost its appeal at the turn of the twentieth century giving way to a vision, in which an organism operates as a genetically uniform, harmonious entity. (shrink)

Here I review Robert Trivers' 2011 book _The Folly of Fools_, in which he advocates the evolutionary theory of deceit and self-deception that he pioneered in his famous preface to Richard Dawkins' _Selfish Gene_. Although the book contains a wealth of interesting discussion on topics ranging from warfare to immunology, I find it lacking on two major fronts. First, it fails to give a proper argument for its central thesis--namely, that self-deception evolved to facilitate deception of others. Second, the (...) book lacks conceptual clarity with respect to the focal term "self-deception.". (shrink)

In 1911, Drs John Freeman and Leonard Noon published an account of a novel treatment for hay fever. Their method of desensitisation consisted of injecting increasing doses of an extract of pollen subcutaneously until the hypersensitivity reaction was diminished or abolished. Over subsequent decades, desensitisation established itself as the cornerstone of clinical allergy in both England and the United States, at least until the advent of novel pharmaceutical agents in the 1950s and 1960s. Although British allergists such as Noon and (...) Freeman were aware of conceptual developments within European immunology and pathology (such as the identification of anaphylaxis by Richet and Portier or von Pirquet's coining of the term allergy), their approach to hay fever was driven by more immediate pragmatic, and indeed financial, considerations. Freeman's immersion in the problems of hay fever and asthma and his pioneering use of allergen desensitisation or immunotherapy were shaped by his adherence to the convictions and bacteriological practices of his principal at St Mary's Hospital, Almroth Wright, and by the drive to produce commercial vaccines which would help to subsidise the experimental and therapeutic work at St Mary's. The aim of this paper is to explore early twentieth-century approaches to hay fever and other allergic diseases by tracing the intellectual and institutional origins of clinical allergy in Britain. (shrink)

This essay assesses the value of social constructivist theories of science to the history of medicine. It highlights particularly the ways in which feminist theorists have turned their attention to gender as a category of analysis in scientific thinking, producing an approach to modern science that asks how it became identified with "male" objectivity, reason, and mind, set in opposition to "female" subjectivity, feeling, and nature.In the history of medicine this new work has allowed a group of scholars to better (...) explain not only how women were marginalized in the profession but also the manner in which politics, male anxiety about shifts in power relations between the sexes, social and political upheaval, professional concerns, and changes in the family all had an impact on the production of knowledge regarding the female body, including the "discovery," definition, and treatment of a wide range of female ailments, from anorexia nervosa to fibroid tumors.Building on the work in the history of medicine already accomplished, the essay offers a critical rereading of the writings of Elizabeth Blackwell, a pioneer nineteenth-century woman physician and leader of the woman's medical movement. It contends that Blackwell, who lived through a revolutionary change in medical thinking brought on by discoveries in immunology and bacteriology, remained critical of "objectivity" as the "best" form of knowing and suspicious of the laboratory medicine that promoted it so enthusiastically. Moreover, her critiques of radical objectivity and scientific reductionism deserve to be recognized as foreshadowing the maternalist strain of thinking among contemporary feminist philosophers and thinkers such as Sara Ruddick and others. (shrink)

The Australian scientist Frank Macfarlane Burnet—winner of the Nobel Prize in 1960 for his contributions to the understanding of immunological tolerance—is perhaps best recognized as one of the formulators of the clonal selection theory of antibody production, widely regarded as the ‘central dogma’ of modern immunology. His work in studies in animal virology, particularly the influenza virus, and rickettsial diseases is also well known. Somewhat less known and publicized is Burnet’s research on bacteriophages, which he conducted in the first (...) decade of his research career, immediately after completing medical school. For his part, Burnet made valuable contributions to the understanding of the nature of bacteriophages, a matter of considerable debate at the time he began his work. Reciprocally, it was while working on the phages that Burnet developed the scientific styles, the habits of mind and laboratory techniques and practices that characterized him for the rest of his career. Using evidence from Burnet’s published work, as well as personal papers from the period he worked on the phages, this paper demonstrates the direct impact that his experiments with phages had on the development of his characteristic scientific style and approaches, which manifested themselves in his later career and theories, and especially in his thinking regarding various immunological problems. (shrink)

This issue is the first in a projected series of issues devoted to the contributions of pioneers in the field of peace psychology, starting with _Peace and Conflict_ Founding Editor, Milton Schwebel. This inaugural issue presents not only portions of the interview with Schwebel, but a brief resumé and representative publications for each decade, 1940-2000. It continues with statements from three of his colleagues providing accounts of his importance to them. Then, a paper dealing with the moral development of child (...) soldiers in conflict throughout the world is discussed. Finally, Schwebel's recent book is the subject of a Review Essay. (shrink)

Much was accomplished in the last decade in understanding how the adaptive immune system evolved to combat pathogens. Essential features of antigen presentation and T lymphocyte recognition were decipherd, setting the stage for further studies that elucidated basic elements of lymphocyte differentiation (including positive and negative selection during lymphocyte ontogeny) and the major interactions that occur among cells in secondary lymphoid organs in an ongoing immune response. The major challenges of today are found in the burgeoning fields of programmed cells (...) death, enzymology of recombination and somatic mutation, development of memory, and the recognition of pathogens by unconventional lymphocytes. (shrink)

A major aim of the books in this series is to promote psychology's appreciation of the neglected giants in its history. The chapters document the significance of these early contributions, many of them made more than a century ago. Most of the chapters are revisions of invited addresses delivered at psychological conventions. Several of the authors are students, colleagues, or offspring of their pioneers and all of them are intrigued by the life and work of the psychologists about whom they (...) have written. All of the portraits are informal; on occasion, even humorous. Some are "impersonations"--telling stories in what were or might have been the pioneer's own words. This book provides source materials for teachers of undergraduate courses in psychology--particularly the history of psychology--who want to add a personal view in their lectures and offer interesting readings for their students. Each of the five volumes in this series contains different profiles thereby bringing more than 100 of the pioneers in psychology more vividly to life. (shrink)

The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for 60 years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal circumstances, induce an immune reaction. In this paper we show that the self/non-self model is no longer an appropriate explanation of experimental data in immunology, and that this inadequacy may be rooted in an excessively strong metaphysical conception of biological identity. We (...) suggest that another hypothesis, one based on the notion of continuity, gives a better account of immune phenomena. Finally, we underscore the mapping between this metaphysical deflation from self to continuity in immunology and the philosophical debate between substantialism and empiricism about identity. (shrink)

This two-part article examines the competition between the clonal selection theory and the instructive theory of the immune response from 1957–1967. In Part I the concept of a temporally extended theory is introduced, which requires attention to the hitherto largely ignored issue of theory individuation. Factors which influence the acceptability of such an extended theory at different temporal points are also embedded in a Bayesian framework, which is shown to provide a rational account of belief change in science. In Part (...) II these factors, as elaborated in the Bayesian framework, are applied to the case of the success of the clonal selection theory and the failure of the instructive theory. (shrink)

Taking up the body turn in sociology, this paper discusses scientific practices as embodied action from the perspective of Husserl’s phenomenological theory of the “Body”. Based on ethnographic data on a biology laboratory it will discuss the importance of the scientist’s Body for the performance of scientific activities. Successful researchers have to be skilled workers using their embodied knowledge for the process of tinkering towards the material transformation of their objects for data production. The researcher’s body then is an instrument (...) of measuring as well as a kind of archive of knowing. Their body becomes a disciplined instrument which has its own place and function inside the laboratory. Furthermore, the appresentational apperception of Bodies (Husserl) is being discussed as a basis for the emotional and ethical concerns towards laboratory-animals. Attitudes towards animals in the laboratory setting (as well as elsewhere) are highly emotional. Nevertheless, following the literature of the sociology of the body, those emotional reactions still follow certain cultural patterns which themselves can be understood as embodied ways of knowing “right” or “wrong”. Besides as an instrument, the scientist’s body can also be understood as a resource of emotional attachment towards animals. It is an instrument for performing transformation as well as one for caring. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Rita Gross as Pioneer in the Study of Women and ReligionRosemary Radford RuetherRita Gross has been a pioneer in shaping both the theory and practice of women and religion and in Feminist theology. Her pathbreaking work in these fields has received insufficient recognition among both feminists and scholars of religion. This session at the 2010 AAR meeting devoted to her work is a small rectification of this (...) neglect. Rita has written more than 150 articles and written or edited around ten books. Three of these volumes—Beyond Androcentrism (1977), Feminism and Religion (1996), and A Garland of Feminist Reflections: Forty Years of Religion Explorations (2009)—span her writing career and exemplify her contributions to the field of women and religion.As Rita Gross makes clear, she went to the University of Chicago in the 1960s to explore the field of comparative religion, not to study women in religion explicitly. She was forced into this focus on women and has continued to return to this concern because of the resistance of the scholars in this field to paying attention to the ways in which half of humanity—women—participates in religion. Her concerns with women's roles in religion were shaped in response to the attitude of her mentors at the University of Chicago who insisted that what women did in religion was unimportant and was, in any case, covered by studying what men did in religion. One of these mentors ridiculed her by asking if she did not realize that the masculine is generic for humanness as a whole and so "includes the feminine." At most one might mention men's view of women. What women themselves think and do is irrelevant. At that time there were very few women in doctoral studies in religion at Chicago, and their teachers made clear that any concern with women as subjects of religion was a sure way to terminate their careers in the field.It was in responding to these kinds of messages from her teachers that Rita began to craft, in the late 1960s and 1970s, a fundamental shift in the methodology of religious studies. This would shape her decision to write her doctoral thesis on women in Australian Aboriginal religion, to edit a group of essays in her 1977 volume, Beyond Androcentrism, as well as doing pioneering work with Nancy Falk in the volume Unspoken Worlds, where they demonstrated the transformative understanding of religions that opens up when scholars focused on women's roles.This methodological shift, which Rita Gross has returned to again and again [End Page 75] through her writings, she called the movement from androcentrism to androgyny. Androcentrism as a bias in religious studies, or any other field, means quite simply the assumption that the male (usually the elite male) is the normative human being. To understand the "essence" of the human in any field it is sufficient to study what this elite male thinks and does. For Rita this is not only an injustice to women, but it also means turning a blind eye to at least half of what is actually going on in this or any other field. In other words, what is wrong about androcentrism as a way of doing study in religion is that it gives one a partial and distorted picture of reality. It is bad empiricism.The shift to androgyny means really looking equally at what women are doing as subjects of religion, not simply adding information about what men think of women. It is not that this information is totally absent or impossible to get. Often it is right there in the primary data, but is ignored by the scholars because of their androcentric bias. Bringing in women's activities and viewpoints as equal does not merely add a missing corner to the picture; it means transforming the whole picture. What men are thinking and doing is relativized and put in a larger context. For example, in understanding Australian Aboriginal religion one discovers not only that are women excluded from men's key rituals, but also that men are excluded from women's key rituals. The whole religion shifts from being understood as male dominant to being... (shrink)

This two-part article examines the competition between the clonal selection theory and the instructive theory of the immune response from 1957–1967. In Part I the concept of a temporally extended theory is introduced, which requires attention to the hitherto largely ignored issue of theory individuation. Factors which influence the acceptability of such an extended theory at different temporal points are also embedded in a Bayesian framework, which is shown to provide a rational account of belief change in science. In Part (...) II these factors, as elaborated in the Bayesian framework, are applied to the case of the success of the clonal selection theory and the failure of the instructive theory. (shrink)

This third volume in a series devoted to luminaries in the history of psychology--features chapter authors who are themselves highly visible and eminent scholars. They provide glimpses of the giants who shaped modern cognitive and behavioral science, and shed new light on their contributions and personalities, often with a touch of humor or whimsy and with fresh personal insights. The animated style, carefully selected details, and lively perspective make the people, ideas, and controversies in the history of psychology come alive. (...) The fields touched on in this and other volumes cover all of the subfields of psychology. As such, all volumes of _Portraits of Pioneers in Psychology_ will be of interest to psychologists, as well as scholars in related fields. The resourceful teacher could use a selection of chapters as supplementary readings to enhance almost any course in the discipline. The major purpose of these books is to provide source materials for students and their teachers in undergraduate and graduate courses in the history of psychology. Each of the five volumes in this series contains different profiles thereby bringing more than 100 of the pioneers in psychology more vividly to life. (shrink)

This book presents a series of informal biographies about major figures in the history of psychology. A unique combination of expertise and human appeal, the volume places the contributions of each pioneer in a new and fascinating perspective. For instance, several of the authors use the novel approach of having the pioneers return to the present day to reflect back on their work as it relates to the here and now. Revisions of speeches given in a popular series of (...) invited addresses at psychological conventions, the chapters offer appealing glimpses into the lives of individuals who made a difference in the early years of psychology as a field of study. Each of the five volumes in this series contains different profiles thereby bringing more than 100 of the pioneers in psychology more vividly to life. (shrink)

This fourth book in the series continues the tradition of the popular earlier volumes by offering lively and entertaining information about some of contemporary psychology's most illustrious ancestors. The 21 chapters, many of them written by today's most visible and eminent authors, concentrate on the lives and achievements of major psychologists from a variety of areas. Created for undergraduate and graduate courses in the history of psychology, the variety of pioneers represented provide enough flexibility to also use it as a (...) supplemental reader in other psychology courses. Each of the five volumes in this series contains different profiles thereby bringing more than 100 of the pioneers in psychology more vividly to life. (shrink)

This book offers glimpses into the personal and scholarly lives of 20 giants in the history of psychology. As in the earlier volumes, prominent scholars were invited to prepare chapters on a pioneer who had made important contributions in their own area of expertise. Some of the psychologists described may be the teachers of the instructors who will be the users of this book, potentially providing a personal connection of the pioneers to the students. A special section provides brief (...) portraits of the editors and authors, containing interesting information about the relationship between the pioneers and the psychologists who describe them. Utilizing an informal, personal, sometimes humorous, style of writing, the book will appeal to students and instructors interested in the history of psychology. Each of the five volumes in this series contains different profiles thereby bringing more than 100 of the pioneers in psychology more vividly to life. (shrink)

Bastiat emphasized the institutional infrastructure of a market economy and the principle of spontaneous order. He began with first principles — the primacy of property and consent — and derived the legitimate functions of government. As a pioneer in constitutional political economy, he examined the relation between economics and politics, employed methodological individualism, and extended the exchange paradigm to collective choice. He showed that the attenuation of economic liberty in the pursuit of distributive justice under majoritarian government would lead (...) to rent-seeking, corruption, and politicization of economic life.Bastiat met l’accent sur l’aménagement institutionnel de l’économie de marché et sur le principe de l’ordre spontané. Son analyse débute avec les principes premiers — la primauté de la propriété et du consentement — et il infère de ces principes les fonctions légitimes du gouvernement. En tant que pionnier de l’économie politique constitutionnelle, il examine les liens entre la sphère économique et la sphère politique, a recours à l’individualisme méthodologique et étend le paradigme de l’échange aux choix collectifs. Il montre que l’érosion de la liberté économique qu’entraîne la recherche d’une justice distributive sous un gouvernement majoritaire mène à la recherche de rentes, à la corruption et à la politisation de la vie économique. (shrink)

In the postgenomic era, interactions between organism and environment are central in disciplines such as epigenetics, medical physiology, and immunology. Particularly in the more "applied" medical fields, an emphasis lies on interactions of the organism with other organisms, that is, other living things. There is, however, a growing amount of research investigating the impact of abiotic triggers on the immune system. While the distinction between biota and abiota features heavily in other contexts, its status is not explicit within (...) class='Hi'>immunology. Do immunologists distinguish living from nonliving triggers? In this article, I will carve out whether and in which ways the biotic/abiotic distinction operates in immunology. I will look into responses to biotic and abiotic stressors in plant and invertebrate model species and ask how and why they are conceptually separated. I will trace the reasons by investigating the disciplinary situatedness of immune phenomena and the import of vertebrate immunology when conceptualizing immune responses in other model organisms. I will then investigate how the convergence of biotic and abiotic stress responses in plants and invertebrates adds to the recent philosophical programs advocating an ecological perspective on immune systems. (shrink)

Following recent trends in the historiography of psychology and psychiatry we argue that psychical research was an important influence in the development of concepts about dissociation. To illustrate this point, we discuss American psychologist and philosopher William James's writings about mediumship, secondary personalities, and hypnosis. Some of James's work on the topic took place in the context of research conducted by the American Society for Psychical Research, such as his early work with the medium Leonora E. Piper . James Following (...) recent trends in the historiography of psychology and psychiatry we argue that psychical research was an important influence in the development of concepts about dissociation. To illustrate this point, we discuss American psychologist and philosopher William James's writings about mediumship, secondary personalities, and hypnosis. Some of James's work on the topic took place in the context of research conducted by the American Society for Psychical Research, such as his early work with the medium Leonora E. Piper . James's work is an example of the influence of psychical research on several aspects of psychology such as early models of the unconscious and of dissociation's work is an example of the influence of psychical research on several aspects of psychology such as early models of the unconscious and of dissociation. (shrink)

Epistemology of science is currently polarized. Descriptive accounts of the social aspects of science coexist uneasily with normative accounts of scientific knowledge. This tension leads students of science to privilege one of these important aspects over the other. I use an episode of recent immunology research to develop an integrative account of scientific inquiry that resolves the tension between sociality and epistemic success. The search for the hematopoietic stem cell by members of Irving Weissman’s laboratory at Stanford University Medical (...) Center exhibits both the goal-oriented character of contemporary immunology and the importance of social interactions in successful achievement of those goals. This episode includes three kinds of epistemic success: characterization of HSC, formation of new interdisciplinary interfaces, and reconciliation of apparently incompatible models. All three depend on coordinating the work of diverse participants via social interactions. Together, they reveal the crucial role of social interactions within and between research groups in producing epistemic success. These features of the search for the HSC generalize to immunology as a whole, and plausibly to other disciplines. This account thus resolves the polarizing tension in epistemology of science, and complements individualistic accounts of scientific knowledge and rationality. (shrink)

Epistemology of science is currently polarized. Descriptive accounts of the social aspects of science coexist uneasily with normative accounts of scientific knowledge. This tension leads students of science to privilege one of these important aspects over the other. I use an episode of recent immunology research to develop an integrative account of scientific inquiry that resolves the tension between sociality and epistemic success. The search for the hematopoietic stem cell (HSC) by members of Irving Weissman’s laboratory at Stanford University (...) Medical Center exhibits both the goal-oriented character of contemporary immunology and the importance of social interactions in successful achievement of those goals. This episode includes three kinds of epistemic success: characterization of HSC, formation of new interdisciplinary interfaces, and reconciliation of apparently incompatible models. All three depend on coordinating the work of diverse participants via social interactions. Together, they reveal the crucial role of social interactions within and between research groups in producing epistemic success. These features of the search for the HSC generalize to immunology as a whole, and plausibly to other disciplines. This account thus resolves the polarizing tension in epistemology of science, and complements individualistic accounts of scientific knowledge and rationality. (shrink)

Written for non-experts, this volume introduces the mechanisms that underlie reticulate evolution. Chapters are either accompanied with glossaries that explain new terminology or timelines that position pioneering scholars and their major discoveries in their historical contexts. The contributing authors outline the history and original context of discovery of symbiosis, symbiogenesis, lateral gene transfer, hybridization or divergence with gene flow, and infectious heredity. By applying key insights from the areas of molecular (phylo)genetics, microbiology, virology, ecology, systematics, immunology, epidemiology and computational (...) science, they demonstrate how reticulate evolution impacts successful survival, fitness and speciation. Reticulate evolution brings forth a challenge to the standard Neo-Darwinian framework, which defines life as the outcome of bifurcation and ramification patterns brought forth by the vertical mechanism of natural selection. Reticulate evolution puts forward a pattern in the tree of life that is characterized by horizontal mergings and lineage crossings induced by symbiosis, symbiogenesis, lateral gene transfer, hybridization or divergence with gene flow, and infective heredity, making the “tree of life” look more like a “web of life.” On an epistemological level, the various means by which hereditary material can be transferred horizontally challenges our classic notions of units and levels of evolution, fitness, modes of transmission, linearity, communities, and biological individuality. The case studies presented examine topics including the origin of the eukaryotic cell and its organelles through symbiogenesis; the origin of algae through primary and secondary symbiosis and dinoflagellates through tertiary symbiosis; the superorganism and holobiont as units of evolution; how endosymbiosis induces speciation in multicellular life forms; transferrable and non-transferrable plasmids and how they symbiotically interact with their host; the means by which pro- and eukaryotic organisms transfer genes laterally (bacterial transformation, transduction and conjugation as well as transposons and other mobile genetic elements); hybridization and divergence with gene flow in sexually-reproducing individuals; current (human) microbiome and viriome studies that impact our knowledge concerning the evolution of organismal health and acquired immunity; and how symbiosis and symbiogenesis can be modelled in computational evolution. (shrink)