What is Life? This is the question asked by Denis Noble in this very personal and at times deeply lyrical book. Noble is a renowned physiologist and systems biologist, and he argues that the genome is not life itself: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that (...) is life. (shrink)

The Modern Synthesis has dominated biology for 80 years. It was formulated in 1942, a decade before the major achievements of molecular biology, including the Double Helix and the Central Dogma. When first formulated in the 1950s these discoveries and concepts seemed initially to completely justify the central genetic assumptions of the Modern Synthesis. The Double Helix provided the basis for highly accurate DNA replication, while the Central Dogma was viewed as supporting the Weismann Barrier, so excluding the inheritance of (...) acquired characteristics. This article examines the language of the Modern Synthesis and reveals that it is based on four important misinterpretations of what molecular biology had shown, so forming the basis of the four Illusions: 1. Natural Selection; 2. The Weismann Barrier; 3. The Rejection of Darwin’s Gemmules; 4. The Central Dogma. A multi-level organisation view of biology avoids these illusions through the principle of biological relativity. Molecular biology does not therefore confirm the assumptions of the Modern Synthesis. (shrink)

What is Life? To answer this question, Denis Noble argues that we must look beyond the gene's eye view. For modern 'systems biology' considers life on a variety of levels, as an intricate web of feedback between gene, cell, organ, body, and environment. He shows how it is both a biologically rigorous and richly rewarding way of understanding life.

In this paper I offer an analysis of Plotinus’ argument for the existence of a quasi-psychic entity, the so-called ‘trace of soul’, that functions as an immanent cause of life for an organism’s body. I argue that Plotinus posits this entity primarily in order to account for the body’s possession of certain quasi-psychic states that are instrumental in his account of soul-body interaction. Since these quasi-psychic states imply that an organism’s body has vitality of its own , and Platonic souls (...) are no part or aspect of any body, Plotinus draws the conclusion that the soul must be a cause of the body’s life by imparting a quasi-psychic qualification to it. In so doing, Plotinus introduces elements of hylomorphism into Platonist psychology, and addresses a problem for the animation of the body that Platonic soul-body dualism may plausibly be thought to face. (shrink)

In this paper, we argue that Plotinus denies deliberative forethought about the physical cosmos to the demiurge on the basis of certain basic and widely shared Platonic and Aristotelian assumptions about the character of divine thought. We then discuss how Plotinus can nonetheless maintain that the cosmos is «providentially» ordered.

Conscious Agency is a major driver of evolution. Artificial Selection (i.e. Conscious Selection by human breeders) was the foil against which Charles Darwin defined Natural Selection. In later work, he extended Artificial Selection to other species. That ability for social (e.g. sexual) selection must have evolved. Jablonka and Ginsburg identify markers of conscious agency, such as Unlimited Associative Learning (UAL), and show that it must have existed at the time of the Cambrian Explosion. To their insights, my commentary argues that (...) the harnessing of stochasticity was also involved in the evolution of the faculty of choice in organisms. (shrink)

In Ennead 3.6, Plotinus maintains that the soul is unaffectable. This thesis is widely taken to imply that his soul is exempt from change and free from emotional ‘affections’. Yet these claims are difficult to reconcile with evidence that Plotinian souls acquire dispositional states, such as virtues, and are subjects of emotional ‘affections’, such as anger. This paper offers an alternative account that aims to address these difficulties. In denying affections to soul, Plotinus is offering a distinction between the soul’s (...) self-actuated motions (or "activities") and the passive motions (or "affections") of bodies. But this distinction does not imply the soul’s changelessness, since Plotinus regards psychic motions that culminate in the soul’s acquisition of new dispositional states as changes. As for emotional ‘affections’, these (as activities) are merely homonymous with the affections denied to soul, and so do not violate the ban on the soul’s affectability. (shrink)

In this paper, we offer a criticism, inspired by Wittgenstein’s rule-following considerations, of the enactivist account of perception and action. We start by setting up a non-descriptivist naturalism regarding the mind and continue by defining enactivism and exploring its more attractive theoretical features. We then proceed to analyse its proposal to understand normativity non-socially. We argue that such a thesis is ultimately committed to the problematic idea that normative practices can be understood as private and factual. Finally, we offer a (...) characterization of normativity as an essentially social phenomenon and apply our criticisms to other approaches that share commitments with enactivism. (shrink)

The extensive range and depth of the twenty commentaries on my target article confirms that something has gone deeply wrong in biology. A wide range of biologists has more than met my invitation for “others to pitch in and develop or counter my arguments.” The commentaries greatly develop those arguments. Also remarkably, none raise issues I would seriously disagree with. I will focus first on the more critical comments, summarise the other comments, and then point the way forward on what (...) I view as a necessary and long-overdue transition in the foundations of biology. (shrink)

In this paper, we demonstrate (1) how harnessing stochasticity can be the basis of creative agency; (2) that such harnessing can resolve the apparent conflict between reductionist (micro-level) accounts of behaviour and behaviour as the outcome of rational and value-driven (macro-level) decisions; (3) how neurophysiological processes can instantiate such behaviour; (4) The processes involved depend on three features of living organisms: (a) they are necessarily open systems; (b) micro-level systems therefore nest within higher-level systems; (c) causal interactions must occur across (...) all the boundaries between the levels of organization. The higher levels constrain the dynamics of lower levels. The experimental evidence and theoretical arguments are shown to be consistent with previous research on the neuronal mechanisms of conscious choice, and with the interconnected multi-level processes by which organisms harness stochasticity, whether conscious or unconscious. (shrink)

This paper seeks to highlight the importance of spatial cognition in Bergson’s Données immédiates by engaging with Robert Watt’s reconstruction of Bergson’s argument that every idea of number involves the idea of space. We focus on the second stage of Watt’s reconstruction, where Bergson argues that only space can provide the distinction required for our counting of otherwise identical items. Watt bases his reconstruction on a premise regarding the possibility that identical objects, in the absence of spatial distinction, might remain (...) identical across different “temporal locations”. Our paper raises the prospect that Bergson is committed to a stronger thesis, namely one implying that identical objects would necessarily remain indistinguishable without the intervention of space. The paper thus concludes by emphasizing the indispensability of space for knowledge according to Bergson. (shrink)

While there has been extensive research on deception, extant literature has not examined how deception is processed solely from the customer's perspective. Extensive qualitative interviews were conducted and analyzed to inform the proposed framework. Cognitive dissonance theory and attribution theory are used to frame the process consumers go through when deception is perceived. When consumers perceive deceit, they will consider attribution before determining intentionality. Internal attributions relieve the company of wrongdoing to some extent, whereas external attributions lead consumers to examine (...) several elements of deception including intent. Unintentional deceit will trigger assessments of magnitude, stability, and switching costs; while less is considered when deceit is intentional. The findings of this research are important for advancing theory in relation to deceit and for helping practitioners understand the importance of changing consumer cognitions before consumers decide to change their behavior by discontinuing the relationship. (shrink)

Research using the intermodal preferential looking paradigm (IPLP) has consistently shown that English‐learning children aged 2 can associate transitive argument structure with causal events. However, studies using the same methodology investigating 2‐year‐old children’s knowledge of the conjoined agent intransitive and semantic role assignment have reported inconsistent findings. The aim of the present study was to establish at what age English‐learning children have verb‐general knowledge of both transitive and intransitive argument structure using a new method: the forced‐choice pointing paradigm. The results (...) suggest that young 2‐year‐olds can associate transitive structures with causal (or externally caused) events and can use transitive structure to assign agent and patient roles correctly. However, the children were unable to associate the conjoined agent intransitive with noncausal events until aged 3;4. The results confirm the pattern from previous IPLP studies and indicate that children may develop the ability to comprehend different aspects of argument structure at different ages. The implications for theories of language acquisition and the nature of the language acquisition mechanism are discussed. (shrink)

This article examines the issues that are at stake in the current resurgence of interest in the subject of habit. We focus on the role that habit has played in conceptions of the relations between body and society, and the respects in which such conceptions have been implicated in processes of governance. We argue that habit has typically constituted a point of leverage for regulatory practices that seek to effect some realignment of the relations between different components of personhood – (...) will, character, memory and instinct, for example – in order to bring about a specific end. In reviewing its functioning in this regard across a range of modern disciplines – philosophy, psychology, sociology – we explore the tensions between its use and interpretation in different lineages: in particular, the Cartesian–Kantian/ravaisson–bergson–deleuze lineages. The article then identifies how these questions are addressed across the contributions collected in this special issue. (shrink)

In this paper, I investigate the foundations of Plotinus’ innovative theory that prime matter is unaffectable. I begin by showing that Plotinus’ main arguments for this thesis (in Ennead 3.6) all rely upon the controversial assumption that the properties prime matter underlies are not properties of prime matter itself. It is then argued that prime matter’s privation of sensible qualities has its conceptual basis in an idiosyncratic understanding of form-matter composition generally, and its primary doctrinal basis in Aristotle’s critical reports (...) on the Platonists’ substratum in Physics 1.9. While Plotinus finds Platonic authority for unaffectible matter in the Receptacle passage of the Timaeus, it is Aristotle’s testimony that provides the crucial impetus for reading that text in this way. On this basis, Plotinus develops a Platonist conception of form’s inherence in matter with distinctively non-Aristotelian features. (shrink)

The distinction between personal level explanations and subpersonal ones has been subject to much debate in philosophy. We understand it as one between explanations that focus on an agent’s interaction with its environment, and explanations that focus on the physical or computational enabling conditions of such an interaction. The distinction, understood this way, is necessary for a complete account of any agent, rational or not, biological or artificial. In particular, we review some recent research in Artificial Life that pretends to (...) do completely without the distinction, while using agent-centred concepts all the way. It is argued that the rejection of agent level explanations in favour of mechanistic ones is due to an unmotivated need to choose among representationalism and eliminativism. The dilemma is a false one if the possibility of a radical form of externalism is considered. (shrink)

Plotinus maintains that there is a single first principle, the One (or the Good), from which all other things derive. He is usually thought to hold this view on the grounds that any other thing’s existence depends on its participation in a paradigm of unity. This paper argues that Plotinus has a further, independent argument for adopting a single first principle, according to which principle pluralism is committed (unacceptably) to attributing good cosmic states of affairs to chance. This argument exhibits (...) similarities to ancient design arguments, but is used to draw the more radical conclusion that there is only one non-derivative existent. (shrink)

In developing his theory of aether in De Caelo 1, Aristotle argues, in DC 1.4, that one circular motion cannot be contrary to another. In this paper, I discuss how Aristotle can maintain this position and accept the existence of celestial spheres that rotate in contrary directions, as he does in his revision of the Eudoxan theory in Metaphysics 12.8.

The recent production of major treatises devoted to elaborating normative ethical theories and the eruption of lively debates concerning the merits of opposed normative systems have been greeted with applause. This reaction is an historical about-face, since for forty or fifty years “ethical” treatises had been attacking the pretensions of traditional moral philosophy, calling for its demise or at the least severely limiting its claims. These skeptical attacks had succeeded in seriously undermining the academic status of moral philosophy and consequently (...) moral philosophy was transformed into “metaethics,” a highly abstract and technical discipline considered much less necessary to the general education of students than what it replaced and with a diminished role in the curriculum. The recent resurgence of interest in normative ethics has generally been lauded as a sign that philosophy has rededicated itself to its proper and time-honored tasks. There is a widespread feeling that the overblown claims of twentieth century skepticism have been whittled down to innocuous proportions and thus that nothing stands in the way of proceeding to construct ethical theories. The study of normative ethical theory now enjoys such respectability and popularity that it is difficult to raise once more the uncomfortable ideas that the ideal of normative ethical theory is a false one, that vanquishing the spectre of noncognitivism is not sufficient for legitimizing it, and that the popular new justifications for the enterprise fail in mischievous ways. (shrink)

In this paper, we draw upon the emerging view of strategic cognition and issue salience and show that CSR giving has evolved into more than an altruistic response to being asked for support, to one which is embedded in the strategic frames of management and which supports organizational identity. The managerial action as a result of such strategic cognition suggests that modern organizations are seeking to develop CSR giving processes that provide them with a competitive advantage. We draw on the (...) resource-based view of organizations and the VRIO framework to provide the theoretical foundations for our argument that CSR implementation in the form of corporate giving to charities can be developed as a dynamic capability. This can provide a competitive advantage by allowing organizations to manage key stakeholder relationships more effectively with benefits which could lead to increased organizational productivity and the ability to execute strategy more effectively. We interview CSR implementation managers from large organizations in Australia and find that the CSR giving process in many firms is evolving into a more sophisticated and strategically motivated process with expectations of a return. Central to this evolution is the appointment of a CSR implementation manager who acts as a boundary spanner between the organization and its key stakeholders. We posit that this corporate investment in their role and supporting structures can lead to the better management of stakeholders by organizations through the dynamic capability of the CSR giving process. We develop a table of best practise to help guide managers entering this sphere. (shrink)

The young Spinoza and the mature Leibniz both characterize the soul as a self-moving spiritual automaton. Though it is unclear if Leibniz’s use of the term was suggested to him from his reading of Spinoza, Leibniz was aware of its presence in Spinoza’s Treatise on the Emendation of the Intellect. Considering Leibniz’s staunch opposition to Spinozism, the question arises as to why he was willing to adopt this term. I propose an answer to this question by comparing the spiritual automaton (...) in both philosophers. For Spinoza, the soul acts as a spiritual automaton when it overcomes imaginative ideas and produces true ideas. For Leibniz, the soul acts as a spiritual automaton when it spontaneously produces its perceptions according to the universal harmony preestablished by God. Thus, for Leibniz contra Spinoza, the spiritual automaton is a means to render intelligible a providential order in which everything happens for the best. (shrink)

The distinction between personal level explanations and subpersonal ones has been subject to much debate in philosophy. We understand it as one between explanations that focus on an agent’s interaction with its environment, and explanations that focus on the physical or computational enabling conditions of such an interaction. The distinction, understood this way, is necessary for a complete account of any agent, rational or not, biological or artificial. In particular, we review some recent research in Artificial Life that pretends to (...) do completely without the distinction, while using agent-centred concepts all the way. It is argued that the rejection of agent level explanations in favour of mechanistic ones is due to an unmotivated need to choose among representationalism and eliminativism. The dilemma is a false one if the possibility of a radical form of externalism is considered. (shrink)

In Silence et langage Stephen A. Noble offers a new interpretation of the development of Merleau-Ponty’s phenomenology which analyses the central position of language within a philosophy of perception predicated upon the interdependence of seeing and speaking.

The is the Editorial of the 2015 JPBMB Special Issue on Integral Biomathics: Life Sciences, Mathematics and Phenomenological Philosophy.

For the mature Leibniz, a living being is a created substance composed of an infinitely complex organic body and a simple, immaterial soul. Soul and body do not interact directly, but rather their states correspond according to a harmony preestablished by God. I show that Leibniz’s theory faces challenges with respect to the question of whether substances need to possess knowledge of how they bring about their effects, and I argue that, to address these challenges, Leibniz turns to a concept (...) of “divine preformation” that he attributes to both soul and body. Insofar as divine preformation provides Leibniz with an explanation for how soul and body can both act without possessing explicit knowledge of what they are doing, it serves as a key tool for justifying the theory of preestablished harmony. (shrink)

Leibniz standardly associates “mechanism” with extended material bodies and their aggregates. In this paper, I identify and analyze a further distinct sense of “mechanism” in Leibniz that extends, by analogy, beyond the domain of material bodies and applies to the operations of immaterial substances such as the monads that serve, for Leibniz, as the metaphysical foundations of physical reality. I argue that in this sense, Leibniz understands “mechanism” as an intelligible process that is capable of providing a sufficient reason for (...) a series of changes. I then apply these findings to enrich our understanding of Leibniz’s well-known mill argument in Monadology ¶17: although material machines and mechanisms cannot produce perceptions, the perceptual activity of immaterial monads is to be understood as “mechanical” according to this analogical sense. (shrink)

This is the editorial to the special edition of Progress in Biophysics and Molecular Biology on the role engagement with Eastern traditions of thought could play in the advancement of science generally and biology and the science of mind in particular.

In this paper we challenge the notion of ‘normativity’ used by some enactive approaches to cognition. We define some varieties of enactivism and their assumptions and make explicit the reasoning behind the co-emergence of individuality and normativity. Then we argue that appealing to dispositions for explaining some living processes can be more illuminating than claiming that all such processes are normative. For this purpose, we will present some considerations, inspired by Wittgenstein, regarding norm-establishing and norm-following and show that attributions of (...) normativity to non-social agents are deeply paradoxical. The main conclusions of our discussion are: (1) circular and internal explanations centred on the stability of living systems are insufficient to account for processes where the environment plays an important role, such as adaptation. Enactivism is not an explanatory alternative to evolutionary biology but needs it as a complement to accounts focused on the internal self-assembly of organisms; (2) though we share enactivism’s anti-representational spirit, we argue that ecological psychology can offer a better account of perception. (shrink)

In al-Sirr al-Maktūm, a magisterial work on astral magic, the twelfth century Persian philosopher-theologian Fakhr al-Dīn al-Rāzī formulated one of the most sophisticated theories of talismanic action at a distance ever produced in the Islamic world. Al-Rāzī deployed Avicennan psychology to explain how a practitioner’s soul might connect with the celestial spheres, the principles of sublunary change, and ‘blend’ their forces into a talismanic metal idol; then, performing a ritual mimetic of his intended effect, could direct these forces to bring (...) about his objective, from a distance, altering sublunary phenomena in accordance with his will. In constructing this theory, Rāzī drew on the psychologizing Avicennan accounts of thaumaturgy and veridical dreams, foregrounding what was common to both: the internal sense known as the wahm. (shrink)

Mathematical models of the heart have developed over a period of about 40 years. Cell types in all regions of the heart have been modelled and they are now being incorporated into anatomically detailed models of the whole organ. This combination is leading to the creation of the first ‘virtual organ,’ which is being used in drug discovery and testing, and in simulating the action of devices, such as cardiac defibrillators. Simulation is a necessary tool of analysis in attempting to (...) understand biological complexity. We often learn as much from the failures as from the successes of mathematical models. It is the iterative interaction between experiment and simulation that is important. Examples are given where this process has been instrumental in some of the major advances in the field. BioEssays 24:1155–1163, 2002. © 2002 Wiley‐Periodicals, Inc. (shrink)

Whatever its grammatical status, the verb “to discern” has an implicit transitive element. That is to say, we always discern about something or between two options. What is the right course of action in this situation and in these circumstances? In our paper, we want to look at responses to this question from the perspective of the theology of liberation. As the name implies, this is first and foremost a theology, a way of seeking to understand and articulate the faith (...) of the believing Christian community. But it is also necessarily political, because it seeks to contribute to the liberation of those who are not free – the poor, the oppressed, those to whom injustice is done, both negatively, by decrying the presence of unfreedom and positively by working for social transformation. It is thus a public theology, a manifestation of the ongoing power of religion to inform and motivate its adherents to engage in attempts to transform the world not only in terms of a post mortem future but here and now. (shrink)

After a vertebrate dies, many of its organ systems, tissues, and cells remain functional while its body no longer works as a whole. We define this state as the “twilight of death” − the transition from a living body to a decomposed corpse. We claim that the study of the twilight of death is important to ethical, legal and medical science. We examined gene expression at the twilight of death in the zebrafish and mouse reaching the conclusion that apparently thousands (...) of transcripts significantly increase in abundance from life to several hours/days postmortem relative to live controls. Transcript dynamics of different genes provided “proof-of-principle” that models accurately predict an individual's elapsed-time-of-death. While many transcripts were associated with survival and stress compensation, others were associated with epigenetic factors, developmental control, and cancer. Future studies are needed to determine whether the high incidence of cancer in transplant recipients is due to the postmortem processes in donor organs. In organismal death, some organ systems, tissues and cells remain functional while the body no longer works as a whole. In the “twilight of death” − the transition from a living body to a decomposed corpse − thousands of gene transcripts increase in abundance relative to live controls. (shrink)

Patients fit with cochlear implants commonly indicate at the time of device fitting and for some time after, that the speech signal sounds abnormal. A high pitch or timbre is one component of the abnormal percept. In this project, our aim was to determine whether a number of years of CI use reduced perceived upshifts in frequency spectrum and/or voice fundamental frequency. The participants were five individuals who were deaf in one ear and who had normal hearing in the other (...) ear. The deafened ears had been implanted with a 18.5 mm electrode array which resulted in signal input frequencies being directed to locations in the spiral ganglion that were between one and two octaves higher than the input frequencies. The patients judged the similarity of a clean signal presented to their implanted ear and candidate, implant-like, signals presented to their normal-hearing ear. Matches to implant sound quality were obtained, on average, at 8 months after device activation and at 35 months after activation. At Time 1, the matches to CI sound quality were characterized, most generally, by upshifts in the frequency spectrum and in voice pitch. At Time 2, for four of the five patients, frequency spectrum values remained elevated. For all five patients F0 values remained elevated. Overall, the data offer little support for the proposition that, for patients fit with shorter electrode arrays, cortical plasticity nudges the cortical representation of the CI voice toward more normal, or less upshifted, frequency values between 8 and 35 months after device activation. Cortical plasticity may be limited when there are large differences between frequencies in the input signal and the locations in the SG stimulated by those frequencies. (shrink)