Fibrillar protein aggregates are the pathological hallmark of a group of age‐dependent neurodegenerative conditions, including Alzheimer's and Parkinson's disease. Aggregates of the microtubule‐associated protein Tau are observed in Alzheimer's disease and primary tauopathies. Tau pathology propagates from cell to cell in a prion‐like process that is likely subject to modulation by extracellular chaperones such as Clusterin. We recently reported that Clusterin delayed Tau fibril formation but enhanced the activity of Tau oligomers to seed aggregation of endogenous Tau in a cellular (...) model. In contrast, Clusterin inhibited the propagation of α‐Synuclein aggregates associated with Parkinson's disease. These findings raise the possibility of a mechanistic link between Clusterin upregulation observed in Alzheimer's disease and the progression of Tau pathology. Here we review the diverse functions of Clusterin in the pathogenesis of neurodegenerative diseases, focusing on evidence that Clusterin may act either as a suppressor or enhancer of pathology. (shrink)

Vacuum Genesis and Spontaneous Emergence of the Universe from Nothing in Reference to the Classical Notion of Causality and Creation ex nihilo The article discousses philosophical and theological reflections inspired by the cosmological model of the origin of the universe from quantum vacuum through quantum tunneling and the model presented by Hartle and Hawking. In the context of the thesis about the possibility of cosmogenesis ex nihilo without the need of God the creator, the question is being raised (...) concerning the ontological status of nothingness and of the laws of nature in the aforementioned models. After pointing to the fact that they do not imply an absolute nothingness in the philosophical sense, the main objectives of both models and philosophical-theological conclusions they inspire are interpreted in the light of the classical principles of potency and act, theory of causation and chance events in nature, elements of classical theology of creation and the classification of sciences in terms of various levels of abstraction, proposed by Aquinas. Noting the fact that some cosmologists cross methodological boundaries of their science, we emphasize the role and significance of their research in a deeper understanding of the philosophical aspects of the origins of the universe, especially the role of potency in the first stages of its existence and evolution. (shrink)

Recent models in quantum cosmology make use of the concept of imaginary time. These models all conjecture a join between regions of imaginary time and regions of real time. We examine the model of James Hartle and Stephen Hawking to argue that the various no-boundary attempts to interpret the transition from imaginary to real time in a logically consistent and physically significant way all fail. We believe this conclusion also applies to quantum tunneling models, such as that proposed by (...) Alexander Vilenkin. We conclude, therefore, that the notion of emerging from imaginary time is incoherent. A consequence of this conclusion seems to be that the whole class of cosmological models appealing to imaginary time is thereby refuted. (shrink)

A possible solution is offered to help resolve the “two times problem” regarding the veridical and illusory nature of time. First it is recognized that the flow of time is part of a wider array of temporal experiences referred to as manifest time, all of which need to be reconciled. Then, an information gathering and utilizing system model is used as a basis for a view of manifest time. The model IGUS robot of Hartle that solves the “unique (...) present” debate is enhanced with veridical and illusory components of not only the flow of time but also the larger entity of manifest time, providing a dualistic IGUS robot that represents all of the important temporal experiences. Based upon a variety of prior experiments, that view suggests that the veridical system is a reflection of accepted spacetime cosmologies and through natural selection begets the illusory system for functional purposes. Thus, there are not two opposing times, one outside and one inside the cranium. There is just one fundamental physical time which the brain developed, now possesses and is itself sufficient for adaption but then enhances. The illusory system is intended to provide a more satisfying experience of physical time, and better adaptive behavior. Future experiments to verify that view are provided. With a complete veridical system of temporal experiences there may be less need to reify certain temporal experiences so that the two times problem is less of a problem and more of a phenomenon. (shrink)

That moral principles underlie and constrain the activity of members of professions such as medicine and law is generally acknowledged. Whether the same can be said of the military profession is a question likely to generate considerable uncertainty. In this paper I shall show that, like other professions, the military profession is informed by a moral teleology. The source of this teleology, for the profession of arms, is manifested in the laws of war. The laws of war, in turn, reflect (...) two humanitarian principles. (shrink)

Ann Hartle - Rousseau: The Sentiment of Existence - Journal of the History of Philosophy 45:3 Journal of the History of Philosophy 45.3 500-501 Muse Search Journals This Journal Contents Reviewed by Ann Hartle Emory University David Gauthier. Rousseau: The Sentiment of Existence. Cambridge-New York: Cambridge University Press, 2006. Pp. xiv + 196. Paper, $22.99. The unity of Rousseau's thought is among the most serious challenges faced by his interpreters. How are we to reconcile the submission of the individual to (...) the general will in the Social Contract with the solitary and free individual of the state of nature in the Discourse on Inequality and the autobiographical works? One of the great merits of this book is that it does offer, as the author promises, a.. (shrink)

Moral Constraints on War offers a principle-by-principle presentation of the transcultural roots of the ethics of war in an age defined by the increasingly international nature of military intervention.

The familiar theories of physics have the feature that the application of the theory to make predictions in specific circumstances can be done by means of an algorithm. We propose a more precise formulation of this feature—one based on the issue of whether or not the physically measurable numbers predicted by the theory are computable in the mathematical sense. Applying this formulation to one approach to a quantum theory of gravity, there are found indications that there may exist no such (...) algorithms in this case. Finally, we discuss the issue of whether the existence of an algorithm to implement a theory should be adopted as a criterion for acceptable physical theories.“Can it then be that there is... something of use for unraveling the universe to be learned from the philosophy of computer design?” —J. A. Wheeler(1). (shrink)

This is the second volume of a two volume study on ethical issues concerning death. Volume 2 is subtitled Death and Whom to Save from It. In this second volume, Kamm deals with rights, duties, and status, developing an account of when it is permissible to harm others, especially when it is permissible to kill others. There is, however, a third book that must be considered if we are to fully understand the import of Volume 2 of Morality, Mortality. This (...) third book is entitled Creation and Abortion. It was originally intended to be included in Morality, Mortality, but, on account of considerations of length, the material on abortion was published separately by Oxford University Press in 1992. Creation and Abortion was prompted by Kamm's attempt to understand and modify Judith Thomson's "A Defense of Abortion.". (shrink)

This paper offers a detailed criticism of different versions of modal scepticism proposed by Van Inwagen and Hawke, and, against these views, attempts to vindicate our reliance on thought experiments in philosophy. More than one different meaning of “ modal scepticism” will be distinguished. Focusing mainly on Hawke’s more detailed view I argue that none of these versions of modal scepticism is compelling, since sceptical conclusions depend on an untenable and, perhaps, incoherent modal epistemology. With a detailed account of modal (...) defeaters at hand I argue that Van Inwagen and Hawke’s scepticism is either groundless, or it leads to boundless and unacceptable modal scepticism. Additionally, I show that Hawke’s conception of analogical modal reasoning is problematic. Either his principle of similarity is arbitrary or it begs the question about modal scepticism. In contrast to Hawke’s restricted view of analogical modal reasoning, I present two examples of analogy-based modal justification of philosophically relevant possibility claims. My criticism of modal scepticism also shows that there is no good reason to insist on a sharp distinction between an unproblematic and a presumably dubious kind of modality. The upshot is that in absence of proper defeaters both Yablo-style conceivability and properly applied analogical reasoning are reliable guides to possibility, and also that modal justification comes in degrees. The proposed framework of defeaters of modal justification as well as the analysed examples of analogical modal reasoning trace out interesting new areas for further discussions. (shrink)

The most striking observable feature of our indeterministic quantum universe is the wide range of time, place, and scale on which the deterministic laws of classical physics hold to an excellent approximation. This essay describes how this domain of classical predictability of every day experience emerges from a quantum theory of the universe’s state and dynamics.

The relationship between tax authorities and taxpayers is essential for tax compliance. The aim of the present paper was to explore systematically the determinants of this relationship and related tax compliance behaviors based on the extended slippery slope framework. We used in-depth qualitative interviews with 33 self-employed taxpayers and 30 tax auditors. Interviewees described the tax relationship along the extended slippery slope framework concepts of power and trust. However, also novel sub-categories of power (e.g., setting deadlines) and trust (e.g., personal (...) assistance) were mentioned. Furthermore, also little-studied categories of tax behavior emerged, such as accepting tax behavior e.g., being available to the tax authorities, or stalling tax behavior e.g., the intentional creation of complexity. The results comprehensively summarize the determinants of the tax relationship and tax compliance behaviors. Additionally, results highlight future research possibilities and illustrate policy interventions. (shrink)

The discovery of “molecular chaperones” has dramatically changed our concept of cellular protein folding. Rather than folding spontaneously, most newly synthesized polypeptide chains seem to acquire their native conformation in a reaction mediated by these versatile helper proteins. Understanding the structure and function of molecular chaperones is likely to yield useful applications for medicine and biotechnology in the future.

Michel de Montaigne, the inventor of the essay, has always been acknowledged as a great literary figure but has never been thought of as a philosophical original. This book treats Montaigne as a serious thinker in his own right, taking as its point of departure Montaigne's description of himself as 'an unpremeditated and accidental philosopher'. Whereas previous commentators have treated Montaigne's Essays as embodying a scepticism harking back to classical sources, Ann Hartle offers an account that reveals Montaigne's thought to (...) be dialectical, transforming sceptical doubt into wonder at the most familiar aspects of life. This major reassessment of a much admired but also much underestimated thinker will interest a wide range of historians of philosophy as well as scholars in comparative literature, French studies and the history of ideas. (shrink)

This paper critically examines David Berman's theological lying interpretation of Hume and identifies two types of theological lying: the denial of atheism strategy and the pious Christian strategy. It is argued that neither reading successfully establishes an atheist interpretation of Hume. Moreover, circumstantial evidence shows that Hume's position was different from that of the atheists of his time. Attributions theological lying to Hume, therefore, are unwarranted and should be rejected, even if we grant that this literary technique was used in (...) the early-modern era. Analysing other non-theistic readings of Hume is beyond the scope of this paper. However, given that Berman presents one of most elaborated atheist reinterpretations of Hume's affirmative theistic passages, the failure of Berman's analysis shows that rejecting these passages should not be the default interpretive approach, and it is reasonable to attribute to Hume a weak, indeterminate theism. (shrink)

Why do so many doctors have profound misgivings about the push to legalise euthanasia and assisted suicide? Ole Hartling uses his background as a physician, university professor and former president of the Danish Council of Ethics to introduce new elements into what can often be understood as an all too simple debate. Alive to the case that assisted dying can be driven by an unattainable yearning for control, Hartling concentrates on two fundamental questions: whether the answer to suffering is to (...) remove the sufferer, and whether self-determination in dying and death is an illusion. He draws on his own experience as a medical doctor to personalize the ethical arguments, share patients' narratives and make references to medical literature. Here is a sceptical stance towards euthanasia, one that is respectful to those who hold different opinions and well-informed about the details and nuances of different euthanasia practices. Written from a Scandinavian perspective, where respect for autonomy and high quality palliative care go hand in hand, Hartling's is a nuanced, valuable contribution to the arguments that surround a question doctors have faced since the birth of medicine. He shows us how the intentions of doing something good can sometimes lead to even greater dilemmas, opening us up to those situations where an inclination to end suffering by ending life is deeply conflicting both for the clinician and for any fellow human being. (shrink)

This book explores the tradition, impact, and contemporary relevance of two key ideas from Western Marxism: Georg Lukács's concept of reification, in which social aspects of humanity are viewed in objectified terms, and Guy Debord's concept of the spectacle, where the world is packaged and presented to consumers in uniquely mediated ways. Bringing the original, yet now often forgotten, theoretical contexts for these terms back to the fore, Johan Hartle and Samir Gandesha offer a new look at the importance of (...) Western Marxism from its early days to the present moment-and reveal why Marxist cultural critique must continue to play a vital role in any serious sociological analysis of contemporary society. (shrink)

Death and the Disinterested Spectator examines the nature of philosophy in light of philosophy's claim to be a preparation for death.

The whole of Marx's project confronts the narrow concerns of political philosophy by embedding it in social philosophy and a certain understanding of the aesthetic. From those of aesthetic production to the "poetry of the future" (as Marx writes in the Eighteenth Brumaire), from the radical modernism of bourgeois development to the very idea of association (which defined one of the main lines of tradition in the history of aesthetics), steady references to Dante, Shakespeare and Goethe, and the idea that (...) bourgeois politics is nothing but a theatrical stage: the aesthetic has a prominent place in the constellation of Marx's thought. This book offers an original and challenging study of both Marx in the aesthetic, and the aesthetic in Marx. It differs from previous discussions of Marxist aesthetic theory as it understands the works of Marx themselves as contributions to thinking the aesthetic. This is an engagement with Marx's aesthetic that takes into account Marx's broader sense of the aesthetic, as identified by Eagleton and Buck-Morss - as a question of sense perception and the body. (shrink)

Montaigne’s _Essays_ are rightfully studied as giving birth to the literary form of that name. Ann Hartle’s _Montaigne and the Origins of Modern Philosophy_ argues that the essay is actually the perfect expression of Montaigne as what he called "a new figure: an unpremeditated and accidental philosopher." Unpremeditated philosophy is philosophy made sociable—brought down from the heavens to the street, where it might be engaged in by a wider audience. In the same philosophical act, Montaigne both transforms philosophy and invents (...) "society," a distinctly modern form of association. Through this transformation, a new, modern character emerges: the individual, who is neither master nor slave and who possesses the new virtues of integrity and generosity. In Montaigne’s radically new philosophical project, Hartle finds intimations of both modern epistemology and modern political philosophy. (shrink)

The philosophical ideal of self-knowledge has been all but forgotten in what Walker Percy calls "the age of theory." Hartle attempts to recover that ancient philosophical task and to articulate what that ideal could mean in the context of our historical situation. She considers and rejects claims that we can attain self-knowledge through theory, anti-theory, or narrative and she defends philosophy as a humanistic, rather than scientific, endeavor. Self-Knowledge in the Age of Theory will be of great interest not only (...) to philosophers but to scholars of literature and other humanities. (shrink)

This article introduces Metaphilosophy's special issue on metatheories of disagreement, with the aim of promoting discussion on the nature of disagreement on a metatheoretical level. The contributions to this issue cover the following key topics related to disagreement: faultless disagreement, metaontological disagreement, metalinguistic disagreement, responses to peer disagreement in philosophy, hinge epistemology and deep disagreement, disagreement asymmetry, factual and nonfactual disagreement, and defining disagreement or verbal dispute. This introduction also provides general background on four major topics in order to contextualize (...) the contributions to the special issue: first, the problem of characterizing the subject matter of disagreements; second, the most prominent accounts of deep disagreement, disagreement asymmetry and hinges; third, the notion of faultless disagreement; and finally, the problem of offering different approaches on what disagreements are. (shrink)

A recently published study(1) has identified a set of candidate genes for human diseases based on findings from Drosophila. Each human expressed sequence tag (EST) in a large database was compared with all known Drosophila genes. After eliminating matches between genes of already known function, the remaining sequences were mapped in the human genome. In each region, the phenotypes of all known human diseases were compared with the phenotypes of known Drosophila mutations in order to identify candidate genes for the (...) human diseases. Are the correspondences real or coincidental? (shrink)

Empirical examinations about cross-cultural variability of intuitions, the well-known publication of Stich and his colleagues criticiz-ing thought-experiments and intuitions in philosophical debates, is still a challenge that faces analytical philosophers, as any systematic investigation of the methodology of philosophy must give answers to these basic questions: What is intuition? What role should intuitions play in philosophy? I present and examine the sceptical argument of experimental philosophers, and claim that experimental philosophers misunderstand the role of evidence in philosophy. My argument will (...) utilize Goldman’s view, according to which intuitions give reliable evidence about a person’s concepts, and this knowledge is valuable for further philosophical research as well. I will argue that the sceptical conclusions of experimental philosophers are harmless against this conception of philosophy, because even from a naturalist perspective certain kind of intuitive judgments about our concepts can be warranted, and this grants the specific epistemic status of intuitions. Of course, the reliability of introspection can be challenged. However, denying self-knowledge about my internal mental states is disputable – as I will show – both from a philosophical and a scientific point of view. (shrink)

Montaigne chooses to write the Essays in French, the vulgar language, rather than in Latin, the language of the learned. He uses only the words that areheard in the streets, markets, and taverns of France. And he speaks about the body and the sexual in a manner that goes beyond the limits of propriety. The language of the Essays perfectly reflects Montaigne’s philosophical project, the re-ordering of philosophy to the lowest rather than the highest, to the ordinary rather than the (...) extraordinary. By bringing the private into the public, he frees the private from shame and creates the new, modern public space, i.e., society. The invention of the essay is the invention of society. (shrink)

Montaigne chooses to write the Essays in French, the vulgar language, rather than in Latin, the language of the learned. He uses only the words that areheard in the streets, markets, and taverns of France. And he speaks about the body and the sexual in a manner that goes beyond the limits of propriety. The language of the Essays perfectly reflects Montaigne’s philosophical project, the re-ordering of philosophy to the lowest rather than the highest, to the ordinary rather than the (...) extraordinary. By bringing the private into the public, he frees the private from shame and creates the new, modern public space, i.e., society. The invention of the essay is the invention of society. (shrink)

U ovome radu istražujem Polanyijeve glavne argumente za akademsku slobodu. Akademska i politička sloboda međusobno su blisko povezane: ako država preuzme kontrolu nad znanošću, to dovodi do kolapsa same slobode u cijelome društvu. Njegovi argumenti protiv totalitarizma oslanjaju se na njegovu anti-pozitivističku filozofiju znanosti. On definira totalitarizam kao poricanje akademske slobode koje se temelji na pragmatičkom poimanju znanosti i instrumentalističkim interpretacijama moralnih vrijednosti. Polanyijeva ideja znanosti je duhovni, idealistički opis zajednice slobodnih intelektualaca koji su strastveno posvećeni potrazi za istinom i (...) imaju autonomnu zajednicu s vlastitim pravilima i autonomnim upravljanjem. Potraga za istinom radi nje same je bitan cilj znanosti, koji se može postići jedino ako znanost ostane slobodna od političkih, ideoloških i ekonomskih utejcaja. Tvrdim da Polanyijevi uvidi mogu biti relevantni i danas, kada znanost može postati instrument profitno orijentiranih praktičnih potreba umjesto potrage za istinom samom i kada se humanistika često smatra nepotrebnom.In the present essay I investigate Polanyi’s main arguments for academic freedom. Academic and political freedom are closely related to each other: if state takes control over science, it will lead to the collapse of freedom itself in the whole society. His arguments against totalitarianism rely on his anti-positivist philosophy of science. He diagnoses totalitarianism as a denial of academic freedom which is based on a pragmatist view of science and instrumentalist interpretation of moral values. Polanyi’s idea of science is a spiritual, idealistic description of a community of free intellectuals who are passionately committed to seeking the truth and have an autonomous community with its own rules and autonomous direction. Seeking the truth for its own sake is the essential goal of science, which can be accomplished only if it remains free from political, ideological and economical influences. I will argue that Polanyi’s insights can still be relevant today, when science can become an instrument of profit-oriented practical needs instead of seeking the truth itself, and the humanities are often considered unnecessary.Dans cet essai, j’examine les principaux arguments de Polany pour la liberté académique. La liberté académique et politique sont étroitement liées : si l’Etat prend le contrôle de la science, cela conduira à l’effondrement de la liberté elle-même dans toute la société. Ses arguments contre le totalitarisme reposent sur sa philosophie anti-positiviste de la science. Il diagnostique le totalitarisme comme un refus de la liberté académique fondé sur une conception pragmatique de la science et une interprétation instrumentaliste des valeurs morales. L’idée de la science de Polany est une description spirituelle, idéaliste, d’une communauté d’intellectuels libres, passionnément dédiés à la recherche de la vérité, et qui ont une communauté avec ses propres règles et une direction autonome. La recherche de la vérité pour elle-même est l’objectif essentiel de la science, ce qui peut être accompli uniquement si elle demeure libre des influences politiques, idéologiques et économiques. J’affirme que les visions de Polany peuvent toujours être pertinentes aujourd’hui, alors que la science peut devenir un instrument des besoins pratiques orientés vers le profit au lieu de chercher la vérité elle-même, et alors que les sciences humaines sont souvent considérées comme inutiles.Im präsenten Artikel gehe ich Polanyis Hauptargumentation für akademische Freiheit auf den Grund. Die akademische und politische Freiheit sind miteinander nahe verwandt: Unterzieht der Staat die Wissenschaft seiner Kontrolle, endet dies im Kollaps der Freiheit selbst in der gesamten Gesellschaft. Polanyis Begründung gegen den Totalitarismus stützt sich auf dessen antipositivistische Philosophie der Wissenschaft. Er diagnostiziert den Totalitarismus als Versagung der akademischen Freiheit, die auf dem pragmatischen Blickpunkt der Wissenschaft als auch der instrumentalistischen Interpretation der Moralwerte basiert. Polanyis Wissenschaftsvorstellung ist eine spirituelle, idealistische Schilderung einer Gemeinschaft freier Intellektueller, die sich der Suche nach Wahrheit glutvoll gewogen zeigt und über eine autonome Community mit eigenen Regeln sowie autonomer Verwaltung verfügt. Die Erkundung der Wahrheit um ihrer selbst willen repräsentiert das essenzielle Vorhaben der Wissenschaft, welches sich allein unter Bewahrung ihrer Independenz von politischen, ideologischen bzw. wirtschaftlichen Einflüssen zuwege bringen lässt. Ich halte dafür, Polanyis Einblicke hätten auch heutzutage Relevanzpotenzial, zu der Zeit, wenn sich die Wissenschaft auf ein Werkzeug des profitorientierten praktischen Begehrens reduzieren könnte, anstatt nach der Wahrheit selbst zu fahnden, und die Geisteswissenschaften gehäuft als entbehrlich abgestempelt werden. (shrink)

The modern philosophical act, as it appears in the Essays of Montaigne, reorders the world by radically altering the relationship between the mind and the world. Montaigne replaces the premodern philosophical act of contemplation with the modern philosophical act of judgment. While contemplation is the natural end or natural completion and perfection of the mind, judgment is the freedom of the mind from nature. Contemplation is the receptive attitude of the mind toward the world; judgment is the attitude of mastery. (...) Contemplation is the ordering of the human to the divine, while judgment reorders man to man himself. This reordering entails a revaluation of all things in relation to man as man. Judgment eliminates the classical distinction between actions that are good in themselves and actions that are for the sake of production, thereby undermining the hierarchy of leisure and work, the foundation of classical civilization. The liberal order is the new form of human association, which replaces the old order. (shrink)

This book addresses the complex relationship between the values of liberal democracy and the values associated with scientific research. The chapters explore how these values mutually reinforce or conflict with one another, in both historical and contemporary contexts. -/- The contributors utilize various approaches to address this timely subject, including historical studies, philosophical analysis, and sociological case studies. The chapters cover a range of topics including academic freedom and autonomy, public control of science, the relationship between scientific pluralism and deliberative (...) democracy, lay-expert relations in a democracy, and the threat of populism and autocracy to scientific inquiry. Taken together the essays demonstrate how democratic values and the epistemic and non-epistemic values associated with science are interconnected. (shrink)

Montaigne’s last words in the Essays—the words that capture his entire project—are “sociable wisdom.” Philosophy has been transformed from the “love of wisdom” to “sociable wisdom” and this transformation is, at the same time, the transformation of the human world, the production of society, a new mode of human association. What is “sociable wisdom” and how has it produced this remarkable effect?Philosophy means “the love of wisdom.” Although the term is believed to have been used first by Pythagoras, Socrates presents (...) us with the most complete picture of the life of philosophy as the love of wisdom. And Socrates is the ancient philosopher most admired by Montaigne. However, the Socrates of the Essays is.. (shrink)

The Essays do not look like philosophy in any traditional sense: there are no arguments, conclusions, or proofs, and no apparent philosophical teaching. Yet, Montaigne does describe himself as a philosopher: “a new figure: an unpremeditated and accidental philosopher.” Unpremeditated and accidental philosophy, however, just looks like the formless and disordered thoughts of ordinary life and conversation. While philosophy is invisible, Montaigne himself is always visible. Philosophy disappears into the pre-philosophical at the same time and in the same act by (...) which Montaigne emerges into the public in his concrete particularity. The Essays do not look like philosophy because philosophy is not a teaching but an act, the act of bringing the private, common man into the public. At the same time and in the same act, Montaigne transforms both philosophy and human association: the philosophical act is the invention of modern society. (shrink)

Aesthetic discourse has always openly or secretly been linked to political projects. According to some main strands of aesthetic discourse modern aesthetics mirrors the structure of social and political emancipation and key elements of aesthetic discourse coincide with the political ontology of the left. Marxist and Post-Marxist critics have emphasized that the struggle for emancipation is indirectly present in the historical constitution of aesthetics as a discipline – although in a merely imaginary and displaced form. Therefore, however, it is also (...) partly of the same structure as what is normally described as “aesthetic”. Against this background aesthetic attributes (‘beauty’) can be ascribed to forms of emancipatory politics as well. (shrink)

A study found that women participating in mammography screening were content with the programme and the paternalistic invitations that directly encourage participation and include a pre-specified time of appointment. We argue that this merely reflects that the information presented to the invited women is seriously biased in favour of participation. Women are not informed about the major harms of screening, and the decision to attend has already been made for them by a public authority. This short-circuits informed decision-making and the (...) legislation on informed consent, and violates the autonomy of the women. Screening invitations must present both benefits and harms in a balanced fashion, and should offer, not encourage, participation. It should be stated clearly that the choice not to participate is as sensible as the choice to do so. To allow this to happen, the responsibility for the screening programmes must be separated from the responsibility for the information material. (shrink)