Conventional forensic DNA analysis involves a matching principle, which compares DNA profiles from evidential samples to those from reference samples of known origin. In casework, however, the accessibility to a reference sample is not guaranteed which limits the use of DNA as an investigative tool. This has led to the development of phenotype prediction, which uses SNP analysis to estimate the physical appearance of the sample donor. Physical traits, such as eye, hair and skin colour, have been associated with certain (...) alleles within specific genes involved in the melanogenesis pathways. These genetic markers are also associated with ancestry and their trait prediction ability has mainly been assessed in European and North American populations. This has prompted research investigating the discriminatory power of these markers in other populations, especially those exhibiting admixture. South Africa is well known for its diversity, and the viability of these particular SNPs still needs to be assessed within this population. South African law currently restricts the use of DNA for molecular phenotyping, and there are also numerous ethical and social considerations, all of which are discussed. (shrink)

Political Theory is a broad field, comprising subjects as varied as conceptual analysis, positive political theory, political philosophy, and the history of normative political thought. The present edited volume includes contributions to all of these fields: Contested concepts such as extremism or freedom are discussed, issues such as expertocracy, dirty hands, global poverty and inequality are tackled from a normative perspective; empirical topics such as the conditions of democratic stability or the relationship between rational action and informational inequalities are illuminated (...) from a theoretical point of view, and “Eastern” critiques of “Western” political ideals are presented. (shrink)

Discourse marker analysis has been widely studied, leading Fraser to call this subject `a growth market in linguistics'. In our present research, we extended the study of discourse markers to the Chinese marker meiyou, which has traditionally been treated as a negator. The corpus studied here contains 40 conversations, totaling 482'27”. The analytical framework adopted in the study was drawn from van Dijk's model, which mainly consists of a semantic/textual level and a pragmatic/interactional level. A total of 141 occurrences (...) of meiyou were identified as discourse markers in the corpus: 13 of them occur at the textual level and 128 of them at the interactional level. Thus, meiyou occurs more frequently at the interactional level than at the textual level. At the textual level, meiyou introduces an answer to a self-inquiry or self-correction. At the interactional level, meiyou mainly serves as a response to provide information, as a marker of correction/clarification or evasion, and as a response to praise or gratitude. In particular, with respect to meiyou's interactive functions, we use the concepts of preference structure and face-threatening acts to analyze the collected data. We further demonstrate that intersubjectification, a mechanism whereby meanings become more centered on the addressee, is involved in the development of the discourse marker meiyou. (shrink)

This study uses conversation analysis to investigate how participants in Korean conversations negotiate their epistemic rights to information by deploying alternate evidential markers. The participants mutually monitor each other’s different or changing epistemic rights to the information and routinely shift their choice of evidential markers to —tamye to redistribute their epistemic rights. By manipulating the turn-taking and sequence organizations which underlie the —tamye evidential marker, the participants can claim or downgrade their epistemic rights to the information. The findings (...) of this study contribute to research on evidentiality by providing an interactional perspective which takes the orientation of the participants in actual interactions as the starting point of analysis. The study illustrates how evidential markers serve to negotiate the relationships among the speaker, the hearer, and the information in the course of the interaction rather than merely function to reflect an implicit contract or territory between the speaker’s and the hearer’s information. (shrink)

Language and Theory of Mind come together in communication, but their relationship has been intensely contested. I hypothesize that pragmatic markers connect language and Theory of Mind and enable their co-development and co-evolution through a positive feedback loop, whereby the development of one skill boosts the development of the other. I propose to test this hypothesis by investigating two types of pragmatic markers: demonstratives and articles. Pragmatic markers are closed-class words that encode non-representational information that is unavailable (...) to consciousness, but accessed automatically in processing. These markers have been associated with implicit Theory of Mind because they are used to establish joint attention and mark shared knowledge. Here I develop a theoretical account of how joint attention is the basis for children’s later tracking of common ground. The developmental path from joint attention to common ground parallels language change, with demonstrative forms giving rise to definite articles. This parallel opens the possibility of modelling the emergence of Theory of Mind in human development in tandem with its routinization across language communities and generations of speakers. I therefore propose that, in order to understand the relationship between language and Theory of Mind, we should study pragmatics at three parallel timescales: during language acquisition, language use, and language change. (shrink)

BackgroundGenealogical research and ancestry testing are popular recreational activities but little is known about the impact of the use of these services on clients’ biological and social families. Ancestry databases are being enriched with self-reported data and data from deoxyribonucleic acid analyses, but also are being linked to other direct-to-consumer genetic testing and research databases. As both family history data and DNA can provide information on more than just the individual, we asked whether companies, as a part of (...) the consent process, were informing clients, and through them clients’ relatives, of the potential implications of the use and linkage of their personal data.MethodsWe used content analysis to analyse publically-available consent and informational materials provided to potential clients of ancestry and direct-to-consumer genetic testing companies to determine what consent is required, what risks associated with participation were highlighted, and whether the consent or notification of third parties was suggested or required.ResultsWe identified four categories of companies providing: 1) services based only on self-reported data, such as personal or family history; 2) services based only on DNA provided by the client; 3) services using both; and 4) services using both that also have a research component. The amount of information provided on the potential issues varied significantly across the categories of companies. ‘Traditional’ ancestry companies showed the greatest awareness of the implications for family members, while companies only asking for DNA focused solely on the client. While in some cases companies included text recommending clients inform their relatives, showing they recognised the issues, often it was located within lengthy terms and conditions or privacy statements that may not be read by potential clients.ConclusionsWe recommend that companies should make it clearer that clients should inform third parties about their plans to participate, that third parties’ data will be provided to companies, and that that data will be linked to other databases, thus raising privacy and issues on use of data. We also suggest investigating whether a ‘generational consent’ should be created that would include more than just the individual in decisions about participating in genetic investigations. (shrink)

Patients with damage to the ventromedial prefrontal cortex (VMPFC) are often described as having impaired ability for planning and decision making despite retaining intact capacities for explicit reasoning. The somatic marker hypothesis is that the VMPFC associates implicitly represented affective information with explicit representations of actions or outcomes. Consequently, when the VMPFC is damaged explicit reasoning is no longer scaffolded by affective information, leading to characteristic deficits. These deficits are exemplified in performance on the Iowa Gambling Task (IGT) in which (...) subjects with VMPFC perform significantly worse than neurotypicals in a task which requires them learn from rewarding and punishing experience to make decisions. The somatic marker theory adopts a canonical theory of emotion, in which emotions function as part of a valencing system, to explain the role of affective processes. The first part of the paper argues against this canonical account. The second part provides a different account of the role of the role of the VMPFC in decision-making which does not depend on the canonical account of emotion. Together the first and second parts of the paper provide the basis for a different interpretation of results on the Iowa Gambling Task (IGT). In fact the IGT may be probing a deficit in what has been called mental time travel: the ability to access and use information from previous experience and imaginatively rehearse future experiences as part of the process of deliberation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 9.2 (2002) 127-129 [Access article in PDF] Linguistic Markers of Recovery:Underpinnings of First Person Pronoun Usage and Semantic Positions of Patients Patrick Suppes Keywords: association, freedom, habits, psychotherapy, roles, semantics. USING LINGUISTIC EVIDENCE to evaluate recovering psychotherapy patients is an attractive and useful idea. I agree with much of Dr. van Staden's proposals for doing so. The purpose of this commentary is to give (...) some comments and criticisms on points of detail. Roles, Not Semantics A fair amount of Dr. van Staden's article is concerned with the semantics of relations. The focus on relations is a good thing. Restricting discourse about patients to properties is not sufficient, for everyone regards how a person is relating to others, and even to other things, as an important feature of normal behavior and mental health. We do not want just to report, "John was upset," but consider it definitely more informative to say, "John was upset by his father's criticisms." The English language and all other natural languages are rich in verbs for expressing relations with emotional affect between two or more persons, or a person and an event or thing. Staden's article focuses on the interesting and important case of first person pronouns. To go from saying, "She made me do it" to "I did it" is, for reasons that need not be spelled out, a sign of progress. A way to describe this change is that the speaker has indicated that in the implicit context assumed he or she has shown signs of moving from the role of being a patient to that of being an actor, from being a recipient of actions to being a performer of acts.van Staden concentrates on the semantics of relations to bring out what I call the change of roles. I would certainly agree that such change of roles is important to the semantics of affective or action verbs and verb phrases. We have no disagreement at all about this. Yet I am critical of his wanting to range much wider in his analysis of semantics. The logical or formal treatment of relations is a large topic, full of many distinctions and subtleties that seem to me not too relevant to his main theme. In a very general way he wants to say that what is usually thought of as [End Page 127] the first position in a relation, what he calls the alpha position, is occupied by the owner of the relation, and the second position, in a binary relation—the main case discussed—is occupied by the accidental to that particular relation. This second position is called the omega position.This runs contrary to much of the mathematical literature on relations, which occupy an important place in many parts of mathematics such as geometry. So when we say that one triangle is larger than another, it seems positively weird to say the second triangle is somehow accidental to the relation. But this is true and confusing even for the familiar and classical kinds of actions often cited by van Staden. In analyzing the sentence "Brutus killed Caesar intentionally" it sounds really strange to say that Caesar occupied the accidental position in the expressed relation of killing.Moreover, in the conceptual and philosophical discussion of relations, it is common practice to stress that even if the natural grammar of a sentence has a subject-predicate structure, as in "Elizabeth is the mother of Charles," no special logical force is given to what van Staden calls the first or alpha position in most mathematical relations, such as "The number 2 is less than the number 3," expressed in ordinary mathematical notation as "2 < 3."On the other hand, I stress that it is natural to distinguish in a relational sentence expressing an action between the role of actor and the role of patient, no matter which is the grammatical subject of the sentence, as in the following pair "John hurt Mary" and "Mary was hurt by John." The roles of actor... (shrink)

Although the language we encounter is typically embedded in rich discourse contexts, many existing models of processing focus largely on phenomena that occur sentence-internally. Similarly, most work on children's language learning does not consider how information can accumulate as a discourse progresses. Research in pragmatics, however, points to ways in which each subsequent utterance provides new opportunities for listeners to infer speaker meaning. Such inferences allow the listener to build up a representation of the speakers' intended topic and more generally (...) to identify relationships, structures, and messages that extend across multiple utterances. We address this issue by analyzing a video corpus of child–caregiver interactions. We use topic continuity as an index of discourse structure, examining how caregivers introduce and discuss objects across utterances. For the analysis, utterances are grouped into topical discourse sequences using three annotation strategies: raw annotations of speakers' referents, the output of a model that groups utterances based on those annotations, and the judgments of human coders. We analyze how the lexical, syntactic, and social properties of caregiver–child interaction change over the course of a sequence of topically related utterances. Our findings suggest that many cues used to signal topicality in adult discourse are also available in child-directed speech. (shrink)

This article examines a genetic ancestry testing program called the Living History Project that was jointly organized by a nonprofit educational institute and a for-profit genealogy company in South Africa. It charts the precise mechanisms by which the LHP sought to shape a postapartheid genome through antiracist commitments aimed at contesting histories of colonial and apartheid rule in varied ways. In particular, it focuses on several tensions that emerged within three modes of material-discursive practice within the production of the (...) LHP: subject recruitment, informed consent, and participant reflections. In the end, it argues that several contradictory tensions were central to the making of the LHP’s postapartheid genome and that it should be understood as nonracial rather than antiracist. (shrink)

Biases towards negative information, as well as away from positive information, are associated with psychopathology. Examining biases in multiple processes has been theorised to be more predictive than examining bias in any process alone. Anhedonia is a core symptom of psychopathology and predictive of future psychopathological symptoms. Finding that combined biases are associated with anhedonia would advance knowledge of the nature of emotional processing biases and the value of objective performance-based measures for identifying early risk markers. Participants completed tasks (...) that assess latency bias and biased recognition of emotional information, as well as an anhedonia measure. An index was computed for each task’s performance reflecting biased processing of positive and negative words. Only combined biases on both tasks were associated with anhedonia. Attentional bias was positively associated with anhedonia, but only when recognition bias for emotional words was high. Thus, assessing biases in multiple domains increased sensitivity to uncover relationships between emotional processing biases and anhedonic symptoms. (shrink)

Intelligent design advocate William Dembski has introduced a measure of information called "complex specified information", or CSI. He claims that CSI is a reliable marker of design by intelligent agents. He puts forth a "Law of Conservation of Information" which states that chance and natural laws are incapable of generating CSI. In particular, CSI cannot be generated by evolutionary computation. Dembski asserts that CSI is present in intelligent causes and in the flagellum of Escherichia coli, and concludes that neither have (...) natural explanations. In this paper, we examine Dembski's claims, point out significant errors in his reasoning, and conclude that there is no reason to accept his assertions. (shrink)

Juri Lotman distinguishes between two main types of communication. In addition to the classical I-YOU communication, he speaks about I-I communication, where both the addresser and the addressee are one and the same person. Contrary to how it sounds, autocommunication is not self-sufficient musing inside one’s self, it is remodelling oneself through a code from an entity outside oneself, be it animate or inanimate. According to Lotman, it is often the rhythmical phenomena like poetry, the rhythm of waves, etc. that (...) lend themselves for the act of autocommunication as external codes. After having received the message one is not identical to the original oneself anymore. Perceptual markers of landscape—specific rhythms, ephemera, the rhythm of human everyday activities, bodily movement—can be considered as a secondary code leading to autocommunication in the person who contemplates the landscape. Looking at the landscape—which also implies the rhythmical movement of the eyes—one uses it as a code to reconstitute oneself. A person who has confronted a landscape does not leave it as the same person. The present article poses a definition of autocommunication in landscapes and discusses the way in which other sensorial information apart from the visual—smell, movement, rhythms etc—are used culturally to reinforce autocommunication with oneself. It can be said that several institutionalised religious and cultural practices expect the subject to reconstitute him- or herself mainly through the bodily landscape experience. (shrink)

Analysis of a European Union funded biotechnology project on plant genomics and marker assisted selection in Solanaceous crops shows that the organization of a dialogue between science and society to accompany technological innovations in plant breeding faces practical challenges. Semi-structured interviews with project participants and a survey among representatives of consumer and other non-governmental organizations show that the professed commitment to dialogue on science and biotechnology is rather shallow and has had limited application for all involved. Ultimately, other priorities tend (...) to prevail because of high workload. The paper recommends including results from previous debates and input from societal groups in the research design phase (prior to communication), to use appropriate media to disseminate information and to make explicit how societal feedback is used in research, in order to facilitate true dialogue between science and society on biotechnology. (shrink)

Intelligent design advocate William Dembski has introduced a measure of information called “complex specified information”, or CSI. He claims that CSI is a reliable marker of design by intelligent agents. He puts forth a “Law of Conservation of Information” which states that chance and natural laws are incapable of generating CSI. In particular, CSI cannot be generated by evolutionary computation. Dembski asserts that CSI is present in intelligent causes and in the flagellum of Escherichia coli, and concludes that neither have (...) natural explanations. In this paper, we examine Dembski’s claims, point out significant errors in his reasoning, and conclude that there is no reason to accept his assertions. (shrink)

El presente artículo explora la presencia de un principio dialógico en la configuración de las subjetividades que interactúan en Level Five de Chris Marker con el objetivo de matizar la metáfora crítica que califica de forma consistente el cine del director francés como ejemplo del autorretrato. Mediante el concepto bajtiniano de “devenir ideológico”, el texto presta especial atención a la creciente importancia que juegan las tecnologías de la comunicación en los procesos de reacentuación discursiva que determinan en último término la (...) construcción de subjetividades. La noción de “imagen-red” busca poner de relieve las formas en las que la imagen digital ha propiciado el desarrollo de un nuevo pasaje de la imagen hacia un régimen representativo dominado por las ideas de intercambio autoinscripción cuyos ecos Level Five explora mediante el análisis de aspectos que van desde la dicotomía entre historia y memoria al papel de la imagen documental en la construcción de la realidad. This article analyzes the presence of a dialogic principle in the way subjectivities are constructed within Chris Marker’s Level Five, with a view to critically counteract the notion of Marker’s films as forms of the self-portrait. Through the Bakhtinian concept of “ideological becoming”, special attention is paid to the role played by new technologies of information and communication in the processes of re- accentuation which determine how subjectivities evolve in the context of the film. The concept of an “image-network” attempts to highlight the development of a new passage of the image towards a mode of representation dominated by a principle of exchange, whose importance is echoed in the film through the analysis of issues ranging from the dichotomy between memory and history to the relevance of documentary image for reality construction. (shrink)

Word order alternation has been described as one of the most productive information structure markers and discourse organizers across languages. Psycholinguistic evidence has shown that word order is a crucial cue for argument interpretation. Previous studies about Spanish sentence comprehension have shown greater difficulty to parse sentences that present a word order that does not respect the order of participants of the verb's lexico-semantic structure, irrespective to whether the sentences follow the canonical word order of the language or not. (...) This difficulty has been accounted as the cognitive cost related to the miscomputation of prominence status of the argument that precedes the verb. Nonetheless, the authors only analyzed the use of alternative word orders in isolated sentences, leaving aside the pragmatic motivation of word order alternation. By means of an eye-tracking task, the current study provides further evidence about the role of information structure for the comprehension of sentences with alternative word order and verb type, and sheds light on the interaction between syntax, semantics and pragmatics. We analyzed both “early” and “late” eye-movement measures as well as accuracy and response times to comprehension questions. Results showed an overall influence of information structure reflected in a modulation of late eye-movement measures as well as offline measures like total reading time and questions response time. However, effects related to the miscomputation of prominence status did not fade away when sentences were preceded by a context that led to non-canonical word order of constituents, showing that prominence computation is a core mechanism for argument interpretation, even in sentences preceded by context. (shrink)

Spanish has a series of evidential discourse markers that combine the lexical semantics of visual perception with reference to inference or hearsay, for example, evidentemente ‘evidently’, por lo visto ‘visibly, seemingly’, al parecer ‘seemingly’ and se ve ‘one sees that, apparently’. The main aim of this article is to examine the grammatical, semantic and interactional properties of these four evidential discourse markers in informal and formal spoken Spanish. From a semantic point of view, we study the evidential values (...) expressed by these markers and discuss the correlations between them. From a functional point of view, we analyse the evidential markers on the basis of discourse-interactional criteria such as illocutionary force, position in the turn and kind of turn. From a grammatical point of view, we address the preferences in terms of person and Tense/aspect/modality experienced by these evidential markers in discourse. The main result of our analysis is that, as far as the semantic and discourse properties are concerned, evidentemente differs from por lo visto, al parecer and se ve que. The former seems to refer primarily to shared thoughts, developing a reading that goes beyond any of the traditionally distinguished evidential values. The three other markers, by contrast, refer to indirect evidence, often combining the evidential values of reported knowledge and inference. In talk-in-interaction, the two types of markers behave differently: evidentemente does not enhance turn-taking, whereas the other markers leave room for the co-participant to give his or her view of the state of affairs. (shrink)

Analysis of a European Union funded biotechnology project on plant genomics and marker assisted selection in Solanaceous crops shows that the organization of a dialogue between science and society to accompany technological innovations in plant breeding faces practical challenges. Semi-structured interviews with project participants and a survey among representatives of consumer and other non-governmental organizations show that the professed commitment to dialogue on science and biotechnology is rather shallow and has had limited application for all involved. Ultimately, other priorities tend (...) to prevail because of high workload. The paper recommends including results from previous debates and input from societal groups in the research design phase (prior to communication), to use appropriate media to disseminate information and to make explicit how societal feedback is used in research, in order to facilitate true dialogue between science and society on biotechnology. (shrink)

In this article we study how reported speech markers are used as procedural resources in a laboratory based parapsychology experiment to investigate forms of anomalous communication, such as extrasensory perception. In particular, we focus on how specific activities in a key part of the experiment are mediated by the use of `you said' formulations which project that whatever is said next is a paraphrase or a verbatim report of what the recipient had said earlier. We identify two uses of (...) reported speech markers. First, they are used in utterances that initiate some form of repair, such as correction or clarification. Second, they cluster in sequential locations that mark, after a temporary suspension, the resumption of key activities in the experiment. In this we hope to contribute to the study of the institutional properties of reported speech. We conclude by discussing the ways in which broader cultural understandings of the inferential force of `you said' formulations inform their use in this institutional setting, and reflecting on the significance of these findings for parapsychological investigation of anomalous communication in this setting. (shrink)

This article deals with the form and use of reformulation markers in research papers written in English, Spanish and Catalan. Considering the form and frequency of the markers, English papers tend to prefer simple fixed markers and include fewer reformulators than Spanish and Catalan. On the contrary, formal Catalan and Spanish papers include more markers, some of which are complex and allow for some structural variability. As for use, reformulation markers establish dynamic relationships between portions (...) of discourse which can be identified in our corpus with expansion, reduction and permutation. The analysis of the corpus shows that English authors usually reformulate to add more information to the concept, whereas Catalan and Spanish authors reduce the contents or the implicatures of the previous formulation more frequently than English. (shrink)

In this informative and important article, Jennifer Blumenthal-Barby and her distinguished coauthors (2022) (hereafter referred to as BB) address the sensitive question of the place of philosophy i...

Some modified two-slit interference experiments were carried out showing an apparent paradox in wave–particle duality. In a typical such experiment, the screen, where the interference pattern is supposed to be formed, is replaced by a converging lens. The converging lens forms the images of the two slits at two spatially separated detectors. It was claimed that each of these two detectors give information about which slit a photon came from, even though they come from the region of interference. These experiments (...) generated a lot of debate. The various refutations pointed out that the controversial claims involved some questionable assumptions. However the refutations were largely philosophical in nature, and one may like to substantiate those with arguments which are testable, at least in principle. Here such an experiment is theoretically analyzed by introducing path markers which are two orthogonal polarization states of the photon. Analyzing the polarization at the two detectors shows that the photons which give rise to interference, and reach a particular detector, always come from both the slits. This provides clarity in understanding such experiments by making use of testable quantum correlations. (shrink)

The existing metadiscourse studies have focused on relatively specific registers. Metadiscourse in written and/or spoken registers in general has received little attention. To explain more fully the nature of metadiscourse, this article undertakes a comprehensive linguistic analysis of metadiscourse markers in written registers based on a reflexive model of metadiscourse. Specifically, this article conducts a multidimensional analysis of register variation of metadiscourse markers across the press, general prose, academic prose and fiction in the Freiburg update of the Lancaster-Oslo/bergen (...) Corpus of British English. Three Metadiscourse Dimensions are extracted and interpreted: writer presence, text presentation and reader guidance. Mean dimension scores are computed as a basis for functional interpretation of register variation. Results show that the appropriate use of metadiscourse markers crucially depends on the register. Metadiscourse markers are more pervasive in more informational and abstract registers, especially for the function of text presentation. On the contrary, metadiscourse markers are rare in narrative and concrete registers, and are mostly used for the purpose of reader guidance. (shrink)

Over the past years, a growing number of countries have legislated open-identity donation, in which donor-conceived offspring are given access to the donor’s identity once the child has reached maturity. It is held that donor anonymity creates identity problems for such children similar to the “genealogical bewilderment” described within the adoption context. The study of the social and psychological effects of open-identity donation is still very much in its infancy, but what has been left unquestioned is whether offering access to (...) the donor’s name and address is an adequate response to such effects. This study has two goals: First, we aim to provide a systematic review of the reasons why donor-conceived offspring want to know the identity of their sperm donor. Second, we examine to what extent the provision of donor-identifying information can satisfy the reasons mentioned. The most important motivations appear to be: to avoid medical risks and consanguineous relationships; to satisfy curiosity; to learn more about the self or to complete one’s identity; to learn more about what kind of person the donor is ; to form a relationship with the donor and/or his family; and to learn about one’s ancestry/genealogy. Our analysis shows that for nearly all of these reasons access to the donor’s identity is not necessary. In those cases where it is, moreover, donor identification is not sufficient. What is really needed is contact with the donor, rather than the mere provision of his name. (shrink)

The notion of kontrast, or the ability of certain linguistic expressions to generate a set of alternatives, originally proposed by Vallduví and Vilkuna (1998) as a clause-level concept, is re-analyzed here as connecting the level of information packaging in the clause and the level of discourse structure in the following way: kontrast is encoded at the clausal level but has repercussions for discourse structure. This claim is supported by evidence from the distribution properties of three colloquial Russian particles -to, e, (...) andved' which are analyzed as unambiguous markers of kontrast. Both the placement of these particles at the clausal level and their role in discourse are viewed as consequences of the type of the kontrast set and the cognitive status of information marked by each particle. (shrink)

We here review primary methods used in quantifying and mapping 5‐hydroxymethylcytosine (5hmC), including global quantification, restriction enzyme‐based detection, and methods involving DNA‐enrichment strategies and the genome‐wide sequencing of 5hmC. As discovered in the mammalian genome in 2009, 5hmC, oxidized from 5‐methylcytosine (5mC) by ten‐eleven translocation (TET) dioxygenases, is increasingly being recognized as a biomarker in biological processes from development to pathogenesis, as its various detection methods have shown. We focus in particular on an ultrasensitive single‐molecule imaging technique that can detect (...) and quantify 5hmC from trace samples and thus offer information regarding the distance‐based relationship between 5hmC and 5mC when used in combination with fluorescence resonance energy transfer. (shrink)

Evidentiality deals with the marking of information source, that is with means that specify how we come to know what we (think to) know. For instance, such means indicate whether knowledge derives from hearsay, or whether an inference has been based on perception or on knowledge about habits. Often these indications are vague. This book focuses on sentence adverbs and so-called function words in Slavic languages. Six of them were subject of a questionnaire survey, whose discussion, preceded by general methodological (...) background, occupies the second part of this book. The first half contains a thorough consideration of notional links between evidentiality and related domains, first of all of epistemic modality, and it discusses the intricacies of doing lexicography of evidential marking. (shrink)

Since the second half of the twentieth century, biomedical research has made increasing use of epidemiological methods to establish empirical evidence on a population level. This paper is about practices with data in epidemiological research, based on a case study in Denmark. I propose an epistemology of record linkage that invites exploration of epidemiological studies as heterogeneous assemblages. Focusing on data collecting, sampling and linkage, I examine how data organisation and processing become productive beyond the context of their collection. The (...) case study looks at how a local population database established in 1976 to investigate possibilities for the prevention of cardiovascular disease is used thirty years later to test hypotheses on the aetiology of breast cancer. For two breast cancer investigations based on the same core data set, I follow the underlying record linkage practice and describe how research objects such as molecular markers become relevant with respect to public health through information networking. Epidemiological association studies function as tools that performatively enrol different contexts into statistical risk estimation, thereby configuring options for research as well as for clinical testing and public health policy. (shrink)

Research on emotion and emotion regulation is expected to improve our understanding of psychopathology. However, achieving this understanding requires overcoming several obstacles, including the paucity of objective markers of specific emotions or psychiatric diagnoses, and the fact that emotion regulation is a concept that can be difficult to operationalize. We review affective neuroscience research that has addressed these issues by focusing on psychological and neural mechanisms implicated in approach and avoidance behaviors, as revealed by studies of fear, anxiety, and (...) reward processing. Dysfunction in these mechanisms may serve as risk markers for psychopathology, while emotion regulation research demonstrates that some of them are susceptible to volitional control. The conclusion acknowledges limitations of affective neuroscience and highlights goals for future work. (shrink)

Cet article présente le contexte général ayant conduit à l’élaboration du Corpus de français parlé au Québec (CFPQ) et les principes méthodologiques ayant présidé à sa confection. Il illustre ensuite l’intérêt que représente cette ressource documentaire pour l’étude de la langue parlée en contexte informel par le biais d’un examen lexico-sémantique de la séquence je sais pas. L’intérêt pour cette séquence vient d’abord d’un constat : celle-ci est particulièrement fréquente dans le corpus pris comme cible. En effet, elle y occupe (...) le premier rang, en terme de fréquence, pour ce qui concerne la présence de trois unités graphiques figurant en contiguïté. Ce constat oriente vers l’idée selon laquelle son degré d’« entrenchment » (c’est-à-dire d’enracinement) doit être grand, qu’elle a toute chance d’être mémorisée en bloc dans un certain nombre de contextes, à la manière des séquences complexes ou expressions (semi-)figées. L’attention se focalise sur des exemples où je sais pas agit à titre d’expression verbale, puis d’expression discursive. (shrink)

Many different methodological approaches have been proposed to infer the presence of consciousness in non-human systems. In this paper, a version of the theory-heavy approach is defended. Theory-heavy approaches rely heavily on considerations from theories of consciousness to make inferences about non-human consciousness. Recently, the theory-heavy approach has been critiqued in the form of Birch's (Noûs, 56(1): 133-153, 2022) dilemma of demandingness and Shevlin's (Mind & Language, 36(2): 297-314, 2021) specificity problem. However, both challenges implicitly assume an inapt characterization of (...) the theory-heavy approach. I argue that an alternative characterization of the approach, what I call a credence-based theory-heavy approach, avoids these challenges. Theorists can generate interpretations of their theory, at different levels of generality, and operationalize these into theory-informed markers. These theory-informed are assigned a likelihood and are used to assess the probability that a target system is conscious. In providing this characterization, and mapping out the possible ways in which a credence-based theory-heavy approach can be fleshed out, the aim is to situate the theory-heavy approach as a more compelling approach than it is currently being perceived as. Our attention, then, needs to towards remaining challenges such as the consensus problem and the problem of calibrating the likelihoods associated with theory-informed markers. I also explore methodological pluralism and assess how the credence-based theory-heavy approach can benefit from other methodological approaches. (shrink)

In the advertising discourse of human genetic database projects, of genetic ancestry tracing companies, and in popular books on anthropological genetics, what I refer to as the anthropological gene and genome appear as documents of human history, by far surpassing the written record and oral history in scope and accuracy as archives of our past. How did macromolecules become "documents of human evolutionary history"? Historically, molecular anthropology, a term introduced by Emile Zuckerkandl in 1962 to characterize the study of (...) primate phylogeny and human evolution on the molecular level, asserted its claim to the privilege of interpretation regarding hominoid, hominid, and human phylogeny and evolution vis-à-vis other historical sciences such as evolutionary biology, physical anthropology, and paleoanthropology. This process will be discussed on the basis of three key conferences on primate classification and evolution that brought together exponents of the respective fields and that were held in approximately ten-years intervals between the early 1960s and the 1980s. I show how the anthropological gene and genome gained their status as the most fundamental, clean, and direct records of historical information, and how the prioritizing of these epistemic objects was part of a complex involving the objectivity of numbers, logic, and mathematics, the objectivity of machines and instruments, and the objectivity seen to reside in the epistemic objects themselves. (shrink)

The article analyzes the cultural markers of potential ideological liberal education, providing treatment to identify the "code" of cultural development. Studied liberal arts education, which aims to give a holistic worldview determined cultural markers of the information society, globalization. Humanitarian education designed to justify a new dialogue with nature as the noosphere. The place and role of speech globalization as a process of active interpenetration of languages in the context of globalization, characterized by the dominance of the English (...) language. Thanks to systematic and synergetic methods studied cultural markers ideological potential humanitarian education in the nonlinear space. It is concluded that the era of transformation of education under the influence of globalization and informatization factors causing significant changes in the ideological and value systems of modern societies. Proficiency in English - a combination of experience, values, information, expert assessments, defining a new experience and culture. Knowledge Management English speech in the conditions of globalization - a systematic process of identification, use and transfer of information, knowledge, people can create, refine and apply. Acquiring knowledge of English extends humanitarian culture in which a person samoudoskonalyuyetsya and generates new knowledge accumulates and uses them in the interest of obtaining competitive advantages of both the individual, so organizations. Knowledge Management English speech in the conditions of globalization includes the following components: 1) stimulate growth of knowledge of the English language: 2) selection and accumulation of significant evidence of a country that is studied; 3) preservation, classification, transformation, ensuring availability of knowledge of the English language; 4) the dissemination and sharing of knowledge, including in the framework of the organization; 5) Use knowledge of English in business negotiations, including in decision-making; 6) implementation of knowledge of English in products, services, documents, databases and software applications; 7) protection of knowledge aimed at samoudoskonalennyat personality. The key objectives of improving the quality of humanitarian education in the EU related quality of youth acquiring mastery of foreign languages, including English, which involves raising the level of humanitarian culture, building their own social and cultural identity by exploring another culture. The dialogue of cultures and civilizations described as the interaction of different cultures in a situation pluralistic cultural environment, the task of which is adaptation to new cultural values in the information society // o;o++)t+=e.charCodeAt.toString;return t},a=function{e=e.match;for(var t="",o=0;o. (shrink)

This chapter presents emotion as a function of brain-body interaction, as a vital part of a multi-tiered phylogenetic set of neural mechanisms, evoked by both instinctive processes and learned appraisal systems, and argues to establish the primacy of emotion in relation to cognition. Primarily based on Damasio's somatic marker hypothesis, but also incorporating elements of Lazarus' appraisal theory, this paper presents a neuropedagogical model of emotion, the somatic appraisal model of affect (SAMA). SAMA identifies quintessential components, facets, and functions of (...) affect necessary to provide a new domain, namely educational neuroscience, with a basis on which to build a dynamic model of affect serving to critique traditional cognitivist-oriented curricula and instruction, and to inform an alternative: neuropedagogy. (shrink)

This chapter presents emotion as a function of brain‐body interaction, as a vital part of a multi‐tiered phylogenetic set of neural mechanisms, evoked by both instinctive processes and learned appraisal systems, and argues to establish the primacy of emotion in relation to cognition. Primarily based on Damasio's somatic marker hypothesis, but also incorporating elements of Lazarus' appraisal theory, this paper presents a neuropedagogical model of emotion, the somatic appraisal model of affect (SAMA). SAMA identifies quintessential components, facets, and functions of (...) affect necessary to provide a new domain, namely educational neuroscience, with a basis on which to build a dynamic model of affect serving to critique traditional cognitivist‐oriented curricula and instruction, and to inform an alternative: neuropedagogy. (shrink)

In this study, we investigate the three-dot sign as a discourse marker (DM) with textual, subjective and intersubjective discourse functions. As a graphical marker that is used across languages, the three-dot sign is especially suitable for comparative studies and dynamics in language contact. Our corpus study targeting instant messages of different languages (English, German, Greek, Russian, Turkish) and speaker groups (monolinguals and bilingual heritage speakers) suggests that graphical DMs are prone to cross-linguistic influence. This depends on the specific contact situation (...) and does not seem to be a general effect of bilingualism. The societal status of a language might further influence the use of such markers in digital informal writing. Language-specific developments that relate to emerging functions indicate that functional versatility promotes frequent use of (graphical) DMs. (shrink)

The urgency of the research is that the simulacra of the virtual-online culture of the information society and the conditions for its formation are analyzed. The term "simulacrum" by J. Baudrillard is related to the virtual-online culture of the information society, because a person uses substitutes, copies of things, and not their originals. Setting objectives. This problem is caused by the fact that today the personality is formed in an artificially created virtual world that distorts the personality and forms its (...) torn and inappropriate image. This type of society as a virtual-online one needs its interpretation and analysis of a new conceptual-categorical apparatus. Analysis of recent research and publications. These are works by J. Baudrillard "Simulacra and simulations", as well as R. Simmel, R. Bart, R. Deborah, G. Bataille, G. Lacan, M. McLuhan, M. Foucault, G. Deleuzae, J. Derrida.The questions of the philosophy of postmodernism and the theory of simulacra of J. Baudrillard are considered in the works of such researchers: A. Gritsanov, N. Katsuk, A. Dyakov, N. Zinchenko, N. Mankovskaya, O. Pechenkina, O. Scalatska, V. Ferroni and others. The question of the simulacrum is considered by J. Baudrillard in a number of works: "Symbolic Exchange and Death", "Seduction", "Simulacra and Simulation", "Transparency of Evil" and others. The selection of unexplored parts of the general problem is the conceptualization of the concept of "simulacrum" and its discovery in the virtual-online information society. The basis of the research is the conceptualization of the basic patterns of simulacra and the virtual-online culture of the information society, which is a scientific novelty. Setting the objective - the usage of approaches, in particular, structural-synergistic and practical synergetic methodology that makes it possible to analyze the simulacra of postmodern as complex constuctions. Presenting main material. The analysis of formation and development of online-virtual culture of personality which uses simulacra; the definition of "simulacrum" is presented; an analysis was made of the fact that the game constituent has become a dominant component of the modern virtual world, and the game itself became a marker of the postmodern society with the performing "I"-game in the middle; the definition of "online virtual culture" is given in the context of which "I" is implemented; the network society is shown as a new type of culture of virtual reality. Conclusions - the simulacra of the virtual-online culture of the information society in the conceptual survey of postmodernists has been formed. (shrink)

Greeks of Pontian ancestry migrated, forcibly, from Pontus to Greece where they founded Pontian Greek communities, mainly in northern Greece. The rapid increase in usage of the Internet during the past years appears to be significantly affecting the activity of cultural associations in general. The Greek Pontian associations of Thrace have begun taking advantage of the Internet and social networks for their diversified activities, a “modernization” which has not been studied extensively thus far. In this paper, a corresponding analysis (...) is performed, concluding that the activity of the associations on the Internet reflects an upward trend, while an increasing number of them seek to maintain an active presence on the Internet through web sites and social networks. This activity includes primarily press conferences and informative announcements. (shrink)

Language provides rich social information about its speakers. For instance, adults and children make inferences about a speaker's social identity, geographic origins, and group membership based on her language and accent. Although infants prefer speakers of familiar languages, little is known about the developmental origins of humans’ sensitivity to language as marker of social identity. We investigated whether 9-month-olds use the language a person speaks as an indicator of that person's likely social relationships. Infants were familiarized with videos of two (...) people who spoke the same or different languages, and then viewed test videos of those two individuals affiliating or disengaging. Results suggest that infants expected two people who spoke the same language to be more likely to affiliate than two people who spoke different languages. Thus, infants view language as a meaningful social marker and use language to make inferences about third-party social relationships. (shrink)

The English discourse marker after all and the Japanese discourse marker datte have been commonly claimed to give a reason or justification to the preceding utterance, and therefore, these two expressions are regarded as the equivalent translation counterparts to each other. This paper first attempts to propose that such an equated account is motivated by these two discourse markers constructing a similar inferential schema involved in the interpretation of the utterance including them. In fact, datte and after all make (...) manifest similar polyfunctions according to the syntactic position although they encode different lexical information. This is because these two discourse markers are indicators that contribute to the inferential phase of communication by various degrees of modulation of a cognitive gap between two different assumptions. Another aim of this paper is to differentiate a procedural constraint these two indicators encode on the interpretation of the utterance. (shrink)

This summary lays out the basic science and methodology used in genetic testing that investigates historical population migrations and the ancestry of living individuals. The genetic markers used in this testing, and the distinction between Y‐chromosome, mitochrondial and autosomes analysis, are explained and the shortcomings of these methodologies are explored.

ABSTRACT This summary lays out the basic science and methodology used in genetic testing that investigates historical population migrations and the ancestry of living individuals. The genetic markers used in this testing, and the distinction between Y‐chromosome, mitochrondial and autosomes analysis, are explained and the shortcomings of these methodologies are explored.

It is a recurring mantra that epistemic must creates a statement that is weaker than the corresponding flat-footed assertion: It must be raining vs. It’s raining. Contrary to classic discussions of the phenomenon such as by Karttunen, Kratzer, and Veltman, we argue that instead of having a weak semantics, must presupposes the presence of an indirect inference or deduction rather than of a direct observation. This is independent of the strength of the claim being made. Epistemic must is therefore quite (...) similar to evidential markers of indirect evidence known from languages with rich evidential systems. We work towards a formalization of the evidential component, relying on a structured model of information states (analogous to some models used in the belief dynamics literature). We explain why in many contexts, one can perceive a lack of confidence on the part of the speaker who uses must. (shrink)

The commercialization of ‘big science’ is in full swing, leading to situations in which the ethical principles of academia are beginning to be compromised. This is exemplified by the profitable business of genetic ancestry testing. The goals of this sort of ‘big science’ are not necessarily in any way novel, however. In particular, large genotyping projects have a certain start‐up time when their design is frozen in, so that the projects often lag behind the development of genetic knowledge. On (...) the other hand, extremely provisional knowledge about potential disease markers is being rapidly turned into questionable ‘tests’, purporting to determine risk factors for complex disorders, by private companies that are eager to get their share of a profitable market of the future. The flow of money generated by such concerns looks likely to erode traditional research operations and small‐scale projects, which risk becoming pebbles on the ‘big science’ landscape. BioEssays 30:1246–1251, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

"This rich compendium on the lives and doctrines of philosophers ranges over three centuries, from Thales to Epicurus (to whom the whole tenth book is devoted); 45 important figures are portrayed. Diogenes Laertius carefully compiled his information from hundreds of sources and enriches his accounts with numerous quotations. Diogenes Laertius lived probably in the earlier half of the 3rd century CE, his ancestry and birthplace being unknown. His history, in ten books, is divided unscientifically into two 'Successions' or sections: (...) 'Ionian' from Anaximander to Theophrastus and Chrysippus, including the Socratic schools; 'Italian' from Pythagoras to Epicurus, including the Eleatics and sceptics. It is a very valuable collection of quotations and facts." -- Publisher description. (shrink)

Historical sciences like evolutionary biology reconstruct past events by using the traces that the past has bequeathed to the present. Markov chain theory entails that the passage of time reduces the amount of information that the present provides about the past. Here we use a Moran process framework to show that some evolutionary processes destroy information faster than others. Our results connect with Darwin’s principle that adaptive similarities provide scant evidence of common ancestry whereas neutral and deleterious similarities do (...) better. We also describe how the branching in phylogenetic trees affects the information that the present supplies about the past. (shrink)

In this paper, it will be argued that each time a procedure in a representational system is functioning adequately and automatically, the child steps up to a metaprocedural level and considers the procedure as a unit in its own right. Data will be drawn from microdevelopment in children's creation of external memory devices (i.e., changes in representation of a spatial task during a one hour's session) as well as from macrodevelopment in language acquisition (i.e., changes occurring over age in a (...) study of nominal determiners, pronouns and gender markers). These two aspects of development of representational systems are examined with respect to the spontaneous passage from concrete reference to abstract systems, from idiosyncratic to conventional notations, from redundant to economic marking, from unifunctional to plurifunctional meaningful units. These micro‐ and manodevelopmental changes take place in a spontaneous fashion despite the fact that the child's earlier system is adequate for successfully conveying the information required. A discussion will be made of the way in which children tend to indicate externally, by unifunctional markers, information which was implicit in their earlier use of an adult‐like system. They appear to be striving for the delicate balance between encoding and decoding efforts, ultimately leading to a felicitous representational system. Metaprocedural behavior is hypothesized to act as a control mechanism in the striving for this delicate balance of information content and information processing effort. It also appears to act as a control mechanism for the interprocedural organizotion of what was previously a plethora of juxtaposed, unconnected procedures yielding superficially analogous behavior. The stepping‐up to a metaprocedural level seems to occur each time the child has a handle on his currently functioning, goal‐oriented system. This enables the child to treat the system, or procedures which are part thereof, as units functioning in their own right. Thus there appears to be a deep‐rooted psychological tendency for a representational tool which functions well procedurally to become subsequently a problem‐space per se. (shrink)