When the use of CRIsPR-Cas9 to edit DNA was first reported in 2012, it was quickly heralded by scientists, policymakers, and journalists as a transformative technology. CRISPR-Cas9 provides the means to change DNA in ways that either were not generally possible using previous genetic technologies or that were orders of magnitude more laborious or inefficient to undertake. CRISPR's possible applications were readily apparent and seemingly endless, from supercharging laboratory research to modifying insects that transmit disease to eliminating genetic conditions. By (...) 2015, Wired magazine was calling the discovery "The Genesis Engine."Against a backdrop of disappointing results from gene transfer... (shrink)
International uproar followed the recent announcement of the birth of twin girls whose genomes had been edited with a breakthrough DNA editing-technology. This technology, called clustered regularly interspaced short palindrome repeats or CRISPR-Cas9, can alter any DNA, including DNA in embryos, meaning that changes can be passed to the offspring of the person that embryo becomes. Should we use gene editing technologies to change ourselves, our children, and future generations to come? The potential uses of CRISPR-Cas9 and other gene editing (...) technologies are unprecedented in human history. By using these technologies, we eradicate certain dreadful diseases. Altering human DNA, however, raises enormously difficult questions. Some of these questions are about safety: Can these technologies be deployed without posing an unreasonable risk of physical harm to current and future generations? Can all physical risks be adequately assessed, and responsibly managed? But gene editing technologies also raise other moral questions, which touch on deeply held, personal, cultural, and societal values: Might such technologies redefine what it means to be healthy, or normal, or cherished? Might they undermine relationships between parents and children, or exacerbate the gap between the haves and have-nots? The broadest form of this second kind of question is the focus of this book: What might gene editing--and related technologies--mean for human flourishing? In the new essays collected here, an interdisciplinary group of scholars asks age--old questions about the nature and well-being of humans in the context of a revolutionary new biotechnology--one that has the potential to change the genetic make-up of both existing people and future generations. Welcoming readers who study related issues and those not yet familiar with the formal study of bioethics, the authors of these essays open up a conversation about the ethics of gene editing. It is through this conversation that citizens can influence laws and the distribution of funding for science and medicine, that professional leaders can shape understanding and use of gene editing and related technologies by scientists, patients, and practitioners, and that individuals can make decisions about their own lives and the lives of their families. (shrink)
One argument Robert and Baylis do not raise in their article on the creation of interspecies chimeras using human cellular material is that the creation of these chimeras would, or could, offend human dignity. Yet, human dignity is one of the most common concerns raised in public debates, academic arguments, and policy documents regarding biotechnology in general, and the creation animal-human chimeras in particular. … The concept is ill-defined within bioethics and … risks being dismissed as meaningless or uselessly vague. (...) However, this lack of definition should not yet cause us to abandon or ignore human dignity. At least in arguments about creating chimeras, an examination of what may be meant by appeals to human dignity can uncover important concerns or arguments that are not captured by other formulations of the debate. (shrink)
In July 2000, the Seminole Nation of Oklahoma passed a resolution that would effectively expel a significant portion of its tribal members. The resolution amended the Nation's constitution by changing its membership criteria. Previously, potential members needed to show descent from an enrollee of the 1906 Dawes Rolls, the official American Indian tribal rolls established by the Dawes Commission to facilitate the allotment of reservation land. The amended constitution requires possession of one-eighth Seminole Indian blood, a requirement that a significant (...) portion of the tribe's membership cannot fulfill. The members of the Nation who fail to meet this new membership criterion all have one thing in common: they are black.Descendents of former slaves who came to live among the Seminole Indians of Florida in the seventeenth and eighteenth centuries, the black Seminoles have been officially recognized by the U.S. government as members of the Seminole Nation of Oklahoma since 1866. (shrink)
In July 2000, the Seminole Nation of Oklahoma passed a resolution that would effectively expel a significant portion of its tribal members. The resolution amended the Nation's constitution by changing its membership criteria. Previously, potential members needed to show descent from an enrollee of the 1906 Dawes Rolls, the official American Indian tribal rolls established by the Dawes Commission to facilitate the allotment of reservation land. The amended constitution requires possession of one-eighth Seminole Indian blood, a requirement that a significant (...) portion of the tribe's membership cannot fulfill. The members of the Nation who fail to meet this new membership criterion all have one thing in common: they are black.Descendents of former slaves who came to live among the Seminole Indians of Florida in the seventeenth and eighteenth centuries, the black Seminoles have been officially recognized by the U.S. government as members of the Seminole Nation of Oklahoma since 1866. (shrink)
The theoretical value of talking to the media isn’t hard to appreciate. Who doesn’t want to shape the public conversation, whether to make it more nuanced and reasoned or to bring injustice and wrongdoing to light? Issues you’ve studied are in the news and you get to be the expert, pointing out what’s wrong, or right, or offering another way of thinking about a difficult question. If you’re lucky, you get your name in print—and in a publication your friends and (...) family actually read. But it can also be intimidating. I used to feel like the hapless witness about to be cross-examined by the wily attorney. I’d heard about the twenty-four-hour news cycle and the push to appeal to the lowest common denominator. .. (shrink)
The theoretical value of talking to the media isn’t hard to appreciate. Who doesn’t want to shape the public conversation, whether to make it more nuanced and reasoned or to bring injustice and wrongdoing to light? Issues you’ve studied are in the news and you get to be the expert, pointing out what’s wrong, or right, or offering another way of thinking about a difficult question. If you’re lucky, you get your name in print—and in a publication your friends and (...) family actually read. But it can also be intimidating. I used to feel like the hapless witness about to be cross-examined by the wily attorney. I’d heard about the twenty-four-hour news cycle and the push to appeal to the lowest common denominator.... (shrink)
چرا به دنبال بورس فروش ویلچر در تهران هستیم -/- یکی از دلایل می تواند امید به قیمت پایین تر ویلچر در محل یا سایتی باشد که با عنوان بورس فروش ویلچر خود را معرفی کرده اند. بخاطر اینکه عزیزان تصور دارند که چنین محل هایی ارزان فروش هستند که با کمال احترام به تفکر آنان تجربه ما نشان داده است که قضیه برعکس این موضوع است و دلیل آن وجود دلالان در چنین محل هایی است. آنجایی که دست دلال (...) فعالیت کند انتظار قیمت مناسب ویلچر داشتن خیال باطلی است. (shrink)
This November I spent three days in Washington, D.C., splitting my time between The March of Dimes Prematurity Prevention Conference and a National Institutes of Health meeting about the use of genome sequencing technology in newborns. The trip was a powerful reminder for me of a problem I've confronted before.
The theoretical value of talking to the media isn’t hard to appreciate. Who doesn’t want to shape the public conversation, whether to make it more nuanced and reasoned or to bring injustice and wrongdoing to light? Issues you’ve studied are in the news and you get to be the expert, pointing out what’s wrong, or right, or offering another way of thinking about a difficult question. If you’re lucky, you get your name in print—and in a publication your friends and (...) family actually read. But it can also be intimidating. I used to feel like the hapless witness about to be cross-examined by the wily attorney. I’d heard about the twenty-four-hour news cycle and the push to appeal to the lowest common denominator... (shrink)
The theoretical value of talking to the media isn’t hard to appreciate. Who doesn’t want to shape the public conversation, whether to make it more nuanced and reasoned or to bring injustice and wrongdoing to light? Issues you’ve studied are in the news and you get to be the expert, pointing out what’s wrong, or right, or offering another way of thinking about a difficult question. If you’re lucky, you get your name in print—and in a publication your friends and (...) family actually read. But it can also be intimidating. I used to feel like the hapless witness about to be cross-examined by the wily attorney. I’d heard about the twenty-four-hour news cycle and the push to appeal to the lowest common denominator... (shrink)
ABSTRACTThe attempts of scholars and scientists to unravel the mystery of the ancestral origins of the Lemba are summarised, focusing on Tudor Parfitt's book, Journey to the Vanished City, and a study by an international group of genetic and social scientists. The impact of this research on identity questions is raised.
