Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

This book introduces generative grammar as an area of study and asks what it tells us about the human mind. Wolfram Hinzen lays the foundation for the unification of modern generative linguistics with the philosophies of mind and language. He introduces Chomsky's program of a 'minimalist' syntax as a novel explanatory vision of the human mind. He explains how the Minimalist Program originated in work in cognitive science, biology, linguistics, and philosophy, and examines its implications for work in these (...) fields. He considers the way the human mind is designed when seen as an arrangement of structural patterns in nature, and argues that its design is the product not so much of adaptive evolutionary history as of principles and processes that are ahistorical and internalist in character. Linguistic meaning, he suggests, arises in the mind as a consequence of structures emerging on formal rather than functional grounds. From this he substantiates an unexpected and deeply unfashionable notion of human nature. Clearly written in nontechnical language and assuming a limited knowledge of the fields it examines and links, Minimal Mind Design will appeal to a wide range of scholars in linguistics, philosophy, and cognitive science. It also provides an exceptionally clear insight into the nature and aims of Chomsky's Minimalist Program. (shrink)

This interdisciplinary book considers the relationship between language and thought from a philosophical perspective, drawing both on the philosophical study of language and the purely formal study of grammar, and arguing that the two should align. The claim is that grammar provides homo sapiens with the ability to think in certain grammatical ways and that this in turn explains the vast cognitive powers of human beings. Evidence is considered from biology, the evolution of language, language disorders, and linguistic phenomena.

This pioneering book lays new foundations for the study of reference and truth.

Properly understood, Kant’s moral philosophy is incompatible with constitutivism. According to the constitutivist, being subject to the moral law cannot be a matter of free choice, and failure to c...

Philosophie ist wissentlicher Einhegungsversuch des Nichtwissens. Wo immer sie daher die Bedeutung und Wirksamkeit des Nichtwissens nicht präsent hält, verfehlt sie ihre Mitte. Das hat sich seit der Antike bis heute nicht geändert. Allerdings blieb es den Interessen der Zeiten und Denker vorbehalten, die Mischformen von Wissen und Nichtwissen in ihrer Eigenart mehr oder weniger eingehend zu analysieren. Selbst wenn die sokratische Formel vom Wissen des Nichtwissens durchgängig gerne zitiert wurde: Wie die Formen des Wissens in ihren schwachen, aber unentbehrlichen (...) Variationen näherhin zu charakterisieren sind, hat über die Zeiten die Philosophen eher selten interessiert. Aber diese schwachen Formen des Wissens wie Ahnung, Mutmaßung und das Gefühl als Grundlage von Situationseinschätzungen sind für unseren Alltag von erheblicher Bedeutung. Wolfram Hogrebe diskutiert in seinem Buch Formen des Wissens in ihrer szenischen Relevanz, ja das Szenische als Wissensform selbst. Ein von der Philosophie bislang völlig ignoriertes Thema. Aber die Philosophie kann gar nicht ignorieren, ohne dennoch auch in ihrem Absehen noch etwas Mitgesehenes hervortreten zu lassen. (shrink)

Mind–body dualism has rarely been an issue in the generative study of mind; Chomsky himself has long claimed it to be incoherent and unformulable. We first present and defend this negative argument but then suggest that the generative enterprise may license a rather novel and internalist view of the mind and its place in nature, different from all of, (i) the commonly assumed functionalist metaphysics of generative linguistics, (ii) physicalism, and (iii) Chomsky’s negative stance. Our argument departs from the empirical (...) observation that the linguistic mind gives rise to hierarchies of semantic complexity that we argue (only) follow from constraints of an essentially mathematical kind. We assume that the faculty of language tightly correlates with the mathematical capacity both formally and in evolution, the latter plausibly arising as an abstraction from the former, as a kind of specialized output. On this basis, and since the semantic hierarchies in question are mirrored in the syntactic complexity of the expression involved, we posit the existence of a higher-dimensional syntax structured on the model of the hierarchy of numbers, in order to explain the semantic facts in question. If so, syntax does not have a physicalist interpretation any more than the hierarchy of number-theoretic spaces does. (shrink)

Die Reihe Monographien und Texte zur Nietzsche-Forschung setzt seit mehreren Jahrzehnten die Agenda in der sich stetig verändernden Nietzsche-Forschung. Die Bände sind interdisziplinär und international ausgerichtet und spiegeln das gesamte Spektrum der Nietzsche-Forschung wider, von der Philosophie über die Literaturwissenschaft bis zur politischen Theorie. Die Reihe veröffentlicht Monographien und Sammelbände, die einem strengen Peer-Review-Verfahren unterliegen. Die Buchreihe wird von einem internationalen Redaktionsteam geleitet.

In der Wissenschaftstheorie des letzten halben Jahrhunderts stand in alter Tradition stets die Frage im Vordergrund, welche Anforderungen an Meinungen gestellt werden mussen, um sie als Wissen im Sinne der Wissenschaften zu qualifizieren. Nachdem gezeigt wurde, dass sich auch zu den anspruchsvollsten Kriterien des Wissens immer noch Gegenbeispiele anfuhren lassen, die wir im intuitiven Sinne nicht als Kandidaten fur Wissen bezeichnen wurden, konnte man sich dahingehend zufrieden geben, dass wir zwar nicht uber garantierende, wohl aber uber autorisierende Kriterien fur Wissen (...) verfugen. Damit war andererseits klar, dass Formen des Nichtwissens in der Philosophie notwendig prasent bleiben. Die vorliegende Arbeit tastet die Spielraume, in denen ein Nichtwissen geradezu konstitutiv ist - also Zonen geschichtlicher Vergewisserung im Gegenwartigen, auch Zonen heuristischer Bemuhungen im Alltag und im Vorfeld von Wissenschaften - ab und analysiert sie in cusanischer Tradition als Mischformen von Wissen und Nichtwissen.". (shrink)

This chapter explores some fundamental consequences of the correspondence between physical process and computations. Most physical questions may be answerable only through irreducible amounts of computation. Those that concern idealized limits of infinite time, volume, or numerical precision can require arbitrarily long computations, and so be considered formally undecidable. The behavior of a physical system may always be calculated by simulating explicitly each step in its evolution. Much of theoretical physics has, however, been concerned with devising shorter methods of calculation (...) that reproduce the outcome without tracing each step. Computational irreducibility is common among the systems investigated in mathematics and computation theory, but it may well be the exception rather than the rule, since most physical questions may be answerable only through irreducible amounts of computation. (shrink)

Dieser Band dokumentiert die Hauptvorträge des XIX. Deutschen Kongresses für Philosophie, der vom 23.-27. September 2002 in Bonn stattfand. Das Thema des Kongresses Grenzen und Grenzüberschreitungen wurde dabei hinsichtlich des gesamten Spektrums philosophischer Fragestellungen beleuchtet. So wird die aktuelle Problematik hinsichtlich der Grenzen technischer Machbarkeit und moralischer Verantwortbarkeit ebenso aufgegriffen wie klassische erkenntnis- und wissenschaftstheoretische Fragestellungen nach den Grenzen unserer kognitiven Möglichkeiten. Weitere Beiträge befassen sich mit Grenzen und Grenzüberschreitungen in der Ästhetik, Geschichtsphilosophie, Kulturphilosophie, Metaphysik, Philosophie des Geistes, Philosophie der (...) Logik und Mathematik, der politischen Philosophie sowie der Religionsphilosophie. Der historischen Dimension des Themas wird ebenfalls Rechnung getragen und zugleich die Diskussion von Grenzen und Grenzüberschreitungen durch die Geschichte der Philosophie zurückverfolgt. (shrink)

Since our visual perception of physical things essentially involves our identifying objects by their colours, any theory of visual perception must contain some account of the colours of things. The central problem with colour has to do with relating our normal, everyday colour perceptions to what science, i.e. physics, teaches us about physical objects and their qualities. Although we perceive colours as categorical surface properties of things, colour perceptions are explained by introducing physical properties like reflectance profiles or dispositions to (...) cause certain experiences in normal human perceivers. Hence, it seems as if colours as they are experienced by us have no place in the physical world, because they are fundamentally different from the properties which we ascribe to physical objects in scientific accounts of colour perceptions. This special issue on perspectives on colour perception presents new suggestions to solve to this major problem. (shrink)

Leading linguists and philosophers report on all aspects of compositionality, the notion that the meaning of an expression can be derived from its parts. This book explores every dimension of this field, reporting critically on different lines of research, revealing connections between them, and highlighting current problems and opportunities.

As world food and fuel prices threaten expanding urban populations, there is greater need for the urban poor to have access and claims over how and where food is produced and distributed. This is especially the case in marginalized urban settings where high proportions of the population are food insecure. The global movement for food sovereignty has been one attempt to reclaim rights and participation in the food system and challenge corporate food regimes. However, given its origins from the peasant (...) farmers' movement, La Via Campesina, food sovereignty is often considered a rural issue when increasingly its demands for fair food systems are urban in nature. Through interviews with scholars, urban food activists, non-governmental and grassroots organizations in Oakland and New Orleans in the United States of America, we examine the extent to which food sovereignty has become embedded as a concept, strategy and practice. We consider food sovereignty alongside other dominant US social movements such as food justice, and find that while many organizations do not use the language of food sovereignty explicitly, the motives behind urban food activism are similar across movements as local actors draw on elements of each in practice. Overall, however, because of the different histories, geographic contexts, and relations to state and capital, food justice and food sovereignty differ as strategies and approaches. We conclude that the US urban food sovereignty movement is limited by neoliberal structural contexts that dampen its approach and radical framework. Similarly, we see restrictions on urban food justice movements that are also operating within a broader framework of market neoliberalism. However, we find that food justice was reported as an approach more aligned with the socio-historical context in both cities, due to its origins in broader class and race struggles. (shrink)

The sense of smell in animals is the initial wellspring of all intuitions of meaning. The first art form expressing such perception is divination, or mantics. The informal mental intuitions of today s humans in the form of suspicions or guesses reveal traces of the ongoing presence of such original divination. The metaphysical aim to provide an eloquent voice for these traces may be understood as metaphysics from below.".

Der Beitrag beschäftigt sich aus problemtheoretischer Sicht zunächst mit drei Richtungen innerhalb der neueren Marx-Rezeption, mit einer gegenwärtig einsetzenden Rückbesinnung auf Marx' Kapitalismusanalyse, mit der den angelsächsischen Sprachraum auszeichnenden praktisch-ethischen Marx-Interpretation sowie mit Habermas' Rekonstruktion des Historischen Materialismus. Diese Rezeptionsrichtungen behandeln in unterschiedlicher Weise das Verhältnis von kritischer Strukturanalyse der Gesellschaft und Emanzipationskonzept, wobei sich die Tendenz zeigt, dass beide von Marx zusammengedachten Theoriekomponenten voneinander abgetrennt werden. Um beide Seiten perspektivisch wieder zusammenzuführen, wird sich in einem zweiten Schritt dem Marxschen (...) Ansatz zugewandt, der in erweiterter Form im Spiegel der sozialanthropologischen Wende Feuerbachs beleuchtet wird. Dessen Wende zum Grundprinzip sozialer Relationalität wird hier als ein unausgeschöpftes theoriegeschichtliches Potenzial angesehen, das eine weitergehende Lösung hinsichtlich der aufgerollten Problematik birgt. (shrink)

The view that proper names are uniformly predicates has recently gained prominence. I review linguistic evidence against it. Overall, the linguistic evidence suggests that proper names function as predicates when they appear in a grammatically predicative position and as referential expressions when they are grammatically in a referential position. Conceptual grounds on which the predicativist view might nonetheless be upheld include ‘uniformity’, i.e., that a single semantic value be lexically specified for names in all of their occurrences irrespective of differences (...) in their grammar. However, ‘being a predicate’ or ‘being referential’ are not lexical properties of words but indications for how these grammatically function on an occasion of their use. Moreover, the intuitively referential and intuitively predicative uses of proper names precisely covary with grammatical differences. A proper name is therefore a predicate when it is predicatively used, not when its grammar and meaning are different. Given this grammar-meaning alignment there is no motivation to posit a novel ‘covert syntax’ for names in their referential uses, which breaks this alignment. Cross-linguistic evidence from languages such as Catalan, which features overt determiners in referential uses of proper names, moreover turns out to strongly support the view that the grammar of human language is systematically sensitive to differences in the referential and predicative uses of names. (shrink)

A traditional view maintains that thought, while expressed in language, is non-linguistic in nature and occurs in non-linguistic beings as well. I assess this view against current theories of the evolutionary design of human grammar. I argue that even if some forms of human thought are shared with non-human animals, a residue remains that characterizes a unique way in which human thought is organized as a system. I explore the hypothesis that the cause of this difference is a grammatical way (...) of structuring semantic information, and I present evidence that the organization of grammar precisely reflects the organization of a specific mode of thought apparently distinctive of humans. Since there appears to be no known non-grammatical structuring principle for the relevant mode of thought, I suggest that grammar is that principle, with no independent ?Language of Thought? needed. (shrink)