Der Zeichnung kommt im Trecento nicht allein in der Praxis, sondern auch als theoretisches Fundament einer „wissenschaftlich“ akzeptierbaren ars eine zentrale Rolle zu. Sie ist Medium der Bewahrung und Erneuerung, zudem auch unverzichtbares Kommunikationsmittel in den verschiedenen öffentlichen Bau- und Ausstattungsprogrammen zwischen Mailand, Florenz und Siena. An Cennino Cenninis umfassendem Praxishandbuch, dem ‚Libro dell′arte‘, sowie an einigen Beispielen der Zeichenkunst um 1400, lässt sich ablesen, dass disegno nicht allein die lernende Nachahmung und den Naturabzug, sondern auch den Auszug aus den (...) gespeicherten Sinneseindrücken meinen kann. Vor allem aber wird durch Cenninis Rede vom „Zeichen in deinem Kopf“ der graphische Akt zur Metapher der Neugestaltung der memorierten Bilddaten durch die vis imaginativa der Fantasie. Die Spuren dieser dem Werkstattgespräch entnommenen bildkünstlerischen Fachterminologie reichen allerdings weit zurück und lassen sich über Francesco Petrarca, die Dante-Kommentatoren und Dante selbst bis in die Zeit um 1300 verfolgen. Bereits in der ‚Vita Nuova‘ kann Dante mit dem terminus technicus „disegnare“ in komplexer allegorischer Rede die Fantasie als kreative Arbeit mit dem Gedächtnis hervorheben und mit einer solchen intermedialen Brechung wirkungsvoll vom verdeutlichenden Hervorbringen eines deutenden inneren Bildes durch die ekphrastisch gesteigerte literarische Repräsentation sprechen. (shrink)

Cells mitigate the detrimental consequences of DNA damage on genome stability by attempting high fidelity repair. Homologous recombination templates DNA double‐strand break (DSB) repair on an identical or near identical donor sequence in a process that can in principle access the entire genome. Other physiological processes, such as homolog recognition and pairing during meiosis, also harness the HR machinery using programmed DSBs to physically link homologs and generate crossovers. A consequence of the homology search process by a long nucleoprotein filament (...) is the formation of multi‐invasions (MI), a joint molecule in which the damaged ssDNA has invaded more than one donor molecule. Processing of MI joint molecules can compromise the integrity of both donor sites and lead to their rearrangement. Here, two mechanisms for the generation of rearrangements as a pathological consequence of MI processing are detailed and the potential relevance for non‐allelic homologous recombination discussed. Finally, it is proposed that MI‐induced crossover formation may be a feature of physiological recombination. (shrink)

Summary A large survey of German and Israeli younger and older adolescents was conducted to reveal their opinions and attitudes towards violence and aggression, their personal engagement in aggressive and violent behaviors in and outside the school environment, their attitudes toward physical activity, their engagement in physical activity, and the linkage between physical activity engagement and conductance of violence and aggression. The findings point out that there are more similarities than differences between German and Israeli adolescents concerning violence and aggression (...) in and outside schools. No linkage between physical activity involvement and the extent of violent and/or aggressive acts is found. The findings pertaining adolescents’ opinions and attitudes toward aggression and violence and their behaviors in and outside school are encouraging. (shrink)

Dietrich Bonhoeffer's theology has bad a role in the development ofthe Protestant Churches in the GDR which was not at all unimportant. Wolf Krötke has a closer look at the reception of Bonhoeffer in the GDR. He describes Bonhoeffer in wide perspectives. They range from a socialist demand on the one hand up to critical claims against socialism on the other hand. In these perspectives the slogan of »Kirche im Sozialismus« plays a prominent and at the same time (...) problematic role. Krötke's study demands a critical inventary of the Bonhoeffer-reception in the GDR and gives a first and cautious contribution to this analysis. (shrink)

Die folgende Bibliographie wurde erstellt auf Anregungen mehrerer Autoren aus der ehemaligen DDR auf der vom APC organisierten Diskussionsrunde „Perspektiven der Philosophie der Chemie“ im November 1995 in der Humboldt-Universität Berlin (s. Mitteilungsblatt 1 (1995)). Im Sinne einer „unzensierten“ Bestandsaufnahme soll sie einen Überblick über chemiephilosophische Aktivitäten der DDR für sowohl systematische Anknüpfungen als auch philosophiehistorische Forschungen bieten. Unter den ebenfalls zahlreich vorliegenden chemiehistorischen Arbeiten sind nur ausgewählte begriffs-, theorien- und disziplinenhistorische sowie philosophiehistorisch relevante Texte berücksichtigt. Ebenfalls aufgenommen sind einige (...) chemiedidaktische Texte mit weltanschaulich-philosophischen oder erkenntnistheoretischen Inhalten. Das thematische Spektrum ist zwar weitgehend auf theoretisch-philosophische Fragen beschränkt, aber hierin durchaus weit gefächert. Hinsichtlich der wissenschaftlichen Originalität und Qualität sind ganz beträchtliche Differenzen festzustellen. Es bleibt dem Leser überlassen, zwischen den zahlreichen Kurzbemerkungen und Paraphrasierungen „offizieller“ Grundsätze des dialektischen Materialismus diejenigen Forschungsarbeiten zu selektieren, die eigenständig reflektierend chemiephilosophisches Neuland beschreiten und eine Grundlage für weitere Forschungen darstellen sollten. Die Bibliographie wurde z.T. aus Angaben der Autoren, überwiegend jedoch durch eigene Recherchen in Bibliographien, den Inhaltverzeichnissen diverser Zeitschriften sowie den Katalogbeständen der Deutschen Bibliothek Leipzig erstellt. Die Angaben sind zum größten Teil kontrolliert und vervollständigt. Mein Dank gilt Prof. Dr. Hubert Laitko (Berlin), Prof. Dr. Gustav Kertscher (Mühlhausen), Dr. Alfred Neubauer (Berlin), Dr. Reinhardt Pester (Berlin), Dr. habil. Horst Remane (Halle), Dr. Wolf-Dietrich Sprung (Rostock) für die Bereitstellung von Veröffentlichungsverzeichnissen sowie insbesondere Prof.. (shrink)

A unique and interdisciplinary collection in which scholars from Philosophy join those from Film Studies, English, and Comparative Literature to explore the nature and limits of love through in-depth reflection on particular works of literature and film.

Bringing these two emergent areas of thought into direct conversation in Before the Law, Cary Wolfe fosters a new discussion about the status of nonhuman animals and the shared plight of humans and animals under biopolitics.

My topic is the materialist appropriation of empiricism – as conveyed in the ‘minimal credo’ nihil est in intellectu quod non fuerit in sensu (which interestingly is not just a phrase repeated from Hobbes and Locke to Diderot, but is also a medical phrase, used by Harvey, Mandeville and others). That is, canonical empiricists like Locke go out of their way to state that their project to investigate and articulate the ‘logic of ideas’ is not a scientific project: “I shall (...) not at present meddle with the Physical consideration of the Mind” (Essay, I.i.2, in Locke 1975; which Kant gets exactly wrong in his reading of Locke, in the Preface to the A edition of the first Critique). Indeed, I have suggested elsewhere, contrary to a prevalent reading of Locke, that the Essay is not the extension to the study of the mind of the methods of natural philosophy; that he is actually not the “underlabourer” of Newton and Boyle he claims politely to be in the Epistle to the Reader (Wolfe and Salter 2009, Wolfe 2010). Rather, Locke says quite directly if we pay heed to such passages, “Our Business here is not to know all things, but those which concern our Conduct” (Essay, I.i.6). There would be more to say here about what this implies for our understanding of empiricism (see Norton 1981 and Gaukroger 2005), but instead I shall focus on a different aspect of this episode: how a non-naturalistic claim which falls under what we now call epistemology (a claim about the senses as the source of knowledge) becomes an ontology – materialism. That is, how an empiricist claim could shift from being about the sources of knowledge to being about the nature of reality (and/or the mind, in which case it needs, as David Hartley saw and Denis Diderot proclaimed more overtly, an account of the relation between mental processes and the brain). (David Armstrong, for one, denied that there could be an identification between empiricism and materialism on this point: eighteenth-century history of science seems to prove him wrong: see Armstrong 1968 and 1978.) Put differently, I want to examine the shift from the logic of ideas in the seventeenth century (Locke) to an eighteenth-century focus on what kind of ‘world’ the senses give us (Condillac), to an assertion that there is only one substance in the universe (Diderot, giving a materialist cast to Spinozism), and that we need an account of the material substrate of mental life. This is neither a ‘scientific empiricism’ nor a linear developmental process from philosophical empiricism to natural science, but something else again: the unpredictable emergence of an ontology on empiricist grounds. (shrink)

While the idea of philosophy as conceptual analysis has attracted many adherents and undergone a number of variations, in general it suffers from an authority problem with two dimensions. First, it is unclear why the analysis of a concept should have objective authority: why explicating what we mean should express how things are. Second, conceptual analysis seems to lack intersubjective authority: why philosophical analysis should apply to more than a parochial group of individuals. I argue that Hegel’s conception of social (...) ontology, focused on his concept of “ethical life” (Sittlichkeit), helps to explain how concepts (and their explication) have both objective and intersubjective authority in the social domain. Hegel claims that modern institutions are the product of self-conscious purposes, so that they are conceptually constituted. Concepts do not just represent these objects and so depend on a contingent relation to them. As many contemporary social ontologists agree, this means that our concepts of these institutions are uniquely epistemically “transparent.” They have objective authority. Concepts have intersubjective authority in the modern world as well, according to Hegel. However, I show that this feature of Hegel’s account does not rely on the solution to a philosophical problem. Rather, since the concepts of modern ethical life are “essentially contested,” their content depends on the practical and political agreement of modern subjects. This means that concepts can only have objective authority if some prior intersubjective agreement has been reached. The role of philosophy as conceptual analysis is thus importantly dependent on political developments. (shrink)

Robert Wolfe writes about the nature of the ajata teachings, or the nature of emptiness and absolute reality.

Sensibility, in any of its myriad realms – moral, physical, aesthetic, medical and so on – seems to be a paramount case of a higher-level, intentional property, not a basic property. Diderot famously made the bold and attributive move of postulating that matter itself senses, or that sensibility (perhaps better translated ‘sensitivity’ here) is a general or universal property of matter, even if he at times took a step back from this claim and called it a “supposition.” Crucially, sensibility is (...) here playing the role of a ‘booster’: it enables materialism to provide a full and rich account of the phenomena of conscious, sentient life, contrary to what its opponents hold: for if matter can sense, and sensibility is not a merely mechanical process, then the loftiest cognitive plateaus are accessible to materialist analysis, or at least belong to one and the same world as the rest of matter. This was noted by the astute anti-materialist critic, the Abbé Lelarge de Lignac, who, in his 1751 Lettres à un Amériquain, criticized Buffon for “granting to the body [la machine, a common term for the body at the time] a quality which is essential to minds, namely sensibility.” This view, here attributed to Buffon and definitely held by Diderot, was comparatively rare. If we look for the sources of this concept, the most notable ones are physiological and medical treatises by prominent figures such as Robert Whytt, Albrecht von Haller and the Montpellier vitalist Théophile de Bordeu. We then have, or so I shall try to sketch out, an intellectual landscape in which new – or newly articulated – properties such as irritability and sensibility are presented either as an experimental property of muscle fibers, that can be understood mechanistically (Hallerian irritability, as studied recently by Hubert Steinke and Dominique Boury) or a property of matter itself (whether specifically living matter as in Bordeu and his fellow montpelliérains Ménuret and Fouquet, or matter in general, as in Diderot). I am by no means convinced that it is one and the same ‘sensibility’ that is at issue in debates between these figures (as when Bordeu attacks Haller’s distinction between irritability and sensibility and claims that ‘his own’ property of sensibility is both more correct and more fundamental in organic beings), but I am interested in mapping out a topography of the problem of sensibility as property of matter or as vital force in mid-eighteenth-century debates – not an exhaustive cartography of all possible positions or theories, but an attempt to understand the ‘triangulation’ of three views: a vitalist view in which sensibility is fundamental, matching up with a conception of the organism as the sum of parts conceived as little lives (Bordeu et al.); a mechanist, or ‘enhanced mechanist’ view in which one can work upwards, step by step from the basic property of irritability to the higher-level property of sensibility (Haller); and, more eclectic, a materialist view which seeks to combine the mechanistic, componential rigour and explanatory power of the Hallerian approach, with the monistic and metaphysically explosive potential of the vitalist approach (Diderot). It is my hope that examining Diderot in the context of this triangulated topography of sensibility as property sheds light on his famous proclamation regarding sensibility as a universal property of matter. (shrink)

A chapter on the specifically 'medical' Epicureanism of La Mettrie, connecting his materialist approach to mind-body issues and his hedonistic ethics.

In the Transcendental Aesthetic (TA), Kant is typically held to make negative assertations about “things in themselves,” namely that they are not spatial or temporal. These negative assertions stand behind the “neglected alternative” problem for Kant’s transcendental idealism. According to this problem, Kant may be entitled to assert that spatio-temporality is a subjective element of our cognition, but he cannot rule out that it may also be a feature of the objective world. In this paper, I show in a new (...) way how Kant’s view (focusing on his conclusions about space) is not subject to this objection, by showing that he does not make the denial about mind-independent reality that he is typically held to make. The argument develops consequences of a new reading of Kant’s expression “an sich selbst” (‘in itself’; ‘in themselves’). I argue that “an sich selbst” or “per se” has a special, judgment-level role, so that this expression does not form new noun-terms adjectivally. It follows that the conceptual unit of Kant’s “Conclusions” in the TA is simply “things” (Dinge), since “things in themselves” is not a nominal expression; Kant adopts the Wolffian ontological use of “thing” as the basic kind-term for any existent. The arguments that things per se are not in space are arguments that space cannot be a necessary property or relations of things as a kind. I show that this does not involve the positive claim about mind-independent reality that inspires the neglected alternative objection. (shrink)

Well prior to the invention of the term ‘biology’ in the early 1800s by Lamarck and Treviranus (and lesser-known figures in the decades prior), and also prior to the appearance of terms such as ‘organism’ under the pen of Leibniz and Stahl in the early 1700s, the question of ‘Life’, that is, the status of living organisms within the broader physico-mechanical universe, agitated different corners of the European intellectual scene. From modern Epicureanism to medical Newtonianism, from Stahlian animism to the (...) discourse on the ‘animal economy’ in vitalist medicine, models of living being were constructed in opposition to ‘merely anatomical’, structural, mechanical models. It is therefore striking that the classic narratives of the Scientific Revolution conspicuously avoid any consideration of what status to grant living beings in a newly physicalized universe (I discuss this in Wolfe 2011, 2019 chapt. 1). Neither Harvey, nor Boyle, nor Locke (to name some likely candidates, the latter having studied with Willis and collaborated with Sydenham) ever ask what makes organisms unique, or conversely, what does not. In this chapter I seek to establish how something we might call ‘the knowledge of Life’, to use an expression of Georges Canguilhem’s, emerged as part of early modernity without being part of the mainstream history of life science. This leads to the question, can one can correlate early modern “knowledge of life” with the emergence of a science called ‘biology’? (see Zammito 2018, Wolfe 2019, Bognon-Küss and Wolfe eds. 2019). It was once fashionable to speak of, e.g. ‘precursors of Darwin’, and then Canguilhem and Foucault famously did away with the category of precursor. But how then do we account for the phase that precedes the constitution of a science? With the case of biology, how do we account for the increasing fascination with the ontology of Life during the decades prior to the ‘naming of biology’, as McLaughlin has called it, at the end of the eighteenth century? This increased focus on Life and the ontology of Life sits awkwardly, both with mainstream narratives of the Scientific Revolution and of the history of biology. In seeking to address this increased focus (in which vitalism plays a role but was by no means the only conceptual actor: Wolfe 2020), I critically examine Foucault’s notorious claim (Foucault 1966) that there was no such thing as ‘Life’ in the eighteenth century and thus no such thing as biology. (shrink)

A textbook on the principles of logical reasoning and scientific method, including chapters covering topics such as argumentation, inductive and deductive reasoning, and scientific observation and experimentation. The book is intended for students of philosophy, logic, and the natural sciences. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. (...) Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

This illuminating introduction to Nietzsche's thought is the substance of a course of three lectures delivered by Wolf at the University of London, University College in February 1915. This study provides a comprehensive and helpful summary of the key elements in Nietzshe's writings.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)